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Article ; Online: Combining monoamine oxidase B and semicarbazide-sensitive amine oxidase enzyme inhibition to address inflammatory disease.

Foot, Jonathan S / Buson, Alberto / Deodhar, Mandar / Findlay, Alison D / Robertson, Alan D / Turner, Craig I / Yow, Tin / Zhou, Wenbin / Jarolimek, Wolfgang

Bioorganic & medicinal chemistry letters

2022 Volume 74, Page(s) 128942

Abstract: The discovery of a dual MAO-B/SSAO inhibitor PXS-5131 is reported. The compound offers a compact ...

Abstract	The discovery of a dual MAO-B/SSAO inhibitor PXS-5131 is reported. The compound offers a compact and rigid three-dimensional structure with superior selectivity over MAO-A. Potency and selectivity are linked to both the double bond geometry and stereochemistry of the allylamine moiety, highlighting the importance of optimal set up of these features in the class of amine oxidase inhibitors. PXS-5131 possesses an attractive preclinical pharmacokinetic profile and has anti-inflammatory properties in models of acute inflammation and neuroinflammation.
MeSH term(s)	Amine Oxidase (Copper-Containing) ; Anti-Inflammatory Agents/pharmacology ; Anti-Inflammatory Agents/therapeutic use ; Monoamine Oxidase ; Monoamine Oxidase Inhibitors/pharmacology
Chemical Substances	Anti-Inflammatory Agents ; Monoamine Oxidase Inhibitors ; Amine Oxidase (Copper-Containing) (EC 1.4.3.21) ; Monoamine Oxidase (EC 1.4.3.4)
Language	English
Publishing date	2022-08-13
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1063195-1
ISSN	1464-3405 ; 0960-894X
ISSN (online)	1464-3405
ISSN	0960-894X
DOI	10.1016/j.bmcl.2022.128942
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Article ; Online: Transformation from follicular lymphoma to biphasic high-grade large B-cell lymphoma with immunophenotypically and genetically distinct diffuse large B cell and Burkitt-like components.

Dunn, Robert G / Foot, Nicola J / Ffolkes, Lorrette / Newell, Barry / Wilkins, Bridget S / Neat, Michael J

Journal of clinical pathology

2013 Volume 66, Issue 4, Page(s) 357–360

MeSH term(s)	Biomarkers, Tumor/analysis ; Biomarkers, Tumor/genetics ; Burkitt Lymphoma/genetics ; Burkitt Lymphoma/immunology ; Burkitt Lymphoma/pathology ; Gene Expression Regulation, Neoplastic ; Gene Rearrangement, B-Lymphocyte, Heavy Chain ; Humans ; Immunoglobulin Heavy Chains/genetics ; Immunohistochemistry ; Immunophenotyping ; In Situ Hybridization, Fluorescence ; Lymph Nodes/immunology ; Lymph Nodes/pathology ; Lymphoma, Follicular/genetics ; Lymphoma, Follicular/immunology ; Lymphoma, Follicular/pathology ; Lymphoma, Large B-Cell, Diffuse/genetics ; Lymphoma, Large B-Cell, Diffuse/immunology ; Lymphoma, Large B-Cell, Diffuse/pathology ; Male ; Middle Aged ; Neoplasm Grading ; Proto-Oncogene Proteins c-bcl-2/genetics ; Proto-Oncogene Proteins c-myc/genetics
Chemical Substances	Biomarkers, Tumor ; Immunoglobulin Heavy Chains ; MYC protein, human ; Proto-Oncogene Proteins c-bcl-2 ; Proto-Oncogene Proteins c-myc
Language	English
Publishing date	2013-04
Publishing country	England
Document type	Case Reports ; Letter
ZDB-ID	80261-x
ISSN	1472-4146 ; 0021-9746
ISSN (online)	1472-4146
ISSN	0021-9746
DOI	10.1136/jclinpath-2012-201260
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Article ; Online: Severe ocular chemical injury in the UK: a British Ophthalmological Surveillance Unit study.

Cronbach, Nicola / Foot, Barny / Scawn, Richard

Eye (London, England)

2024

Abstract: Background: Severe ocular chemical injury is a potentially devastating condition which most commonly affects men of working age. Workplace injuries previously accounted for the majority of incidents, but there has been a recent increase in assaults ... ...

