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Article ; Online: Human parainfluenza virus type 2 V protein inhibits mitochondrial apoptosis pathway through two ways.

Saka, Naoki / Nishio, Machiko / Ohta, Keisuke

2024 Volume 594, Page(s) 110053

Abstract: Paramyxoviruses are reported to block apoptosis for their replication, but the mechanisms remain unclear. Furthermore, regulation of mitochondrial apoptosis by paramyxoviruses has been hardly reported. We investigated whether and how human parainfluenza ... ...

Abstract	Paramyxoviruses are reported to block apoptosis for their replication, but the mechanisms remain unclear. Furthermore, regulation of mitochondrial apoptosis by paramyxoviruses has been hardly reported. We investigated whether and how human parainfluenza virus type 2 (hPIV-2) counteracts apoptosis. Infection of recombinant hPIV-2 carrying mutated V protein showed higher caspase 3/7 activity and higher cytochrome c release from mitochondria than wild type hPIV-2 infection. This indicates that V protein controls mitochondrial apoptosis pathway. hPIV-2 V protein interacted with Bad, an apoptotic promoting protein, and this interaction inhibited the binding of Bad to Bcl-X
MeSH term(s)	Humans ; Parainfluenza Virus 2, Human/metabolism ; Mitochondria/metabolism ; Apoptosis ; Carrier Proteins/metabolism ; bcl-X Protein/genetics ; bcl-X Protein/metabolism
Chemical Substances	Carrier Proteins ; bcl-X Protein
Language	English
Publishing date	2024-03-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	200425-2
ISSN	1096-0341 ; 0042-6822
ISSN (online)	1096-0341
ISSN	0042-6822
DOI	10.1016/j.virol.2024.110053
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Article ; Online: Nairovirus polymerase mutations associated with the establishment of persistent infection in human cells.

Ohta, Keisuke / Saka, Naoki / Nishi, Yuzuha / Nishio, Machiko

Journal of virology

2024 Volume 98, Issue 3, Page(s) e0169823

Abstract: Crimean-Congo hemorrhagic fever virus (CCHFV), a tick-borne virus of the : Importance: We investigated whether and how nairoviruses persistently infect human cells, using Hazara orthonairovirus (HAZV), a surrogate model for Crimean-Congo hemorrhagic ... ...

Abstract	Crimean-Congo hemorrhagic fever virus (CCHFV), a tick-borne virus of the Importance: We investigated whether and how nairoviruses persistently infect human cells, using Hazara orthonairovirus (HAZV), a surrogate model for Crimean-Congo hemorrhagic fever virus. We established a human cell line that was persistently infected with HAZV. Five mutations were found in L protein of persistently infected HAZV (HAZVpi): mut1, mut2, mut3, mut4, and mut5. Among them, Lmut1 and Lmut4 restricted viral growth by low polymerase activity and low growth rate, respectively, leading to inhibition of viral overgrowth. The restriction of viral growth caused by Lmut1 and Lmut4 was compensated by other mutations, including Lmut2, Lmut3, and Lmut5. Each of the mutations found in L protein of HAZVpi was concluded to cooperatively modulate viral growth, which facilitates the establishment of persistent infection. Suppression of innate immunity also potentially contributes to virus persistence. This is the first presentation of a possible mechanism behind how nairoviruses establish persistent infection in human cells.
MeSH term(s)	Animals ; Humans ; Cell Line ; Hemorrhagic Fever Virus, Crimean-Congo/physiology ; Hemorrhagic Fever, Crimean/virology ; Mutation ; Nairovirus/genetics ; Persistent Infection ; Bunyaviridae Infections/virology
Language	English
Publishing date	2024-02-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	80174-4
ISSN	1098-5514 ; 0022-538X
ISSN (online)	1098-5514
ISSN	0022-538X
DOI	10.1128/jvi.01698-23
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Zs.A 609: Show issues

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Article ; Online: The bipartite promoter of

Saka, Naoki / Ohta, Keisuke / Kolakofsky, Daniel / Nishio, Machiko

Journal of virology

2023 Volume 97, Issue 11, Page(s) e0091823

Abstract: Importance: The realization that segmented negative-strand RNA virus genome ribonucleoproteins are never free as their RNA ends are always bound to the viral polymerase has highlighted the problem of how these genome segments are replicated and express ... ...

