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  1. Article ; Online: Surgical management of brain metastases.

    Ranasinghe, Moksha G / Sheehan, Jonas M

    Neurosurgical focus

    2007  Volume 22, Issue 3, Page(s) E2

    Abstract: Metastatic brain tumors continue to increase in incidence as patients with cancer live longer. The options for management continue to evolve as well, with advances in radiation-based treatment, chemotherapy, and surgery. Although metastatic brain tumors ... ...

    Abstract Metastatic brain tumors continue to increase in incidence as patients with cancer live longer. The options for management continue to evolve as well, with advances in radiation-based treatment, chemotherapy, and surgery. Although metastatic brain tumors are frequently treated without surgical intervention, there continues to be a significant role for surgery in caring for patients with these lesions. Study data have proven that surgery has a positive effect on survival and quality of life in properly selected patients. Those with a suitable age, functional status, systemic disease control, and several metastases may be suitable for surgical treatment. Advances in preoperative imaging and planning as well as intraoperative surgical adjuncts have lowered the morbidity associated with resection. With proper patient selection and operative and postoperative management, resection continues to play a significant and evolving role in the care of patients with metastatic brain tumor.
    MeSH term(s) Brain Neoplasms/radiotherapy ; Brain Neoplasms/secondary ; Brain Neoplasms/surgery ; Humans ; Neoplasm Metastasis/therapy ; Neurosurgical Procedures/standards ; Neurosurgical Procedures/statistics & numerical data ; Patient Selection ; Postoperative Care/standards ; Postoperative Complications/etiology ; Postoperative Complications/physiopathology ; Radiotherapy/standards ; Radiotherapy/statistics & numerical data ; Survival Rate/trends ; Treatment Outcome
    Language English
    Publishing date 2007-03-15
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2026589-X
    ISSN 1092-0684 ; 1092-0684
    ISSN (online) 1092-0684
    ISSN 1092-0684
    DOI 10.3171/foc.2007.22.3.3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Idiopathic hypertrophic spinal pachymeningitis.

    Ranasinghe, Moksha G / Zalatimo, Omar / Rizk, Elias / Specht, Charles S / Reiter, G Timothy / Harbaugh, Robert E / Sheehan, Jonas

    Journal of neurosurgery. Spine

    2011  Volume 15, Issue 2, Page(s) 195–201

    Abstract: Spinal idiopathic hypertrophic pachymeningitis (IHP) is a rare, chronic, nonspecific, granulomatous inflammatory disorder of the dura with unknown etiology. It can cause a localized or diffuse thickening of the dura mater with compression of the spinal ... ...

    Abstract Spinal idiopathic hypertrophic pachymeningitis (IHP) is a rare, chronic, nonspecific, granulomatous inflammatory disorder of the dura with unknown etiology. It can cause a localized or diffuse thickening of the dura mater with compression of the spinal canal and possible myelopathic symptoms. The authors report 3 consecutive cases of spinal IHP with a review of the literature. The diagnosis of spinal IHP was based on biopsy and pathological confirmation. Typical MR imaging findings suggestive of spinal IHP were noted in all cases. The clinical course may be marked by deterioration despite conservative therapy and may require surgical intervention to prevent irreversible neurological damage. Therefore, prompt diagnosis and institution of proper treatment is critical.
    MeSH term(s) Adult ; Aged ; Dura Mater/pathology ; Female ; Glucocorticoids/therapeutic use ; Humans ; Laminectomy ; Magnetic Resonance Imaging ; Male ; Meningitis/complications ; Meningitis/drug therapy ; Meningitis/pathology ; Meningitis/surgery ; Prednisone/therapeutic use ; Spinal Cord Compression/drug therapy ; Spinal Cord Compression/etiology ; Spinal Cord Compression/pathology ; Spinal Cord Compression/surgery ; Treatment Outcome
    Chemical Substances Glucocorticoids ; Prednisone (VB0R961HZT)
    Language English
    Publishing date 2011-08
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 2158643-3
    ISSN 1547-5646 ; 1547-5654
    ISSN (online) 1547-5646
    ISSN 1547-5654
    DOI 10.3171/2011.4.SPINE1037
    Database MEDical Literature Analysis and Retrieval System OnLINE

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