Abstract	Background: Severe ocular chemical injury is a potentially devastating condition which most commonly affects men of working age. Workplace injuries previously accounted for the majority of incidents, but there has been a recent increase in assaults involving corrosive substances throughout the UK. The objectives of this study were to determine the incidence and demographics of severe ocular chemical injury and describe current surgical management practices. Methods: Cases were prospectively ascertained through the British Ophthalmological Surveillance Unit monthly reporting system during 2019-21. In total, 20 cases involving 29 eyes met the inclusion criteria. Results: The reported incidence of severe ocular chemical injury during the pre-pandemic period of the study was 0.24 per million. Cases due to alleged assault have become more common than workplace injuries. A total of 81% patients had persistent complications at 6 months requiring ongoing treatment, and 60% patients required surgical intervention. Conclusion: Although there are limitations with the case ascertainment methods, severe ocular chemical injury remains rare within the UK. There has been a proportionate increase in cases related to alleged assault compared with previous similar studies. Amniotic membrane grafting remains the most commonly performed surgical procedure in these patients.
Language	English
Publishing date	2024-04-18
Publishing country	England
Document type	Journal Article
ZDB-ID	91001-6
ISSN	1476-5454 ; 0950-222X
ISSN (online)	1476-5454
ISSN	0950-222X
DOI	10.1038/s41433-024-03073-6
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Article ; Online: Fosfomycin resistance in community-acquired urinary pathogens from Western Cape, South Africa.

Mosime, Lesedi B / Newton-Foot, Mae / Nel, Pieter

Southern African journal of infectious diseases

2022 Volume 37, Issue 1, Page(s) 321

Abstract: Oral fosfomycin is commonly used to treat uncomplicated urinary tract infections (UTI) and whilst resistance has been reported in many healthcare facilities in South Africa, the current prevalence remains unknown. This study investigated the prevalence ... ...

Abstract	Oral fosfomycin is commonly used to treat uncomplicated urinary tract infections (UTI) and whilst resistance has been reported in many healthcare facilities in South Africa, the current prevalence remains unknown. This study investigated the prevalence and mechanisms of fosfomycin resistance amongst urinary pathogens in the Western Cape, South Africa. Of the 200 isolates collected during the study period (2019-2020), seven (3.5%) were fosfomycin resistant. Mutations in the
Language	English
Publishing date	2022-01-19
Publishing country	South Africa
Document type	Journal Article
ZDB-ID	3046282-4
ISSN	2313-1810 ; 2312-0053
ISSN (online)	2313-1810
ISSN	2312-0053
DOI	10.4102/sajid.v37i1.321
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Article ; Online: Fluorescence in situ hybridisation analysis of formalin-fixed paraffin-embedded tissue sections in the diagnostic work-up of non-Burkitt high grade B-cell non-Hodgkin's lymphoma: a single centre's experience.

Foot, Nicola J / Dunn, Robert G / Geoghegan, Helen / Wilkins, Bridget S / Neat, Michael J

Journal of clinical pathology

2011 Volume 64, Issue 9, Page(s) 802–808

Abstract: Aims: In recent years the genetic aberrations associated with diffuse large B-cell lymphoma and ... with features intermediate between diffuse large B-cell lymphoma and Burkitt lymphoma' have been increasingly ... grade B-cell non-Hodgkin's lymphomas (HG-BNHL).: Methods: BCL6, IGH-BCL2 and MYC status were ...