Abstract	Importance: The realization that segmented negative-strand RNA virus genome ribonucleoproteins are never free as their RNA ends are always bound to the viral polymerase has highlighted the problem of how these genome segments are replicated and express their mRNAs while their RNA ends remain associated with the polymerase throughout the cycles of RNA synthesis. This study of the length and nucleotide composition of the
MeSH term(s)	RNA, Viral/genetics ; RNA, Double-Stranded ; Promoter Regions, Genetic ; Nucleotides ; RNA Viruses/genetics ; Nairovirus/genetics ; RNA, Messenger
Chemical Substances	RNA, Viral ; RNA, Double-Stranded ; Nucleotides ; RNA, Messenger
Language	English
Publishing date	2023-11-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	80174-4
ISSN	1098-5514 ; 0022-538X
ISSN (online)	1098-5514
ISSN	0022-538X
DOI	10.1128/jvi.00918-23
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Zs.A 609: Show issues

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Article ; Online: Measuring functional ability in Healthy Ageing: testing its validity using Japanese nationwide longitudinal data.

Nishio, Marisa / Haseda, Maho / Inoue, Kosuke / Saito, Masashige / Kondo, Naoki

Age and ageing

2024 Volume 53, Issue 1

Abstract: Background: The United Nations Decade of Healthy Ageing 2021-2030 suggests nations should monitor functional ability as an indicator of healthy ageing progress. Functional ability is the attribute of people to do something they value and consists of ... ...

Abstract	Background: The United Nations Decade of Healthy Ageing 2021-2030 suggests nations should monitor functional ability as an indicator of healthy ageing progress. Functional ability is the attribute of people to do something they value and consists of five domains. We examined its validity in terms of a construct, cross-validation across multiple waves' data, and predictivity for subsequent well-being. Methods: Using panel data from 35,093 community-dwelling adults aged ≥65 years from the Japan Gerontological Evaluation Study, we performed factor analyses to explore the construct of functional ability domains in both 2013 and 2016. A modified Poisson regression analysis was employed to test their associations with well-being (subjective health and happiness) in 2019. Results: The mean age (standard deviation) of participants was 72.1 (5.0) years, and 52.0% were women. A total of 85.0% reported good subjective health, and 50.6% reported high happiness levels. Factor analyses with 31 logically checked candidate items from 2016 data suggested a three-factor model comprising 24 items, which were compatible with the 2013 data results. Based on the World Health Organization's original domains, we named domains as domain #1: ability to build and maintain relationships; domain #2: ability to meet basic needs + ability to move around and domain #3: ability to learn, grow and make decisions + ability to contribute. All three domains predicted both subjective health and happiness in 2019. Conclusions: Empirical data from Japan supports the functional ability concept among older individuals. Validating this concept with data from other nations is warranted.
MeSH term(s)	Humans ; Female ; Aged ; Male ; Healthy Aging ; Japan ; Activities of Daily Living ; Independent Living ; Geriatrics
Language	English
Publishing date	2024-01-26
Publishing country	England
Document type	Journal Article
ZDB-ID	186788-x
ISSN	1468-2834 ; 0002-0729
ISSN (online)	1468-2834
ISSN	0002-0729
DOI	10.1093/ageing/afad224
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Zs.A 877: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article: Hazara orthonairovirus nucleoprotein facilitates viral cell-to-cell spread by modulating tight junction protein, claudin-1.

Ohta, Keisuke / Saka, Naoki / Fukasawa, Masayoshi / Nishio, Machiko

Frontiers in microbiology

2023 Volume 14, Page(s) 1192956

Abstract: Background: Tight junctions act as a barrier that prevents invasion of pathogens through epithelial cells. This study aims to elucidate the correlation between tight junctions and nairoviruses using Hazara orthonairovirus (HAZV) as a surrogate model for ...

