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Book: Liver and pancreatobiliary surgery

Sutcliffe, Robert P.

with liver transplantation

(Oxford specialist handbooks in surgery)

2010

Author's details	Robert P. Sutcliffe
Series title	Oxford specialist handbooks in surgery
Language	English
Size	XVII, 295 S. : Ill., graph. Darst.
Publisher	Oxford Univ. Press
Publishing place	Oxford
Publishing country	Great Britain
Document type	Book
HBZ-ID	HT016130004
ISBN	978-0-19-920538-7 ; 0-19-920538-8
Database	Catalogue ZB MED Medicine, Health

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Article ; Online: Current postoperative nutritional practice after pancreatoduodenectomy in the UK: national survey and snapshot audit.

Halle-Smith, James M / Pathak, Samir / Frampton, Adam / Pandanaboyana, Sanjay / Sutcliffe, Robert P / Davidson, Brian R / Smith, Andrew M / Roberts, Keith J

BJS open

2024 Volume 8, Issue 2

MeSH term(s)	Humans ; Pancreaticoduodenectomy ; Practice Patterns, Physicians' ; Medical Audit ; United Kingdom
Language	English
Publishing date	2024-03-20
Publishing country	England
Document type	Journal Article
ISSN	2474-9842
ISSN (online)	2474-9842
DOI	10.1093/bjsopen/zrae021
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Article ; Online: Pancreatic anastomosis training models: Current status and future directions.

Joshi, Kunal / Espino, Daniel M / Shepherd, Duncan Et / Mahmoodi, Nasim / Roberts, Keith J / Chatzizacharias, Nikolaos / Marudanayagam, Ravi / Sutcliffe, Robert P

Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.

2024

Abstract: Postoperative pancreatic fistula (POPF) is a major cause of morbidity and mortality after pancreatoduodenectomy (PD), and previous research has focused on patient-related risk factors and comparisons between anastomotic techniques. However, it is ... ...

Abstract	Postoperative pancreatic fistula (POPF) is a major cause of morbidity and mortality after pancreatoduodenectomy (PD), and previous research has focused on patient-related risk factors and comparisons between anastomotic techniques. However, it is recognized that surgeon experience is an important factor in POPF outcomes, and that there is a significant learning curve for the pancreatic anastomosis. The aim of this study was to review the current literature on training models for the pancreatic anastomosis, and to explore areas for future research. It is concluded that research is needed to understand the mechanical properties of the human pancreas in an effort to develop a synthetic model that closely mimics its mechanical properties. Virtual reality (VR) is an attractive alternative to synthetic models for surgical training, and further work is needed to develop a VR pancreatic anastomosis training module that provides both high fidelity and haptic feedback.
Language	English
Publishing date	2024-04-01
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2056680-3
ISSN	1424-3911 ; 1424-3903
ISSN (online)	1424-3911
ISSN	1424-3903
DOI	10.1016/j.pan.2024.03.020
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Article ; Online: Can preoperative Carbohydrate Antigen 19-9 predict metastatic pancreatic cancer? Results of a systematic review and meta-analysis.

Raza, Syed S / Khan, Hala / Hajibandeh, Shahab / Hajibandeh, Shahin / Bartlett, David / Chatzizacharias, Nikolaos / Roberts, Keith / Marudanayagam, Ravi / Sutcliffe, Robert P

HPB : the official journal of the International Hepato Pancreato Biliary Association

2024

Abstract: ... 95 % CI, 642.08-1166.74, P < 0.0001). The between-study heterogeneity was significant ...

Abstract	Background: To investigate the relationship between preoperative Carbohydrate Antigen19-9(CA19-9)and pancreatic cancer occult metastasis. Methods: Systematic search of MEDLINE, CENTRAL, Web of Science and bibliographic reference lists were conducted. All comparative observational studies investigating the predictive ability of preoperative CA 19-9 in patients with pancreatic cancer were considered. Mean CA-19-9 value in the pancreatic cancer patients with and without metastasis were evaluated. Best cut-off value of CA 19-9 for metastasis was determined using ROC analysis. Results: Ten comparative observational studies reporting a total of 1431 pancreatic cancer patients with (n = 496) and without (n = 935) metastasis were included. Subsequent meta-analysis demonstrated that mean preoperative CA 19-9 level was significantly higher in patients with metastases compared to those without (MD: 904.4; 95 % CI, 642.08-1166.74, P < 0.0001). The between-study heterogeneity was significant (I Conclusions: CA 19-9 level is significantly higher in patients with metastatic pancreatic cancer. A preoperative CA 19-9 value of 336 should be considered as an acceptable cut-off value to design prospective studies.
Language	English
Publishing date	2024-02-01
Publishing country	England
Document type	Journal Article
ZDB-ID	2131251-5
ISSN	1477-2574 ; 1365-182X
ISSN (online)	1477-2574
ISSN	1365-182X
DOI	10.1016/j.hpb.2024.01.017
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Article: Terlipressin versus placebo in living donor liver transplantation.

