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Article ; Online: Administration of Supplemental Oxygen.

Wittebole, Xavier / Duprez, Frédéric / Montiel, Virginie

2021 Volume 385, Issue 17, Page(s) e61

MeSH term(s)	Humans ; Oxygen
Chemical Substances	Oxygen (S88TT14065)
Language	English
Publishing date	2021-10-18
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	207154-x
ISSN	1533-4406 ; 0028-4793
ISSN (online)	1533-4406
ISSN	0028-4793
DOI	10.1056/NEJMc2113496
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Article ; Online: Is there a role for immune-enhancing therapies for acutely ill patients with coronavirus disease 2019?

Wittebole, Xavier / Montiel, Virginie / Mesland, Jean-Baptiste

Current opinion in critical care

2021 Volume 27, Issue 5, Page(s) 480–486

Abstract: Purpose of review: Although the so-called cytokine storm has been early described and related to a dramatic evolution in severe COVID-19 patients, it soon became clear that those patients display clinical and biological evidence of an immunosuppressive ... ...

Abstract	Purpose of review: Although the so-called cytokine storm has been early described and related to a dramatic evolution in severe COVID-19 patients, it soon became clear that those patients display clinical and biological evidence of an immunosuppressive state characterized, among other, by a profound lymphopenia. The negative role of this immune suppression on the outcome raises the question on immune therapies that might improve patient's condition. Recent findings: Important positive effects of active immune therapies, such as IL-7 or thymosin-α are already described and warrant confirmation in larger prospective trials. For other therapies, such as interferons, firm conclusions for critically ill COVID-19 patients are lacking as those patients were often excluded from the published trials. Treatment with immunoglobulins or convalescent plasma is a passive strategy to provide specific immunity. Unfortunately, results from large RCTs do not support their use presently. Summary: In this article, we provide a review on active and passive immune boosting strategies that might help treating the most severe COVID-19 patients. We mainly focus on active strategies that include IL-7, thymosin-α, interferons, and vitamin D. Although some positive effects are described, they certainly warrant confirmation in large randomized controlled trials.
MeSH term(s)	COVID-19/therapy ; Coronavirus Infections ; Humans ; Immunization, Passive ; Prospective Studies ; SARS-CoV-2 ; COVID-19 Serotherapy
Language	English
Publishing date	2021-07-31
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1235629-3
ISSN	1531-7072 ; 1070-5295
ISSN (online)	1531-7072
ISSN	1070-5295
DOI	10.1097/MCC.0000000000000862
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Article ; Online: Biological Assessment of the NO-Dependent Endothelial Function.

Boughaleb, Hasnae / Lobysheva, Irina / Dei Zotti, Flavia / Balligand, Jean-Luc / Montiel, Virginie

Molecules (Basel, Switzerland)

2022 Volume 27, Issue 22

Abstract: Nitric oxide (NO) is implicated in numerous physiological processes, including vascular homeostasis. Reduced NO bioavailability is a hallmark of endothelial dysfunction, a prequel to many cardiovascular diseases. Biomarkers of an early NO-dependent ... ...

