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  1. Article ; Online: Pediatric pineal region tumors: institutional experience of surgical managements with posterior interhemispheric transtentorial approach.

    Tomita, Tadanori / Alden, Tord D / Dipatri, Arthur J

    Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery

    2022  Volume 39, Issue 9, Page(s) 2293–2305

    Abstract: Purpose: Resecting pineal region tumors in children is often challenging. Several approaches have been proposed and practiced. A personal series of pediatric pineal region tumors resected through craniotomy with posterior interhemispheric occipital ... ...

    Abstract Purpose: Resecting pineal region tumors in children is often challenging. Several approaches have been proposed and practiced. A personal series of pediatric pineal region tumors resected through craniotomy with posterior interhemispheric occipital transtentorial (OT) approach are reviewed. We present the surgical techniques, pitfalls, and their results.
    Material and methods: Eighty patients ranging in age from 3 months to 21 years old, and treated over 3 decades were reviewed. Hydrocephalus caused the main presenting symptoms and was noted in 74 patients. It was treated prior to the craniotomy for tumor resection with endoscopic third ventriculostomy (ETV) in 33, external ventricular drainage in 26, and precraniotomy shunt in 15. Nine patients had ETV together with endoscopic biopsy. All patients had a parieto-occipital craniotomy in a prone position. Through a tentorial section, a gross total resection of the tumor was attempted except for germinomas.
    Results: The tumor pathology showed 32 germ cell tumors (GCT), 22 benign astrocytomas, 13 pineal parenchymal tumors, 5 ATRTs, 3 papillary tumors, and 5 others. Of GCTs, 18 were teratomas. The extent of resection consisted of 55 gross total resections, 13 subtotal resections, 10 partial, and 2 biopsies with one postoperative death. Hemiparesis in 2, cerebellar ataxia in another 2, and hemiballismus in 1 were transient and improved over time. One had permanent hemisensory loss and another patient had bilateral oculomotor palsy. Postoperative homonymous hemianopia occurred in 2 patients but subsided over a short period of time. Parinaud's sign was noted in 24 patients, of which 16 were transient.
    Conclusion: The posterior interhemispheric OT approach provides a safe route and comfortable access to the pineal region in children. A great majority of postoperative neurological complications are the results of direct manipulations of the midbrain at tumor resection. Identification and preservation of the tumor-brain interface are of paramount importance. GCTs other than teratomas are treated with neoadjuvant chemotherapy and may eliminate the need for craniotomy. Exophytic midbrain JPAs are amenable to resection.
    MeSH term(s) Child ; Humans ; Pinealoma/surgery ; Pinealoma/pathology ; Retrospective Studies ; Brain Neoplasms/surgery ; Pineal Gland/surgery ; Postoperative Complications/epidemiology ; Postoperative Complications/etiology ; Teratoma
    Language English
    Publishing date 2022-07-11
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 605988-0
    ISSN 1433-0350 ; 0302-2803 ; 0256-7040
    ISSN (online) 1433-0350
    ISSN 0302-2803 ; 0256-7040
    DOI 10.1007/s00381-022-05595-4
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    Zs.A 2036: Show issues Location:
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  2. Article ; Online: The Clinical Impact of Vagal Nerve Stimulator Implantation on Laryngopharyngeal Function in Children: A Single-Center Experience.

    Hazkani, Inbal / Farje, Doris / Alden, Tord / DiPatri, Arthur / Tennant, Amy / Ghadersohi, Saied / Thompson, Dana M / Rastatter, Jeffrey

    Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery

    2023  Volume 168, Issue 6, Page(s) 1521–1528

    Abstract: Objective: A vagal nerve stimulator (VNS) has been established as the treatment of choice for children with refractory epilepsy. The outcomes of the procedure have been well documented in adults but are less clear in children. The goal of our study was ... ...