Abstract	Background: Tight junctions act as a barrier that prevents invasion of pathogens through epithelial cells. This study aims to elucidate the correlation between tight junctions and nairoviruses using Hazara orthonairovirus (HAZV) as a surrogate model for Crimean-Congo hemorrhagic fever virus. Methods: mRNA, total protein, and cell surface protein levels of tight junction proteins were examined by quantitative real-time reverse transcription polymerase chain reaction, immunoblot and flow cytometry, respectively. HAZV growth was measured by plaque assay. Immunofluorescence assay was used to examine viral cell-to-cell spread. The interaction between HAZV nucleoprotein and claudin-1 was analyzed by immunoprecipitation. Results: HAZV infection induced mRNA of several tight junction proteins, especially claudin-1. HAZV infection also induced cell surface expression of claudin-1 protein. Claudin-1 overexpression inhibited the growth of HAZV by blocking its cell-to-cell spread. In contrast, HAZV nucleoprotein completely inhibited HAZV-induced cell surface expression of claudin-1, and this inhibition required interaction between HAZV nucleoprotein and claudin-1. Conclusion: HAZV nucleoprotein was shown to bind to claudin-1 to negatively regulate its cell surface expression, and so can promote cell-to-cell spread of HAZV. This is the first presentation of a possible mechanism behind how nairoviruses counteract tight junction barrier function.
Language	English
Publishing date	2023-05-23
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587354-4
ISSN	1664-302X
ISSN	1664-302X
DOI	10.3389/fmicb.2023.1192956
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Article ; Online: Knowledge of Chronic Kidney Disease among the General Population

Naoki Nakagawa / Saori Nishio

Journal of Personalized Medicine, Vol 12, Iss 1837, p

A Questionnaire Survey in Hokkaido Prefecture, Japan

2022 Volume 1837

Abstract: Public education programs about chronic kidney disease (CKD) are important activities worldwide. The present study investigated the knowledge of CKD in the general population of 58 out of 179 cities or towns in Hokkaido between 1 April and 30 September ... ...

Abstract	Public education programs about chronic kidney disease (CKD) are important activities worldwide. The present study investigated the knowledge of CKD in the general population of 58 out of 179 cities or towns in Hokkaido between 1 April and 30 September 2019. A total of 15,012 respondents who underwent specific health checkups at these centers answered the questionnaire. In response to a questionnaire item asking about the respondent’s familiarity with the term “CKD”, only 6% of the respondents answered “know it well” and 13% answered “heard of it”. In contrast, in response to a questionnaire item asking about the respondent’s familiarity with “chronic kidney disease”, 31% answered “know it well” and 33% answered “heard of it”. The leading avenue by which the respondents learned about CKD was television, followed by newspapers, magazines, and a family doctor or nurse. The leading component that the respondents considered essential for the diagnosis of CKD was proteinuria. These results indicated that the knowledge of CKD in Hokkaido prefecture is still inadequate. Many people did not appear to realize that the term “CKD” represents “chronic kidney disease”. Further continuous public education efforts are required to enlighten people about CKD.
Keywords	knowledge ; chronic kidney disease ; perception ; questionnaire ; Japan ; Medicine ; R
Subject code	950
Language	English
Publishing date	2022-11-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
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Article: Ability of older male caregivers to seek help when caring for a wife or mother with dementia living at home.

Nishio, Midori / Sakanashi, Sayori / Uchida, Naoki / Oma, Shinji / Kimura, Hiromi / Kukihara, Hiroko / Koga, Kayoko

Journal of rural medicine : JRM

2023 Volume 18, Issue 3, Page(s) 182–188

Abstract: Objective: ...

Abstract	Objective:
Language	English
Publishing date	2023-07-07
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2768933-5
ISSN	1880-4888 ; 1880-487X
ISSN (online)	1880-4888
ISSN	1880-487X
DOI	10.2185/jrm.2022-039
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Article ; Online: Lymphatic drainage patterns of malignant skin tumors in the head and neck region: a single-center retrospective study.

Nishio, Takuya / Maeda, Taku / Ishikawa, Kosuke / Murao, Naoki / Fuyama, Kanako / Yamamoto, Yuhei / Hayashi, Toshihiko

International journal of clinical oncology

2024 Volume 29, Issue 5, Page(s) 582–591

Abstract: Background: This study aimed to clarify the relationship between primary site and lymphatic drainage pattern for malignant skin tumors in the head and neck region. Malignant melanoma and squamous cell carcinoma in the head and neck region are known to ... ...