Abstract	Nitric oxide (NO) is implicated in numerous physiological processes, including vascular homeostasis. Reduced NO bioavailability is a hallmark of endothelial dysfunction, a prequel to many cardiovascular diseases. Biomarkers of an early NO-dependent endothelial dysfunction obtained from routine venous blood sampling would be of great interest but are currently lacking. The direct measurement of circulating NO remains a challenge due by its high reactivity and short half-life. The current techniques measure stable products from the NO signaling pathway or metabolic end products of NO that do not accurately represent its bioavailability and, therefore, endothelial function per se. In this review, we will concentrate on an original technique of low temperature electron paramagnetic resonance spectroscopy capable to directly measure the 5-α-coordinated heme nitrosyl-hemoglobin in the T (tense) state (5-α-nitrosyl-hemoglobin or HbNO) obtained from fresh venous human erythrocytes. In humans, HbNO reflects the bioavailability of NO formed in the vasculature from vascular endothelial NOS or exogenous NO donors with minor contribution from erythrocyte NOS. The HbNO signal is directly correlated with the vascular endothelial function and inversely correlated with vascular oxidative stress. Pilot studies support the validity of HbNO measurements both for the detection of endothelial dysfunction in asymptomatic subjects and for the monitoring of such dysfunction in patients with known cardiovascular disease. The impact of therapies or the severity of diseases such as COVID-19 infection involving the endothelium could also be monitored and their incumbent risk of complications better predicted through serial measurements of HbNO.
MeSH term(s)	Humans ; Nitric Oxide/metabolism ; COVID-19 ; Hemoglobins/metabolism ; Endothelium, Vascular/metabolism
Chemical Substances	hemoglobin A, glycosylated-nitric oxide complex ; Nitric Oxide (31C4KY9ESH) ; Hemoglobins
Language	English
Publishing date	2022-11-16
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules27227921
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Article ; Online: Polyhydroxyalkanoates and 5-aminolevulinic acid production by a mixed phototrophic culture using medium-chain carboxylic acids from winery effluents.

Montiel-Corona, Virginia / Buitrón, Germán

Bioresource technology

2023 Volume 373, Page(s) 128704

Abstract: This work aimed to obtain polyhydroxyalkanoates (PHA) and 5-aminolevulinic acid (5-ALA) from medium-chain carboxylic acids (MCCA) using a mixed culture enriched in Rhodopseudomnas palustris. MCCA, obtained from residual wine lees, were tested in batch ... ...

Abstract	This work aimed to obtain polyhydroxyalkanoates (PHA) and 5-aminolevulinic acid (5-ALA) from medium-chain carboxylic acids (MCCA) using a mixed culture enriched in Rhodopseudomnas palustris. MCCA, obtained from residual wine lees, were tested in batch photofermentation experiments. First, the influence of individual MCCA (hexanoic, heptanoic, and octanoic acids) was evaluated; then, the MCCA coming directly from a fermentation reactor (LC-effluent) or after acids extraction (HC-effluent) were studied. Nutrient supplementation, bicarbonate, and acetic acid addition were also tested. Results showed that PHA production was higher in hexanoic (328 mg PHA/L) compared to heptanoic (152 mg PHA/L) and octanoic (164 mg PHA/L) acids. Bicarbonate addition and acetic acid as co-substrate improved the MCCA consumption, the PHA content and production rate. The HC-effluent, without nutrient supplementation, was allowed to increase 2.5 times the PHA content (reaching 40 % w/w and 584 mg/L) and to double 5-ALA production (7.6 µM) compared to the LC-effluent condition.
MeSH term(s)	Carboxylic Acids ; Aminolevulinic Acid ; Polyhydroxyalkanoates/metabolism ; Bicarbonates ; Fermentation ; Bioreactors ; Acetic Acid
Chemical Substances	Carboxylic Acids ; Aminolevulinic Acid (88755TAZ87) ; Polyhydroxyalkanoates ; Bicarbonates ; Acetic Acid (Q40Q9N063P)
Language	English
Publishing date	2023-02-04
Publishing country	England
Document type	Journal Article
ZDB-ID	1065195-0
ISSN	1873-2976 ; 0960-8524
ISSN (online)	1873-2976
ISSN	0960-8524
DOI	10.1016/j.biortech.2023.128704
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Article ; Online: HELIOS-expressing human CD8 T cells exhibit limited effector functions.

