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Article ; Online: Presence of an H

Fukao, Miki / Kondo, Eri / Nishino, Hiroki / Hattori, Ryutaro / Horie, Asuka / Hashimoto, Yukiya

European journal of drug metabolism and pharmacokinetics

2016 Volume 41, Issue 6, Page(s) 819–824

Abstract: Background and objectives: We have recently found an H: Methods: We investigated the uptake and ...

Abstract	Background and objectives: We have recently found an H Methods: We investigated the uptake and efflux of quinidine in MDCK cells. Results: The uptake of 100 µM quinidine into MDCK cells was decreased by acidification of extracellular pH or alkalization of intracellular pH. In addition, the uptake of quinidine was highly temperature sensitive, but was extracellular Na Conclusions: The present findings suggested that the renal new antiport system is involved in the bidirectional membrane transport of quinidine in MDCK cells.
Language	English
Publishing date	2016-12
Publishing country	France
Document type	Journal Article
ZDB-ID	196729-0
ISSN	2107-0180 ; 0398-7639 ; 0378-7966
ISSN (online)	2107-0180
ISSN	0398-7639 ; 0378-7966
DOI	10.1007/s13318-015-0314-1
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Zs.A 1236: Show issues

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Article ; Online: The protective effects of blueberry honey from Canada against H

Hattori, Noriko / Narita, Yukio / Mitsui, Taichi / Uehara, Saori / Ichihara, Kenji

Journal of oral biosciences

2022 Volume 64, Issue 3, Page(s) 359–365

Abstract: ... performed: H: Results: Of the 13 types of honey used, Canadian blueberry honey exhibited ... the protective effect on H: Conclusion: Canadian blueberry honey, but not the other types of honey, prevents H ...

Abstract	Objectives: Several clinical trials have been conducted worldwide to evaluate the efficacy of honey against stomatitis. However, it is unclear which types of honey are effective at preventing and/or treating stomatitis. This study aimed to evaluate the potencies of several types of honey in preventing and/or curing aphthous stomatitis in in vitro studies. Methods: The following experiments were performed: H Results: Of the 13 types of honey used, Canadian blueberry honey exhibited the protective effect on H Conclusion: Canadian blueberry honey, but not the other types of honey, prevents H
MeSH term(s)	Antioxidants/pharmacology ; Blueberry Plants/genetics ; Canada ; Heme Oxygenase-1/genetics ; Honey ; Humans ; Hydrogen Peroxide/pharmacology ; Mouth Mucosa/metabolism ; RNA, Messenger/metabolism ; Stomatitis/prevention & control ; Water
Chemical Substances	Antioxidants ; RNA, Messenger ; Water (059QF0KO0R) ; Hydrogen Peroxide (BBX060AN9V) ; Heme Oxygenase-1 (EC 1.14.14.18)
Language	English
Publishing date	2022-08-19
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2218267-6
ISSN	1880-3865 ; 1349-0079
ISSN (online)	1880-3865
ISSN	1349-0079
DOI	10.1016/j.job.2022.08.001
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Article ; Online: Inverse Agonistic Activity of Antihistamines and Suppression of Histamine H

Mizuguchi, Hiroyuki / Ono, Shohei / Hattori, Masashi / Fukui, Hiroyuki

Journal of pharmacological sciences

2019 Volume 118, Issue 1, Page(s) 117–121

Abstract: Histamine H ...

Abstract	Histamine H
Language	English
Publishing date	2019-06-11
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2104264-0
ISSN	1347-8648 ; 1347-8613
ISSN (online)	1347-8648
ISSN	1347-8613
DOI	10.1254/jphs.11177SC
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Zs.A 237: Show issues

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Article: Continuous 24-h Levodopa-Carbidopa Intestinal Gel Infusion After a Levodopa Holiday Suppressed Refractory Dyskinesia Despite Increasing Levodopa Dose.

Nishikawa, Noriko / Hatano, Taku / Kamiyama, Daiki / Haginiwa-Hasegawa, Haruna / Oyama, Genko / Hattori, Nobutaka

Journal of movement disorders

2022 Volume 15, Issue 3, Page(s) 290–292

Language	English
Publishing date	2022-07-26
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	3021788-X
ISSN	2093-4939 ; 2005-940X
ISSN (online)	2093-4939
ISSN	2005-940X
DOI	10.14802/jmd.22021
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Article ; Online: Functional characteristics of a renal H

Matsui, Ryutaro / Hattori, Ryutaro / Usami, Youhei / Koyama, Masumi / Hirayama, Yuki / Matsuba, Emi / Hashimoto, Yukiya

Drug metabolism and pharmacokinetics

2017 Volume 33, Issue 1, Page(s) 96–102

Abstract: We have recently found an H ...

