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  1. Article: Correction: Comparison Between Levothyroxine and Lifestyle Intervention on Subclinical Hypothyroidism in Women: A Review.

    Matlock, Claire L / Vanhoof, Anna R / Rangrej, Shahid B / Rathore, Rajni

    Cureus

    2023  Volume 15, Issue 5, Page(s) c114

    Abstract: This corrects the article DOI: 10.7759/cureus.38309.]. ...

    Abstract [This corrects the article DOI: 10.7759/cureus.38309.].
    Language English
    Publishing date 2023-05-05
    Publishing country United States
    Document type Published Erratum
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.c114
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Comparison Between Levothyroxine and Lifestyle Intervention on Subclinical Hypothyroidism in Women: A Review.

    Matlock, Claire L / Vanhoof, Anna R / Rangrej, Shahid B / Rathore, Rajni

    Cureus

    2023  Volume 15, Issue 4, Page(s) e38309

    Abstract: Subclinical hypothyroidism (SCH) or "mild thyroid failure" is defined as elevated serum thyroid-stimulating hormone (TSH) in the presence of normal free thyroxine (T4). The incidence of SCH is estimated at 4.4-8.5% of the general population and occurs ... ...

    Abstract Subclinical hypothyroidism (SCH) or "mild thyroid failure" is defined as elevated serum thyroid-stimulating hormone (TSH) in the presence of normal free thyroxine (T4). The incidence of SCH is estimated at 4.4-8.5% of the general population and occurs more frequently in women. Given that it falls below the diagnostic threshold, SCH is monitored rather than treated. Its management is a common topic of debate as SCH frequently progresses into overt hypothyroidism and is linked to long-term hyperlipidemia, endothelial dysfunction, cardiovascular disease, heart failure, and cerebrovascular disease. Premature hormone administration and lifestyle interventions have been explored as treatment options to mitigate the symptoms of SCH. Our review compares both modalities' efficacy and potential for standardized clinical practice. A trial of levothyroxine demonstrated significant results in specific SCH demographics, such as patients who are pregnant or trying to conceive, those with goiter, those with thyroid peroxidase (TPO) antibody status, those with steadily increasing TSH, children, and adolescents. All other SCH patients presenting with chronic symptoms may also be reasonably considered for a three- to six-month trial of treatment. Lifestyle modifications through improved sleep hygiene, a diet within the recommended daily allowance (RDA) for iodine and selenium, increased exercise, and smoking cessation also proved efficacious. Our findings indicate that a synergistic approach to treatment is most favorable. Lifestyle modifications neither show adverse effects nor contraindications and can be safely recommended alone or alongside levothyroxine for the treatment of SCH.
    Language English
    Publishing date 2023-04-29
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.38309
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Tandem electrooxidation - reductive amination of biobased isohexides towards bicyclic diamines.

    Windels, Simon / Vanhoof, Jef / Spittaels, Sander / Coeck, Robin / De Vos, Dirk / Cuypers, Thomas

    ChemSusChem

    2024  , Page(s) e202301627

    Abstract: Isohexide-derived diamines are considered preferred precursors for the production of biobased polyurethanes and polyamides. However, current synthesis methods from isohexides suffer from serious issues concerning selectivity and the recyclability of the ... ...

    Abstract Isohexide-derived diamines are considered preferred precursors for the production of biobased polyurethanes and polyamides. However, current synthesis methods from isohexides suffer from serious issues concerning selectivity and the recyclability of the process auxiliaries (e.g. homogeneous catalysts), which renders a translation to the industry highly unlikely. Here, we report on the production of such diamine building blocks, via a tandem electrooxidation - reductive amination process in which the process auxiliaries can be easily recycled. The application of (immobilized) TEMPO in combination with simple halides (e.g. NaBr) in the electrochemical step even enables the oxidation of the sterically hindered exo-OHs of the isohexides to the corresponding diketones (yield up to 99%). In the subsequent reductive amination, the produced ketones are atom-efficiently converted to isohexide diamines utilizing NH3, H2, and Ru/C and an acid resin cocatalyst.
    Language English
    Publishing date 2024-03-29
    Publishing country Germany
    Document type Journal Article
    ISSN 1864-564X
    ISSN (online) 1864-564X
    DOI 10.1002/cssc.202301627
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Metal-Free Electrocatalytic Diacetoxylation of Alkenes.