Neyens, Damien / Hirsch, Thibault / Abdel Aziz Issa Abdel Hadi, Achraqat / Dauguet, Nicolas / Vanhaver, Christophe / Bayard, Alexandre / Wildmann, Claude / Luyckx, Mathieu / Squifflet, Jean-Luc / D'Hondt, Quentin / Duhamel, Céline / Huaux, Antoine / Montiel, Virginie / Dechamps, Mélanie / van der Bruggen, Pierre

Frontiers in immunology

2023 Volume 14, Page(s) 1308539

Abstract: Introduction: The transcription factor HELIOS is primarily known for its expression in CD4 regulatory T cells, both in humans and mice. In mice, HELIOS is found in exhausted CD8 T cells. However, information on human HELIOS: Methods: In this study, ... ...

Abstract	Introduction: The transcription factor HELIOS is primarily known for its expression in CD4 regulatory T cells, both in humans and mice. In mice, HELIOS is found in exhausted CD8 T cells. However, information on human HELIOS Methods: In this study, we characterized by flow cytometry and transcriptomic analyses human HELIOS Results: These T cells primarily consist of memory cells and constitute approximately 21% of blood CD8 T cells. In comparison with memory HELIOS Discussion: Our findings emphasize that HELIOS is expressed across various CD8 T cell populations, highlighting its significance beyond its role as a transcription factor for Treg or exhausted murine CD8 T cells. The significance of the connection between HELIOS and HLA-E restriction is yet to be understood.
MeSH term(s)	Humans ; Animals ; Mice ; HLA-E Antigens ; CD8-Positive T-Lymphocytes ; Tumor Necrosis Factor-alpha ; Transcription Factors/genetics ; Cytomegalovirus Infections
Chemical Substances	HLA-E Antigens ; Tumor Necrosis Factor-alpha ; Transcription Factors
Language	English
Publishing date	2023-12-22
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2023.1308539
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Article ; Online: Development of SARS-CoV2 humoral response including neutralizing antibodies is not sufficient to protect patients against fatal infection.

Choteau, Mathilde / Scohy, Anaïs / Messe, Stéphane / Luyckx, Mathieu / Dechamps, Mélanie / Montiel, Virginie / Yombi, Jean Cyr / Gruson, Damien / Limaye, Nisha / Michiels, Thomas / Dumoutier, Laure

Scientific reports

2022 Volume 12, Issue 1, Page(s) 2077

Abstract: More than a year after the start of the pandemic, COVID-19 remains a global health emergency. Although the immune response against SARS-CoV-2 has been extensively studied, some points remain controversial. One is the role of antibodies in viral clearance ...

Abstract	More than a year after the start of the pandemic, COVID-19 remains a global health emergency. Although the immune response against SARS-CoV-2 has been extensively studied, some points remain controversial. One is the role of antibodies in viral clearance and modulation of disease severity. While passive transfer of neutralizing antibodies protects against SARS-CoV-2 infection in animal models, titers of anti-SARS-CoV-2 antibodies have been reported to be higher in patients suffering from more severe forms of the disease. A second key question for pandemic management and vaccine design is the persistence of the humoral response. Here, we characterized the antibody response in 187 COVID-19 patients, ranging from asymptomatic individuals to patients who died from COVID-19, and including patients who recovered. We developed in-house ELISAs to measure titers of IgG, IgM and IgA directed against the RBD or N regions in patient serum or plasma, and a spike-pseudotyped neutralization assay to analyse seroneutralization. Higher titers of virus-specific antibodies were detected in patients with severe COVID-19, including deceased patients, compared to asymptomatic patients. This demonstrates that fatal infection is not associated with defective humoral response. Finally, most of recovered patients still had anti-SARS-CoV-2 IgG more than 3 months after infection.
MeSH term(s)	Adult ; Aged ; Antibodies, Neutralizing/immunology ; Antibodies, Viral/immunology ; COVID-19/immunology ; COVID-19/mortality ; Female ; Humans ; Immunity, Humoral ; Male ; Middle Aged ; SARS-CoV-2/immunology
Chemical Substances	Antibodies, Neutralizing ; Antibodies, Viral
Language	English
Publishing date	2022-02-08
Publishing country	England
Document type	Clinical Trial ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-022-06038-5
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Surgical mask on top of high-flow nasal cannula improves oxygenation in critically ill COVID-19 patients with hypoxemic respiratory failure.

