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Article ; Online: Real-world healthcare costs of localized and regionally advanced cutaneous melanoma in the Netherlands.

Leeneman, Brenda / Blommestein, Hedwig M / Coupé, Veerle M H / Hendriks, Mathijs P / Kruit, Wim H J / Plaisier, Peter W / van Ruth, Serge / Ten Tije, Albert J / Wouters, Michel W J M / Franken, Margreet G / Uyl-de Groot, Carin A

Melanoma research

2021 Volume 31, Issue 3, Page(s) 249–257

Abstract: The aim of this study was to provide insight into real-world healthcare costs of patients initially diagnosed with localized or regionally advanced melanoma in three Dutch hospitals between 2003 and 2011. Patients were stratified according to their stage ...

Abstract	The aim of this study was to provide insight into real-world healthcare costs of patients initially diagnosed with localized or regionally advanced melanoma in three Dutch hospitals between 2003 and 2011. Patients were stratified according to their stage at diagnosis and recurrence status. Costs were calculated by applying unit costs to individual patient resource use and reported for the full disease course, the initial treatment episode, and treatment episodes for disease recurrence (stratified by type of recurrence). We included 198 patients with localized melanoma and 98 patients with regionally advanced melanoma. Total costs were much higher for patients with disease recurrence than for patients without disease recurrence: €20 007 versus €3032 for patients with localized melanoma and €19 519 versus €5951 for patients with regionally advanced melanoma. This was owing to the costs of disease recurrence because the costs of the initial treatment were comparable between patients with and without disease recurrence. Costs of disease recurrence were dependent on the type of recurrence: €4414, €4604, €8129 and €10 393 for a local recurrence, intralymphatic metastases, regional lymph node metastases and distant metastases, respectively. In conclusion, healthcare costs of patients with localized and regionally advanced melanoma were rather low for the initial treatment. Costs became, however, more substantial in case of disease recurrence. In the context of a rapidly changing treatment paradigm, it remains crucial to monitor treatment outcomes as well as healthcare expenditures.
MeSH term(s)	Female ; Health Care Costs/standards ; Humans ; Male ; Melanoma/economics ; Melanoma/epidemiology ; Netherlands ; Retrospective Studies ; Skin Neoplasms/economics ; Skin Neoplasms/epidemiology ; Melanoma, Cutaneous Malignant
Language	English
Publishing date	2021-06-01
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1095779-0
ISSN	1473-5636 ; 0960-8931
ISSN (online)	1473-5636
ISSN	0960-8931
DOI	10.1097/CMR.0000000000000732
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Article ; Online: Eponyms of Sir Jonathan Hutchinson.

van Ruth, Serge / Toonstra, Johan

International journal of dermatology

2008 Volume 47, Issue 7, Page(s) 754–758

Abstract: Sir Jonathan Hutchinson was an extraordinary man. He was trained as a surgeon and a pathologist, but was also keenly interested in dermatology, the study of syphilis, ophthalmology, and neurology. His observations with detailed descriptions of skin ... ...

Abstract	Sir Jonathan Hutchinson was an extraordinary man. He was trained as a surgeon and a pathologist, but was also keenly interested in dermatology, the study of syphilis, ophthalmology, and neurology. His observations with detailed descriptions of skin diseases were remarkable. His medical bibliography staggeringly consists of over 1000 published reports. This description of the eponyms attributed to Hutchinson--illustrated with clinical images, an old plate, and a portrait--demonstrates his important contribution to dermatology.
MeSH term(s)	Dermatology/history ; Eponyms ; History, 19th Century ; History, 20th Century ; Humans ; Hutchinson's Melanotic Freckle/diagnosis ; Hutchinson's Melanotic Freckle/history ; Hutchinson's Melanotic Freckle/radiotherapy ; Male ; Middle Aged ; Skin Diseases/diagnosis ; Skin Diseases/history
Language	English
Publishing date	2008-07
Publishing country	England
Document type	Biography ; Case Reports ; Historical Article ; Journal Article ; Portraits
ZDB-ID	412254-9
ISSN	1365-4632 ; 0011-9059 ; 1461-1244
ISSN (online)	1365-4632
ISSN	0011-9059 ; 1461-1244
DOI	10.1111/j.1365-4632.2008.03696.x
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Article ; Online: Stage-specific disease recurrence and survival in localized and regionally advanced cutaneous melanoma.