    Vanhoof, Jef R / De Smedt, Pieter J / Derhaeg, Jan / Ameloot, Rob / De Vos, Dirk E

    Angewandte Chemie (International ed. in English)

    2023  Volume 62, Issue 49, Page(s) e202311539

    Abstract: 1,2-Dioxygenation of alkenes leads to a structural motif ubiquitous in organic synthons, natural products and active pharmaceutical ingredients. Straightforward and green synthesis protocols starting from abundant raw materials are required for facile ... ...

    Abstract 1,2-Dioxygenation of alkenes leads to a structural motif ubiquitous in organic synthons, natural products and active pharmaceutical ingredients. Straightforward and green synthesis protocols starting from abundant raw materials are required for facile and sustainable access to these crucial moieties. Especially industrially abundant aliphatic alkenes have proven to be arduous substrates in sustainable 1,2-dioxygenation methods. Here, we report a highly efficient electrocatalytic diacetoxylation of alkenes under ambient conditions using a simple iodobenzene mediator and acetic acid as both the solvent and an atom-efficient reactant. This transition metal-free method is applicable to a wide range of alkenes, even challenging feedstock alkenes such as ethylene and propylene, with a broad functional group tolerance and excellent faradaic efficiencies up to 87 %. In addition, this protocol can be extrapolated to alkenoic acids, resulting in cyclization of the starting materials to valuable lactone derivatives. With aromatic alkenes, a competing mechanism of direct anodic oxidation exists which enables reaction under catalyst-free conditions. The synthetic method is extensively investigated with cyclic voltammetry.
    Language English
    Publishing date 2023-09-28
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2011836-3
    ISSN 1521-3773 ; 1433-7851
    ISSN (online) 1521-3773
    ISSN 1433-7851
    DOI 10.1002/anie.202311539
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Physicians receiving gifts.

    Vanhoof, Ron

    Canadian family physician Medecin de famille canadien

    2014  Volume 60, Issue 3, Page(s) 225

    MeSH term(s) Family Practice/ethics ; Gift Giving ; Humans ; Physician-Patient Relations/ethics
    Language English
    Publishing date 2014-03-13
    Publishing country Canada
    Document type Letter ; Comment
    ZDB-ID 603565-6
    ISSN 1715-5258 ; 0008-350X
    ISSN (online) 1715-5258
    ISSN 0008-350X
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    In stock of ZB MED Cologne/Königswinter

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  6. Article ; Online: Nonsynaptic Error Backpropagation in Long-Term Cognitive Networks.

    Nopoles, Gonzalo / Vanhoenshoven, Frank / Falcon, Rafael / Vanhoof, Koen

    IEEE transactions on neural networks and learning systems

    2019  Volume 31, Issue 3, Page(s) 865–875

    Abstract: We introduce a neural cognitive mapping technique named long-term cognitive network (LTCN) that is able to memorize long-term dependencies between a sequence of input and output vectors, especially in those scenarios that require predicting the values of ...

    Abstract We introduce a neural cognitive mapping technique named long-term cognitive network (LTCN) that is able to memorize long-term dependencies between a sequence of input and output vectors, especially in those scenarios that require predicting the values of multiple dependent variables at the same time. The proposed technique is an extension of a recently proposed method named short-term cognitive network that aims at preserving the expert knowledge encoded in the weight matrix while optimizing the nonlinear mappings provided by the transfer function of each neuron. A nonsynaptic, backpropagation-based learning algorithm powered by stochastic gradient descent is put forward to iteratively optimize four parameters of the generalized sigmoid transfer function associated with each neuron. Numerical simulations over 35 multivariate regression and pattern completion data sets confirm that the proposed LTCN algorithm attains statistically significant performance differences with respect to other well-known state-of-the-art methods.
    Language English
    Publishing date 2019-05-06
    Publishing country United States
    Document type Journal Article
    ISSN 2162-2388
    ISSN (online) 2162-2388
    DOI 10.1109/TNNLS.2019.2910555
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  7. Article: Birth control v. abortion.

    Vanhoof, R A

    Canadian Medical Association journal

    2010  Volume 131, Issue 6, Page(s) 544

    Language English
    Publishing date 2010-03-22
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 215506-0
    ISSN 1488-2329 ; 0008-4409 ; 0820-3946
    ISSN (online) 1488-2329
    ISSN 0008-4409 ; 0820-3946
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    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.136: Show issues Location:
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  8. Article: Direct Electrocatalytic N–H Aziridination of Aromatic Alkenes Using Ammonia

    Vanhoof, Jef R. / De Smedt, Pieter J. / Krasniqi, Besir / Ameloot, Rob / Sakellariou, Dimitrios / De Vos, Dirk E.

