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Article: Effect of Laser Peening on the Corrosion Properties of 304L Stainless Steel.

Yoo, Young-Ran / Choi, Seung-Heon / Kim, Young-Sik

2023 Volume 16, Issue 2

Abstract: Dry canisters used in nuclear power plants can be subject to localized corrosion, including stress corrosion cracking. External and residual tensile stress can facilitate the occurrence of stress corrosion cracking. Residual stress can arise from welding ...

Abstract	Dry canisters used in nuclear power plants can be subject to localized corrosion, including stress corrosion cracking. External and residual tensile stress can facilitate the occurrence of stress corrosion cracking. Residual stress can arise from welding and plastic deformation. Mitigation methods of residual stress depend upon the energy used and include laser peening, ultrasonic peening, ultrasonic nanocrystal surface modification, shot peening, or water jet peening. Among these, laser peening technology irradiates a continuous laser beam on the surface of metals and alloys at short intervals to add compressive residual stress as a shock wave is caused. This research studied the effect of laser peening with/without a thin aluminum layer on the corrosion properties of welded 304L stainless steel. The intergranular corrosion rate of the laser-peened specimen was a little faster than the rate of the non-peened specimen. However, laser peening enhanced the polarization properties of the cross-section of 304L stainless steel, while the properties of the surface were reduced by laser peening. This behavior was discussed on the basis of the microstructure and residual stress.
Language	English
Publishing date	2023-01-13
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2487261-1
ISSN	1996-1944
ISSN	1996-1944
DOI	10.3390/ma16020804
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Squamous cell carcinoma arising from a cholesteatoma of the maxillary sinus: a case report

Kim, Tae-Gyun / Whangbo, Chang-Ho / Yoo, Jae-Ho / Park, Hee-Jun / Geum, Sang-Yen / Shin, Seung-Heon / Ye, Mi Kyung

Brazilian journal of otorhinolaryngology

2024 Volume 90, Issue 3, Page(s) 101408

Language	English
Publishing date	2024-02-22
Publishing country	Brazil
Document type	Case Reports
ZDB-ID	2428110-4
ISSN	1808-8686 ; 1808-8694
ISSN (online)	1808-8686
ISSN	1808-8694
DOI	10.1016/j.bjorl.2024.101408
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Changes in the Epidemiologic Pattern of Primary CNS Tumors in Response to the Aging Population: An Updated Nationwide Cancer Registry Data in the Republic of Korea.

Byun, Yoon Hwan / Ha, Johyun / Kang, Ho / Park, Chul-Kee / Jung, Kyu-Won / Yoo, Heon

JCO global oncology

2024 Volume 10, Page(s) e2300352

Abstract: Purpose: Primary CNS tumors (PCNSTs) are tumors originating from the brain and surrounding tissues. These tumors account for a significant proportion of cancer deaths and morbidity globally. Accurate epidemiologic data are essential for shaping clinical ...

Abstract	Purpose: Primary CNS tumors (PCNSTs) are tumors originating from the brain and surrounding tissues. These tumors account for a significant proportion of cancer deaths and morbidity globally. Accurate epidemiologic data are essential for shaping clinical practices, research priorities, and health care policies. This study presents the latest 2020 national data on PCNSTs from the Republic of Korea (ROK) and explores the trends in incidence and their societal implications in the context of an aging population. Methods: This is a cross-sectional, observational study conducted using data sourced from the Korea National Cancer Incidence Database by the Korea Central Cancer Registry. The study analyzed national data on PCNSTs in the ROK for the years 2010, 2013, 2016, and 2020. Results: In 2020, 15,568 new PCNST cases were diagnosed in the ROK. The overall crude rate was 30.32, and the age-standardized rate was 19.37 per 100,000 persons. A decade-long trend analysis revealed an increasing trend in newly diagnosed glioblastoma and lymphoma, and a decreasing trend in embryonal tumors, in relation to the aging population of the ROK. Conclusion: This study shows the significant impact of demographic shifts on the epidemiologic patterns of PCNSTs in the ROK. Our findings emphasize the need for collaborative efforts to address the rising challenges posed by the changing incidence of PCNSTs related to an aging population.
MeSH term(s)	Humans ; Aging ; Cross-Sectional Studies ; Neoplasms/epidemiology ; Registries ; Republic of Korea/epidemiology ; Routinely Collected Health Data
Language	English
Publishing date	2024-01-31
Publishing country	United States
Document type	Observational Study ; Journal Article
ISSN	2687-8941
ISSN (online)	2687-8941
DOI	10.1200/GO.23.00352
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Article ; Online: Extracellular Vesicles from Cerebrospinal Fluid of Leptomeningeal Metastasis Patients Deliver MiR-21 and Induce Methotrexate Resistance in Lung Cancer Cells.