    Abstract Objective: A vagal nerve stimulator (VNS) has been established as the treatment of choice for children with refractory epilepsy. The outcomes of the procedure have been well documented in adults but are less clear in children. The goal of our study was to review laryngopharyngeal (LP) function following VNS implantation in children.
    Study design: Case series with chart review.
    Setting: Tertiary-care children's hospital.
    Methods: Voice, swallowing, and sleep apnea symptoms were extracted from the charts of children who underwent VNS implantation between 2013 and 2021. A questionnaire was sent to parents of implanted children to ascertain the degree of the social and functional impact of the implant.
    Results: There were 69 patients, aged 2.3 to 21.4 years old, who met the inclusion criteria. LP symptoms were most common during the first year following implantation; 26 patients (37.6%) demonstrated at least 1 symptom (voice alteration, chronic cough, sleep-disordered breathing, or dysphagia), and 15 patients required adjustments to their implant settings. The incidence of symptoms and the need to adjust VNS settings significantly dropped during years 2 to 5 and 6 to 8 (22% vs 7% and 5%, respectively, p = .0002). The mean score of the Pediatric Voice Handicap Index differed greatly from a normal control group on each subscale and the total score.
    Conclusion: LP dysfunction in children following VNS implantation is comparable to adults, with the most burden noticed during the first year after implantation. The presence of voice alterations did not correlate with the presence of dysphagia and sleep-disordered breathing. Thorough evaluation, preferably by a multidisciplinary team, is required to assess LP dysfunction postoperatively.
    MeSH term(s) Adult ; Humans ; Child ; Child, Preschool ; Adolescent ; Young Adult ; Deglutition Disorders ; Sleep Apnea Syndromes ; Cough ; Deglutition ; Hypopharynx ; Treatment Outcome
    Language English
    Publishing date 2023-01-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 392085-9
    ISSN 1097-6817 ; 0161-6439 ; 0194-5998
    ISSN (online) 1097-6817
    ISSN 0161-6439 ; 0194-5998
    DOI 10.1002/ohn.196
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  3. Article ; Online: Opioid-Free Analgesia is Safe and Effective in Anterior Cervical Spine Surgery: A Randomized Controlled Trial.

    Segebarth, P Bradley / Schallmo, Michael / Odum, Susan / Hietpas, Kayla / Michalek, Caleb / Chapman, T Matthew / Leas, Daniel / Milam, R Alden / Hamid, Nady

    Clinical spine surgery

    2024  

    Abstract: Study design: Randomized controlled trial (RCT).: Objective: Compare the efficacy of a multimodal, opioid-free (OF) pain management pathway with a traditional opioid-containing (OC) pathway in patients undergoing anterior cervical procedures.: ... ...

    Abstract Study design: Randomized controlled trial (RCT).
    Objective: Compare the efficacy of a multimodal, opioid-free (OF) pain management pathway with a traditional opioid-containing (OC) pathway in patients undergoing anterior cervical procedures.
    Summary of background data: Previous studies have compared opioid-based pain regimens to opioid-sparing regimens following cervical spine surgery, but have been limited by high rates of crossover, retrospective designs, reliance on indwelling pain catheters, opioid utilization for early postoperative analgesia, and/or a lack of patient-reported outcome measures.
    Methods: This is a RCT in which patients were allocated to either an OF or OC perioperative pain management protocol. Eligible study participants included adult (age up to 18 y) patients who underwent primary, 1-level or 2-level anterior cervical surgery [anterior cervical discectomy and fusion (ACDF), anterior cervical disc arthroplasty (ACDA), or hybrid (ACDF and ACDA at different levels)] for degenerative pathology. The primary outcome variable was subjective pain level at 24 hours postoperative. The final study cohort consisted of 50 patients (22 OF, 28 OC).
    Results: Patients in the OF group reported lower median postoperative pain levels at 6 hours (4 for OF vs. 7 for OC; P=0.041) and 24 hours (3 for OF vs. 5 for OC; P=0.032). At 2-week and 6-week follow-up, pain levels were similar between groups. Patients in the OF group reported greater comfort at 12 hours (9 for OF vs. 5 for OC; P=0.003) and 24 hours (9 for OF vs. 5 for OC; P=0.011) postoperatively. Notably, there were no significant differences in patients' reported pain satisfaction, overall surgical satisfaction, or overall sense of physical and mental well-being. In addition, there were no significant differences in falls, delirium, or constipation postoperatively.
    Conclusions: A multimodal OF pain management pathway following anterior cervical surgery for degenerative disease results in statistically noninferior pain control and equivalent patient-reported outcome measures compared with a traditional OC pathway.
    Language English
    Publishing date 2024-03-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2849646-2
    ISSN 2380-0194 ; 2380-0186
    ISSN (online) 2380-0194
    ISSN 2380-0186
    DOI 10.1097/BSD.0000000000001608
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    Zs.A 2427: Show issues Location:
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  4. Article ; Online: Community-based Versus Traditional Research Among Older Minority Women With Urinary Incontinence.