    ACS sustainable chemistry & engineering. 2021 Aug. 18, v. 9, no. 34

    2021  

    Abstract: The electrocatalytic N–H aziridination of simple aromatic alkenes is reported, using ammonia (NH₃) as an atom-efficient nitrogen source. Yields of up to 98% are achieved, with H₂ as the only byproduct, by employing an undivided cell with a graphite anode ...

    Abstract The electrocatalytic N–H aziridination of simple aromatic alkenes is reported, using ammonia (NH₃) as an atom-efficient nitrogen source. Yields of up to 98% are achieved, with H₂ as the only byproduct, by employing an undivided cell with a graphite anode and a nickel cathode. The use of iodide as a redox mediator is essential to obtain the desired products. Mechanistic studies (cyclic voltammetry and multiple NMR techniques) reveal interactions between anodically formed iodine (I₂) and NH₃ creating NH₂I as a reactive species involved in the aziridination.
    Keywords alkenes ; ammonia ; anodes ; byproducts ; cathodes ; graphene ; green chemistry ; iodides ; iodine ; nickel ; nitrogen ; voltammetry
    Language English
    Dates of publication 2021-0818
    Size p. 11596-11603.
    Publishing place American Chemical Society
    Document type Article
    ISSN 2168-0485
    DOI 10.1021/acssuschemeng.1c04473
    Database NAL-Catalogue (AGRICOLA)

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  9. Article ; Online: On the Behavior of Fuzzy Grey Cognitive Maps

    Concepción, Leonardo / Nápoles, Gonzalo / Bello, Rafael / Vanhoof, Koen

    Rough Sets

    Abstract: Fuzzy Cognitive Maps (FCMs) are recurrent neural networks made up of well-defined neurons and causal relations. Fuzzy Grey Cognitive Maps (FGCMs) are an extension of FCMs, intended to surpass the intrinsic uncertainties modeling real-world problems by ... ...

    Abstract Fuzzy Cognitive Maps (FCMs) are recurrent neural networks made up of well-defined neurons and causal relations. Fuzzy Grey Cognitive Maps (FGCMs) are an extension of FCMs, intended to surpass the intrinsic uncertainties modeling real-world problems by means of Grey theory. Despite the rising number of studies about FGCM-based models, little has been investigated with regard to the convergence of such networks. In this paper, we build a mathematical basis to uncover the behavior FGCM-based models equipped with transfer F-functions. To do so, we propose sufficient conditions for the existence and unicity of fixed-point attractors. Also, the results reported in the literature on the convergence of FGCMs, are compared with ours. Furthermore, we elucidate the reach and depth of our findings, especially and not exclusive to the prediction of FCMs’ behavior.
    Keywords covid19
    Publisher PMC
    Document type Article ; Online
    DOI 10.1007/978-3-030-52705-1_34
    Database COVID19

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  10. Article: London in Lockdown: Mobility in the Pandemic City

    Batty, Michael / Murcio, Roberto / Iacopini, Iacopo / Vanhoof, Maarten / Milton, Richard

    Abstract: This chapter looks at the spatial distribution and mobility patterns of essential and non-essential workers before and during the COVID-19 pandemic in London and compares them to the rest of the UK. In the 3-month lockdown that started on 23 March 2020, ... ...

    Abstract This chapter looks at the spatial distribution and mobility patterns of essential and non-essential workers before and during the COVID-19 pandemic in London and compares them to the rest of the UK. In the 3-month lockdown that started on 23 March 2020, 20% of the workforce was deemed to be pursuing essential jobs. The other 80%% were either furloughed, which meant being supported by the government to not work, or working from home. Based on travel journey data between zones (trips were decomposed into essential and non-essential trips. Despite some big regional differences within the UK, we find that essential workers have much the same spatial patterning as non-essential for all occupational groups containing essential and non-essential workers. Also, the amount of travel time saved by working from home during the Pandemic is roughly the same proportion -80%-as the separation between essential and non-essential workers. Further, the loss of travel, reduction in workers, reductions in retail spending as well as increases in use of parks are examined in different London boroughs using Google Mobility Reports which give us a clear picture of what has happened over the last 6 months since the first Lockdown. These reports also now imply that a second wave of infection is beginning.
    Keywords covid19
    Publisher ArXiv
    Document type Article
    Database COVID19

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