Abstract	Aims: In recent years the genetic aberrations associated with diffuse large B-cell lymphoma and the new subtype described in the 2008 revision of the WHO classification, 'B-cell lymphoma, unclassifiable, with features intermediate between diffuse large B-cell lymphoma and Burkitt lymphoma' have been increasingly well defined. Recurrent genetic abnormalities include rearrangements involving MYC (8q24), BCL2 (18q21) and BCL6 (3q27); as the prognostic and therapeutic implications associated with these abnormalities are clarified their accurate identification at diagnosis is becoming increasingly critical. We describe our experience of using a panel of fluorescence in situ hybridisation (FISH) probes on formalin-fixed paraffin-embedded tissue sections in the diagnostic work-up of 162 patients with non-Burkitt high grade B-cell non-Hodgkin's lymphomas (HG-BNHL). Methods: BCL6, IGH-BCL2 and MYC status were determined prospectively in sequential patients presenting with HG-BNHL, with respect to the presence of rearrangements and copy number changes. Small numbers of samples were analysed retrospectively or were studied at relapse in previously untested patients. Results: FISH analysis was successful in 160/162 (99%) cases, with abnormalities detected in 118/160 (74%). Conclusions: FISH analysis of formalin-fixed paraffin-embedded tissue sections is a highly reproducible technique with an excellent success rate for the detection of genetic abnormalities which will play an increasingly important role in improving risk stratification of patients with HG-BNHL.
MeSH term(s)	B-Lymphocytes/pathology ; Burkitt Lymphoma/diagnosis ; Burkitt Lymphoma/genetics ; DNA Copy Number Variations ; DNA-Binding Proteins/genetics ; Fixatives ; Formaldehyde ; Gene Rearrangement, B-Lymphocyte, Heavy Chain/genetics ; Genes, Immunoglobulin Heavy Chain ; In Situ Hybridization, Fluorescence ; Lymphoma, B-Cell/diagnosis ; Lymphoma, B-Cell/genetics ; Paraffin Embedding/methods ; Proto-Oncogene Proteins c-bcl-6 ; Proto-Oncogene Proteins c-myc/genetics
Chemical Substances	BCL6 protein, human ; DNA-Binding Proteins ; Fixatives ; Proto-Oncogene Proteins c-bcl-6 ; Proto-Oncogene Proteins c-myc ; Formaldehyde (1HG84L3525)
Language	English
Publishing date	2011-09
Publishing country	England
Document type	Journal Article
ZDB-ID	80261-x
ISSN	1472-4146 ; 0021-9746
ISSN (online)	1472-4146
ISSN	0021-9746
DOI	10.1136/jclinpath-2011-200015
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Article ; Online: Using cultural-historical activity theory to analyze social service practices evolving from the Norwegian HUSK projects.

Foot, Kirsten

Journal of evidence-informed social work

2015 Volume 12, Issue 1, Page(s) 112–123

Abstract: ... b) comparative analysis of the efforts to advance multi-sector collaboration in some of the HUSK ...

Abstract	The HUSK projects catalyzed innovation in the practices of providing social services that could yield useful insights both within and outside of Norway if analyzed in these two ways: (a) retrospective analysis of the development of individual HUSK projects in light of their cultural-historical contexts, and (b) comparative analysis of the efforts to advance multi-sector collaboration in some of the HUSK projects. Such analyses require a practice-based research approach that takes into account culture and history. In this article the author explains how cultural-historical activity theory provides such an approach, illustrated via several HUSK cases. The author suggests five questions for future analyses of the HUSK projects and argues that insights gleaned from such analyses could contribute significantly to research on-and the provision of-social services.
MeSH term(s)	Culture ; Evidence-Based Practice ; Humans ; Norway ; Program Evaluation/methods ; Retrospective Studies ; Social Welfare ; Social Work/organization & administration
Language	English
Publishing date	2015
Publishing country	United States
Document type	Journal Article
ISSN	2376-1415
ISSN (online)	2376-1415
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Article: Assignment of B-cell lymphoma 6, member B (zinc finger protein) gene (BCL6B) to human chromosome 17p13.1 by in situ hybridization.

Fitzgibbon, J / Neat, M J / Jones, L / Foot, N / Lister, T A / Gupta, R K

Cytogenetics and cell genetics

2000 Volume 89, Issue 3-4, Page(s) 218–219

MeSH term(s)	Chromosome Mapping ; Chromosomes, Human, Pair 17/genetics ; Humans ; In Situ Hybridization, Fluorescence ; Repressor Proteins/genetics ; Zinc Fingers
Chemical Substances	BCL6B protein, human ; Repressor Proteins
Language	English
Publishing date	2000
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	186001-x
ISSN	1421-9816 ; 0301-0171
ISSN (online)	1421-9816
ISSN	0301-0171
DOI	10.1159/000015617
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Article ; Online: Estimating the rate of severe visual loss (wipe-out) following cataract surgery, a British Ophthalmological Surveillance Unit (BOSU) study.

