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  1. Article ; Online: Extensively Drug-Resistant Pseudomonas and Eye Drops-Stay Vigilant.

    Jeang, Lauren J / Tuli, Sonal S

    JAMA ophthalmology

    2024  

    Language English
    Publishing date 2024-03-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2701705-9
    ISSN 2168-6173 ; 2168-6165
    ISSN (online) 2168-6173
    ISSN 2168-6165
    DOI 10.1001/jamaophthalmol.2024.0219
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  2. Article ; Online: Therapy for contact lens-related ulcers.

    Jeang, Lauren / Tuli, Sonal S

    Current opinion in ophthalmology

    2022  Volume 33, Issue 4, Page(s) 282–289

    Abstract: Purpose of review: The current review covers the current literature and practice patterns of antimicrobial therapy for contact lens-related microbial keratitis (CLMK). Although the majority of corneal ulcers are bacterial, fungus and acanthamoeba are ... ...

    Abstract Purpose of review: The current review covers the current literature and practice patterns of antimicrobial therapy for contact lens-related microbial keratitis (CLMK). Although the majority of corneal ulcers are bacterial, fungus and acanthamoeba are substantial contributors in CLMK and are harder to treat due to the lack of commercially available topical medications and low efficacy of available topical therapy.
    Recent findings: Topical antimicrobials remain the mainstay of therapy for corneal ulcers. Fluoroquinolones may be used as monotherapy for small, peripheral bacterial ulcers. Antibiotic resistance is a persistent problem. Fungal ulcers are less responsive to topical medications and adjunct oral or intrastromal antifungal medications may be helpful. Acanthamoeba keratitis continues to remain a therapeutic challenge but newer antifungal and antiparasitic agents may be helpful adjuncts. Other novel and innovative therapies are being studied currently and show promise.
    Summary: Contact lens-associated microbial keratitis is a significant health issue that can cause vision loss. Treatment remains a challenge but many promising diagnostics and procedures are in the pipeline and offer hope.
    MeSH term(s) Antifungal Agents/therapeutic use ; Bacteria ; Contact Lenses/adverse effects ; Corneal Ulcer/diagnosis ; Corneal Ulcer/drug therapy ; Humans ; Keratitis/drug therapy ; Ulcer/drug therapy
    Chemical Substances Antifungal Agents
    Language English
    Publishing date 2022-05-25
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1049383-9
    ISSN 1531-7021 ; 1040-8738
    ISSN (online) 1531-7021
    ISSN 1040-8738
    DOI 10.1097/ICU.0000000000000861
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  3. Article ; Online: Complications of Contact Lenses.

    Kates, Malcolm M / Tuli, Sonal

    JAMA

    2021  Volume 325, Issue 18, Page(s) 1912

    MeSH term(s) Conjunctivitis, Allergic/etiology ; Contact Lenses/adverse effects ; Corneal Injuries/etiology ; Corneal Neovascularization/etiology ; Corneal Ulcer/etiology ; Disinfection/methods ; Dry Eye Syndromes/etiology ; Eye Infections/etiology ; Humans ; Keratitis/etiology
    Language English
    Publishing date 2021-05-11
    Publishing country United States
    Document type Patient Education Handout
    ZDB-ID 2958-0
    ISSN 1538-3598 ; 0254-9077 ; 0002-9955 ; 0098-7484
    ISSN (online) 1538-3598
    ISSN 0254-9077 ; 0002-9955 ; 0098-7484
    DOI 10.1001/jama.2020.20328
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  4. Article ; Online: What Is LASIK Eye Surgery?

    Kates, Malcolm M / Tuli, Sonal

    JAMA

    2020  Volume 324, Issue 8, Page(s) 815

    MeSH term(s) Astigmatism/surgery ; Cornea/surgery ; Humans ; Hyperopia/surgery ; Keratomileusis, Laser In Situ ; Myopia/surgery
    Language English
    Publishing date 2020-08-25
    Publishing country United States
    Document type Patient Education Handout
    ZDB-ID 2958-0
    ISSN 1538-3598 ; 0254-9077 ; 0002-9955 ; 0098-7484
    ISSN (online) 1538-3598
    ISSN 0254-9077 ; 0002-9955 ; 0098-7484
    DOI 10.1001/jama.2020.1286
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  5. Article: Overview of Corneal Transplantation for the Nonophthalmologist.