Abstract	We have recently found an H
MeSH term(s)	Animals ; Biological Transport/physiology ; Cation Transport Proteins/metabolism ; Dogs ; Hydrophobic and Hydrophilic Interactions ; Ion Transport/physiology ; Kidney/metabolism ; LLC-PK1 Cells ; Madin Darby Canine Kidney Cells ; Proton Pumps/metabolism ; Quinidine/metabolism ; Rats ; Rats, Wistar ; Swine
Chemical Substances	Cation Transport Proteins ; Proton Pumps ; Quinidine (ITX08688JL)
Language	English
Publishing date	2017-12-05
Publishing country	England
Document type	Journal Article
ZDB-ID	2095748-8
ISSN	1880-0920 ; 1347-4367 ; 0916-1139
ISSN (online)	1880-0920
ISSN	1347-4367 ; 0916-1139
DOI	10.1016/j.dmpk.2017.11.313
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Zs.A 3734: Show issues

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Article ; Online: Insertion of a methylene group into the backbone of an antisense oligonucleotide reveals the importance of deoxyribose recognition by RNase H.

Masaki, Yoshiaki / Tabira, Ayano / Hattori, Shihori / Wakatsuki, Shunsuke / Seio, Kohji

Organic & biomolecular chemistry

2022 Volume 20, Issue 45, Page(s) 8917–8924

Abstract: RNase H acts as a key effector in gene knockdown by antisense oligonucleotides (ASOs ... Although various chemical modifications have been developed to regulate RNase H-mediated cleavage, precise control ... of phosphate groups or deoxyriboses is more important in the recognition of DNA/RNA duplex by RNase H ...

Abstract	RNase H acts as a key effector in gene knockdown by antisense oligonucleotides (ASOs). Although various chemical modifications have been developed to regulate RNase H-mediated cleavage, precise control is yet to be achieved. In this study, we tried to address the question of whether the interaction of phosphate groups or deoxyriboses is more important in the recognition of DNA/RNA duplex by RNase H. To answer this question, we investigated the effect of methylene group insertion at the 5'-upstream or 3'-downstream phosphorothioate groups on RNase H-mediated cleavage. By inserting a methylene group at the 5'-upside or 3'-downside, the distance between phosphates or deoxyriboses could be changed in a different pattern. Maximum suppression of the cleavage reaction was observed when a methylene group was inserted at the 5'-phosphate group of the nucleoside which is known to distinguish ribose and deoxyribose
MeSH term(s)	Ribonuclease H/chemistry ; Oligonucleotides, Antisense/chemistry ; Deoxyribose ; Oligonucleotides/chemistry ; Phosphates
Chemical Substances	Ribonuclease H (EC 3.1.26.4) ; Oligonucleotides, Antisense ; Deoxyribose (533-67-5) ; Oligonucleotides ; Phosphates
Language	English
Publishing date	2022-11-23
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2097583-1
ISSN	1477-0539 ; 1477-0520
ISSN (online)	1477-0539
ISSN	1477-0520
DOI	10.1039/d2ob01667b
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Article ; Online: Drain Amylase Concentrations at 3 h After Gastrectomy Enhance Early Prediction of Postoperative Peripancreatic Inflammatory Fluid Collection.

Nakanishi, Koki / Kanda, Mitsuro / Tanaka, Chie / Takeda, Shigeomi / Tanaka, Katsuhito / Shimizu, Dai / Inokawa, Yoshikuni / Hattori, Norifumi / Hayashi, Masamichi / Nakayama, Goro / Fujiwara, Michitaka / Kodera, Yasuhiro

World journal of surgery

2022 Volume 46, Issue 3, Page(s) 648–655

Abstract: ... problematic. This study aimed to investigate the clinical significance of measuring the D-AMY at 3 h after ...