    Pearson, Sharee / Temple, Luisa / Bishop, Tonya / Ukaegbu, Alice / Alden, Jessica / Kwagyan, John / Sanses, Tatiana V D

    Female pelvic medicine & reconstructive surgery

    2021  Volume 28, Issue 4, Page(s) 201–206

    Abstract: ... Pearson χ2, Fisher exact, and t tests were used. The effect of CBPR on research retention rates was ...

    Abstract Objective: The aim of this study was to evaluate research retention of older minority women with urinary incontinence (UI) using a community-based participatory research (CBPR) versus a traditional research approach.
    Methods: An ancillary prospective study was conducted within an ongoing pilot randomized clinical trial to treat UI. Participants were recruited using CBPR in collaboration with a local community versus a traditional research approach at an academic center. Inclusion criteria were women 65 years and older and symptomatic UI. The primary outcome was the randomization rate defined as the proportion of women randomized into the randomized clinical trial out of screened participants. Screening and consent rates were also evaluated. Pearson χ2, Fisher exact, and t tests were used. The effect of CBPR on research retention rates was expressed as odds ratio (OR) with 95% confidence intervals (CI).
    Results: There were 10 and 88 women screened in the CBPR and traditional research groups, respectively. The CBPR participants were Hispanic (n = 10, 100%) and older (78.4 ± 8.3 years; P < 0.01). Most of the traditional research participants were non-Hispanic Black (n = 55, 62.5%) and younger (71.0 ± 4.9 years). The CBPR group had higher rates of screening (76.9% vs 40.6%; P = 0.01), consent (80% vs 44.3%; P = 0.045), and randomization (50.0% vs 14.8%; P < 0.01) compared with the traditional research group. Community-based participatory research increased the odds of research retention during screening (OR, 4.9; 95% CI, 1.3-18.2), consent (OR, 5.0; 95% CI, 1.0-25.0), and randomization (OR, 5.8; 95% CI, 1.5-22.7).
    Conclusion: Compared with traditional research, CBPR yielded higher research retention among older minority women with UI in a clinical study.
    MeSH term(s) Female ; Humans ; Male ; Prospective Studies ; Urinary Incontinence
    Language English
    Publishing date 2021-08-11
    Publishing country United States
    Document type Journal Article ; Randomized Controlled Trial ; Research Support, N.I.H., Extramural
    ZDB-ID 2542707-6
    ISSN 2154-4212 ; 2151-8378
    ISSN (online) 2154-4212
    ISSN 2151-8378
    DOI 10.1097/SPV.0000000000001089
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    Zs.A 4599: Show issues Location:
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  5. Article ; Online: Upper extremity nerve transfers for acute flaccid myelitis: a systematic literature review.

    Texakalidis, P / Xenos, D / Murthy, N K / Karras, C L / Trybula, S J / Behbahani, M / DeCuypere, M G / Lam, S K / Alden, T D

    Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery

    2022  Volume 38, Issue 3, Page(s) 521–526

    Abstract: Background: Acute flaccid myelitis (AFM) is a rare disease that commonly affects young children. AFM's pathophysiology involves loss of lower motor neurons following a viral infection and induces acute asymmetric flaccid paralysis most commonly in the ... ...