Gavriilidis, Paschalis / Hidalgo, Ernest / Sutcliffe, Robert P / Roberts, Keith J

Hepatobiliary & pancreatic diseases international : HBPD INT

2021 Volume 21, Issue 1, Page(s) 76–79

MeSH term(s)	Humans ; Liver Transplantation ; Living Donors ; Placebos ; Terlipressin/therapeutic use
Chemical Substances	Placebos ; Terlipressin (7Z5X49W53P)
Language	English
Publishing date	2021-02-13
Publishing country	Singapore
Document type	Letter
ZDB-ID	2241386-8
ISSN	1499-3872
ISSN	1499-3872
DOI	10.1016/j.hbpd.2021.02.003
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Article ; Online: Diagnosis and treatment of diaphragmatic endometriosis: results of an international patient survey.

Piccus, Rachel / Mann, Christopher / Sutcliffe, Robert P

European journal of obstetrics, gynecology, and reproductive biology

2021 Volume 260, Page(s) 48–51

Abstract: ... difference in age (P = 0.19), timing of diagnosis (P = 0.59) or type of procedure (excision or ablation) (P ...

Abstract	Objectives: To quantify the delays associated with the diagnosis and treatment of diaphragmatic endometriosis (DE), and to evaluate patient-reported postoperative outcomes. Study design: An anonymous survey was designed to collect data regarding demographics, duration and nature of DE symptoms, type of surgery and postoperative outcomes. Members of endometriosis patient associations in 14 countries were invited to complete the survey if they had been diagnosed with DE. Factors associated with postoperative outcomes were analyzed using Mann-Whitney U and Fisher's exact tests. Results: Data was available from 136 respondents (median age 34 years). 98 % of respondents were from Europe, North America or Oceania. The most frequently reported symptoms of DE were moderate-severe pain in the upper abdomen (68 %), chest (64 %) and shoulder (54 %). Pain was right-sided in 54 %, left-sided in 11 % and bilateral in 35 %. Of 122 respondents who initially consulted a primary care physician, a gynaecology referral occurred after a median of five consultations (range 1-100). The median time between first primary care consultation and diagnosis of DE was two years (range 0-23). 31 % were diagnosed >1 year after their first gynaecology consultation (range 1-13 years), and 30 % required two or more laparoscopies before diagnosis. 116 respondents underwent surgical treatment. Postoperative data was available for 113 respondents, and 65 % reported either a significant improvement or complete resolution of symptoms. There was no significant difference in age (P = 0.19), timing of diagnosis (P = 0.59) or type of procedure (excision or ablation) (P = 0.13) between respondents who did and did not experience symptomatic relief after surgery. 61 % reported long-lasting symptomatic relief after a median of 1 year, whilst 39 % reported ongoing moderate-severe pain or have undergone further surgery for recurrent symptoms. Conclusion: The diagnosis and treatment of diaphragmatic endometriosis is often delayed, due to lack of awareness by patients and healthcare professionals. The diagnosis of DE requires a high index of suspicion and involvement of surgeons trained in laparoscopic liver mobilization. Recurrent symptoms are common following surgical treatment, and international collaborative studies are required to determine the long-term outcomes of this condition.
MeSH term(s)	Adult ; Endometriosis/diagnosis ; Endometriosis/epidemiology ; Endometriosis/surgery ; Europe ; Female ; Humans ; Laparoscopy ; Pain ; Surveys and Questionnaires
Language	English
Publishing date	2021-03-10
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	190605-7
ISSN	1872-7654 ; 0301-2115 ; 0028-2243
ISSN (online)	1872-7654
ISSN	0301-2115 ; 0028-2243
DOI	10.1016/j.ejogrb.2021.03.003
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Article: Hepatic vein reconstruction during hepatectomy: A feasible and underused technique.