Abstract	Background: Despite numerous studies of peripancreatic inflammatory fluid collection (PIFC) that report on the relevance of the drain amylase concentration (D-AMY), early prediction using this assay is problematic. This study aimed to investigate the clinical significance of measuring the D-AMY at 3 h after gastrectomy (POD0) for gastric cancer. Methods: This retrospective analysis included consecutive patients who underwent gastrectomy combined with peripancreatic lymph node dissection. The predictive value of D-AMY on POD0 and postoperative day 1 (POD1) for clinically relevant PIFC was evaluated together or individually. Results: Analyses were performed in 204 patients. Twenty (9.8%) patients experienced PIFC. D-AMY cutoffs of 721 IU/L on POD0 and 1695 IU/L on POD1 were determined using the receiver operating characteristic curve analysis for predicting PIFC. The D-AMY on POD0 had higher sensitivity (80%) but lower specificity (66.3%) for prediction of PIFC, compared with those of D-AMY on POD1 (65%, 89.1%, respectively). When combination marker analysis was performed, the highest risk group (D-AMY ≥ the cutoff values of POD0 and POD1) were associated with an elevated rate of occurrence (44%) and a high positive likelihood ratio (7.36) compared with those of the single cutoff group. The lowest risk group (D-AMY < the cutoff values on POD0 and POD1) was associated with a low rate of occurrence (2.5%) and low negative likelihood ratio (0.24) compared with those of the single cutoff group. Conclusions: Combined measurements of D-AMYs on POD0 and POD1 enhanced early prediction of PIFC after gastrectomy.
MeSH term(s)	Amylases ; Drainage ; Gastrectomy/adverse effects ; Humans ; Pancreatic Fistula ; Postoperative Complications/diagnosis ; Postoperative Complications/epidemiology ; Retrospective Studies
Chemical Substances	Amylases (EC 3.2.1.-)
Language	English
Publishing date	2022-01-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	224043-9
ISSN	1432-2323 ; 0364-2313
ISSN (online)	1432-2323
ISSN	0364-2313
DOI	10.1007/s00268-021-06401-z
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Zs.A 1336: Show issues

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Article ; Online: H/D solvent isotope effects on the photoracemization reaction of enantiomeric the tris(2,2'-bipyridine)ruthenium(ii) complex and its analogues.

Asahara, Masahiro / Kurimoto, Haruhiko / Nakamizu, Masato / Hattori, Shingo / Shinozaki, Kazuteru

Physical chemistry chemical physics : PCCP

2020 Volume 22, Issue 11, Page(s) 6361–6369

Abstract: This work assessed solvent isotope effects on the photoracemization rate and emission lifetime for [Ru(bpy)3]2+ (bpy = 2,2'-bipyridine) in water. An analysis of the effects of temperature on photoracemization rate and emission lifetime demonstrated that ... ...

Abstract	This work assessed solvent isotope effects on the photoracemization rate and emission lifetime for [Ru(bpy)3]2+ (bpy = 2,2'-bipyridine) in water. An analysis of the effects of temperature on photoracemization rate and emission lifetime demonstrated that the transition from one enantiomer to the other is unaffected by the isotopic composition of the solvent. The results also showed that deactivation from the metal-to-ligand charge-transfer (3MLCT) excited state to the ground state is responsible for the solvent isotope effect on the photoracemization rate. The photoracemization reaction was found to proceed via a bond-breaking mechanism. In this process, a five-coordinated species produced through breaking of the Ru-N bond in the 3d-d* state undergoes a structural change to produce an achiral five-coordinated species. An analysis of the effect of temperature on emission lifetime, excluding the activation to the 3d-d* state that leads to the structural change, showed that the solvent isotopic composition affects deactivation from the 4th MLCT state.
Language	English
Publishing date	2020-01-17
Publishing country	England
Document type	Journal Article
ZDB-ID	1476244-4
ISSN	1463-9084 ; 1463-9076
ISSN (online)	1463-9084
ISSN	1463-9076
DOI	10.1039/c9cp06758b
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Article: [Association of the combined estimated 24-h urinary Na/K ratio and body mass index with blood pressure: Cross-sectional data from the KOBE study].

Nozawa, Miki / Kuwabara, Kazuyo / Kubota, Yoshimi / Nishida, Yoko / Kubo, Sachimi / Hirata, Takumi / Higashiyama, Aya / Hirata, Aya / Hattori, Hiroko / Sata, Mizuki / Kadota, Aya / Sugiyama, Daisuke / Miyamatsu, Naomi / Miyamoto, Yoshihiro / Okamura, Tomonori

Nihon koshu eisei zasshi] Japanese journal of public health

2020 Volume 67, Issue 10, Page(s) 722–733

Abstract: ... of the combined estimated 24-h urinary Na/K ratio (24h-u-Na/K) (high or low) and BMI (high or low) with the risk ...

