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Article ; Online: Generation of Synthetic Rat Brain MRI Scans with a 3D Enhanced Alpha Generative Adversarial Network

André Ferreira / Ricardo Magalhães / Sébastien Mériaux / Victor Alves

Applied Sciences, Vol 12, Iss 4844, p

2022 Volume 4844

Abstract: Translational brain research using Magnetic Resonance Imaging (MRI) is becoming increasingly popular as animal models are an essential part of scientific studies and more ultra-high-field scanners are becoming available. Some disadvantages of MRI are the ...

Abstract	Translational brain research using Magnetic Resonance Imaging (MRI) is becoming increasingly popular as animal models are an essential part of scientific studies and more ultra-high-field scanners are becoming available. Some disadvantages of MRI are the availability of MRI scanners and the time required for a full scanning session. Privacy laws and the 3Rs ethics rule also make it difficult to create large datasets for training deep learning models. To overcome these challenges, an adaptation of the alpha Generative Adversarial Networks (GANs) architecture was used to test its ability to generate realistic 3D MRI scans of the rat brain in silico. As far as the authors are aware, this was the first time a GAN-based approach was used to generate synthetic MRI data of the rat brain. The generated scans were evaluated using various quantitative metrics, a Turing test, and a segmentation test. The last two tests proved the realism and applicability of the generated scans to real problems. Therefore, by using the proposed new normalisation layer and loss functions, it was possible to improve the realism of the generated rat MRI scans, and it was shown that using the generated data improved the segmentation model more than using the conventional data augmentation.
Keywords	alpha generative adversarial network ; data augmentation ; synthetic data ; MRI rat brain ; Technology ; T ; Engineering (General). Civil engineering (General) ; TA1-2040 ; Biology (General) ; QH301-705.5 ; Physics ; QC1-999 ; Chemistry ; QD1-999
Subject code	610
Language	English
Publishing date	2022-05-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Surgical management of rectal cancer with synchronous treatment of prostate cancer.

Brière, Raphaëlle / Martin, André-Guy / Letarte, François / Fournier, François Rouleau / Bouchard, Philippe / Drolet, Sébastien

Langenbeck's archives of surgery

2024 Volume 409, Issue 1, Page(s) 133

Abstract: Purpose: To assess the safety and efficacy of synchronous treatments for rectal (RC) and prostate (PC) cancers.: Methods: Single-center retrospective study (2007-2021) of patients treated with neoadjuvant radiotherapy (RT) and total mesorectal ... ...

Abstract	Purpose: To assess the safety and efficacy of synchronous treatments for rectal (RC) and prostate (PC) cancers. Methods: Single-center retrospective study (2007-2021) of patients treated with neoadjuvant radiotherapy (RT) and total mesorectal excision (TME) for RC with synchronous PC treatment. The endpoints were 30-day postoperative severe complications, R0 resection rates, 3-year disease-free survival (DFS) and 3-year overall survival (OS). Results: Among the 16 patients, 15 (93.7%) received neoadjuvant pelvic RT (40-50.4 Gray) followed by either transperineal high dose rate prostate brachytherapy (62.5%), prostate external RT boost (25.0%), or androgen deprivation therapy (ADT) alone (6.3%). One (6.3%) patient received neoadjuvant rectal brachytherapy and ADT. Pelvic RT was combined with chemotherapy in 87.5% of cases. TME was performed in all patients with low anterior resection (87.5%) or abdominoperineal resection (12.5%), primarily using minimally invasive surgery (87.5%). The R0 resection rate was 93.8%. Six (37.5%) patients experienced 30-day Clavien-Dindo grade IIIb complications, including one (7.1%) anastomotic leak. After a median follow-up of 39.0 months, 63.6% of diverting ileostomies were reversed. Three-year DFS from RC was 71.4% (CI 40.2-88.3) and 3-year OS was 84.4% (CI 95% 50.4-95.9). No PC recurrence or death occurred. Conclusions: Synchronous management of RC and PC with pelvic RT followed by curative prostate RT doses and TME showed acceptable morbidity and oncologic results. Prostate brachytherapy, the most commonly used treatment modality, allowed avoidance of prostatectomy and additional external RT to the rectum. PC should not limit the curative intent of RC, as all recurrences were from rectal origin.
MeSH term(s)	Male ; Humans ; Prostatic Neoplasms/radiotherapy ; Prostatic Neoplasms/surgery ; Androgen Antagonists/therapeutic use ; Retrospective Studies ; Follow-Up Studies ; Rectal Neoplasms/surgery ; Rectal Neoplasms/radiotherapy ; Neoadjuvant Therapy ; Treatment Outcome
Chemical Substances	Androgen Antagonists
Language	English
Publishing date	2024-04-20
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1423681-3
ISSN	1435-2451 ; 1435-2443
ISSN (online)	1435-2451
ISSN	1435-2443
DOI	10.1007/s00423-024-03327-7
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Article: Laboratory Study of the Effects of the Mixer Type and Mixing Time on the Volumetric Properties and Performance of a HMA with 30 Percent Reclaimed Asphalt Pavement.