    Abstract Background: Acute flaccid myelitis (AFM) is a rare disease that commonly affects young children. AFM's pathophysiology involves loss of lower motor neurons following a viral infection and induces acute asymmetric flaccid paralysis most commonly in the upper extremities. Nerve transfers have emerged as a treatment option for these patients with permanent motor deficits.
    Objective: To summarize the literature and report safety and efficacy outcomes following nerve transfers for recovery of shoulder abduction and external rotation, and elbow flexion and extension in pediatric patients with AFM. Recovery of at least antigravity function was defined as a successful outcome. This systematic review was performed according to the PRISMA guidelines. The PubMed, Embase and Cochrane databases were utilized.
    Results: Five studies comprising 44 patients (median age 2.95 years; 71% male), and 93 upper extremity nerve transfers were included. Thirty-eight patients received 65 nerve transfer procedures aiming for recovery of shoulder abduction and/or external rotation with a transfer to the axillary and/or suprascapular nerve. The recovery of shoulder abduction and external rotation was achieved in 40.7% (n = 11/27) and 60% (n = 6/10) of patients, respectively. Time from injury to surgery showed an inverse relationship with the odds for successful recovery (OR: 0.81; 95% CI: 0.64-1.02; p = 0.07); however, statistical significance was not reached. Successful recovery of elbow flexion with a transfer to the musculocutaneous was reported at a rate of 92.3% (n = 12/13). Successful re-innervation of the radial nerve with recovery of elbow extension was found in 75% (n = 6/8) of patients. No complications were reported.
    Conclusions: Upper extremity nerve transfers appear to be promising and safe for AFM patients. Shoulder abduction is the most challenging upper extremity function to recover. Further studies are warranted to identify whether nerve transfers are associated with superior outcomes when performed earlier.
    MeSH term(s) Brachial Plexus Neuropathies/surgery ; Central Nervous System Viral Diseases/surgery ; Child ; Child, Preschool ; Female ; Humans ; Male ; Myelitis/surgery ; Nerve Transfer/methods ; Neuromuscular Diseases ; Range of Motion, Articular ; Recovery of Function/physiology ; Upper Extremity
    Language English
    Publishing date 2022-01-04
    Publishing country Germany
    Document type Journal Article ; Review ; Systematic Review
    ZDB-ID 605988-0
    ISSN 1433-0350 ; 0302-2803 ; 0256-7040
    ISSN (online) 1433-0350
    ISSN 0302-2803 ; 0256-7040
    DOI 10.1007/s00381-021-05419-x
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    Zs.A 2036: Show issues Location:
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  6. Article ; Online: The Effects of Monosodium Glutamate on PSMA Radiotracer Uptake in Men with Recurrent Prostate Cancer: A Prospective, Randomized, Double-Blind, Placebo-Controlled Intraindividual Imaging Study.

    Harsini, Sara / Saprunoff, Heather / Alden, Tina / Mohammadi, Behnoud / Wilson, Don / Bénard, François

    Journal of nuclear medicine : official publication, Society of Nuclear Medicine

    2020  Volume 62, Issue 1, Page(s) 81–87

    Abstract: The prostate-specific membrane antigen (PSMA) is an excellent target for theranostic applications in prostate cancer. However, PSMA-targeted radioligand therapy can cause undesirable effects due to high accumulation of PSMA radiotracers in salivary ... ...

