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Article ; Online: Correction: Ying et al. Dynamic Change in Starch Biosynthetic Enzymes Complexes during Grain-Filling Stages in BEIIb Active and Deficient Rice.

Ying, Yining / Xu, Feifei / Zhang, Zhongwei / Tappiban, Piengtawan / Bao, Jinsong

International journal of molecular sciences

2023 Volume 24, Issue 10

Abstract: In the original publication [ ... ]. ...

Abstract	In the original publication [...].
Language	English
Publishing date	2023-05-11
Publishing country	Switzerland
Document type	Published Erratum
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms24108583
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: SIRT1/P53 in retinal pigment epithelial cells in diabetic retinopathy: a gene co-expression analysis and He-Ying-Qing-Re formula treatment.

Zhang, Shuyan / Wu, Jiajun / Wang, Leilei / Mu, Lin / Xu, Xiaoyu / Li, Jiahui / Tang, Guoyi / Chen, Guang / Zhang, Cheng / Zhang, Yinjian / Feng, Yibin

Frontiers in molecular biosciences

2024 Volume 11, Page(s) 1366020

Abstract: ... visual impairment or blindness. He-Ying-Qing-Re formula (HF), a traditional Chinese medicinal concoction, has been ...

Abstract	Objective: Diabetic retinopathy (DR) is a severe diabetic complication that leads to severe visual impairment or blindness. He-Ying-Qing-Re formula (HF), a traditional Chinese medicinal concoction, has been identified as an efficient therapy for DR with retinal vascular dysfunction for decades and has been experimentally reported to ameliorate retinal conditions in diabetic mice. This study endeavors to explore the therapeutic potential of HF with key ingredients in DR and its underlying novel mechanisms. Methods: Co-expression gene modules and hub genes were calculated by weighted gene co-expression network analysis (WGCNA) based on transcriptome sequencing data from high-glucose-treated adult retinal pigment epithelial cell line-19 (ARPE-19). The chromatographic fingerprint of HF was established by ultra-performance liquid chromatography coupled with high-resolution mass spectrometry (UPLC-Q-TOF-MS). The molecular affinity of the herbal compound was measured by molecular docking. Reactive oxygen species (ROS) was measured by a DCFDA/H2DCFDA assay. Apoptosis was detected using the TUNEL Assay Kit, while ELISA, Western blot, and real-time quantitative reverse transcription polymerase chain reaction (qRT-PCR) were used for detecting the cytokine, protein, and mRNA expressions, respectively. Results: Key compounds in HF were identified as luteolin, paeoniflorin, and nobiletin. For WGCNA, ME-salmon ("protein deacetylation") was negatively correlated with ME-purple ("oxidative impairment") in high-glucose-treated ARPE-19. Luteolin has a high affinity for SIRT1 and P53, as indicated by molecular docking. Luteolin has a hypoglycemic effect on type I diabetic mice. Moreover, HF and luteolin suppress oxidative stress production (ROS and MDA), inflammatory factor expression (IL-6, TNF-α, IL1-β, and MCP-1), and apoptosis, as shown in the Conclusion: Using HF and its active compound luteolin as therapeutic agents offers a promising approach to diabetic retinopathy treatment. It primarily suppressed protein acetylation and oxidative stress via the SIRT1/P53 pathway in retinal pigment epithelial cells.
Language	English
Publishing date	2024-04-03
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2814330-9
ISSN	2296-889X
ISSN	2296-889X
DOI	10.3389/fmolb.2024.1366020
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Article ; Online: Systematic Quality Evaluation of Epimedium wushanense T. S. Ying Based on Two Quality Control Standards: Total Flavonoid Glycosides and Epimedin C.

Wang, Congying / Tian, Shuyun / Tang, Qin / Zhou, Ziwei / Peng, Xinheng / Cai, Xiaoxue / Xu, Yanqin

Chemistry & biodiversity

2023 Volume 20, Issue 3, Page(s) e202200579

Abstract: ... Ying, so as to provide reference for its germplasm screening and resource utilization. Seven ...