Montiel, Virginie / Robert, Arnaud / Robert, Annie / Nabaoui, Anas / Marie, Tourneux / Mestre, Natalia Morales / Guillaume, Maerckx / Laterre, Pierre-François / Wittebole, Xavier

Annals of intensive care

2020 Volume 10, Issue 1, Page(s) 125

Abstract: Objective: Critically ill patients admitted in ICU because of COVID-19 infection display severe hypoxemic respiratory failure. The Surviving Sepsis Campaign recommends oxygenation through high-flow nasal cannula over non-invasive ventilation. The ... ...

Abstract	Objective: Critically ill patients admitted in ICU because of COVID-19 infection display severe hypoxemic respiratory failure. The Surviving Sepsis Campaign recommends oxygenation through high-flow nasal cannula over non-invasive ventilation. The primary outcome of our study was to evaluate the effect of the addition of a surgical mask on a high-flow nasal cannula system on oxygenation parameters in hypoxemic COVID-19 patients admitted in ICU who do not require urgent intubation. The secondary outcomes were relevant changes in PaCO Design: We prospectively assessed 21 patients admitted in our mixed Intensive Care Unit of the Cliniques Universitaires Saint Luc. Main results: While FiO2 was unchanged, we demonstrate a significant increase of PaO Conclusion: A surgical mask placed on patient's face already treated by a High-flow nasal cannula device improves COVID-19 patient's oxygenation admitted in Intensive Care Unit for severe hypoxemic respiratory failure without any clinically relevant side.
Keywords	covid19
Language	English
Publishing date	2020-09-29
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2617094-2
ISSN	2110-5820
ISSN	2110-5820
DOI	10.1186/s13613-020-00744-x
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Article ; Online: Development of SARS-CoV2 humoral response including neutralizing antibodies is not sufficient to protect patients against fatal infection

Mathilde Choteau / Anaïs Scohy / Stéphane Messe / Mathieu Luyckx / Mélanie Dechamps / Virginie Montiel / Jean Cyr Yombi / Damien Gruson / Nisha Limaye / Thomas Michiels / Laure Dumoutier

Scientific Reports, Vol 12, Iss 1, Pp 1-

2022 Volume 12

Abstract: Abstract More than a year after the start of the pandemic, COVID-19 remains a global health emergency. Although the immune response against SARS-CoV-2 has been extensively studied, some points remain controversial. One is the role of antibodies in viral ... ...

Abstract	Abstract More than a year after the start of the pandemic, COVID-19 remains a global health emergency. Although the immune response against SARS-CoV-2 has been extensively studied, some points remain controversial. One is the role of antibodies in viral clearance and modulation of disease severity. While passive transfer of neutralizing antibodies protects against SARS-CoV-2 infection in animal models, titers of anti-SARS-CoV-2 antibodies have been reported to be higher in patients suffering from more severe forms of the disease. A second key question for pandemic management and vaccine design is the persistence of the humoral response. Here, we characterized the antibody response in 187 COVID-19 patients, ranging from asymptomatic individuals to patients who died from COVID-19, and including patients who recovered. We developed in-house ELISAs to measure titers of IgG, IgM and IgA directed against the RBD or N regions in patient serum or plasma, and a spike-pseudotyped neutralization assay to analyse seroneutralization. Higher titers of virus-specific antibodies were detected in patients with severe COVID-19, including deceased patients, compared to asymptomatic patients. This demonstrates that fatal infection is not associated with defective humoral response. Finally, most of recovered patients still had anti-SARS-CoV-2 IgG more than 3 months after infection.
Keywords	Medicine ; R ; Science ; Q
Subject code	616
Language	English
Publishing date	2022-02-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Increased Angiotensin-Converting Enzyme 2 and Loss of Alveolar Type II Cells in COVID-19-related Acute Respiratory Distress Syndrome.

