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Article ; Online: mCrutch: A Novel m-Health Approach Supporting Continuity of Care.

Arcobelli, Valerio Antonio / Zauli, Matteo / Galteri, Giulia / Cristofolini, Luca / Chiari, Lorenzo / Cappello, Angelo / De Marchi, Luca / Mellone, Sabato

Sensors (Basel, Switzerland)

2023 Volume 23, Issue 8

Abstract: This paper reports the architecture of a low-cost smart crutches system for mobile health applications. The prototype is based on a set of sensorized crutches connected to a custom Android application. Crutches were instrumented with a 6-axis inertial ... ...

Abstract	This paper reports the architecture of a low-cost smart crutches system for mobile health applications. The prototype is based on a set of sensorized crutches connected to a custom Android application. Crutches were instrumented with a 6-axis inertial measurement unit, a uniaxial load cell, WiFi connectivity, and a microcontroller for data collection and processing. Crutch orientation and applied force were calibrated with a motion capture system and a force platform. Data are processed and visualized in real-time on the Android smartphone and are stored on the local memory for further offline analysis. The prototype's architecture is reported along with the post-calibration accuracy for estimating crutch orientation (5° RMSE in dynamic conditions) and applied force (10 N RMSE). The system is a mobile-health platform enabling the design and development of real-time biofeedback applications and continuity of care scenarios, such as telemonitoring and telerehabilitation.
MeSH term(s)	Humans ; Biomechanical Phenomena ; Smartphone ; Mobile Applications ; Telemedicine ; Continuity of Patient Care ; Gait
Language	English
Publishing date	2023-04-21
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2052857-7
ISSN	1424-8220 ; 1424-8220
ISSN (online)	1424-8220
ISSN	1424-8220
DOI	10.3390/s23084151
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Strigolactones as Broad-Spectrum Antivirals against β-Coronaviruses through Targeting the Main Protease M

Biolatti, Matteo / Blangetti, Marco / Baggieri, Melissa / Marchi, Antonella / Gioacchini, Silvia / Bajetto, Greta / Arnodo, Davide / Bucci, Paola / Fioravanti, Raoul / Kojouri, Maedeh / Bersani, Matteo / D'Arrigo, Giulia / Siragusa, Lydia / Ghinato, Simone / De Andrea, Marco / Gugliesi, Francesca / Albano, Camilla / Pasquero, Selina / Visentin, Ivan /

D'Ugo, Emilio / Esposito, Francesca / Malune, Paolo / Tramontano, Enzo / Prandi, Cristina / Spyrakis, Francesca / Magurano, Fabio / Dell'Oste, Valentina

ACS infectious diseases

2023 Volume 9, Issue 7, Page(s) 1310–1318

Abstract: The current SARS-CoV-2 pandemic and the likelihood that new coronavirus strains will emerge in the immediate future point out the urgent need to identify new pan-coronavirus inhibitors. Strigolactones (SLs) are a class of plant hormones with multifaceted ...

Abstract	The current SARS-CoV-2 pandemic and the likelihood that new coronavirus strains will emerge in the immediate future point out the urgent need to identify new pan-coronavirus inhibitors. Strigolactones (SLs) are a class of plant hormones with multifaceted activities whose roles in plant-related fields have been extensively explored. Recently, we proved that SLs also exert antiviral activity toward herpesviruses, such as human cytomegalovirus (HCMV). Here we show that the synthetic SLs TH-EGO and EDOT-EGO impair β-coronavirus replication including SARS-CoV-2 and the common cold human coronavirus HCoV-OC43. Interestingly,
MeSH term(s)	Humans ; COVID-19 ; Antiviral Agents/pharmacology ; Antiviral Agents/chemistry ; SARS-CoV-2 ; Peptide Hydrolases
Chemical Substances	Antiviral Agents ; GR24 strigolactone ; Peptide Hydrolases (EC 3.4.-)
Language	English
Publishing date	2023-06-26
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2373-8227
ISSN (online)	2373-8227
DOI	10.1021/acsinfecdis.3c00219
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Article ; Online: The long-term user experience of an m-Health application

Jakeline Karla Locatelli / Silvana Alba Scortegagna / Ana Carolina Bertoletti De Marchi

RECIIS, Vol 17, Iss

2023 Volume 4

Abstract: Low user engagement in m-Health applications has been driving the use of retention techniques ... showed no engagement with the m-health app over time. The main factors contributing to the lack ... m-Health interventions, it is important to understand users' behavioral characteristics, motivations ...

Abstract	Low user engagement in m-Health applications has been driving the use of retention techniques that aim to ensure a satisfactory long-term user experience. The aim was to understand the experience of hypertensive patients interacting with a mobile health application for 12 months. A qualitative/exploratory study was conducted after 12 months, with the same experimental group of participants as the non-randomized controlled clinical trial conducted in 2019. The mean age of the 16 participants was 57 years (SD=8), of which11 were female. All had low socioeconomic and educational levels. Content analysis showed no engagement with the m-health app over time. The main factors contributing to the lack of engagement were; inability of the user to use the app, lack of support and technical problems. When designing m-Health interventions, it is important to understand users' behavioral characteristics, motivations for treatment, level of involvement in health care, and ability to use technology.
Keywords	Saúde digital ; Autocuidado ; Experiência do usuário ; m-Health ; Engajamento ; Communication. Mass media ; P87-96 ; Public aspects of medicine ; RA1-1270
Subject code	360
Language	English
Publishing date	2023-12-01T00:00:00Z
Publisher	Instituto de Comunicação e Informação Científica e Tecnológica em Saúde (Icict) da Fundação Oswaldo Cruz (Fiocruz)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: GW190521: A Binary Black Hole Merger with a Total Mass of 150 M_{⊙}.