Leeneman, Brenda / Franken, Margreet G / Coupé, Veerle M H / Hendriks, Mathijs P / Kruit, Wim / Plaisier, Peter W / van Ruth, Serge / Verstijnen, José A M C / Wouters, Michel W J M / Blommestein, Hedwig M / Uyl-de Groot, Carin A

European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology

2019 Volume 45, Issue 5, Page(s) 825–831

Abstract: Objective: To investigate stage-specific survival from diagnosis, stage-specific disease recurrence, and post-recurrence survival in patients diagnosed with localized and regionally advanced cutaneous melanoma.: Methods: A retrospective, ... ...

Abstract	Objective: To investigate stage-specific survival from diagnosis, stage-specific disease recurrence, and post-recurrence survival in patients diagnosed with localized and regionally advanced cutaneous melanoma. Methods: A retrospective, observational cohort study was conducted in six Dutch hospitals. We included patients with a first diagnosis of stage I, II, or III melanoma between January 2003 and December 2011. Descriptive statistics were used to summarize time to first recurrence and type of first recurrence. Overall survival (OS) from diagnosis and post-recurrence OS were assessed using the Kaplan-Meier method. Results: A total of 3,093 patients had a first diagnosis of stage I (n = 2,299), II (n = 565), or III (n = 229) melanoma. Median OS was not yet reached for patients with stage I, 9.5 years for patients with stage II, and 6.8 years for patients with stage III. Fifty-seven patients (8%) with stage IB, 137 patients (29%) with stage II, and 81 patients (47%) with stage III developed disease recurrence. Median time to first recurrence was 2.8, 1.5, and 1.0 years for patients with stage IB, II, and III, respectively. Most patients (79%) developed regional lymph node or distant metastases as first recurrence. Median post-recurrence OS was 2.8, 3.9, and 0.5 years for patients with intralymphatic, regional lymph node, and distant metastases, respectively. Conclusion: A substantial number of patients developed disease recurrence. Of these patients, a considerably high proportion developed distant metastases which had a great impact on survival. Identifying disease recurrence at its earliest stage is crucial because metastatic melanoma remains incurable for most patients.
MeSH term(s)	Adult ; Aged ; Female ; Humans ; Male ; Melanoma/pathology ; Melanoma/surgery ; Middle Aged ; Neoplasm Recurrence, Local/pathology ; Neoplasm Recurrence, Local/surgery ; Neoplasm Staging ; Retrospective Studies ; Skin Neoplasms/pathology ; Survival Rate
Language	English
Publishing date	2019-02-05
Publishing country	England
Document type	Journal Article ; Multicenter Study ; Observational Study
ZDB-ID	632519-1
ISSN	1532-2157 ; 0748-7983
ISSN (online)	1532-2157
ISSN	0748-7983
DOI	10.1016/j.ejso.2019.01.225
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Zs.A 1149: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article: Response to correspondence from Kauimarz Sethna, Faheez Mohamed and Paul H. Sugarbaker, EJSO 2002; 28 (8): 897.

Zoetmulder, Frans A N / van Ruth, Serge

European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology

2003 Volume 29, Issue 5, Page(s) 480

MeSH term(s)	Antineoplastic Combined Chemotherapy Protocols/administration & dosage ; Biopsy, Needle ; Chemotherapy, Cancer, Regional Perfusion/methods ; Combined Modality Therapy ; Digestive System Surgical Procedures/methods ; Humans ; Mesothelioma, Cystic/mortality ; Mesothelioma, Cystic/pathology ; Mesothelioma, Cystic/therapy ; Neoplasm Staging ; Peritoneal Neoplasms/mortality ; Peritoneal Neoplasms/pathology ; Peritoneal Neoplasms/therapy ; Prognosis ; Risk Assessment ; Survival Analysis ; Treatment Outcome
Language	English
Publishing date	2003-06-10
Publishing country	England
Document type	Comment ; Letter
ZDB-ID	632519-1
ISSN	0748-7983
ISSN	0748-7983
DOI	10.1016/s0748-7983(02)00326-8
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Zs.MO 549: Show issues