Bérubé, Marc-André / Lamothe, Sébastien / Bilodeau, Kevin / Carter, Alan

Materials (Basel, Switzerland)

2023 Volume 16, Issue 3

Abstract: This study examined the effects of the laboratory mixer type and mixing time on a hot-mix asphalt (HMA) using three different types of mixers and four different mixing times. The asphalt mix used is a semi-open graded mix (ESG-10) with 30% reclaimed ... ...

Abstract	This study examined the effects of the laboratory mixer type and mixing time on a hot-mix asphalt (HMA) using three different types of mixers and four different mixing times. The asphalt mix used is a semi-open graded mix (ESG-10) with 30% reclaimed asphalt pavement (RAP), and a range of tests were conducted including bitumen extraction by ignition, particle size distribution, maximum specific gravity (G
Language	English
Publishing date	2023-02-03
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2487261-1
ISSN	1996-1944
ISSN	1996-1944
DOI	10.3390/ma16031300
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Mechanistic Learning for Combinatorial Strategies With Immuno-oncology Drugs: Can Model-Informed Designs Help Investigators?

Ciccolini, Joseph / Barbolosi, Dominique / André, Nicolas / Barlesi, Fabrice / Benzekry, Sébastien

JCO precision oncology

2022 Volume 4, Page(s) 486–491

Language	English
Publishing date	2022-01-20
Publishing country	United States
Document type	Journal Article
ISSN	2473-4284
ISSN (online)	2473-4284
DOI	10.1200/PO.19.00381
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: How do local actors coordinate to implement a successful biogas project?

Niang, Amadou / Torre, André / Bourdin, Sébastien

Environmental science & policy. 2022 Oct., v. 136

2022

Abstract: Anaerobic digestion has recently gained interest in contributing to territorial strategy regarding the deployment of the circular economy and energy transition. Most projects bring together multiple actors from a wide variety of backgrounds. The article ... ...

Abstract	Anaerobic digestion has recently gained interest in contributing to territorial strategy regarding the deployment of the circular economy and energy transition. Most projects bring together multiple actors from a wide variety of backgrounds. The article analyzes the evolution of synergies and cooperative behaviors between local stakeholders over the period 2010–2020 in an anaerobic digestion cluster in France. The study draws on social network analysis and proximity theory, which have recently been used for analyzing regional innovation systems, local clusters, territorial governance, and rural development. We reveal that local stakeholders develop dense relational networks that vary and evolve throughout the project. Different groups exist and behave in a semi-autonomous manner. All the actors are located in close geographical proximity. Still, their links in terms of organized proximities are related to various types of relations, resulting from cognitive resemblances or common origins. This explains the persistence and resilience of local relationships and how they maintain a collaborative dynamic over time.
Keywords	anaerobic digestion ; circular economy ; cognition ; energy ; environmental science ; governance ; issues and policy ; rural development ; social networks ; stakeholders ; France
Language	English
Dates of publication	2022-10
Size	p. 337-347.
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	1454687-5
ISSN	1462-9011
ISSN	1462-9011
DOI	10.1016/j.envsci.2022.06.019
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: The Circular Economy as a Means of Territorialisation of the EU Industry

Sebastien Bourdin / André Torre

Symphonya, Iss

2020 Volume 2

Abstract: This contribution essentially aims to highlight the circular economy in territorial development and the new industrial strategy for Europe. We highlight the main challenges of the circular economy and present the main obstacles to its deployment today. ... ...