Abbott, R / Abbott, T D / Abraham, S / Acernese, F / Ackley, K / Adams, C / Adhikari, R X / Adya, V B / Affeldt, C / Agathos, M / Agatsuma, K / Aggarwal, N / Aguiar, O D / Aich, A / Aiello, L / Ain, A / Ajith, P / Akcay, S / Allen, G /

Allocca, A / Altin, P A / Amato, A / Anand, S / Ananyeva, A / Anderson, S B / Anderson, W G / Angelova, S V / Ansoldi, S / Antier, S / Appert, S / Arai, K / Araya, M C / Areeda, J S / Arène, M / Arnaud, N / Aronson, S M / Arun, K G / Asali, Y / Ascenzi, S / Ashton, G / Aston, S M / Astone, P / Aubin, F / Aufmuth, P / AultONeal, K / Austin, C / Avendano, V / Babak, S / Bacon, P / Badaracco, F / Bader, M K M / Bae, S / Baer, A M / Baird, J / Baldaccini, F / Ballardin, G / Ballmer, S W / Bals, A / Balsamo, A / Baltus, G / Banagiri, S / Bankar, D / Bankar, R S / Barayoga, J C / Barbieri, C / Barish, B C / Barker, D / Barkett, K / Barneo, P / Barone, F / Barr, B / Barsotti, L / Barsuglia, M / Barta, D / Bartlett, J / Bartos, I / Bassiri, R / Basti, A / Bawaj, M / Bayley, J C / Bazzan, M / Bécsy, B / Bejger, M / Belahcene, I / Bell, A S / Beniwal, D / Benjamin, M G / Bentley, J D / Bergamin, F / Berger, B K / Bergmann, G / Bernuzzi, S / Berry, C P L / Bersanetti, D / Bertolini, A / 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Prestegard, T / Principe, M / Prodi, G A / Prokhorov, L / Punturo, M / Puppo, P / Pürrer, M / Qi, H / Quetschke, V / Quinonez, P J / Raab, F J / Raaijmakers, G / Radkins, H / Radulesco, N / Raffai, P / Rafferty, H / Raja, S / Rajan, C / Rajbhandari, B / Rakhmanov, M / Ramirez, K E / Ramos-Buades, A / Rana, Javed / Rao, K / Rapagnani, P / Raymond, V / Razzano, M / Read, J / Regimbau, T / Rei, L / Reid, S / Reitze, D H / Rettegno, P / Ricci, F / Richardson, C J / Richardson, J W / Ricker, P M / Riemenschneider, G / Riles, K / Rizzo, M / Robertson, N A / Robinet, F / Rocchi, A / Rodriguez-Soto, R D / Rolland, L / Rollins, J G / Roma, V J / Romanelli, M / Romano, R / Romel, C L / Romero-Shaw, I M / Romie, J H / Rose, C A / Rose, D / Rose, K / Rosińska, D / Rosofsky, S G / Ross, M P / Rowan, S / Rowlinson, S J / Roy, P K / Roy, Santosh / Roy, Soumen / Ruggi, P / Rutins, G / Ryan, K / Sachdev, S / Sadecki, T / Sakellariadou, M / Salafia, O S / Salconi, L / Saleem, M / Salemi, F / Samajdar, A / Sanchez, E J / Sanchez, L E / Sanchis-Gual, N / Sanders, J R / Santiago, K A / Santos, E / Sarin, N / Sassolas, B / Sathyaprakash, B S / Sauter, O / Savage, R L / Savant, V / Sawant, D / Sayah, S / Schaetzl, D / Schale, P / Scheel, M / Scheuer, J / Schmidt, P / Schnabel, R / Schofield, R M S / Schönbeck, A / Schreiber, E / Schulte, B W / Schutz, B F / Schwarm, O / Schwartz, E / Scott, J / Scott, S M / Seidel, E / Sellers, D / Sengupta, A S / Sennett, N / Sentenac, D / Sequino, V / Sergeev, A / Setyawati, Y / Shaddock, D A / Shaffer, T / Sharifi, S / Shahriar, M S / Sharma, A / Sharma, P / Shawhan, P / Shen, H / Shikauchi, M / Shink, R / Shoemaker, D H / Shoemaker, D M / Shukla, K / ShyamSundar, S / Siellez, K / Sieniawska, M / Sigg, D / Singer, L P / Singh, D / Singh, N / Singha, A / Singhal, A / Sintes, A M / Sipala, V / Skliris, V / Slagmolen, B J J / Slaven-Blair, T J / Smetana, J / Smith, J R / Smith, R J E / Somala, S / Son, E J / Soni, S / Sorazu, B / Sordini, V / Sorrentino, F 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Physical review letters

2021 Volume 125, Issue 10, Page(s) 101102

Abstract: ... with masses of 85_{-14}^{+21} M_{⊙} and 66_{-18}^{+17} M_{⊙} (90% credible intervals). We infer ... with only a 0.32% probability of being below 65 M_{⊙}. We calculate the mass of the remnant to be 142_{-16 ... 28} M_{⊙}, which can be considered an intermediate mass black hole (IMBH). The luminosity distance ...