Abstract	Two quality control standards, total flavonoid glycosides of Epimedii Folium and epimedin C of Epimedii Wushanensis Folium, were used to systematically evaluate the quality of Epimedium wushanense T. S. Ying, so as to provide reference for its germplasm screening and resource utilization. Seven representative populations of E. wushanense covering its main distribution areas were uniformly sampled during the flowering period. There were significant quality differences among the populations of E. wushanense. According to the quality standard of total flavonoid glycosides, all populations were superior to the quality standard of the Chinese Pharmacopoeia for Epimedii Folium, with more than 1.5 % total flavonoid glycosides. The variation ranges of epimedin A, epimedin B, epimedin C, icariin and total flavonoid glycosides were 0.40-0.76 %, 0.51-0.83 %, 1.70-9.31 %, 0.40-1.23 % and 3.05-10.61 %, respectively. According to the quality standard of epimedin C, all populations were better than the quality standard of the Chinese Pharmacopoeia for Epimedii Wushanensis Folium, with more than 1.0 % epimedin C. The variation range of epimedin C was 2.22-10.06 %. When comparing the results of the two methods, a trend of slightly lower mean values was found for total flavonoid glycosides, except for the HBXW population. The quality of E. wushanense was superior to both the quality standard of Epimedii Folium and Epimedii Wushanense Folium in the Chinese Pharmacopoeia. Epimedin C was the most abundant component. Among the investigated populations, HBXW and HBGK exhibited the highest quality, and may provide excellent genetic resources for standardized cultivation. In addition, the habitat of these populations can also serve a reference for cultivation conditions.
MeSH term(s)	Glycosides ; Epimedium ; Flavonoids ; Drugs, Chinese Herbal ; Quality Control
Chemical Substances	epimedin C (110642-44-9) ; Glycosides ; Flavonoids ; Drugs, Chinese Herbal
Language	English
Publishing date	2023-02-20
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2139001-0
ISSN	1612-1880 ; 1612-1872
ISSN (online)	1612-1880
ISSN	1612-1872
DOI	10.1002/cbdv.202200579
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Article ; Online: Effects of "Shi Ying Zi" powder and osthole on immune and antioxidant function of Eimeria tenella-infected broilers.

Cheng, Yi / Geng, Zhe / Li, Yunhe / Song, Xu / Li, Lixia / Wen, Anxiang / Yin, Zhongqiong

Experimental parasitology

2022 Volume 246, Page(s) 108451

Abstract: Shi Ying Zi" powder is a traditional Chinese herbal formula for preventing and treating ... Eimeria tenella infection. In this research, we evaluated the antioxidation and immune effect of "Shi Ying Zi ... of "Shi Ying Zi" powder and osthole alleviated the pathological changes in the cecum, spleen and bursa ...

Abstract	"Shi Ying Zi" powder is a traditional Chinese herbal formula for preventing and treating coccidiosis. In our previous studies, it showed anticoccidial effects and exhibited the potential to control Eimeria tenella infection. In this research, we evaluated the antioxidation and immune effect of "Shi Ying Zi" powder and its effective active ingredient osthole on coccidiosis-infected broilers to explore the mechanism of its anticoccidial effect. We analyzed changes in the antioxidant index, the pathological changes in cecum, immune index of serum and composition of cecal flora. The results showed that the use of "Shi Ying Zi" powder and osthole alleviated the pathological changes in the cecum, spleen and bursa of Fabricius, upregulated the spleen and bursal weigh index. "Shi Ying Zi" powder of 10 g/kg effectively rocovered the contents of interleukins and immunoglobulin in serum. Osthole increased the proportion of Firmicutes, Actino-bacteria and Lactobacillus in the cecum. In summary, "Shi Ying Zi" powder and osthole have anticoccidial effects, and they also can active the immunity, antioxidant functions and upregulate the beneficial bacteria population in Eimeria tenella-infected broilers.
MeSH term(s)	Animals ; Antioxidants/pharmacology ; Antioxidants/therapeutic use ; Eimeria tenella ; Chickens ; Powders ; Coccidiosis/drug therapy ; Coccidiosis/veterinary ; Bacteria ; Poultry Diseases/drug therapy ; Poultry Diseases/prevention & control ; Cecum/pathology
Chemical Substances	Antioxidants ; osthol (XH1TI1759C) ; Powders
Language	English
Publishing date	2022-12-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	391089-1
ISSN	1090-2449 ; 0014-4894
ISSN (online)	1090-2449
ISSN	0014-4894
DOI	10.1016/j.exppara.2022.108451
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Article: Anticoccidial Effect of Herbal Powder "Shi Ying Zi" in Chickens Infected with

Song, Xu / Li, Yunhe / Chen, Shufan / Jia, Renyong / Huang, Yongyuan / Zou, Yuanfeng / Li, Lixia / Zhao, Xinxin / Yin, Zhongqiong

Animals : an open access journal from MDPI

2020 Volume 10, Issue 9

Abstract: Coccidiosis is one of the most economically important diseases affecting the poultry industry. Currently, anticoccidial drugs used in veterinary clinics show many deficiencies, and new control measures are urgently needed. This study presents an ... ...