    Zhou, Yujia / Wang, Theodore / Tuli, Sonal S / Steigleman, Walter A / Shah, Ankit A

    Transplantation direct

    2023  Volume 9, Issue 2, Page(s) e1434

    Abstract: Corneal transplant is a procedure that aims to replace dysfunctional corneal tissue with a transparent graft and is one of the most widely performed transplant surgeries, but its public and professional awareness is low outside of ophthalmology. Corneal ... ...

    Abstract Corneal transplant is a procedure that aims to replace dysfunctional corneal tissue with a transparent graft and is one of the most widely performed transplant surgeries, but its public and professional awareness is low outside of ophthalmology. Corneal tissue consists of 5 major layers that serve to maintain its structural integrity and refractive shape: the epithelium, Bowman's layer, the stroma, Descemet's membrane, and the endothelium. Failure or irreversible damage to any layer of the cornea may be an indication for corneal transplant, and variants of this procedure may be full thickness or selectively lamellar. Complications related to corneal transplantation may occur anywhere from during surgery to years afterward, including rejection, dehiscence, cataract, and glaucoma. Complications should be managed by an ophthalmologist, but other physicians should be aware of prophylactic medications. Topical immunosuppressants and steroids are effective for preventing and treating rejection episodes, whereas there is little evidence to support the use of systemic immunosuppression. Eye protection is recommended for any corneal transplant recipient. Physicians should counsel patients on corneal donation, especially if outside the United States, where donor tissue is in short supply.
    Language English
    Publishing date 2023-01-12
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2373-8731
    ISSN 2373-8731
    DOI 10.1097/TXD.0000000000001434
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  6. Article: Status of Women in Academic Ophthalmology

    Tuli, Sonal S.

    Journal of Academic Ophthalmology

    2019  Volume 11, Issue 02, Page(s) e59–e64

    Abstract: Objective: The purpose of this study was to evaluate the status of women in academic ophthalmology in the United States and compare this to academic clinical departments in other clinical specialties.: Methods: The study reviewed data from the ... ...

    Abstract Objective: The purpose of this study was to evaluate the status of women in academic ophthalmology in the United States and compare this to academic clinical departments in other clinical specialties.
    Methods: The study reviewed data from the American Association of Medical Colleges for the years 2003 to 2017. The number and percentage of women at different ranks, as well as number of women Chairs of clinical academic departments, were collected by specialty. The number of women residents from 2007 to 2017 was obtained from datasets published by the Accreditation Council for Graduate Medical Education. Trends of the percentage of women at different ranks were compared.
    Results: The percentage of women residents in ophthalmology has remained constant at around 42%, although it has declined slightly over the last 3 years. On the other hand, the number of women faculty in academic ophthalmology has gradually increased from 24 to 34% over 15 years. This increase has largely been at the Assistant Professor rank, with only a modest increase at the Professor rank.
    Discussion: The percentage of women in ophthalmology continues to lag behind the average for all clinical departments at every level. While this gender disparity is rapidly closing for Assistant Professors and slowly closing for Associate Professors and Chairs, it is widening for Professors. This demonstrates that women in ophthalmology are making some strides but are not being promoted to Professor at the same rate as other specialties. This may be the result of explicit and implicit biases, as well as phenomena such as imposter syndrome that are more common in women.
    Keywords gender disparity ; women ; academic ophthalmology ; rank
    Language English
    Publishing date 2019-07-01
    Publisher Thieme Medical Publishers
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 2897840-7
    ISSN 2475-4757 ; 2475-4757
    ISSN (online) 2475-4757
    ISSN 2475-4757
    DOI 10.1055/s-0039-3401849
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  7. Article ; Online: Reticular epithelial edema after penetrating keratoplasty in a patient taking netarsudil.