Abstract	On May 21, 2019 at 03:02:29 UTC Advanced LIGO and Advanced Virgo observed a short duration gravitational-wave signal, GW190521, with a three-detector network signal-to-noise ratio of 14.7, and an estimated false-alarm rate of 1 in 4900 yr using a search sensitive to generic transients. If GW190521 is from a quasicircular binary inspiral, then the detected signal is consistent with the merger of two black holes with masses of 85_{-14}^{+21} M_{⊙} and 66_{-18}^{+17} M_{⊙} (90% credible intervals). We infer that the primary black hole mass lies within the gap produced by (pulsational) pair-instability supernova processes, with only a 0.32% probability of being below 65 M_{⊙}. We calculate the mass of the remnant to be 142_{-16}^{+28} M_{⊙}, which can be considered an intermediate mass black hole (IMBH). The luminosity distance of the source is 5.3_{-2.6}^{+2.4} Gpc, corresponding to a redshift of 0.82_{-0.34}^{+0.28}. The inferred rate of mergers similar to GW190521 is 0.13_{-0.11}^{+0.30} Gpc^{-3} yr^{-1}.
Language	English
Publishing date	2021-02-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	208853-8
ISSN	1079-7114 ; 0031-9007
ISSN (online)	1079-7114
ISSN	0031-9007
DOI	10.1103/PhysRevLett.125.101102
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Article ; Online: Variation of immunoglobulins G, A, and M and bovine serum albumin concentration in Holstein cow colostrum.

Costa, A / Goi, A / Penasa, M / Nardino, G / Posenato, L / De Marchi, M

Animal : an international journal of animal bioscience

2021 Volume 15, Issue 7, Page(s) 100299

Abstract: Immunoglobulins G (IgG), A (IgA), and M (IgM) represent 70-80% of total proteins in cattle ...

Abstract	Immunoglobulins G (IgG), A (IgA), and M (IgM) represent 70-80% of total proteins in cattle colostrum and are essential for the passive transfer of antibodies from the dam to the calf. Considering the practical difficulties of colostrum sample collection and the high cost of analysis, non-genetic sources of variation of the three immunoglobulins fractions have been scarcely studied together on a large scale in dairy cows. In the present study, IgG, IgA, IgM, and bovine serum albumin (BSA) were determined in colostrum samples of Holstein cows through bovine-specific radial immunodiffusion kits; such phenotypes allowed to investigate the effects of parity, herd, and calving season, and interactions. Only the first colostrum was considered in the present study, as the calf was separated from the dam immediately after birth and was not allowed to suckle. The average of IgG (n = 676), IgA (n = 573), IgM (n = 658), total immunoglobulins (n = 525), and BSA (n = 614) was 91.31, 4.20, 105.99, 5.05, and 2.47 g/L, respectively, and all traits positively correlated to each other. Overall, the immunoglobulins were less concentrated in colostrum of first- and second-parity cows than later-parity cows. These findings suggest that colostrum quality, based on Ig, is overall greater in cows that experienced more than two lactations, likely due to a greater experience of the immune system and to a wider immune heritage compared to younger cows. As regards the effect of calving season, the concentration of all Ig tended to be generally greater in colostrum sampled from August to November. Moreover, there were differences in IgG, IgA, and IgM concentration among the nine herds involved. Future studies will investigate the relationships of these traits with yield, and gross and detailed composition of bovine colostrum and will consider their genetic background to evaluate potential selection strategies to improve colostrum quality.
MeSH term(s)	Animals ; Cattle ; Colostrum ; Female ; Immunodiffusion/veterinary ; Immunoglobulin G ; Immunoglobulins ; Lactation ; Pregnancy ; Serum Albumin, Bovine
Chemical Substances	Immunoglobulin G ; Immunoglobulins ; Serum Albumin, Bovine (27432CM55Q)
Language	English
Publishing date	2021-06-22
Publishing country	England
Document type	Journal Article
ZDB-ID	2257920-5
ISSN	1751-732X ; 1751-7311
ISSN (online)	1751-732X
ISSN	1751-7311
DOI	10.1016/j.animal.2021.100299
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Article ; Online: Effectiveness of visible - Near infrared spectroscopy coupled with simulated annealing partial least squares analysis to predict immunoglobulins G, A, and M concentration in bovine colostrum.

Franzoi, M / Costa, A / Goi, A / Penasa, M / De Marchi, M

Food chemistry

2021 Volume 371, Page(s) 131189

Abstract: Visible - near infrared spectroscopy coupled with variable selection using simulated annealing PLS regression was tested to predict immunoglobulin fractions (g/L) of bovine colostrum, namely IgG, IgA and IgM. Immunoglobulins were quantified in 678 ... ...