Abstract	Coccidiosis is one of the most economically important diseases affecting the poultry industry. Currently, anticoccidial drugs used in veterinary clinics show many deficiencies, and new control measures are urgently needed. This study presents an anticoccidial herbal powder "Shi Yin Zi", which consists of
Language	English
Publishing date	2020-08-24
Publishing country	Switzerland
Document type	Journal Article
ISSN	2076-2615
ISSN	2076-2615
DOI	10.3390/ani10091484
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Article ; Online: Anticoccidial Effect of Herbal Powder “Shi Ying Zi” in Chickens Infected with Eimeria tenella

Xu Song / Yunhe Li / Shufan Chen / Renyong Jia / Yongyuan Huang / Yuanfeng Zou / Lixia Li / Xinxin Zhao / Zhongqiong Yin

Animals, Vol 10, Iss 1484, p

2020 Volume 1484

Abstract: ... These results suggest that “Shi Ying Zi” powder possesses a potent anticoccidial effect and exhibits ...

Abstract	Coccidiosis is one of the most economically important diseases affecting the poultry industry. Currently, anticoccidial drugs used in veterinary clinics show many deficiencies, and new control measures are urgently needed. This study presents an anticoccidial herbal powder “Shi Yin Zi”, which consists of Cnidium monnieri (L.) Cuss, Taraxacum mongolicum Hand.-Mazz., and sodium chloride. In chickens infected with Eimeria tenella , supplementation with “Shi Yin Zi” powder for 3 d prior to infection or treatment with “Shi Yin Zi” powder after infection could improve the survival rate and relative growth rate and alleviate the pathological changes in the cecum, liver, and kidney. “Shi Yin Zi” powder could recover the levels of alanine aminotransferase, creatinine, albumin, and triglycerides in serum. The hemorrhage occurrence and total number of oocysts in feces were reduced. The anti-coccidial indexes reached 165 for the prophylactic effect and 144 for the therapeutic effect. The anti-coccidial effects were equal to positive controls (monensin and sulfamlopyrazine). These results suggest that “Shi Ying Zi” powder possesses a potent anticoccidial effect and exhibits the potential to control E. tenella infection.
Keywords	anticoccidial drug ; coccidiosis ; “Shi Yin Zi” powder ; Veterinary medicine ; SF600-1100 ; Zoology ; QL1-991
Subject code	630
Language	English
Publishing date	2020-08-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Anticoccidial Effect of Herbal Powder “Shi Ying Zi” in Chickens Infected with Eimeria tenella

Song, Xu / Li, Yunhe / Chen, Shufan / Jia, Renyong / Huang, Yongyuan / Zou, Yuanfeng / Li, Lixia / Zhao, Xinxin / Yin, Zhongqiong

Animals. 2020 Aug. 24, v. 10, no. 9

2020

Abstract: ... These results suggest that “Shi Ying Zi” powder possesses a potent anticoccidial effect and exhibits ...

Abstract	Coccidiosis is one of the most economically important diseases affecting the poultry industry. Currently, anticoccidial drugs used in veterinary clinics show many deficiencies, and new control measures are urgently needed. This study presents an anticoccidial herbal powder “Shi Yin Zi”, which consists of Cnidium monnieri (L.) Cuss, Taraxacum mongolicum Hand.-Mazz., and sodium chloride. In chickens infected with Eimeria tenella, supplementation with “Shi Yin Zi” powder for 3 d prior to infection or treatment with “Shi Yin Zi” powder after infection could improve the survival rate and relative growth rate and alleviate the pathological changes in the cecum, liver, and kidney. “Shi Yin Zi” powder could recover the levels of alanine aminotransferase, creatinine, albumin, and triglycerides in serum. The hemorrhage occurrence and total number of oocysts in feces were reduced. The anti-coccidial indexes reached 165 for the prophylactic effect and 144 for the therapeutic effect. The anti-coccidial effects were equal to positive controls (monensin and sulfamlopyrazine). These results suggest that “Shi Ying Zi” powder possesses a potent anticoccidial effect and exhibits the potential to control E. tenella infection.
Keywords	Cnidium monnieri ; Eimeria tenella ; Taraxacum mongolicum ; alanine transaminase ; albumins ; blood serum ; cecum ; coccidiosis ; coccidiostats ; creatinine ; feces ; hemorrhage ; kidneys ; liver ; monensin ; oocysts ; poultry industry ; protective effect ; sodium chloride ; survival rate ; therapeutics
Language	English
Dates of publication	2020-0824
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
Note	NAL-light
ISSN	2076-2615
DOI	10.3390/ani10091484
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Neuroprotective effect of He-Ying-Qing-Re formula on retinal ganglion cell in diabetic retinopathy.