    Abstract The prostate-specific membrane antigen (PSMA) is an excellent target for theranostic applications in prostate cancer. However, PSMA-targeted radioligand therapy can cause undesirable effects due to high accumulation of PSMA radiotracers in salivary glands and kidneys. This study assessed orally administered monosodium glutamate (MSG) as a potential means of reducing kidney and salivary gland radiation exposure using a PSMA-targeting radiotracer.
    MeSH term(s) Aged ; Antigens, Surface/metabolism ; Biological Transport/drug effects ; Double-Blind Method ; Glutamate Carboxypeptidase II/metabolism ; Humans ; Lysine/analogs & derivatives ; Lysine/metabolism ; Male ; Middle Aged ; Placebos ; Positron Emission Tomography Computed Tomography ; Prospective Studies ; Prostatic Neoplasms/diagnostic imaging ; Prostatic Neoplasms/metabolism ; Radioactive Tracers ; Recurrence ; Sodium Glutamate/pharmacology ; Urea/analogs & derivatives ; Urea/metabolism
    Chemical Substances 2-(3-(1-carboxy-5-((6-fluoropyridine-3-carbonyl)amino)pentyl)ureido)pentanedioic acid ; Antigens, Surface ; Placebos ; Radioactive Tracers ; Urea (8W8T17847W) ; FOLH1 protein, human (EC 3.4.17.21) ; Glutamate Carboxypeptidase II (EC 3.4.17.21) ; Lysine (K3Z4F929H6) ; Sodium Glutamate (W81N5U6R6U)
    Language English
    Publishing date 2020-05-08
    Publishing country United States
    Document type Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ZDB-ID 80272-4
    ISSN 1535-5667 ; 0097-9058 ; 0161-5505 ; 0022-3123
    ISSN (online) 1535-5667
    ISSN 0097-9058 ; 0161-5505 ; 0022-3123
    DOI 10.2967/jnumed.120.246983
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    Zs.A 114: Show issues Location:
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  7. Article ; Online: Prospective, multicenter clinical trial comparing the M6-C compressible cervical disc with anterior cervical discectomy and fusion for the treatment of single-level degenerative cervical radiculopathy: 5-year results of an FDA investigational device exemption study.

    Phillips, Frank M / Coric, Domagoj / Sasso, Rick / Lanman, Todd / Lavelle, William / Lauryssen, Carl / Albert, Todd / Cammisa, Frank / Milam, Robert Alden

    The spine journal : official journal of the North American Spine Society

    2023  Volume 24, Issue 2, Page(s) 219–230

    Abstract: Background context: Various total disc replacement (TDR) designs have been compared to anterior cervical discectomy and fusion (ACDF) with favorable short and long-term outcomes in FDA-approved investigational device exemption (IDE) trials. The unique ... ...

    Abstract Background context: Various total disc replacement (TDR) designs have been compared to anterior cervical discectomy and fusion (ACDF) with favorable short and long-term outcomes in FDA-approved investigational device exemption (IDE) trials. The unique design of M6-C, with a compressible viscoelastic nuclear core and an annular structure, has previously demonstrated favorable clinical outcomes through 24 months.
    Purpose: To evaluate the long-term safety and effectiveness of the M6-C compressible artificial cervical disc and compare to ACDF at 5 years.
    Study design: Prospective, multicenter, concurrently and historically controlled, FDA-approved IDE clinical trial.
    Patient sample: Subjects with one-level symptomatic degenerative cervical radiculopathy were enrolled and received M6-C (n=160) or ACDF (n=189) treatment as part of the IDE study. Safety outcomes were evaluated at 5 years for all subjects. The primary effectiveness endpoint was available at 5 years for 113 M6-C subjects and 106 ACDF controls.
    Outcome measures: The primary endpoint of this analysis was composite clinical success (CCS) at 60 months. Secondary endpoints were function and pain (neck disability index, VAS), physical quality of life (SF-36, SF-12), safety, neurologic, and radiographic assessments.
    Methods: Propensity score subclassification was used to control for selection bias and match baseline covariates of the control group to the M6-C subjects. Sixty-month CCS rates were estimated for each treatment group using a generalized linear model controlling for propensity score.
    Results: At 5 years postoperatively, the M6-C treatment resulted in 82.3% CCS while the ACDF group showed 67.0% CCS (superiority p=.013). Secondary endpoints indicated that significantly more M6-C subjects achieved VAS neck and arm pain improvements and showed maintained or improved physical functioning on quality-of-life measures compared to baseline assessments. The M6-C group-maintained flexion-extension motion, with significantly greater increases from baseline disc height and disc angle than observed in the control group. The rates of M6-C subsequent surgical interventions (SSI; 3.1%) and definitely device- or procedure-related serious adverse events (SAE failure; 3.1%) were similar to ACDF rates (SSI=5.3%, SAE failure=4.8%; p>.05 for both).
    Conclusions: Subjects treated with the M6-C artificial disc demonstrated superior 5-year achievement of clinical success when compared to ACDF controls. In addition, significantly more subjects in the M6-C group showed improved pain and physical functioning scores than observed in ACDF subjects, with no difference in reoperation rates or safety outcomes.
    MeSH term(s) Humans ; Cervical Vertebrae/surgery ; Diskectomy/adverse effects ; Diskectomy/methods ; Follow-Up Studies ; Intervertebral Disc Degeneration/surgery ; Neck Pain/surgery ; Prospective Studies ; Quality of Life ; Radiculopathy/surgery ; Spinal Fusion/methods ; Total Disc Replacement/adverse effects ; Total Disc Replacement/methods ; Treatment Outcome
    Language English
    Publishing date 2023-11-10
    Publishing country United States
    Document type Clinical Trial ; Journal Article ; Multicenter Study
    ZDB-ID 2037072-6
    ISSN 1878-1632 ; 1529-9430
    ISSN (online) 1878-1632
    ISSN 1529-9430
    DOI 10.1016/j.spinee.2023.10.020
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    Zs.A 5898: Show issues Location:
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  8. Article ; Online: Angiogenesis is critical for the exercise-mediated enhancement of axon regeneration following peripheral nerve injury.