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Article ; Online: RORγt inhibition selectively targets IL-17 producing iNKT and γδ-T cells enriched in Spondyloarthritis patients

Koen Venken / Peggy Jacques / Céline Mortier / Mark E. Labadia / Tine Decruy / Julie Coudenys / Kathleen Hoyt / Anita L. Wayne / Robert Hughes / Michael Turner / Sofie Van Gassen / Liesbet Martens / Dustin Smith / Christian Harcken / Joseph Wahle / Chao-Ting Wang / Eveline Verheugen / Nadia Schryvers / Gaëlle Varkas /

Heleen Cypers / Ruth Wittoek / Yves Piette / Lieve Gyselbrecht / Serge Van Calenbergh / Filip Van den Bosch / Yvan Saeys / Gerald Nabozny / Dirk Elewaut

Nature Communications, Vol 10, Iss 1, Pp 1-

2019 Volume 15

Abstract: The role of innate T cell subsets in the pathogenesis of spondyloarthritis (SpA) is not well understood. Here, the authors examine the role of invariant natural killer T (iNKT) and γδ-T cells in SpA and show that disease-derived iNKT and γδ-T cells have ... ...

Abstract	The role of innate T cell subsets in the pathogenesis of spondyloarthritis (SpA) is not well understood. Here, the authors examine the role of invariant natural killer T (iNKT) and γδ-T cells in SpA and show that disease-derived iNKT and γδ-T cells have unique and Th17-skewed phenotype and gene expression profiles within inflamed joints.
Keywords	Science ; Q
Language	English
Publishing date	2019-01-01T00:00:00Z
Publisher	Nature Publishing Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: RORγt inhibition selectively targets IL-17 producing iNKT and γδ-T cells enriched in Spondyloarthritis patients

Heleen Cypers / Ruth Wittoek / Yves Piette / Lieve Gyselbrecht / Serge Van Calenbergh / Filip Van den Bosch / Yvan Saeys / Gerald Nabozny / Dirk Elewaut

Nature Communications, Vol 10, Iss 1, Pp 1-

2019 Volume 15

Abstract	The role of innate T cell subsets in the pathogenesis of spondyloarthritis (SpA) is not well understood. Here, the authors examine the role of invariant natural killer T (iNKT) and γδ-T cells in SpA and show that disease-derived iNKT and γδ-T cells have unique and Th17-skewed phenotype and gene expression profiles within inflamed joints.
Keywords	Science ; Q
Language	English
Publishing date	2019-01-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Total body topical 5-fluorouracil for extensive non-melanoma skin cancer.

van Ruth, Serge / Jansman, Frank G A / Sanders, Cornelis J

Pharmacy world & science : PWS

2006 Volume 28, Issue 3, Page(s) 159–162

Abstract: Background: Topical 5-fluorouracil 5% cream is one of the treatment modalities for non-melanoma skin cancer (NMSC). There is a lack of suitable therapies to treat patients with extensive NMSC. In this paper we report two patients with extensive NMSC ... ...