Zhang, Cheng / Xu, Yu / Tan, Hor-Yue / Li, Sha / Wang, Ning / Zhang, Yinjian / Feng, Yibin

Journal of ethnopharmacology

2017 Volume 214, Page(s) 179–189

Abstract: Ethnopharmacology relevance: He-Ying-Qing-Re Formula (HF) was empirically modified from Si-Miao ...

Abstract	Ethnopharmacology relevance: He-Ying-Qing-Re Formula (HF) was empirically modified from Si-Miao-Yong-An Decoction (SD), which was recorded in the literature of Divine Doctor's Secret Transmission, and has been utilized for centuries to treat vasculopathy through clearing heat and accelerating bloodstream. HF has been used as an effective holistic treatment of diabetic retinopathy (DR) for decades and experimentally reported to ameliorate retinal condition in diabetic mice. Aim of the study: Our study aims to investigate the effect of HF in preventing sustained hyperglycemia and hyperlipidemia-associated retinal ganglion cell (RGC) cell death and its possible mechanism. Materials and methods: Chromatographic fingerprint of HF was obtained upon the UPLC-based analytic system; Diabetic retinopathy was established in streptozotocin (STZ) injection-induced hyperglycemic mice; Alterations of retinal structure was assayed by H&E staining. Expression of PSD-95 and CHOP in retinae was assessed by immunofluorescence; RGC cell line (mRGC) was used for in vitro study. Cell death was analyzed by flow cytometry; Intracellular reactive oxygen species (ROS) was measured by 2',7'-dichlorofluorescin diacetate (DCFDA); Apoptosis-related proteins and signaling were monitored with immunoblotting and colorimetric assay. Results: Chlorogenic acid, ferulic acid, and rutin were identified in HF. HF attenuates the loss of RGCs, thinning of inner retinal layers in diabetic mice. Furthermore, expressions of Brn3a and PSD-95 were restored while CHOP level was downregulated upon HF treatment. In vitro study, HF alleviates H Conclusion: HF administration was a valid therapeutic approach for DR treatment, oriented at the blockade of endoplasmic reticulum- and mitochondria-dependent oxidative stress-induced retinal neurodegeneration including RGC apoptosis.
MeSH term(s)	Activating Transcription Factor 4/metabolism ; Animals ; Antioxidants/pharmacology ; Apoptosis/drug effects ; Apoptosis Regulatory Proteins/metabolism ; Blood Glucose/drug effects ; Blood Glucose/metabolism ; Cell Line ; Cytoprotection ; Diabetes Mellitus, Experimental/blood ; Diabetes Mellitus, Experimental/complications ; Diabetes Mellitus, Experimental/drug therapy ; Diabetic Retinopathy/blood ; Diabetic Retinopathy/etiology ; Diabetic Retinopathy/pathology ; Diabetic Retinopathy/prevention & control ; Disks Large Homolog 4 Protein/metabolism ; Dose-Response Relationship, Drug ; Drugs, Chinese Herbal/pharmacology ; Endoplasmic Reticulum Stress/drug effects ; Hydrogen Peroxide/toxicity ; Hypoglycemic Agents/pharmacology ; Male ; Mice, Inbred C57BL ; Mitochondria/drug effects ; Mitochondria/metabolism ; Mitochondria/pathology ; Neuroprotective Agents/pharmacology ; Oxidative Stress/drug effects ; Reactive Oxygen Species/metabolism ; Retinal Ganglion Cells/drug effects ; Retinal Ganglion Cells/metabolism ; Retinal Ganglion Cells/pathology ; Signal Transduction/drug effects ; Time Factors ; Transcription Factor CHOP/metabolism
Chemical Substances	Antioxidants ; Apoptosis Regulatory Proteins ; Atf4 protein, mouse ; Blood Glucose ; Ddit3 protein, mouse ; Disks Large Homolog 4 Protein ; Dlg4 protein, mouse ; Drugs, Chinese Herbal ; Hypoglycemic Agents ; Neuroprotective Agents ; Reactive Oxygen Species ; he-ying-qing-re ; Activating Transcription Factor 4 (145891-90-3) ; Transcription Factor CHOP (147336-12-7) ; Hydrogen Peroxide (BBX060AN9V)
Language	English
Publishing date	2017-12-15
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2017.12.018
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Zs.A 1494: Show issues

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Article ; Online: Paenibacillus qinlingensis sp. nov., an indole-3-acetic acid-producing bacterium isolated from roots of Sinopodophyllum hexandrum (Royle) Ying.