Ahuja, Manish / Joshi, Kunal / Coldham, Chris / Muiesan, Paulo / Dasari, Bobby / Abradelo, Manuel / Marudanayagam, Ravi / Mirza, Darius / Isaac, John / Bartlett, David / Chatzizacharias, Nikolaos A / Sutcliffe, Robert P / Roberts, Keith J

Hepatobiliary & pancreatic diseases international : HBPD INT

2024

Language	English
Publishing date	2024-01-15
Publishing country	Singapore
Document type	Letter
ZDB-ID	2241386-8
ISSN	1499-3872
ISSN	1499-3872
DOI	10.1016/j.hbpd.2024.01.002
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Article ; Online: Abdominal drainage is contraindicated after uncomplicated hepatectomy: Results of a meta-analysis of randomized controlled trials.

Hajibandeh, Shahin / Hajibandeh, Shahab / Raza, Syed Soulat / Bartlett, David / Dasari, Bobby V M / Sutcliffe, Robert P

Surgery

2022 Volume 173, Issue 2, Page(s) 401–411

Abstract: ... were included. Patients in both groups were of comparable age (P = .23), sex (P = .49), proportion ... of major hepatectomy (P = .93), minor hepatectomy (P = .96), cirrhosis (P = .78), and malignant pathologies ... P = .61). Drainage after hepatectomy was associated with significantly higher overall complications ...

Abstract	Background: No conclusive recommendations exist regarding use of abdominal drainage in hepatectomy. The practice of abdominal drainage remains commonplace despite unfavorable outcomes reported by randomized controlled trials. We aimed to compare the impact of abdominal drainage on outcomes of hepatectomy. Methods: A systematic search of electronic information sources and bibliographic reference lists was conducted. A combination of free text and controlled vocabulary search adapted to thesaurus headings, search operators, and limits in each of the above databases was applied. Overall perioperative and wound-related complications, bile leak, intra-abdominal collections (including those requiring an intervention), and the length of hospital stay were the evaluated outcome parameters. Results: Seven randomized controlled trials reporting 1,064 patients undergoing hepatectomy with (n = 533) or without (n = 531) placement of abdominal drain were included. Patients in both groups were of comparable age (P = .23), sex (P = .49), proportion of major hepatectomy (P = .93), minor hepatectomy (P = .96), cirrhosis (P = .78), and malignant pathologies (P = .61). Drainage after hepatectomy was associated with significantly higher overall complications (RR: 1.37, P = .0003) and wound-related complications (risk ratio: 2.29, P = .01) compared to no drainage. Moreover, there was no significant difference in bile leak (risk ratio: 2.15, P = .19), intra-abdominal collections (risk ratio: 1.13, P = .70), intra-abdominal collections requiring interventions (risk ratio: 1.19, P = .71), or length of hospital stay (mean difference: 0.37, P = .67) between the 2 groups. The trial sequential analysis confirmed conclusiveness of the findings. Conclusion: Abdominal drainage after hepatectomy increases overall and wound-related complications, without any reduction in the risk of intra-abdominal collections needing an intervention. Routine drainage after an uncomplicated hepatectomy should be avoided, with the possible exception of the presence of a bilioenteric anastomosis.
MeSH term(s)	Humans ; Abdomen/surgery ; Drainage/adverse effects ; Hepatectomy/methods ; Length of Stay ; Postoperative Complications/epidemiology ; Randomized Controlled Trials as Topic
Language	English
Publishing date	2022-11-22
Publishing country	United States
Document type	Journal Article ; Meta-Analysis ; Review
ZDB-ID	202467-6
ISSN	1532-7361 ; 0039-6060
ISSN (online)	1532-7361
ISSN	0039-6060
DOI	10.1016/j.surg.2022.10.023
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Article ; Online: Meta-analysis of fenestrating versus reconstituting subtotal cholecystectomy in the management of difficult gallbladder.

Hajibandeh, Shahin / Hajibandeh, Shahab / Parente, Alessandro / Laing, Richard W / Bartlett, David / Athwal, Tejinderjit S / Sutcliffe, Robert P

HPB : the official journal of the International Hepato Pancreato Biliary Association

2023 Volume 26, Issue 1, Page(s) 8–20

Abstract: ... Although fenestrating STC was associated with a significantly higher rate of bile leak (OR: 2.47, p = 0.007) compared ... to reconstituting STC, both approaches were comparable in terms of resolution of bile leak without (RD: -0.02, p = 0 ... 86) or with (OR: 1.84, p = 0.40) postoperative ERCP. Moreover, there was no significant difference ...