Abstract	Visible - near infrared spectroscopy coupled with variable selection using simulated annealing PLS regression was tested to predict immunoglobulin fractions (g/L) of bovine colostrum, namely IgG, IgA and IgM. Immunoglobulins were quantified in 678 samples using the gold standard radial immunodiffusion. Samples were divided in calibration (50%) and validation (50%) datasets. Maximum number of selected variables were limited to 200 and root mean squared error in cross validation (RMSE
MeSH term(s)	Animals ; Cattle ; Colostrum ; Female ; Humans ; Immunodiffusion ; Immunoglobulin G ; Least-Squares Analysis ; Pregnancy ; Spectroscopy, Near-Infrared
Chemical Substances	Immunoglobulin G
Language	English
Publishing date	2021-09-20
Publishing country	England
Document type	Journal Article
ZDB-ID	243123-3
ISSN	1873-7072 ; 0308-8146
ISSN (online)	1873-7072
ISSN	0308-8146
DOI	10.1016/j.foodchem.2021.131189
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Article ; Online: GW190814: Gravitational Waves from the Coalescence of a 23 M$_\odot$ Black Hole with a 2.6 M$_\odot$ Compact Object

Collaboration, The LIGO Scientific / Abbott, the Virgo Collaboration R. / Abbott, T. D. / Abraham, S. / Acernese, F. / Ackley, K. / Adams, C. / Adhikari, R. X. / Adya, V. B. / Affeldt, C. / Agathos, M. / Agatsuma, K. / Aggarwal, N. / Aguiar, O. D. / Aich, A. / Aiello, L. / Ain, A. / Ajith, P. / Akcay, S. /