Im, Ji Hye / Lee, Kyue-Yim / Seo, Yoona / Rhim, Jiho / Dho, Yun-Sik / Yoo, Byong Chul / Park, Jong Bae / Shin, Sang Hoon / Yoo, Heon / Kim, Jong Heon / Gwak, Ho-Shin

International journal of molecular sciences

2024 Volume 25, Issue 6

Abstract: Leptomeningeal metastasis (LM) is a common and fatal complication of advanced non-small cell lung cancer (NSCLC) caused by the spread of malignant cells to the leptomeninges and cerebrospinal fluid (CSF). While intra-CSF methotrexate (MTX) chemotherapy ... ...

Abstract	Leptomeningeal metastasis (LM) is a common and fatal complication of advanced non-small cell lung cancer (NSCLC) caused by the spread of malignant cells to the leptomeninges and cerebrospinal fluid (CSF). While intra-CSF methotrexate (MTX) chemotherapy can improve prognosis, eventual MTX resistance deters continued chemotherapy. Recent studies have shown that increased miRNA-21 (miR-21) expression in the CSF of patients with LM after intraventricular MTX-chemotherapy is associated with poor overall survival; however, the molecular mechanisms underlying this resistance are poorly understood. Here, we confirm, in 36 patients with NSCLC-LM, that elevated miR-21 expression prior to treatment correlates with poor prognosis. MiR-21 overexpression or sponging results in a corresponding increase or decrease in MTX resistance, demonstrating that cellular miR-21 expression correlates with drug resistance. MiR-21-monitoring sensor and fluorescent extracellular vesicle (EV) staining revealed that EV-mediated delivery of miR-21 could modulate MTX resistance. Moreover, EVs isolated from the CSF of LM patients containing miR-21 could enhance the cell proliferation and MTX resistance of recipient cells. These results indicate that miR-21 can be transferred from cell-to-cell via EVs and potentially modulate MTX sensitivity, suggesting that miR-21 in CSF EVs may be a prognostic and therapeutic target for overcoming MTX resistance in patients with NSCLC-LM.
MeSH term(s)	Humans ; Lung Neoplasms/drug therapy ; Lung Neoplasms/genetics ; Lung Neoplasms/pathology ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Carcinoma, Non-Small-Cell Lung/genetics ; Carcinoma, Non-Small-Cell Lung/pathology ; Methotrexate/pharmacology ; Methotrexate/therapeutic use ; MicroRNAs/genetics ; MicroRNAs/therapeutic use ; Extracellular Vesicles/genetics ; Extracellular Vesicles/pathology
Chemical Substances	Methotrexate (YL5FZ2Y5U1) ; MicroRNAs ; MIRN21 microRNA, human
Language	English
Publishing date	2024-03-08
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms25063124
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Article ; Online: Automated non-contact measurement of the spine curvature at the sagittal plane using a deep neural network.

Park, Sangsoo / Yoo, Hyun-Joon / Jang, Jin Su / Lee, Sang-Heon

Clinical biomechanics (Bristol, Avon)

2023 Volume 111, Page(s) 106146

Abstract: Background: Non-radiographical techniques have been suggested to measure the spine curvature at the sagittal plane. However, a neural network has not been used to measure the curvature.: Methods: A single video camera captured images of a standing ... ...