Abstract	Aims: To evaluate comparative outcomes of fenestrating and reconstituting subtotal cholecystectomy (STC) in patients with difficult gallbladder. Methods: A systematic search of electronic data sources and bibliographic reference lists were conducted. All comparative studies reporting outcomes of laparoscopic fenestrating and reconstituting STC were included and their risk of bias were assessed using ROBINS-I tool. Results: Seven comparative studies were included enrolling 590 patients undergoing laparoscopic STC using either fenestrating (n = 353) or reconstituting (n = 237) approaches. Although fenestrating STC was associated with a significantly higher rate of bile leak (OR: 2.47, p = 0.007) compared to reconstituting STC, both approaches were comparable in terms of resolution of bile leak without (RD: -0.02, p = 0.86) or with (OR: 1.84, p = 0.40) postoperative ERCP. Moreover, there was no significant difference in development of bile duct injury (RD: -0.02, p = 0.16), need for postoperative ERCP (OR: 1.36, p = 0.49), wound infection (RD: 0.03, p = 0.27), re-operation (OR: 0.95, p = 0.95), gallbladder remnant cholecystitis (OR: 0.21, p = 0.09) or need for completion cholecystectomy (RD: 0.01, p = 0.59) between two groups. Conclusions: Fenestrating STC is associated with a higher risk of bile leak than the reconstructing technique. This issue can be mitigated by routine use of drains, delayed drain removal, and in selected cases endoscopic therapy. We encourage the fenestrating approach considering trends in improved short- and long-term outcomes.
MeSH term(s)	Humans ; Cholecystectomy/adverse effects ; Cholecystectomy/methods ; Cholecystectomy, Laparoscopic/adverse effects ; Cholecystitis/surgery ; Laparoscopy
Language	English
Publishing date	2023-09-07
Publishing country	England
Document type	Journal Article ; Meta-Analysis ; Review ; Systematic Review
ZDB-ID	2131251-5
ISSN	1477-2574 ; 1365-182X
ISSN (online)	1477-2574
ISSN	1365-182X
DOI	10.1016/j.hpb.2023.09.005
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Article: Older patients with proximal femur fractures and SARS-CoV-2 infection - An observational study.

Burahee, Abdus S / Barry, Veronica E / Sutcliffe, Robert P / Mahroof, Sabreena

SICOT-J

2021 Volume 7, Page(s) 5

Abstract: ... significantly higher Charlson comorbidity scores compared to the control group (5 vs. 4; p = 0.047). Only 5 ... patients was 14% compared to 0% in the negative controls (p = 0.22).: Interpretation: COVID-19 infection ...

Abstract	Background: Older patients are at increased risk of severe COVID-19 infection and associated mortality. There are limited data evaluating the outcome of older patients with hip fractures treated during the COVID-19 pandemic, and it has been suggested that these patients should be treated non-operatively due to high mortality risk. The aim of this study was to report the outcomes of COVID-19 infected hip fracture patients treated at a single centre. Methods: This was a retrospective cohort study. Data were collected from February 2020 (after the first confirmed COVID-19 infected patient was reported in the Midlands region of the UK). All patients admitted to the hospital with femoral neck fractures were included. Patient demographics, comorbidity, COVID-19 status, and short-term clinical outcomes were obtained by review of electronic medical records. The outcomes of COVID-19 infected patients were compared with non-COVID-19 patients treated during the study period. Results: Twenty-nine patients were included (mean age of 80 years), of whom 14 (48%) were tested positive for COVID-19 infection in the postoperative period. Overall, 26 patients (90%) underwent surgical treatment. COVID-19 infected patients had significantly higher Charlson comorbidity scores compared to the control group (5 vs. 4; p = 0.047). Only 5 COVID-19 infected patients (36%) required supplemental oxygen therapy in the postoperative period, and no patients required respiratory or other organ support. The 30-day mortality rate in COVID-19 patients was 14% compared to 0% in the negative controls (p = 0.22). Interpretation: COVID-19 infection did not increase the mortality rate of older patients undergoing surgery for hip fractures during the pandemic. The authors recommend careful assessment of patient fitness and prompt surgical treatment. In addition, it was noted that nearly all admissions were either given large boluses of Vitamin D or were on maintenance supplementation, which may have affected the severity of the response to COVID-19 infections.
Language	English
Publishing date	2021-02-17
Publishing country	France
Document type	Journal Article
ISSN	2426-8887
ISSN	2426-8887
DOI	10.1051/sicotj/2021001
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