Abstract	This contribution essentially aims to highlight the circular economy in territorial development and the new industrial strategy for Europe. We highlight the main challenges of the circular economy and present the main obstacles to its deployment today. Finally, we propose the establishment of a European industrial and territorial ecology.
Keywords	Circular Economy ; Europe ; Industrial and Territorial Ecology ; Marketing. Distribution of products ; HF5410-5417.5
Language	English
Publishing date	2020-12-01T00:00:00Z
Publisher	Niccolò Cusano University-Rome
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Laboratory Investigation Into the Effect of the Storage Capacity of a City Block on Unsteady Urban Flood Flows

Mejía‐Morales, Miguel Angel / Mignot, Emmanuel / Paquier, André / Proust, Sébastien

Water Resources Research. 2023 Apr., v. 59, no. 4 p.e2022WR032984-

2023

Abstract: The increasing occurrence of urban flooding in recent years demands a more accurate flood hazard assessment. Therefore, a better understanding of the predominant hydraulic processes in urban flood flows is required. The present paper reports an ... ...

Abstract	The increasing occurrence of urban flooding in recent years demands a more accurate flood hazard assessment. Therefore, a better understanding of the predominant hydraulic processes in urban flood flows is required. The present paper reports an experimental study conducted in a laboratory scale model, which represents an urban area consisting of a rectangular city block and four surrounding streets. The objective is to quantify the impact of open areas within the city block on the key features of floodwaters. Tests are carried out under unsteady flow conditions, by using three inflow hydrographs with different unsteadiness levels. For each inflow hydrograph, the space available for floodwater volume storage within the block (storage capacity, ϕ) is varied, keeping the boundary conditions unchanged. A case where the city block has no space for floodwater storage (i.e., ϕ = 0) is used as a reference case. The results indicate that the unsteadiness level of the inflow hydrograph, especially during the rising stage, has a strong influence on the floodwater volume stored within the city block. The increase in storage capacity within the city block leads to a reduction of the global peak outflow discharge, a decrease in flow depths and a local increase in velocities in some streets and within the city block. Finally, with these variations in floodwater features, the level of risk to pedestrians is also impacted, increasing locally when the storage capacity of the block increases.
Keywords	hazard characterization ; hydrograph ; models ; research ; risk ; transient flow ; urban areas ; water
Language	English
Dates of publication	2023-04
Publishing place	John Wiley & Sons, Ltd
Document type	Article ; Online
Note	JOURNAL ARTICLE
ZDB-ID	5564-5
ISSN	1944-7973 ; 0043-1397
ISSN (online)	1944-7973
ISSN	0043-1397
DOI	10.1029/2022WR032984
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Can the 2D shallow water equations model flow intrusion into buildings during urban floods?

Dewals, Benjamin / Kitsikoudis, Vasileios / Angel Mejía-Morales, Miguel / Archambeau, Pierre / Mignot, Emmanuel / Proust, Sébastien / Erpicum, Sébastien / Pirotton, Michel / Paquier, André

Journal of Hydrology. 2023 Apr., v. 619 p.129231-

2023

Abstract: The multiple flow paths existing in urban environments lead to complex flow fields during urban flooding. Modelling these flow processes with three-dimensional numerical models may be scientifically sound; however, such numerical models are ... ...