Abstract	Background: Non-radiographical techniques have been suggested to measure the spine curvature at the sagittal plane. However, a neural network has not been used to measure the curvature. Methods: A single video camera captured images of a standing posture at the sagittal plane from twenty healthy males. Six marker positions along the spine's contour in each image were identified for measuring inclination, thoracic kyphosis, and lumbar lordosis angles. We estimated three inflection points around the neck, hip, and between the neck and hip, followed by identifying two adjacent marker positions per inflection point to compute its tangent. The angular deviation of each tangent line from the horizontal was computed to measure inclination angles. Thoracic kyphosis and lumbar lordosis angles were computed by the angular difference between the two adjacent tangents. A deep neural network was trained with 500,000 iterations using the labeled images from 18 participants (388 and 44 images for training and test set) and then evaluated using the unseen images (2 participants, 48 images; evaluation set). Findings: The mean total training and test errors were <2 pixels (∼ 0.6 cm). The total error in the evaluation set was qualitatively comparable (∼ 3 pixels = ∼ 0.9 cm), suggesting the model performance was maintained in the unseen data. The angle values between labeled and network-predicted marker positions were similar in the evaluation set. Interpretation: The network training with a relatively small number of images was successful based on the small error values observed in the evaluation set. The model may be an affordable, automated, and non-contact measurement tool for the human spine curvature.
MeSH term(s)	Male ; Humans ; Lordosis ; Lumbar Vertebrae/diagnostic imaging ; Kyphosis ; Posture ; Standing Position ; Spine/diagnostic imaging
Language	English
Publishing date	2023-11-10
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	632747-3
ISSN	1879-1271 ; 0268-0033
ISSN (online)	1879-1271
ISSN	0268-0033
DOI	10.1016/j.clinbiomech.2023.106146
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Article ; Online: The use of animal models in rheumatoid arthritis research.

Kong, Jin-Sun / Jeong, Gi Heon / Yoo, Seung-Ah

Journal of Yeungnam medical science

2022 Volume 40, Issue 1, Page(s) 23–29

Abstract: The pathological hallmark of rheumatoid arthritis (RA) is a synovial pannus that comprises proliferating and invasive fibroblast-like synoviocytes, infiltrating inflammatory cells, and an associated neoangiogenic response. Animal models have been ... ...

Abstract	The pathological hallmark of rheumatoid arthritis (RA) is a synovial pannus that comprises proliferating and invasive fibroblast-like synoviocytes, infiltrating inflammatory cells, and an associated neoangiogenic response. Animal models have been established to study these pathological features of human RA. Spontaneous and induced animal models of RA primarily reflect inflammatory aspects of the disease. Among various induced animal models, collagen-induced arthritis (CIA) and collagen antibody-induced arthritis (CAIA) models are widely used to study the pathogenesis of RA. Improved transplantation techniques for severe combined immunodeficiency (SCID) mouse models of RA can be used to evaluate the effectiveness of potential therapeutics in human tissues and cells. This review provides basic information on various animal models of RA, including CIA and CAIA. In addition, we describe a SCID mouse coimplantation model that can measure the long-distance migration of human RA synoviocytes and cartilage destruction induced by these cells.
Language	English
Publishing date	2022-11-22
Publishing country	Korea (South)
Document type	Journal Article
ISSN	2799-8010
ISSN (online)	2799-8010
DOI	10.12701/jyms.2022.00773
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Article: New take-off to an international journal.

Yoo, Heon

Brain tumor research and treatment

2013 Volume 1, Issue 1, Page(s) 1

Language	English
Publishing date	2013-12-31
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	3018737-0
ISSN	2288-2413 ; 2288-2405
ISSN (online)	2288-2413
ISSN	2288-2405
DOI	10.14791/btrt.2013.1.1.1
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Article: Osteoporosis Is Associated with an Increased Risk of Colorectal Neoplasms Regardless of Sex: Nationwide Population-Based Cohort Study.

Yoo, Seung Heon / Nam, Ji Hyung / Oh, Dong Jun / Park, Geun U / Kim, Sang Hoon / Kang, Hyoun Woo / Kim, Jae Hak / Lim, Yun Jeong

Diagnostics (Basel, Switzerland)

2024 Volume 14, Issue 6

Abstract: Vitamin D may have anticancer effects against colorectal cancer (CRC). Bone mineral density (BMD) reflects the long-term vitamin D status. This study investigated the association between osteoporosis and colorectal neoplasms (CRN). The data were obtained ...

Abstract	Vitamin D may have anticancer effects against colorectal cancer (CRC). Bone mineral density (BMD) reflects the long-term vitamin D status. This study investigated the association between osteoporosis and colorectal neoplasms (CRN). The data were obtained from the National Health Insurance Service sample cohort, which included 60,386 osteoporosis patients and 8224 controls who underwent BMD in 2002-2019. The logistic regression models included age, sex, income level, and comorbidity. Sensitivity tests were performed using the data from the National Health Screening Program. In total, 7706 (11.2%) patients were diagnosed with CRN, and the proportion was significantly higher in osteoporosis patients than in controls (11.7% vs. 8.1%). In the multivariate analysis, osteoporosis was associated with an increased risk of CRN (odds ratio (OR) = 1.91, 95% confidence interval = 1.75-2.09,
Language	English
Publishing date	2024-03-21
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662336-5
ISSN	2075-4418
ISSN	2075-4418
DOI	10.3390/diagnostics14060666
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Article ; Online: The efficacy of slow-rate ventriculolumbar perfusion chemotherapy for leptomeningeal carcinomatosis: a phase II study.