Abstract	Background: This study aimed to clarify the relationship between primary site and lymphatic drainage pattern for malignant skin tumors in the head and neck region. Malignant melanoma and squamous cell carcinoma in the head and neck region are known to have poor prognosis because of lymph node metastasis. Nevertheless, numerous aspects of lymphatic drainage patterns remain elusive. Methods: We statistically analyzed data of 47 patients with malignant skin tumors in the head and neck region. Information was collected on the patients' clinical characteristics, primary tumor site, and lymphatic drainage patterns. Results: The parotid lymph nodes drained the greatest amount of lymph from skin tumors of the head and neck. Important lymphatic drainage pathways were the superficial cervical nodes for primary tumors in the buccal/nasal region, level IA and level IB nodes for primary tumors in the lip region, the occipital nodes, posterior auricular nodes, and level VA nodes in the parietal/occipital region, and the preauricular nodes in the auricular region. Conclusion: These findings have considerable significance in terms of understanding lymphatic drainage patterns for malignant skin tumors in the head and neck and may be useful for clinical decision-making and when planning treatment. Further research and clinical applications are expected to contribute to an improved prognosis in patients with cutaneous head and neck malignancies.
MeSH term(s)	Humans ; Male ; Skin Neoplasms/pathology ; Female ; Head and Neck Neoplasms/pathology ; Middle Aged ; Retrospective Studies ; Aged ; Lymphatic Metastasis/pathology ; Adult ; Melanoma/pathology ; Aged, 80 and over ; Lymph Nodes/pathology ; Carcinoma, Squamous Cell/pathology ; Prognosis ; Melanoma, Cutaneous Malignant
Language	English
Publishing date	2024-03-30
Publishing country	Japan
Document type	Journal Article
ZDB-ID	1400227-9
ISSN	1437-7772 ; 1341-9625
ISSN (online)	1437-7772
ISSN	1341-9625
DOI	10.1007/s10147-024-02487-2
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Article ; Online: Hazara Orthonairovirus Nucleoprotein Antagonizes Type I Interferon Production by Inhibition of RIG-I Ubiquitination.

Ohta, Keisuke / Saka, Naoki / Nishio, Machiko

Viruses

2022 Volume 14, Issue 9

Abstract: Viruses have evolved various strategies to evade the host innate immune system. The relationship between nairoviruses and the interferon (IFN) system is poorly understood. We investigated whether and how nairoviruses antagonize host innate immunity using ...

Abstract	Viruses have evolved various strategies to evade the host innate immune system. The relationship between nairoviruses and the interferon (IFN) system is poorly understood. We investigated whether and how nairoviruses antagonize host innate immunity using Hazara orthonairovirus (HAZV) as a surrogate model for Crimean-Congo hemorrhagic fever virus. HAZV nucleoprotein (N) was found to interact with the tripartite motif-containing protein 25 (TRIM25). The N-terminal region of N protein and the C-terminal region of TRIM25 are important for their interaction. Overexpression of N protein results in weakened interaction of TRIM25 with retinoic acid-inducible gene I (RIG-I). Furthermore, K63-linked polyubiquitination of RIG-I is inhibited in the presence of N protein. Our data collectively suggest that HAZV N protein interferes with the binding of TRIM25 to RIG-I and subsequent K63-linked polyubiquitination of RIG-I, which leads to inhibition of type I IFN production.
MeSH term(s)	DEAD Box Protein 58/genetics ; Immunity, Innate ; Interferon Type I/metabolism ; Nairovirus ; Nucleoproteins/metabolism ; Tretinoin ; Ubiquitin-Protein Ligases/metabolism ; Ubiquitination
Chemical Substances	Interferon Type I ; Nucleoproteins ; Tretinoin (5688UTC01R) ; Ubiquitin-Protein Ligases (EC 2.3.2.27) ; DEAD Box Protein 58 (EC 3.6.4.13)
Language	English
Publishing date	2022-09-04
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2516098-9
ISSN	1999-4915 ; 1999-4915
ISSN (online)	1999-4915
ISSN	1999-4915
DOI	10.3390/v14091965
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Article ; Online: Corrigendum to "Community social networks, individual social participation and dietary behavior among older Japanese adults: Examining mediation using nonlinear structural equation models for three-wave longitudinal data".

Nishio, Marisa / Takagi, Daisuke / Shinozaki, Tomohiro / Kondo, Naoki

Preventive medicine

2021 Volume 153, Page(s) 106750

Language	English
Publishing date	2021-08-13
Publishing country	United States
Document type	Published Erratum
ZDB-ID	184600-0
ISSN	1096-0260 ; 0091-7435
ISSN (online)	1096-0260
ISSN	0091-7435
DOI	10.1016/j.ypmed.2021.106750
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