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N. / Jaranowski, P. / Jariwala, D. / Jaume, R. / Jenkins, A. C. / Jiang, J. / Johns, G. R. / Johnson-McDaniel, N. K. / Jones, A. W. / Jones, D. I. / Jones, J. D. / Jones, P. / Jones, R. / Jonker, R. J. G. / Ju, L. / Junker, J. / Kalaghatgi, C. V. / Kalogera, V. / Kamai, B. / Kandhasamy, S. / Kang, G. / Kanner, J. B. / Kapadia, S. J. / Karki, S. / Kashyap, R. / Kasprzack, M. / Kastaun, W. / Katsanevas, S. / Katsavounidis, E. / Katzman, W. / Kaufer, S. / Kawabe, K. / K'ef'elian, F. / Keitel, D. / Keivani, A. / Kennedy, R. / Key, J. S. / Khadka, S. / Khalili, F. Y. / Khan, I. / Khan, S. / Khan, Z. A. / Khazanov, E. A. / Khetan, N. / Khursheed, M. / Kijbunchoo, N. / Kim, Chunglee / Kim, G. J. / Kim, J. C. / Kim, K. / Kim, W. / Kim, W. S. / Kim, Y.-M. / Kimball, C. / King, P. J. / Kinley-Hanlon, M. / Kirchhoff, R. / Kissel, J. S. / Kleybolte, L. / Klimenko, S. / Knowles, T. D. / Knyazev, E. / Koch, P. / Koehlenbeck, S. M. / Koekoek, G. / Koley, S. / Kondrashov, V. / Kontos, A. / Koper, N. / Korobko, M. / Korth, W. Z. / Kovalam, M. / Kozak, D. B. / Kringel, V. / Krishnendu, N. V. / Kr'olak, A. / Krupinski, N. / Kuehn, G. / Kumar, A. / Kumar, P. / Kumar, Rahul / Kumar, Rakesh / Kumar, S. / Kuo, L. / Kutynia, A. / Lackey, B. D. / Laghi, D. / Lalande, E. / Lam, T. L. / Lamberts, A. / Landry, M. / Landry, P. / Lane, B. B. / Lang, R. N. / Lange, J. / Lantz, B. / Lanza, R. K. / Rosa, I. La / Lartaux-Vollard, A. / Lasky, P. D. / Laxen, M. / Lazzarini, A. / Lazzaro, C. / Leaci, P. / Leavey, S. / Lecoeuche, Y. K. / Lee, C. H. / Lee, H. M. / Lee, H. W. / Lee, J. / Lee, K. / Lehmann, J. / Leroy, N. / Letendre, N. / Levin, Y. / Li, A. K. Y. / Li, J. / li, K. / Li, T. G. F. / Li, X. / Linde, F. / Linker, S. D. / Linley, J. N. / Littenberg, T. B. / Liu, J. / Liu, X. / Llorens-Monteagudo, M. / Lo, R. K. L. / Lockwood, A. / London, L. T. / Longo, A. / Lorenzini, M. / Loriette, V. / Lormand, M. / Losurdo, G. / Lough, J. D. / Lousto, C. O. / Lovelace, G. / Luck, H. / Lumaca, D. / Lundgren, A. P. / Ma, Y. / Macas, R. / Macfoy, S. / MacInnis, M. / Macleod, D. M. / MacMillan, I. A. O. / Macquet, A. / Hernandez, I. Magana / Magana-Sandoval, F. / Magee, R. M. / Majorana, E. / Maksimovic, I. / Malik, A. / Man, N. / Mandic, V. / Mangano, V. / Mansell, G. L. / Manske, M. / Mantovani, M. / Mapelli, M. / Marchesoni, F. / Marion, F. / M'arka, S. / M'arka, Z. / Markakis, C. / Markosyan, A. S. / Markowitz, A. / Maros, E. / Marquina, A. / Marsat, S. / Martelli, F. / Martin, I. W. / Martin, R. M. / Martinez, V. / Martynov, D. V. / Masalehdan, H. / Mason, K. / Massera, E. / Masserot, A. / Massinger, T. J. / Masso-Reid, M. / Mastrogiovanni, S. / Matas, A. / Matichard, F. / Mavalvala, N. / Maynard, E. / McCann, J. J. / McCarthy, R. / McClelland, D. E. / McCormick, S. / McCuller, L. / McGuire, S. C. / McIsaac, C. / McIver, J. / McManus, D. J. / McRae, T. / McWilliams, S. T. / Meacher, D. / Meadors, G. D. / Mehmet, M. / Mehta, A. K. / Villa, E. Mejuto / Melatos, A. / Mendell, G. / Mercer, R. A. / Mereni, L. / Merfeld, K. / Merilh, E. L. / Merritt, J. D. / Merzougui, M. / Meshkov, S. / Messenger, C. / Messick, C. / Metzdorff, R. / Meyers, P. M. / Meylahn, F. / Mhaske, A. / Miani, A. / Miao, H. / Michaloliakos, I. / Michel, C. / Middleton, H. / Milano, L. / Miller, A. L. / Millhouse, M. / Mills, J. C. / Milotti, E. / Milovich-Goff, M. C. / Minazzoli, O. / Minenkov, Y. / Mishkin, A. / Mishra, C. / Mistry, T. / Mitra, S. / Mitrofanov, V. P. / Mitselmakher, G. / Mittleman, R. / Mo, G. / Mogushi, K. / Mohapatra, S. R. P. / Mohite, S. R. / Molina-Ruiz, M. / Mondin, M. / Montani, M. / Moore, C. J. / Moraru, D. / Morawski, F. / Moreno, G. / Morisaki, S. / Mours, B. / Mow-Lowry, C. M. / Mozzon, S. / Muciaccia, F. / Mukherjee, Arunava / Mukherjee, D. / Mukherjee, S. / Mukherjee, Subroto / Mukund, N. / Mullavey, A. / Munch, J. / Muniz, E. A. / Murray, P. G. / Nagar, A. / Nardecchia, I. / Naticchioni, L. / Nayak, R. K. / Neil, B. F. / Neilson, J. / Nelemans, G. / Nelson, T. J. N. / Nery, M. / Neunzert, A. / Ng, K. Y. / Ng, S. / Nguyen, C. / Nguyen, P. / Nichols, D. / Nichols, S. A. / Nissanke, S. / Nocera, F. / Noh, M. / North, C. / Nothard, D. / Nuttall, L. K. / Oberling, J. / O'Brien, B. D. / Oganesyan, G. / Ogin, G. H. / Oh, J. J. / Oh, S. H. / Ohme, F. / Ohta, H. / Okada, M. A. / Oliver, M. / Olivetto, C. / Oppermann, P. / Oram, Richard J. / O'Reilly, B. / Ormiston, R. G. / Ortega, L. F. / O'Shaughnessy, R. / Ossokine, S. / Osthelder, C. / Ottaway, D. J. / Overmier, H. / Owen, B. J. / Pace, A. E. / Pagano, G. / Page, M. A. / Pagliaroli, G. / Pai, A. / Pai, S. A. / Palamos, J. R. / Palashov, O. / Palomba, C. / Pan, H. / Panda, P. K. / Pang, P. T. H. / Pankow, C. / Pannarale, F. / Pant, B. C. / Paoletti, F. / Paoli, A. / Parida, A. / Parker, W. / Pascucci, D. / Pasqualetti, A. / Passaquieti, R. / Passuello, D. / Patricelli, B. / Payne, E. / Pearlstone, B. L. / Pechsiri, T. C. / Pedersen, A. J. / Pedraza, M. / Pele, A. / Penn, S. / Perego, A. / Perez, C. J. / P'erigois, C. / Perreca, A. / Perries, S. / Petermann, J. / Pfeiffer, H. P. / Phelps, M. / Phukon, K. S. / Piccinni, O. J. / Pichot, M. / Piendibene, M. / Piergiovanni, F. / Pierro, V. / Pillant, G. / Pinard, L. / Pinto, I. M. / Piotrzkowski, K. / Pirello, M. / Pitkin, M. / Plastino, W. / Poggiani, R. / Pong, D. Y. T. / Ponrathnam, S. / Popolizio, P. / Porter, E. K. / Powell, J. / Prajapati, A. K. / Prasai, K. / Prasanna, R. / Pratten, G. / Prestegard, T. / Principe, M. / Prodi, G. A. / Prokhorov, L. / Punturo, M. / Puppo, P. / Purrer, M. / Qi, H. / Quetschke, V. / Quinonez, P. J. / Raab, F. J. / Raaijmakers, G. / Radkins, H. / Radulesco, N. / Raffai, P. / Rafferty, H. / Raja, S. / Rajan, C. / Rajbhandari, B. / Rakhmanov, M. / Ramirez, K. E. / Ramos-Buades, A. / Rana, Javed / Rao, K. / Rapagnani, P. / Raymond, V. / Razzano, M. / Read, J. / Regimbau, T. / Rei, L. / Reid, S. / Reitze, D. H. / Rettegno, P. / Ricci, F. / Richardson, C. J. / Richardson, J. W. / Ricker, P. M. / Riemenschneider, G. / Riles, K. / Rizzo, M. / Robertson, N. A. / Robinet, F. / Rocchi, A. / Rodriguez-Soto, R. D. / Rolland, L. / Rollins, J. G. / Roma, V. J. / Romanelli, M. / Romano, R. / Romel, C. L. / Romero-Shaw, I. M. / Romie, J. H. / Rose, C. A. / Rose, D. / Rose, K. / Rosi'nska, D. / Rosofsky, S. G. / Ross, M. P. / Rowan, S. / Rowlinson, S. J. / Roy, P. K. / Roy, Santosh / Roy, Soumen / Ruggi, P. / Rutins, G. / Ryan, K. / Sachdev, S. / Sadecki, T. / Sakellariadou, M. / Salafia, O. S. / Salconi, L. / Saleem, M. / Salemi, F. / Samajdar, A. / Sanchez, E. J. / Sanchez, L. E. / Sanchis-Gual, N. / Sanders, J. R. / Santiago, K. A. / Santos, E. / Sarin, N. / Sassolas, B. / Sathyaprakash, B. S. / Sauter, O. / Savage, R. L. / Savant, V. / Sawant, D. / Sayah, S. / Schaetzl, D. / Schale, P. / Scheel, M. / Scheuer, J. / Schmidt, P. / Schnabel, R. / Schofield, R. M. S. / Schonbeck, A. / Schreiber, E. / Schulte, B. W. / Schutz, B. F. / Schwarm, O. / Schwartz, E. / Scott, J. / Scott, S. M. / Seidel, E. / Sellers, D. / Sengupta, A. S. / Sennett, N. / Sentenac, D. / Sequino, V. / Sergeev, A. / Setyawati, Y. / Shaddock, D. A. / Shaffer, T. / Shahriar, M. S. / Sharma, A. / Sharma, P. / Shawhan, P. / Shen, H. / Shikauchi, M. / Shink, R. / Shoemaker, D. H. / Shoemaker, D. M. / Shukla, K. / ShyamSundar, S. / Siellez, K. / Sieniawska, M. / Sigg, D. / Singer, L. P. / Singh, D. / Singh, N. / Singha, A. / Singhal, A. / Sintes, A. M. / Sipala, V. / Skliris, V. / Slagmolen, B. J. J. / Slaven-Blair, T. J. / Smetana, J. / Smith, J. R. / Smith, R. J. E. / Somala, S. / Son, E. J. / Soni, S. / Sorazu, B. / Sordini, V. / Sorrentino, F. / Souradeep, T. / Sowell, E. / Spencer, A. P. / Spera, M. / Srivastava, A. K. / Srivastava, V. / Staats, K. / Stachie, C. / Standke, M. / Steer, D. A. / Steinhoff, J. / Steinke, M. / Steinlechner, J. / Steinlechner, S. / Steinmeyer, D. / Stevenson, S. / Stocks, D. / Stops, D. J. / Stover, M. / Strain, K. A. / Stratta, G. / Strunk, A. / Sturani, R. / Stuver, A. L. / Sudhagar, S. / Sudhir, V. / Summerscales, T. Z. / Sun, L. / Sunil, S. / Sur, A. / Suresh, J. / Sutton, P. J. / Swinkels, B. L. / Szczepa'nczyk, M. J. / Tacca, M. / Tait, S. C. / Talbot, C. / Tanasijczuk, A. J. / Tanner, D. B. / Tao, D. / T'apai, M. / Tapia, A. / Martin, E. N. Tapia San / Tasson, J. D. / Taylor, R. / Tenorio, R. / Terkowski, L. / Thirugnanasambandam, M. P. / Thomas, M. / Thomas, P. / Thompson, J. E. / Thondapu, S. R. / Thorne, K. A. / Thrane, E. / Tinsman, C. L. / Saravanan, T. R. / Tiwari, Shubhanshu / Tiwari, S. / Tiwari, V. / Toland, K. / Tonelli, M. / Tornasi, Z. / Torres-Forn'e, A. / Torrie, C. I. / Melo, I. Tosta e / Toyra, D. / Trail, E. A. / Travasso, F. / Traylor, G. / Tringali, M. C. / Tripathee, A. / Trovato, A. / Trudeau, R. J. / Tsang, K. W. / Tse, M. / Tso, R. / Tsukada, L. / Tsuna, D. / Tsutsui, T. / Turconi, M. / Ubhi, A. S. / Ueno, K. / Ugolini, D. / Unnikrishnan, C. S. / Urban, A. L. / Usman, S. A. / Utina, A. C. / Vahlbruch, H. / Vajente, G. / Valdes, G. / Valentini, M. / Bakel, N. van / Beuzekom, M. van / Brand, J. F. J. van den / Broeck, C. Van Den / Vander-Hyde, D. C. / Schaaf, L. van der / Heijningen, J. V. Van / Veggel, A. A. van / Vardaro, M. / Varma, V. / Vass, S. / Vas'uth, M. / Vecchio, A. / Vedovato, G. / Veitch, J. / Veitch, P. J. / Venkateswara, K. / Venugopalan, G. / Verkindt, D. / Veske, D. / Vetrano, F. / Vicer'e, A. / Viets, A. D. / Vinciguerra, S. / Vine, D. J. / Vinet, J.-Y. / Vitale, S. / Vivanco, Francisco Hernandez / Vo, T. / Vocca, H. / Vorvick, C. / Vyatchanin, S. P. / Wade, A. R. / Wade, L. E. / Wade, M. / Walet, R. / Walker, M. / Wallace, G. S. / Wallace, L. / Walsh, S. / Wang, J. Z. / Wang, S. / Wang, W. H. / Ward, R. L. / Warden, Z. A. / Warner, J. / Was, M. / Watchi, J. / Weaver, B. / Wei, L.-W. / Weinert, M. / Weinstein, A. J. / Weiss, R. / Wellmann, F. / Wen, L. / Wessels, P. / Westhouse, J. W. / Wette, K. / Whelan, J. T. / Whiting, B. F. / Whittle, C. / Wilken, D. M. / Williams, D. / Willis, J. L. / Willke, B. / Winkler, W. / Wipf, C. C. / Wittel, H. / Woan, G. / Woehler, J. / Wofford, J. K. / Wong, C. / Wright, J. L. / Wu, D. S. / Wysocki, D. M. / Xiao, L. / Yamamoto, H. / Yang, L. / Yang, Y. / Yang, Z. / Yap, M. J. / Yazback, M. / Yeeles, D. W. / Yu, Hang / Yu, Haocun / Yuen, S. H. R. / Zadro.zny, A. K. / Zadro.zny, A. / Zanolin, M. / Zelenova, T. / Zendri, J.-P. / Zevin, M. / Zhang, J. / Zhang, L. / Zhang, T. / Zhao, C. / Zhao, G. / Zhou, M. / Zhou, Z. / Zhu, X. J. / Zimmerman, A. B. / Zucker, M. E. / Zweizig, J.