Jang, Soojin / Gwak, Ho-Shin / Joo, Jungnam / Doh, Yoon-Sik / Shin, Sang-Hoon / Yoo, Heon / Wang, Kyu-Chang

Acta neurochirurgica

2024 Volume 166, Issue 1, Page(s) 117

Abstract: Purpose: This study aimed to evaluate the symptomatic response and side effects of ventriculolumbar perfusion (VLP) methotrexate chemotherapy with a low perfusion rate in patients with leptomeningeal metastasis.: Methods: Patients in a single-arm, ... ...

Abstract	Purpose: This study aimed to evaluate the symptomatic response and side effects of ventriculolumbar perfusion (VLP) methotrexate chemotherapy with a low perfusion rate in patients with leptomeningeal metastasis. Methods: Patients in a single-arm, two-stage phase II trial based on Simon's minimax design received VLP with a reduced (15 cc/h) perfusion rate with the purpose of decreasing constitutional side effects such as nausea/vomiting, insomnia, and confusion. The primary outcome was control of increased intracranial pressure (ICP). The secondary outcome was an occurrence of side effects. The results were compared with those of a previous trial of VLP with a 20-cc/h perfusion rate. Results: Total 90 patients were enrolled. Out of 65 patients with increased ICP, 32 achieved normalized ICP after VLP chemotherapy (bias-adjusted response rate = 51%). The incidence of moderate-to-severe nausea/vomiting was reduced to 46% from 64% in the previous study, and that of sleep disturbance was increased to 13% from 9%, but both failed to reach statistical significance. The incidence of moderate-to-severe confusion was significantly reduced to 12% from 23% in the previous study (p = 0.04). Median overall survival was better among patients with controlled ICP than among those who remained with increased ICP (193 days vs. 94 days, p = 0.013). Conclusion: Compared with a higher perfusion rate, the low perfusion rate failed to provide non-inferior ICP control or improved side effects, except for confusion. The relationship between VLP perfusion rate and ICP control needs to be evaluated in future trials adjusting for bias from uncompleted protocol due to poor general condition.
MeSH term(s)	Humans ; Meningeal Carcinomatosis/drug therapy ; Meningeal Carcinomatosis/secondary ; Methotrexate/therapeutic use ; Nausea/chemically induced ; Nausea/drug therapy ; Perfusion ; Vomiting/chemically induced ; Vomiting/drug therapy
Chemical Substances	Methotrexate (YL5FZ2Y5U1)
Language	English
Publishing date	2024-03-01
Publishing country	Austria
Document type	Clinical Trial, Phase II ; Journal Article
ZDB-ID	80010-7
ISSN	0942-0940 ; 0001-6268
ISSN (online)	0942-0940
ISSN	0001-6268
DOI	10.1007/s00701-024-05989-0
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Article ; Online: Electrochemically Activated Expanded Graphite with Tailor-Made Pores for Magnesium-Organocation Hybrid Batteries.

Mohanty, Sangram Keshari / Cao, Lei / Choi, Byeong Kil / Ryu, Ji Heon / Park, Jin Kyoon / Yoo, Hyun Deog

ChemSusChem

2023 Volume 16, Issue 11, Page(s) e202300691

Abstract: ... at Pusan National University, and Prof. Ji Heon Ryu at Tech University of Korea (Republic of Korea ... Invited for this month's cover are the groups of Prof. Hyun Deog Yoo and Prof. Jin Kyoon Park ...

Abstract	Invited for this month's cover are the groups of Prof. Hyun Deog Yoo and Prof. Jin Kyoon Park at Pusan National University, and Prof. Ji Heon Ryu at Tech University of Korea (Republic of Korea). The cover image illustrates the generation of tailor-made pores by the electrochemical activation of expanded graphite for a magnesium-organocation hybrid battery. The Research Article itself is available at 10.1002/cssc.202300035.
MeSH term(s)	Humans ; Graphite ; Magnesium ; Electric Power Supplies
Chemical Substances	Graphite (7782-42-5) ; Magnesium (I38ZP9992A)
Language	English
Publishing date	2023-06-09
Publishing country	Germany
Document type	Journal Article
ISSN	1864-564X
ISSN (online)	1864-564X
DOI	10.1002/cssc.202300691
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