Ramsden, Conor / Shweikh, Yusrah / Kam, Ronald / Bunce, Catey / Foot, Barny / Viswanathan, Ananth

Eye (London, England)

2023 Volume 37, Issue 18, Page(s) 3787–3792

Abstract: Background: A sudden, irreversible reduction in visual acuity ('wipe-out') is a feared complication of cataract surgery. Current literature on wipe-out is limited in quantity and quality, and largely predates modern cataract surgery and imaging ... ...

Abstract	Background: A sudden, irreversible reduction in visual acuity ('wipe-out') is a feared complication of cataract surgery. Current literature on wipe-out is limited in quantity and quality, and largely predates modern cataract surgery and imaging techniques. The objectives of our study were to estimate the incidence of wipe-out and to identify potential risk factors. Methods: We prospectively collated cases of wipe-out occurring in the UK during a 25-month study period using the British Ophthalmic Surveillance Unit reporting system. A total of 21 potential cases of wipe-out were reported, 5 of which met all inclusion and exclusion criteria. Results: The estimated incidence of wipe-out during the study period was 0.00000298, or approximately 3 cases per million cataract operations. All cases of wipe-out occurred exclusively in patients with advanced glaucoma (mean deviation -21.0 decibels or worse in the operated eye), with an over-representation of black people (40%) in our case series. A prior diagnosis of retinal vein occlusion (60%) and elevated post-operative IOP (40%) were more common among individuals suffering from wipe-out compared to the general population, suggesting these factors may contribute to the pathogenesis of wipe-out. Conclusions: Our study shows that wipe-out is a rare complication, affecting approximately 3 per million undergoing cataract surgery. Patients with advanced glaucoma, black patients, and those with previous retinal vein occlusions may be at greater risk of wipe-out. We hope that the findings of our study will be used to help inform treatment decision-making and the cataract surgery consent process.
MeSH term(s)	Humans ; Glaucoma/surgery ; Cataract Extraction/adverse effects ; Risk Factors ; Retinal Vein Occlusion/complications ; Cataract/complications
Language	English
Publishing date	2023-06-16
Publishing country	England
Document type	Journal Article
ZDB-ID	91001-6
ISSN	1476-5454 ; 0950-222X
ISSN (online)	1476-5454
ISSN	0950-222X
DOI	10.1038/s41433-023-02606-9
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Article ; Online: Incidence of Acanthamoeba Keratitis in the United Kingdom in 2015: A Prospective National Survey.

Jasim, Haneen / Grzeda, Mariusz / Foot, Barny / Tole, Derek / Hoffman, Jeremy J

Cornea

2023 Volume 43, Issue 3, Page(s) 269–276

Abstract: Purpose: The aims of this study were to quantify the incidence of Acanthamoeba keratitis (AK) in the United Kingdom and investigate risk factors and management parameters.: Methods: This was a prospective population-based study from January to ... ...

Abstract	Purpose: The aims of this study were to quantify the incidence of Acanthamoeba keratitis (AK) in the United Kingdom and investigate risk factors and management parameters. Methods: This was a prospective population-based study from January to December 2015 through the British Ophthalmic Surveillance Unit. Data were collected on demographics, clinical features, and management. Incidence rates were calculated from estimates of population and contact lens (CL) user numbers. Statistical analysis compared annualized incidences per million and altered risk ratios for AK with the England and Wales 24 months 1997/1998 to 1998/1999 study. Results: The study identified 124 AK cases, an overall incidence of 2.35 per million. CL wearers accounted for 108 of 124 cases (87%), in whom the AK incidence was 26.94 per million. Herpes keratitis was initially misdiagnosed in 25 of 124 cases (20.2%). The highest incidence of AK was among planned replacement soft CL (PRSCL) wearers (50.65 per million), 7-fold greater than for daily disposable CL (DDSCL) users (7.24 per million). There was a significant increase in AK incidence ( P < 0.001) compared with both 1997/1998 [risk ratio 1.92, 95% confidence interval (CI) 1.38-2.66] and 1998/1999 (risk ratio 2.13, 95% CI 1.52-2.98) together with a higher incidence per million CL users of 26.94 versus 21.14 (1997/1998) and 17.53 (1998/1999). Conclusions: This study provides the first published data on the nationwide incidence of AK in the United Kingdom. The findings confirm an increasing incidence of AK, particularly among contact lens wearers since 1997/1998 to 1998/1999. PRSCLs were identified as a significant risk factor compared with DDSCLs. Misdiagnosis and treatment delays remain an ongoing problem for patients with AK.
MeSH term(s)	Humans ; Acanthamoeba Keratitis/diagnosis ; Acanthamoeba Keratitis/epidemiology ; Acanthamoeba Keratitis/etiology ; Incidence ; Prospective Studies ; United Kingdom/epidemiology ; Contact Lenses, Hydrophilic/adverse effects ; Risk Factors
Language	English
Publishing date	2023-12-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	604826-2
ISSN	1536-4798 ; 0277-3740
ISSN (online)	1536-4798
ISSN	0277-3740
DOI	10.1097/ICO.0000000000003445
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Article ; Online: Associations between stimulant use and return to illicit opioid use following initiation onto medication for opioid use disorder.