Gerard, Ludovic / Lecocq, Marylene / Bouzin, Caroline / Hoton, Delphine / Schmit, Gregory / Pereira, Joao Pinto / Montiel, Virginie / Plante-Bordeneuve, Thomas / Laterre, Pierre-François / Pilette, Charles

American journal of respiratory and critical care medicine

2021 Volume 204, Issue 9, Page(s) 1024–1034

Abstract: Rationale: ...

Abstract	Rationale:
MeSH term(s)	Adult ; Aged ; Alveolar Epithelial Cells/metabolism ; Angiotensin-Converting Enzyme 2/metabolism ; Biomarkers/metabolism ; COVID-19/diagnosis ; COVID-19/metabolism ; COVID-19/physiopathology ; Case-Control Studies ; Female ; Humans ; Immunohistochemistry ; Logistic Models ; Male ; Middle Aged ; Peptidyl-Dipeptidase A/metabolism ; Proportional Hazards Models ; Respiratory Distress Syndrome/diagnosis ; Respiratory Distress Syndrome/metabolism ; Respiratory Distress Syndrome/virology ; Retrospective Studies ; Severity of Illness Index ; Up-Regulation
Chemical Substances	Biomarkers ; ACE protein, human (EC 3.4.15.1) ; Peptidyl-Dipeptidase A (EC 3.4.15.1) ; ACE2 protein, human (EC 3.4.17.23) ; Angiotensin-Converting Enzyme 2 (EC 3.4.17.23)
Language	English
Publishing date	2021-08-27
Publishing country	United States
Document type	Journal Article
ZDB-ID	1180953-x
ISSN	1535-4970 ; 0003-0805 ; 1073-449X
ISSN (online)	1535-4970
ISSN	0003-0805 ; 1073-449X
DOI	10.1164/rccm.202012-4461OC
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Article ; Online: Polyhydroxyalkanoates and 5-aminolevulinic acid production by a mixed phototrophic culture using medium-chain carboxylic acids from winery effluents

Montiel-Corona, Virginia / Buitrón, G.

Bioresource Technology. 2023 Feb. 04, p.128704-

2023 , Page(s) 128704–

Abstract	This work aimed to obtain polyhydroxyalkanoates (PHA) and 5-aminolevulinic acid (5-ALA) from medium-chain carboxylic acids (MCCA) using a mixed culture enriched in Rhodopseudomnas palustris. MCCA, obtained from residual wine lees, were tested in batch photofermentation experiments. First, the influence of individual MCCA (hexanoic, heptanoic, and octanoic acids) was evaluated; then, the MCCA coming directly from a fermentation reactor (LC-effluent) or after acids extraction (HC-effluent) were studied. Nutrient supplementation, bicarbonate, and acetic acid addition were also tested. Results showed that PHA production was higher in hexanoic (328 mg PHA/L) compared to heptanoic (152 mg PHA/L) and octanoic (164 mg PHA/L) acids. Bicarbonate addition and acetic acid as co-substrate improved the MCCA consumption, the PHA content and production rate. The HC-effluent, without nutrient supplementation, was allowed to increase 2.5 times the PHA content (reaching 40% w/w and 584 mg/L) and to double 5-ALA production (7.6 µM) compared to the LC-effluent condition.
Keywords	acetic acid ; aminolevulinic acid ; bicarbonates ; fermentation ; mixed culture ; polyhydroxyalkanoates ; wines ; 5-aminolevulinic acid ; purple bacteria ; winery effluents ; medium chain carboxylic acids
Language	English
Dates of publication	2023-0204
Publishing place	Elsevier Ltd
Document type	Article ; Online
Note	Pre-press version
ZDB-ID	1065195-0
ISSN	1873-2976 ; 0960-8524
ISSN (online)	1873-2976
ISSN	0960-8524
DOI	10.1016/j.biortech.2023.128704
Database	NAL-Catalogue (AGRICOLA)

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