    Jeang, Lauren J / Shah, Ankit S / Hammer, Jon D / Tuli, Sonal S

    Digital journal of ophthalmology : DJO

    2022  Volume 28, Issue 8, Page(s) 34–37

    Abstract: Netarsudil is a relatively new medication for the treatment of primary open-angle glaucoma and ocular hypertension. It has been associated with red eyes and burning after instillation. Reticular epitheliopathy is a relatively rare complication of ... ...

    Abstract Netarsudil is a relatively new medication for the treatment of primary open-angle glaucoma and ocular hypertension. It has been associated with red eyes and burning after instillation. Reticular epitheliopathy is a relatively rare complication of netarsudil that has been described in patients with preexisting corneal edema. We report the case of a healthy 76-year-old woman who developed reticular epitheliopathy after full-thickness penetrating keratoplasty that completely resolved following discontinuation of the medication. In cases where netarsudil is initiated for treatment of glaucoma or, off-label, endothelial dysfunction, reticular epithelial edema should be considered in patients complaining of a decline in vision and severe pain.
    MeSH term(s) Aged ; Benzoates ; Edema/complications ; Female ; Glaucoma/etiology ; Glaucoma, Open-Angle/complications ; Glaucoma, Open-Angle/drug therapy ; Glaucoma, Open-Angle/surgery ; Humans ; Intraocular Pressure ; Keratoplasty, Penetrating/adverse effects ; beta-Alanine/analogs & derivatives
    Chemical Substances Benzoates ; beta-Alanine (11P2JDE17B) ; netarsudil (W6I5QDT7QI)
    Language English
    Publishing date 2022-06-27
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2030129-7
    ISSN 1542-8958 ; 1542-8958
    ISSN (online) 1542-8958
    ISSN 1542-8958
    DOI 10.5693/djo.02.2022.02.002
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  8. Article ; Online: Comparison of the fluorescein angiography-guided and indocyanine green angiography-guided photodynamic therapy in the treatment of non-resolving central serous chorioretinopathy.

    Ebrahimiadib, Nazanin / Mirzaei, Arash / Esfandiarifard, Shaghayegh / Tuli, Sonal / Najibzadeh, Ehsan / Imani Fooladi, Marjan / Fadakar, Kaveh

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 1682

    Abstract: To compare the functional and anatomical outcome of fluorescein angiography (FA) versus indocyanine green angiography (ICGA) guided photodynamic therapy (PDT) in the treatment of non-resolving central serous chorioretinopathy (CSCR). In this prospective ... ...

    Abstract To compare the functional and anatomical outcome of fluorescein angiography (FA) versus indocyanine green angiography (ICGA) guided photodynamic therapy (PDT) in the treatment of non-resolving central serous chorioretinopathy (CSCR). In this prospective interventional case series, all patients with non-resolving CSCR, defined as persistent SRF involving subfoveal area for at least three months, were nonrandomly assigned to receive either FA or ICGA-guided half dose PDT. Baseline and 4 months post-treatment data including best corrected visual acuity (BCVA), the status of foveal subretinal fluid, subfoveal choroidal thickness, choroidal vascularity index, pigment epithelial detachment area, treatment and PDT spot numbers were collected. Thirty-six eyes were included; 24 received ICGA-guided and 12 received FA-guided PDT. Overall, improvement in BCVA and choroidal parameters were observed in all patients. There was no significant difference in baseline parameters as well as follow-up measurements between groups. However, the mean total energy dose and spot number in the IGCA-guided PDT were significantly higher than the FA-guided PDT group (P = 0.001). Both FA-guided and ICGA-guided half-dose PDT were effective in the treatment of non-resolving CSCR, with favorable functional and anatomical outcome. In FA group, PDT with smaller spot sizes and fewer numbers of spots were applied.
    MeSH term(s) Humans ; Central Serous Chorioretinopathy/diagnostic imaging ; Central Serous Chorioretinopathy/drug therapy ; Photosensitizing Agents/therapeutic use ; Verteporfin/therapeutic use ; Indocyanine Green ; Photochemotherapy ; Fluorescein Angiography ; Prospective Studies ; Porphyrins ; Tomography, Optical Coherence ; Chronic Disease ; Retrospective Studies
    Chemical Substances Photosensitizing Agents ; Verteporfin (0X9PA28K43) ; Indocyanine Green (IX6J1063HV) ; Porphyrins
    Language English
    Publishing date 2023-01-30
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-28890-9
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  9. Article: Topical Corticosteroids in the Management of Bacterial Keratitis.