Abstract	Background: Topical 5-fluorouracil 5% cream is one of the treatment modalities for non-melanoma skin cancer (NMSC). There is a lack of suitable therapies to treat patients with extensive NMSC. In this paper we report two patients with extensive NMSC treated by total body application of topical 5-fluorouracil 5% cream. Observations: Topical 5-fluorouracil 5% cream was applied twice daily to the total body, including normal appearing skin. During the treatment, weekly blood samples were taken for measurement of 5-fluorouracil levels. All samples showed a 5-fluorouracil level less than the detection level of 10 microg/l. Total body 5- fluorouracil 5% cream was shown to be an effective treatment in our patients; the majority of lesions cleared in both patients. Conclusions: In conclusion, total body topical 5- fluorouracil 5% cream application was successful in two patients with extensive NMSC. No detectable serum level of 5-fluorouracil could be determined. Pain and secondary infections were important side effects in our patients. However, in patients with extensive NMSC this treatment may be considered.
MeSH term(s)	Administration, Topical ; Aged ; Antimetabolites, Antineoplastic/administration & dosage ; Antimetabolites, Antineoplastic/blood ; Antimetabolites, Antineoplastic/therapeutic use ; Basal Cell Nevus Syndrome/drug therapy ; Fluorouracil/administration & dosage ; Fluorouracil/blood ; Fluorouracil/therapeutic use ; Humans ; Male ; Neoplasms, Basal Cell/drug therapy ; Skin Neoplasms/drug therapy
Chemical Substances	Antimetabolites, Antineoplastic ; Fluorouracil (U3P01618RT)
Language	English
Publishing date	2006-06
Publishing country	Germany
Document type	Case Reports ; Journal Article
ZDB-ID	1145408-8
ISSN	1573-739X ; 0928-1231
ISSN (online)	1573-739X
ISSN	0928-1231
DOI	10.1007/s11096-006-9030-x
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Article ; Online: RORγt inhibition selectively targets IL-17 producing iNKT and γδ-T cells enriched in Spondyloarthritis patients.

Venken, Koen / Jacques, Peggy / Mortier, Céline / Labadia, Mark E / Decruy, Tine / Coudenys, Julie / Hoyt, Kathleen / Wayne, Anita L / Hughes, Robert / Turner, Michael / Van Gassen, Sofie / Martens, Liesbet / Smith, Dustin / Harcken, Christian / Wahle, Joseph / Wang, Chao-Ting / Verheugen, Eveline / Schryvers, Nadia / Varkas, Gaëlle /

Cypers, Heleen / Wittoek, Ruth / Piette, Yves / Gyselbrecht, Lieve / Van Calenbergh, Serge / Van den Bosch, Filip / Saeys, Yvan / Nabozny, Gerald / Elewaut, Dirk

Nature communications

2019 Volume 10, Issue 1, Page(s) 9

Abstract: Dysregulated IL-23/IL-17 responses have been linked to psoriatic arthritis and other forms of spondyloarthritides (SpA). RORγt, the key Thelper17 (Th17) cell transcriptional regulator, is also expressed by subsets of innate-like T cells, including ... ...

Abstract	Dysregulated IL-23/IL-17 responses have been linked to psoriatic arthritis and other forms of spondyloarthritides (SpA). RORγt, the key Thelper17 (Th17) cell transcriptional regulator, is also expressed by subsets of innate-like T cells, including invariant natural killer T (iNKT) and γδ-T cells, but their contribution to SpA is still unclear. Here we describe the presence of particular RORγt
MeSH term(s)	Case-Control Studies ; Humans ; Interleukin-17/metabolism ; Natural Killer T-Cells/metabolism ; Nuclear Receptor Subfamily 1, Group F, Member 3/antagonists & inhibitors ; Nuclear Receptor Subfamily 1, Group F, Member 3/metabolism ; Receptors, Antigen, T-Cell, gamma-delta/metabolism ; Receptors, Interleukin/metabolism ; Spondylarthritis/immunology ; T-Lymphocyte Subsets/metabolism
Chemical Substances	IL23R protein, human ; Interleukin-17 ; Nuclear Receptor Subfamily 1, Group F, Member 3 ; RORC protein, human ; Receptors, Antigen, T-Cell, gamma-delta ; Receptors, Interleukin
Language	English
Publishing date	2019-01-02
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-018-07911-6
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Article: Surgical treatment of malignant pleural mesothelioma: a review.

van Ruth, Serge / Baas, Paul / Zoetmulder, Frans A N

Chest

2002 Volume 123, Issue 2, Page(s) 551–561

Abstract: Despite many years of clinical research, there is still no effective therapy for malignant pleural mesothelioma (MPM). Untreated, the prognosis is poor, with a median survival of < 1 year. Single-agent or combination chemotherapy as well as radiotherapy ... ...