Foot, Canyon / Korthuis, Philip T / Tsui, Judith I / Luo, Sean X / Chan, Brian / Cook, Ryan R

Addiction (Abingdon, England)

2023 Volume 119, Issue 1, Page(s) 149–157

Abstract: Aim: The aim of this study was to estimate how ongoing stimulant use affects return to illicit opioid use after initiation onto medication for opioid use disorder (MOUD).: Design: This was a secondary analysis of pooled data from two clinical trials ... ...

Abstract	Aim: The aim of this study was to estimate how ongoing stimulant use affects return to illicit opioid use after initiation onto medication for opioid use disorder (MOUD). Design: This was a secondary analysis of pooled data from two clinical trials comparing buprenorphine (BUP-NX) and extended-release naltrexone (XR-NTX). Setting: Thirteen opioid treatment programs and HIV clinics across 10 states in the United States from 2014 to 2019 took part in this study. Participants: A total of 528 participants who initiated MOUD as part of trial participation were included. Nearly half (49%) were between 30 and 49 years of age, 69% were male and 66% were non-Hispanic White. Measurements: The primary outcome was first self-reported day of non-prescribed opioid use following MOUD initiation, and the exposure of interest was daily stimulant use (methamphetamine, amphetamines or cocaine). Both were defined using time-line follow-back. Among participants reporting at least 1 day of illicit opioid use, we also examined relapse to ongoing use, defined as (1) 7 days of continuous opioid use or (2) 4 consecutive weeks with self-reported opioid use, one or more positive urine drug screens (UDS) for opioids or one or more missing UDS. Findings: Forty-seven per cent of participants reported stimulant use following MOUD initiation, 58% returned to illicit opioid use and 66% of those relapsed to ongoing use. Stimulant use was strongly associated with increased risk of misusing opioids after MOUD initiation when measured daily [adjusted hazard ratio (aHR) = 9.23, 95% confidence interval (CI) = 6.80-12.50, P < 0.001] and over a 7-day period (aHR = 1.27 for each additional day, CI = 1.18-1.37, P < 0.001). Using stimulants weekly or more often was associated with increased likelihood of relapse to ongoing opioid use compared with less than weekly or no stimulant use (adjusted odds ratio = 2.30, CI = 1.05-5.39, P = 0.044). Conclusions: People initiated on medication for opioid use disorder who subsequently use stimulants appear to be more likely to return to and continue using non-prescribed opioids compared with those without stimulant use. The association appears to be stronger among patients who initiate buprenorphine compared with those who initiate extended-release naltrexone.
MeSH term(s)	Female ; Humans ; Male ; Analgesics, Opioid/adverse effects ; Buprenorphine/therapeutic use ; Central Nervous System Stimulants/adverse effects ; Delayed-Action Preparations/therapeutic use ; Naltrexone/therapeutic use ; Opioid-Related Disorders/drug therapy ; Opioid-Related Disorders/epidemiology ; Recurrence ; United States/epidemiology ; Adult ; Middle Aged ; Clinical Trials as Topic
Chemical Substances	Analgesics, Opioid ; Buprenorphine (40D3SCR4GZ) ; Central Nervous System Stimulants ; Delayed-Action Preparations ; Naltrexone (5S6W795CQM)
Language	English
Publishing date	2023-09-15
Publishing country	England
Document type	Journal Article
ZDB-ID	1141051-6
ISSN	1360-0443 ; 0965-2140
ISSN (online)	1360-0443
ISSN	0965-2140
DOI	10.1111/add.16334
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