    Wariyar, Supriya S / Brown, Alden D / Tian, Tina / Pottorf, Tana S / Ward, Patricia J

    Experimental neurology

    2022  Volume 353, Page(s) 114029

    Abstract: Enhancing axon regeneration is a major focus of nerve injury research, and the quality of the surgical nerve repair plays a large role in the aggregate success of nerve regeneration. Additionally, exercise is known to promote successful axon regeneration ...

    Abstract Enhancing axon regeneration is a major focus of nerve injury research, and the quality of the surgical nerve repair plays a large role in the aggregate success of nerve regeneration. Additionally, exercise is known to promote successful axon regeneration after surgical nerve repair. In this study, we asked how exercise-induced nerve regeneration is affected when a transected nerve is repaired with or without fibrin glue. Fibrin glue repaired nerves exhibited greater vasculature within the tissue bridge compared to nerves that were intrinsically repaired. Fibrin glue repaired nerves also exhibited more robust axon regeneration after exercise compared to nerves that were not repaired with fibrin glue. When angiogenesis of the tissue bridge was prevented, exercise was unable to enhance regeneration despite the presence of fibrin glue. These findings suggest that the biological properties of fibrin glue enhance angiogenesis within the repair site, and a vascularized bridge is required for enhanced axon elongation with exercise. The combination of fibrin glue repair and exercise resulted in notable differences in vascular growth, axon elongation, neuromuscular junction reinnervation, and functional recovery. Fibrin glue should be considered as an adjuvant for nerve repair to enhance the subsequent efficacy of activity- and physical therapy-based treatment interventions.
    MeSH term(s) Axons ; Fibrin Tissue Adhesive ; Humans ; Nerve Regeneration ; Peripheral Nerve Injuries ; Sciatic Nerve/injuries ; Tissue Adhesives
    Chemical Substances Fibrin Tissue Adhesive ; Tissue Adhesives
    Language English
    Publishing date 2022-03-05
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 207148-4
    ISSN 1090-2430 ; 0014-4886
    ISSN (online) 1090-2430
    ISSN 0014-4886
    DOI 10.1016/j.expneurol.2022.114029
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    Zs.A 184: Show issues Location:
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  9. Article ; Online: Structural Characterization of the Reaction and Substrate Specificity Mechanisms of Pathogenic Fungal Acetyl-CoA Synthetases.