Abstract	Objective　Several studies have suggested that high dietary Na/K ratio and body mass index (BMI) increase the prevalence of hypertension. However, there have been a few reports on the combination of these two factors and their relationship with hypertension. This study aimed to examine the association of the combined estimated 24-h urinary Na/K ratio (24h-u-Na/K) (high or low) and BMI (high or low) with the risk of high blood pressure.Method　We performed a cross-sectional study involving 1,112 participants (340 men and 772 women) of the Kobe Orthopedic and Biomedical Epidemiological study (KOBE study) who had no cardiovascular diseases or current anti-hypertensive medications. Sex-specific analyses were performed. The 24h-u-Na/K ratio was calculated from an estimation formula using collected spot urine. Participants were divided into four groups based on their 24h-u-Na/K ratio (low or high) and BMI (low or high), with the cutoff points being the median and 25 kg/m
MeSH term(s)	Blood Pressure ; Body Mass Index ; Cross-Sectional Studies ; Diet, Sodium-Restricted ; Female ; Fruit ; Humans ; Hypertension/diagnosis ; Hypertension/etiology ; Hypertension/prevention & control ; Japan ; Male ; Potassium/urine ; Risk Assessment/methods ; Sodium/urine ; Vegetables
Chemical Substances	Sodium (9NEZ333N27) ; Potassium (RWP5GA015D)
Language	Japanese
Publishing date	2020-12-22
Publishing country	Japan
Document type	Journal Article
ZDB-ID	45044-3
ISSN	0546-1766
ISSN	0546-1766
DOI	10.11236/jph.67.10_722
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Zs.A 3721: Show issues

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Article ; Online: Estimated 24 h Urinary Sodium-to-Potassium Ratio Is Related to Renal Function Decline: A 6-Year Cohort Study of Japanese Urban Residents.

Hattori, Hiroko / Hirata, Aya / Kubo, Sachimi / Nishida, Yoko / Nozawa, Miki / Kawamura, Kuniko / Hirata, Takumi / Kubota, Yoshimi / Sata, Mizuki / Kuwabara, Kazuyo / Higashiyama, Aya / Kadota, Aya / Sugiyama, Daisuke / Miyamatsu, Naomi / Miyamoto, Yoshihiro / Okamura, Tomonori

International journal of environmental research and public health

2020 Volume 17, Issue 16

Abstract: ... normal range of renal function are limited. We investigated the effects of an estimated 24 h urinary Na/K ...

Abstract	The effect of the sodium-to-potassium ratio (Na/K) on renal function within the clinically normal range of renal function are limited. We investigated the effects of an estimated 24 h urinary Na/K (e24hUNa/K) on a 6-year renal function decline among 927 urban Japanese community dwellers with no history of cardiovascular diseases and medication for hypertension, diabetes, or dyslipidemia. We partitioned the subjects into quartiles according to the e24hUNa/K. The estimated glomerular filtration rate (eGFR) was calculated using the chronic kidney disease epidemiology collaboration (CKD/EPI) formula and renal function decline was defined as an absolute value at or above the third quartile of the eGFR decline rate. A multivariable logistic regression model was used for estimation. Compared with the first quartile of the e24hUNa/K, multivariable-adjusted odds ratios (ORs) for eGFR decline in the second, third, and fourth quartiles were 0.96 (95% confidence interval: 0.61-1.51), 1.06 (0.67-1.66), and 1.65 (1.06-2.57), respectively. These results were similar when the simple spot urine Na/K ratio was used in place of the e24hUNa/K. Apparently healthy urban residents with an almost within normal range mean baseline eGFR and high e24hUNa/K ratios had an increased risk for a future decline in renal function. Reducing the Na/K ratio may be important in the prevention of chronic kidney disease in its early stage.
MeSH term(s)	Aged ; Cohort Studies ; Disease Progression ; Female ; Glomerular Filtration Rate ; Humans ; Japan/epidemiology ; Kidney/physiopathology ; Middle Aged ; Potassium/urine ; Renal Insufficiency, Chronic/epidemiology ; Renal Insufficiency, Chronic/urine ; Risk Factors ; Sodium/urine ; Urban Population
Chemical Substances	Sodium (9NEZ333N27) ; Potassium (RWP5GA015D)
Keywords	covid19
Language	English
Publishing date	2020-08-11
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1660-4601
ISSN (online)	1660-4601
DOI	10.3390/ijerph17165811
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