Abstract: We report the observation of a compact binary coalescence involving a 22.2 - 24.3 $M_{\odot}$ black ... hole and a compact object with a mass of 2.50 - 2.67 $M_{\odot}$ (all measurements quoted at the 90$ ...

Abstract	We report the observation of a compact binary coalescence involving a 22.2 - 24.3 $M_{\odot}$ black hole and a compact object with a mass of 2.50 - 2.67 $M_{\odot}$ (all measurements quoted at the 90$\%$ credible level). The gravitational-wave signal, GW190814, was observed during LIGO's and Virgo's third observing run on August 14, 2019 at 21:10:39 UTC and has a signal-to-noise ratio of 25 in the three-detector network. The source was localized to 18.5 deg$^2$ at a distance of $241^{+41}_{-45}$ Mpc; no electromagnetic counterpart has been confirmed to date. The source has the most unequal mass ratio yet measured with gravitational waves, $0.112^{+0.008}_{-0.009}$, and its secondary component is either the lightest black hole or the heaviest neutron star ever discovered in a double compact-object system. The dimensionless spin of the primary black hole is tightly constrained to $\leq 0.07$. Tests of general relativity reveal no measurable deviations from the theory, and its prediction of higher-multipole emission is confirmed at high confidence. We estimate a merger rate density of 1-23 Gpc$^{-3}$ yr$^{-1}$ for the new class of binary coalescence sources that GW190814 represents. Astrophysical models predict that binaries with mass ratios similar to this event can form through several channels, but are unlikely to have formed in globular clusters. However, the combination of mass ratio, component masses, and the inferred merger rate for this event challenges all current models for the formation and mass distribution of compact-object binaries.
Keywords	covid19
Publisher	ArXiv
Document type	Article ; Online
DOI	10.3847/2041-8213/ab960f
Database	COVID19

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Article ; Online: Serum oncostatin M at baseline predicts mucosal healing in Crohn's disease patients treated with infliximab.

Bertani, Lorenzo / Fornai, Matteo / Fornili, Marco / Antonioli, Luca / Benvenuti, Laura / Tapete, Gherardo / Baiano Svizzero, Giovanni / Ceccarelli, Linda / Mumolo, Maria Gloria / Baglietto, Laura / de Bortoli, Nicola / Bellini, Massimo / Marchi, Santino / Costa, Francesco / Blandizzi, Corrado

Alimentary pharmacology & therapeutics

2020 Volume 52, Issue 2, Page(s) 284–291

Abstract: Background: Oncostatin M is upregulated in Crohn's disease inflamed intestinal mucosa, and has ... with inflammatory bowel diseases.: Aim: To evaluate the suitability of serum oncostatin M as a predictive marker of response ... All patients underwent colonoscopy at week 54 to evaluate mucosal healing. Serum oncostatin M and faecal ...

Abstract	Background: Oncostatin M is upregulated in Crohn's disease inflamed intestinal mucosa, and has been suggested as a promising biomarker to predict responsiveness to anti-TNF therapy in patients with inflammatory bowel diseases. Aim: To evaluate the suitability of serum oncostatin M as a predictive marker of response to infliximab in Crohn's disease. Methods: We included patients treated with infliximab monotherapy. All patients underwent colonoscopy at week 54 to evaluate mucosal healing. Serum oncostatin M and faecal calprotectin were measured at baseline and after 14 weeks of treatment. Mann-Whitney test was used to evaluate correlation of oncostatin M and faecal calprotectin at baseline and week 14 with mucosal healing at week 54. Their accuracy in predicting mucosal healing was assessed by area under the curve (AUC). Results: In a cohort of 45 included patients, 27 displayed mucosal healing. At both baseline and week 14, oncostatin M levels were significantly lower in patients with mucosal healing than in patients not achieving this endpoint (P < 0.001). Faecal calprotectin levels at week 14 were lower also in responders than nonresponders (P < 0.001). Oncostatin M values at baseline and week 14 were significantly associated (Spearman correlation = 0.92, P < 0.001). The diagnostic accuracy of oncostatin M at baseline in predicting mucosal healing (AUC = 0.91) was greater than faecal calprotectin (AUC = 0.51, P < 0.001). Conclusion: These results suggest that oncostatin M can predict the outcome of infliximab treatment. Compared with faecal calprotectin, the predictive capability of oncostatin M was appreciable at baseline, thus indicating oncostatin M as a promising biomarker for driving therapeutic choices in Crohn's disease.
MeSH term(s)	Adult ; Antirheumatic Agents/therapeutic use ; Biomarkers/analysis ; Biomarkers/blood ; Colonoscopy ; Crohn Disease/blood ; Crohn Disease/drug therapy ; Crohn Disease/pathology ; Feces/chemistry ; Female ; Gastrointestinal Agents/therapeutic use ; Humans ; Inflammatory Bowel Diseases ; Infliximab/therapeutic use ; Intestinal Mucosa/drug effects ; Intestinal Mucosa/pathology ; Leukocyte L1 Antigen Complex/analysis ; Male ; Middle Aged ; Oncostatin M/blood ; Tumor Necrosis Factor-alpha/therapeutic use ; Young Adult
Chemical Substances	Antirheumatic Agents ; Biomarkers ; Gastrointestinal Agents ; Leukocyte L1 Antigen Complex ; Tumor Necrosis Factor-alpha ; Oncostatin M (106956-32-5) ; Infliximab (B72HH48FLU)
Language	English
Publishing date	2020-06-07
Publishing country	England
Document type	Clinical Trial ; Journal Article
ZDB-ID	639012-2
ISSN	1365-2036 ; 0269-2813 ; 0953-0673
ISSN (online)	1365-2036
ISSN	0269-2813 ; 0953-0673
DOI	10.1111/apt.15870
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Article: Effectiveness of visible – Near infrared spectroscopy coupled with simulated annealing partial least squares analysis to predict immunoglobulins G, A, and M concentration in bovine colostrum