    Tuli, Sonal S

    Current ophthalmology reports

    2013  Volume 1, Issue 4

    Abstract: Bacterial keratitis can cause significant morbidity from ulceration of the cornea and the resultant scarring. The use of steroids to decrease these complications is controversial with arguments for and against their use. The SCUT (Steroids for Corneal ... ...

    Abstract Bacterial keratitis can cause significant morbidity from ulceration of the cornea and the resultant scarring. The use of steroids to decrease these complications is controversial with arguments for and against their use. The SCUT (Steroids for Corneal Ulcers Trial) was initiated in 2006 to definitively determine whether steroids in bacterial keratitis were beneficial or harmful. While the SCUT showed no benefit or harm overall, subgroup analyses showed that larger, more central ulcers with very poor initial visual acuity may benefit. On the other hand, Nocardia ulcers that were treated with steroids had worse outcomes. The study did have some limitations as the patient population was not typical for bacterial keratitis in the United States, and there were some criticisms of the therapeutic approach so the question is still not definitively answered.
    Language English
    Publishing date 2013-10-10
    Publishing country United States
    Document type Journal Article
    ISSN 2167-4868
    ISSN 2167-4868
    DOI 10.1007/s40135-013-0026-0
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  10. Article ; Online: Comparison of the fluorescein angiography-guided and indocyanine green angiography-guided photodynamic therapy in the treatment of non-resolving central serous chorioretinopathy

    Nazanin Ebrahimiadib / Arash Mirzaei / Shaghayegh Esfandiarifard / Sonal Tuli / Ehsan Najibzadeh / Marjan Imani Fooladi / Kaveh Fadakar

    Scientific Reports, Vol 13, Iss 1, Pp 1-

    2023  Volume 8

    Abstract: Abstract To compare the functional and anatomical outcome of fluorescein angiography (FA) versus indocyanine green angiography (ICGA) guided photodynamic therapy (PDT) in the treatment of non-resolving central serous chorioretinopathy (CSCR). In this ... ...

    Abstract Abstract To compare the functional and anatomical outcome of fluorescein angiography (FA) versus indocyanine green angiography (ICGA) guided photodynamic therapy (PDT) in the treatment of non-resolving central serous chorioretinopathy (CSCR). In this prospective interventional case series, all patients with non-resolving CSCR, defined as persistent SRF involving subfoveal area for at least three months, were nonrandomly assigned to receive either FA or ICGA-guided half dose PDT. Baseline and 4 months post-treatment data including best corrected visual acuity (BCVA), the status of foveal subretinal fluid, subfoveal choroidal thickness, choroidal vascularity index, pigment epithelial detachment area, treatment and PDT spot numbers were collected. Thirty-six eyes were included; 24 received ICGA-guided and 12 received FA-guided PDT. Overall, improvement in BCVA and choroidal parameters were observed in all patients. There was no significant difference in baseline parameters as well as follow-up measurements between groups. However, the mean total energy dose and spot number in the IGCA-guided PDT were significantly higher than the FA-guided PDT group (P = 0.001). Both FA-guided and ICGA-guided half-dose PDT were effective in the treatment of non-resolving CSCR, with favorable functional and anatomical outcome. In FA group, PDT with smaller spot sizes and fewer numbers of spots were applied.
    Keywords Medicine ; R ; Science ; Q
    Subject code 616 ; 610
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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