Xin, Kaiyun / Li, Muhang / Chen, Chaoqiong / Yang, Xu / Li, Qiqi / Cheng, Juanli / Zhang, Lei / Shen, Xihui

International journal of systematic and evolutionary microbiology

2017 Volume 67, Issue 3, Page(s) 589–595

Abstract: A novel indole-3-acetic acid-producing bacterium, designated TEGT-2T, was isolated from the roots of Sinopodophyllum hexandrum collected from the Qinling Mountains in shaanxi province, northwestern China, and was subjected to a taxonomic study by using a ...

Abstract	A novel indole-3-acetic acid-producing bacterium, designated TEGT-2T, was isolated from the roots of Sinopodophyllum hexandrum collected from the Qinling Mountains in shaanxi province, northwestern China, and was subjected to a taxonomic study by using a polyphasic approach. Cells of strain TEGT-2T were Gram-stain-positive, strictly aerobic, endospore-forming rods and motile by means of peritrichous flagella. Phylogenetic analyses based on 16S rRNA gene sequences showed that strain TEGT-2T was a member of the genus Paenibacillus, exhibiting the highest sequence similarity to Paenibacillus pectinilyticus KCTC 13222T (97.9 %), Paenibacillus frigoriresistens CCTCC AB 2011150T (97.3 %), Paenibacillus ferrarius CCTCC AB 2013369T (96.9 %) and Paenibacillus alginolyticus NBRC 15375T (96.5 %). The only menaquinone detected was MK-7, and the major fatty acid was anteiso-C15 : 0. The major polar lipids were diphosphatidylglycerol, phosphatidylglycerol, phosphatidylethanolamine, two unidentified aminophospholipids, two unidentified phospholipids, an unidentified aminolipid and two unidentified lipids. meso-Diaminopimelic acid was detected in the peptidoglycan. The DNA G+C content was 46.6 mol%. DNA-DNA relatedness values for strain TEGT-2T with respect to its closest phylogenetic relatives Paenibacilluspectinilyticus KCTC 13222T and Paenibacillus. frigoriresistens CCTCC AB 2011150T were lower than 40 %. Based on the phenotypic, phylogenetic and genotypic data, strain TEGT-2T is considered to represent a novel species of the genus Paenibacillus, for which the name Paenibacillus qinlingensis sp. nov. is proposed. The type strain is TEGT-2T (=CCTCC AB 2015258T=KCTC 33806T).
MeSH term(s)	Bacterial Typing Techniques ; Base Composition ; Berberidaceae/microbiology ; Cell Wall/chemistry ; China ; DNA, Bacterial/genetics ; Diaminopimelic Acid/chemistry ; Fatty Acids/chemistry ; Indoleacetic Acids/metabolism ; Nucleic Acid Hybridization ; Paenibacillus/classification ; Paenibacillus/genetics ; Paenibacillus/isolation & purification ; Peptidoglycan/chemistry ; Phospholipids/chemistry ; Phylogeny ; Plant Roots/microbiology ; RNA, Ribosomal, 16S/genetics ; Sequence Analysis, DNA ; Vitamin K 2/analogs & derivatives ; Vitamin K 2/chemistry
Chemical Substances	DNA, Bacterial ; Fatty Acids ; Indoleacetic Acids ; Peptidoglycan ; Phospholipids ; RNA, Ribosomal, 16S ; Vitamin K 2 (11032-49-8) ; Diaminopimelic Acid (583-93-7) ; indoleacetic acid (6U1S09C61L) ; menaquinone 7 (8427BML8NY)
Language	English
Publishing date	2017-04-03
Publishing country	England
Document type	Journal Article
ZDB-ID	2002336-4
ISSN	1466-5034 ; 1466-5026
ISSN (online)	1466-5034
ISSN	1466-5026
DOI	10.1099/ijsem.0.001666
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Zs.A 409: Show issues

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Book: Gu ke Ying Han ci hui

Lü, Long / Xu, Yongsheng

An English-Chinese dictionary of orthopaedics

2007

Title variant	English-Chinese dictionary of orthopaedics
Author's details	zhu bian Lü Long, Xu Yongsheng ; zhu shen Pan Shaochuan
MeSH term(s)	Orthopedics
Language	Chinese ; English
Size	viii, 398 p. ;, 21 cm.
Edition	Di 1 ban.
Publisher	Qing hua da xue chu ban she
Publishing place	Beijing
Document type	Book
ISBN	9787302151685 ; 7302151687
Database	Catalogue of the US National Library of Medicine (NLM)

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