Abstract	Despite many years of clinical research, there is still no effective therapy for malignant pleural mesothelioma (MPM). Untreated, the prognosis is poor, with a median survival of < 1 year. Single-agent or combination chemotherapy as well as radiotherapy have not shown persistent improvements in response or survival. In general, MPM is a disease confined to the pleural cavity for a long time before metastasizing. Therefore, focus on local treatment seems rational. Surgical resection has been considered the mainstay of treatment by some. However, surgery alone results in high recurrence rates, and the survival benefit remains questionable. In recent years, the emphasis has been on surgery combined with adjuvant therapies. In this article, the present state of surgical management of MPM will be reviewed.
MeSH term(s)	Chemotherapy, Adjuvant ; Combined Modality Therapy ; Humans ; Mesothelioma/drug therapy ; Mesothelioma/mortality ; Mesothelioma/radiotherapy ; Mesothelioma/surgery ; Pleural Neoplasms/drug therapy ; Pleural Neoplasms/mortality ; Pleural Neoplasms/radiotherapy ; Pleural Neoplasms/surgery ; Radiotherapy, Adjuvant ; Survival Rate ; Treatment Outcome
Language	English
Publishing date	2002-10-21
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1032552-9
ISSN	1931-3543 ; 0012-3692
ISSN (online)	1931-3543
ISSN	0012-3692
DOI	10.1378/chest.123.2.551
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Ui III Zs.45: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 349: Show issues

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Article: High risk of colostomy with primary radiotherapy for anal cancer.

de Bree, Eelco / van Ruth, Serge / Dewit, Luc G H / Zoetmulder, Frans A N

Annals of surgical oncology

2007 Volume 14, Issue 1, Page(s) 100–108

Abstract: Background: Radiotherapy (RT) has become the primary treatment of choice for anal cancer in an effort to avoid colostomy. The current role of surgery appears generally to be underestimated, since diverting colostomy or abdominoperineal resection still ... ...

Abstract	Background: Radiotherapy (RT) has become the primary treatment of choice for anal cancer in an effort to avoid colostomy. The current role of surgery appears generally to be underestimated, since diverting colostomy or abdominoperineal resection still often seems to be necessary for complications and local treatment failure after RT. Methods: The data of 83 patients primarily treated by RT with curative intent throughout a 20-year period in our institute were analyzed regarding the need for colostomy. Results: Totally, 28 patients (34%) required creation of a colostomy after primary RT for local failure or treatment-related complications during a mean follow-up period of 39 months. The 3-year actuarial colostomy-free rate was 59% (mean 85 +/- 9 months). Early stage disease, low T-score and absence of infiltration in adjacent organs were associated with a reduced need for colostomy in univariate analysis. In multivariate analysis only T-score was an independent variable in predicting prolonged colostomy-free interval. In this study, no statistically significant differences were noted for gender, age, nodal status, total radiation dose, radiation boost and concurrent chemotherapy. Conclusions: In approximately one-third of the patients treated by anal sphincter saving management with curative aimed primary RT, the creation of a colostomy appeared to be necessary for RT complications and local treatment failure. Therefore, patients should be well informed regarding the considerable risk of need for colostomy after RT for anal cancer.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Anus Neoplasms/radiotherapy ; Anus Neoplasms/surgery ; Carcinoma, Squamous Cell/radiotherapy ; Carcinoma, Squamous Cell/surgery ; Colostomy ; Disease-Free Survival ; Female ; Humans ; Male ; Middle Aged ; Neoplasm Invasiveness ; Neoplasm Recurrence, Local/surgery ; Neoplasm, Residual ; Radiation Injuries/etiology ; Radiation Injuries/surgery ; Radiotherapy Dosage ; Risk Factors ; Treatment Failure
Language	English
Publishing date	2007-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	1200469-8
ISSN	1534-4681 ; 1068-9265
ISSN (online)	1534-4681
ISSN	1068-9265
DOI	10.1245/s10434-006-9118-5
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