    Jezewski, Andrew J / Alden, Katy M / Esan, Taiwo E / DeBouver, Nicholas D / Abendroth, Jan / Bullen, Jameson C / Calhoun, Brandy M / Potts, Kristy T / Murante, Daniel M / Hagen, Timothy J / Fox, David / Krysan, Damian J

    ACS chemical biology

    2021  Volume 16, Issue 8, Page(s) 1587–1599

    Abstract: Acetyl CoA synthetases (ACSs) ... ...

    Abstract Acetyl CoA synthetases (ACSs) are
    MeSH term(s) Acetate-CoA Ligase/antagonists & inhibitors ; Acetate-CoA Ligase/chemistry ; Acetate-CoA Ligase/metabolism ; Adenosine Monophosphate/analogs & derivatives ; Adenosine Monophosphate/metabolism ; Crystallography, X-Ray ; Enzyme Inhibitors/chemistry ; Enzyme Inhibitors/metabolism ; Fungal Proteins/antagonists & inhibitors ; Fungal Proteins/chemistry ; Fungal Proteins/metabolism ; Fungi/enzymology ; Molecular Structure ; Protein Binding ; Structure-Activity Relationship ; Substrate Specificity
    Chemical Substances Enzyme Inhibitors ; Fungal Proteins ; Adenosine Monophosphate (415SHH325A) ; Acetate-CoA Ligase (EC 6.2.1.1)
    Language English
    Publishing date 2021-08-09
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ISSN 1554-8937
    ISSN (online) 1554-8937
    DOI 10.1021/acschembio.1c00484
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  10. Article ; Online: Vulnerabilities in social anxiety: Integrating intra- and interpersonal perspectives.

    Ginat-Frolich, Rivkah / Gilboa-Schechtman, Eva / Huppert, Jonathan D / Aderka, Idan M / Alden, Lynn E / Bar-Haim, Yair / Becker, Eni S / Bernstein, Amit / Geva, Ronny / Heimberg, Richard G / Hofmann, Stefan G / Kashdan, Todd B / Koster, Ernst H W / Lipsitz, Joshua / Maner, Jon K / Moscovitch, David A / Philippot, Pierre / Rapee, Ronald M / Roelofs, Karin /
    Rodebaugh, Thomas L / Schneier, Franklin R / Schultheiss, Oliver C / Shahar, Ben / Stangier, Ulrich / Stein, Murray B / Stopa, Lusia / Taylor, Charles T / Weeks, Justin W / Wieser, Matthias J

    Clinical psychology review

    2024  Volume 109, Page(s) 102415

    Abstract: What are the major vulnerabilities in people with social anxiety? What are the most promising directions for translational research pertaining to this condition? The present paper provides an integrative summary of basic and applied translational ... ...

    Abstract What are the major vulnerabilities in people with social anxiety? What are the most promising directions for translational research pertaining to this condition? The present paper provides an integrative summary of basic and applied translational research on social anxiety, emphasizing vulnerability factors. It is divided into two subsections: intrapersonal and interpersonal. The intrapersonal section synthesizes research relating to (a) self-representations and self-referential processes; (b) emotions and their regulation; and (c) cognitive biases: attention, interpretation and judgment, and memory. The interpersonal section summarizes findings regarding the systems of (a) approach and avoidance, (b) affiliation and social rank, and their implications for interpersonal impairments. Our review suggests that the science of social anxiety and, more generally, psychopathology may be advanced by examining processes and their underlying content within broad psychological systems. Increased interaction between basic and applied researchers to diversify and elaborate different perspectives on social anxiety is necessary for progress.
    MeSH term(s) Humans ; Emotions ; Fear ; Judgment ; Attention ; Anxiety/psychology ; Interpersonal Relations
    Language English
    Publishing date 2024-03-11
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 604577-7
    ISSN 1873-7811 ; 0272-7358
    ISSN (online) 1873-7811
    ISSN 0272-7358
    DOI 10.1016/j.cpr.2024.102415
    Database MEDical Literature Analysis and Retrieval System OnLINE

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