Abstract	The multiple flow paths existing in urban environments lead to complex flow fields during urban flooding. Modelling these flow processes with three-dimensional numerical models may be scientifically sound; however, such numerical models are computationally demanding. To ascertain whether urban floods can be modelled with faster tools, this study investigated for the first time the capacity of the 2D shallow water equations (SWE) in modelling the flow patterns within and around urban blocks with openings, i.e., involving flow exchanges between the flows in the streets and within the urban blocks (e.g., through alleys leading to courtyards or through broken windows or doors). Laboratory experiments of idealized urban floods were simulated with two academic 2D SWE models, with their most notable difference being the parameterization of the eddy viscosity. Specifically, the first model had a turbulence closure based on flow depth and friction velocity while the second model had a depth-averaged k-ε turbulence closure. Thirteen urban layouts were considered with steady flow and five with unsteady flow. Both models simulated the flow depths accurately for the steady cases. The discharge distribution in the streets and the flow velocities were predicted with lower accuracy, particularly in layouts with large open spaces. The average deviation of the modelled discharge distribution at the outlets was 2.5% and 7.3% for the first and second model, respectively. For the unsteady cases, only the first model was tested. It predicted well the velocity pattern during the falling limb of a flood wave, while it did not reproduce all recirculation zones in the rising limb. The peak flow depths in the streets and the peak discharges at the outlets were predicted with an average deviation of 6.7% and 8.6%, respectively. Even though some aspects of the flow in an urban setup are 3D, the findings of this study support the modelling of such processes with 2D SWE models.
Keywords	friction velocity ; models ; steady flow ; transient flow ; turbulent flow ; viscosity ; Experimental hydraulics ; Numerical modelling ; Open channel flow ; Shallow water equations ; Turbulence ; Urban flood
Language	English
Dates of publication	2023-04
Publishing place	Elsevier B.V.
Document type	Article ; Online
Note	Pre-press version
ZDB-ID	1473173-3
ISSN	1879-2707 ; 0022-1694
ISSN (online)	1879-2707
ISSN	0022-1694
DOI	10.1016/j.jhydrol.2023.129231
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Neutrality, normality, abnormality and pathology in coronal knee alignment: Why and how should we define it in the era of personalised medicine?

Hirschmann, Michael T / von Eisenhart-Rothe, Rüdiger / Graichen, Heiko / Vendittoli, Pascal-André / Chen, Antonia F / Lustig, Sebastien / Leal, Joan / Tibesku, Carsten / Bonnin, Michel

Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA

2024 Volume 32, Issue 3, Page(s) 515–517

MeSH term(s)	Humans ; Precision Medicine ; Knee Joint/pathology ; Lower Extremity ; Knee/pathology ; Osteoarthritis, Knee/pathology ; Tibia/pathology ; Retrospective Studies
Language	English
Publishing date	2024-02-28
Publishing country	Germany
Document type	Editorial
ZDB-ID	1159064-6
ISSN	1433-7347 ; 0942-2056
ISSN (online)	1433-7347
ISSN	0942-2056
DOI	10.1002/ksa.12107
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Article ; Online: L’économie circulaire, quels enjeux de développement pour les territoires ?

Amadou Niang / Sébastien Bourdin / André Torre

Développement Durable et Territoires, Vol

2020 Volume 11

Abstract: The circular economy, a new economic model that respects the environment, alternative to the linear economy, is presented as an opportunity for territorial sustainable development. In the context of socio-ecological transition, its approaches are thus ... ...

Abstract	The circular economy, a new economic model that respects the environment, alternative to the linear economy, is presented as an opportunity for territorial sustainable development. In the context of socio-ecological transition, its approaches are thus increasingly experienced locally but the question of their territoriality and their links with sustainable spatial development remains scientifically unstable. This article is a review of the bibliography which aims to analyze the territoriality of circular economy approaches and to assess if they can become an opportunity to ensure sustainable territorial development.
Keywords	circular economy ; territoriality ; sustainable territorial development ; innovation ; proximity ; territorial governance ; Environmental sciences ; GE1-350 ; Social Sciences ; H
Language	French
Publishing date	2020-04-01T00:00:00Z
Publisher	Réseau Développement Durable et Territoires Fragiles
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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