Franzoi, M. / Costa, A. / Goi, A. / Penasa, M. / De Marchi, M.

Food chemistry. 2022 Mar. 01, v. 371

2022

Abstract	Visible - near infrared spectroscopy coupled with variable selection using simulated annealing PLS regression was tested to predict immunoglobulin fractions (g/L) of bovine colostrum, namely IgG, IgA and IgM. Immunoglobulins were quantified in 678 samples using the gold standard radial immunodiffusion. Samples were divided in calibration (50%) and validation (50%) datasets. Maximum number of selected variables were limited to 200 and root mean squared error in cross validation (RMSECV) was used as loss function. Performance of the final model developed using the calibration dataset was assessed on the validation dataset. Overall, simulated annealing PLS improved validation RMSECV compared to ordinary PLS regression by 3% to 17%. The present study demonstrated the effectiveness of the calibration model for accurate quantification of IgG, the most abundant immunoglobulin of bovine colostrum (RMSECV = 13.28 g/L; R² = 0.83). These outcomes could be useful to assess colostrum quality intended for animal and human usage.
Keywords	cow colostrum ; data collection ; food chemistry ; humans ; immunoglobulin G ; models ; near-infrared spectroscopy
Language	English
Dates of publication	2022-0301
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	243123-3
ISSN	1873-7072 ; 0308-8146
ISSN (online)	1873-7072
ISSN	0308-8146
DOI	10.1016/j.foodchem.2021.131189
Database	NAL-Catalogue (AGRICOLA)

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Article: Variation of immunoglobulins G, A, and M and bovine serum albumin concentration in Holstein cow colostrum

Costa, A. / Goi, A. / Penasa, M. / Nardino, G. / Posenato, L. / De Marchi, M.

Animal. 2021 July, v. 15, no. 7

2021

Abstract: Immunoglobulins G (IgG), A (IgA), and M (IgM) represent 70–80% of total proteins in cattle ...

Abstract	Immunoglobulins G (IgG), A (IgA), and M (IgM) represent 70–80% of total proteins in cattle colostrum and are essential for the passive transfer of antibodies from the dam to the calf. Considering the practical difficulties of colostrum sample collection and the high cost of analysis, non-genetic sources of variation of the three immunoglobulins fractions have been scarcely studied together on a large scale in dairy cows. In the present study, IgG, IgA, IgM, and bovine serum albumin (BSA) were determined in colostrum samples of Holstein cows through bovine-specific radial immunodiffusion kits; such phenotypes allowed to investigate the effects of parity, herd, and calving season, and interactions. Only the first colostrum was considered in the present study, as the calf was separated from the dam immediately after birth and was not allowed to suckle. The average of IgG (n = 676), IgA (n = 573), IgM (n = 658), total immunoglobulins (n = 525), and BSA (n = 614) was 91.31, 4.20, 105.99, 5.05, and 2.47 g/L, respectively, and all traits positively correlated to each other. Overall, the immunoglobulins were less concentrated in colostrum of first- and second-parity cows than later-parity cows. These findings suggest that colostrum quality, based on Ig, is overall greater in cows that experienced more than two lactations, likely due to a greater experience of the immune system and to a wider immune heritage compared to younger cows. As regards the effect of calving season, the concentration of all Ig tended to be generally greater in colostrum sampled from August to November. Moreover, there were differences in IgG, IgA, and IgM concentration among the nine herds involved. Future studies will investigate the relationships of these traits with yield, and gross and detailed composition of bovine colostrum and will consider their genetic background to evaluate potential selection strategies to improve colostrum quality.
Keywords	Holstein ; bovine serum albumin ; calves ; cow colostrum ; genetic background ; herds ; immune system ; immunoglobulin G ; parity (reproduction)
Language	English
Dates of publication	2021-07
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	2257920-5
ISSN	1751-732X ; 1751-7311
ISSN (online)	1751-732X
ISSN	1751-7311
DOI	10.1016/j.animal.2021.100299
Database	NAL-Catalogue (AGRICOLA)

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