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  1. Article ; Online: Biomarkers that predict attacks of acute intermittent porphyria.

    Takata, Tadayuki / Morishita, Asahiro / Kobara, Hideki / Deguchi, Kazushi / Masaki, Tsutomu

    Translational gastroenterology and hepatology

    2022  Volume 7, Page(s) 44

    Language English
    Publishing date 2022-10-25
    Publishing country China
    Document type Journal Article
    ISSN 2415-1289
    ISSN (online) 2415-1289
    DOI 10.21037/tgh-21-50
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Claw Hand as a Manifestation of Fixed Dystonia.

    Deguchi, Kazushi / Takata, Tadayuki / Kobara, Hideki / Masaki, Tsutomu

    Internal medicine (Tokyo, Japan)

    2021  Volume 60, Issue 17, Page(s) 2875

    MeSH term(s) Dystonia/diagnosis ; Dystonia/etiology ; Hand ; Humans ; Limb Deformities, Congenital
    Language English
    Publishing date 2021-03-15
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 32371-8
    ISSN 1349-7235 ; 0021-5120 ; 0918-2918
    ISSN (online) 1349-7235
    ISSN 0021-5120 ; 0918-2918
    DOI 10.2169/internalmedicine.6592-20
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 240: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  3. Article ; Online: Zinc deficiency induces hypertension by paradoxically amplifying salt sensitivity under high salt intake in mice.

    Yamamoto, Marie / Takata, Tomoaki / Hanada, Hinako / Taniguchi, Sosuke / Hamada, Shintaro / Mae, Yukari / Iyama, Takuji / Kanda, Tsutomu / Isomoto, Hajime

    Clinical and experimental nephrology

    2024  

    Abstract: Background: Hypertension is one of the major etiologies that cause chronic kidney disease (CKD) and can exacerbate kidney dysfunction. Zinc is an essential trace element playing a role in blood pressure regulation, and zinc deficiency, a common ... ...

    Abstract Background: Hypertension is one of the major etiologies that cause chronic kidney disease (CKD) and can exacerbate kidney dysfunction. Zinc is an essential trace element playing a role in blood pressure regulation, and zinc deficiency, a common comorbidity in patients with CKD, can cause hypertension. However, the precise mechanism underlying zinc deficiency-induced hypertension is unknown. Sodium (Na
    Methods: Adult mice were fed a zinc-adequate (ZnA) or zinc-deficient (ZnD) diet combined with/without high salt in drinking water (HS) for 4 weeks (n = 6 each). Changes in blood pressure, urinary sodium excretion, and the expressions of the proximal tubular Na
    Results: Urinary Na
    Conclusion: The combination of zinc deficiency and high salt causes hypertension. Zinc is associated with salt-sensitivity, potentially through NHE3 and NCC regulation.
    Language English
    Publishing date 2024-04-06
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 1338768-6
    ISSN 1437-7799 ; 1342-1751
    ISSN (online) 1437-7799
    ISSN 1342-1751
    DOI 10.1007/s10157-024-02478-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4922: Show issues Location:
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  4. Article ; Online: Time Course of Focal Lesions in Hypoglycemia.

    Takata, Tadayuki / Yamana, Hiroki / Kamada, Hideki / Masaki, Tsutomu

    Internal medicine (Tokyo, Japan)

    2020  Volume 60, Issue 6, Page(s) 967–968

    MeSH term(s) Hemiplegia ; Humans ; Hypoglycemia/diagnosis ; Hypoglycemia/etiology ; Magnetic Resonance Imaging
    Language English
    Publishing date 2020-10-21
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 32371-8
    ISSN 1349-7235 ; 0021-5120 ; 0918-2918
    ISSN (online) 1349-7235
    ISSN 0021-5120 ; 0918-2918
    DOI 10.2169/internalmedicine.5494-20
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Porencephaly causing limb size asymmetry.

    Takata, Tadayuki / Kume, Kodai / Kobara, Hideki / Deguchi, Kazushi / Masaki, Tsutomu

    Acta neurologica Belgica

    2021  Volume 122, Issue 3, Page(s) 859–860

    MeSH term(s) Brain ; Brain Diseases ; Humans ; Magnetic Resonance Imaging ; Malformations of Cortical Development ; Porencephaly
    Language English
    Publishing date 2021-03-16
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 127315-2
    ISSN 2240-2993 ; 0300-9009
    ISSN (online) 2240-2993
    ISSN 0300-9009
    DOI 10.1007/s13760-021-01652-y
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  6. Article ; Online: Hypertension with hyperintense spinal cord swelling.

    Takaba, Keita / Takata, Tadayuki / Kita, Makoto / Deguchi, Kazushi / Masaki, Tsutomu

    Acta neurologica Belgica

    2021  Volume 121, Issue 3, Page(s) 761–763

    MeSH term(s) Aged ; Cervical Vertebrae/diagnostic imaging ; Humans ; Hypertension/diagnostic imaging ; Hypertension/etiology ; Male ; Medulla Oblongata/diagnostic imaging ; Posterior Leukoencephalopathy Syndrome/complications ; Posterior Leukoencephalopathy Syndrome/diagnostic imaging ; Spinal Cord Diseases/complications ; Spinal Cord Diseases/diagnostic imaging ; Thoracic Vertebrae/diagnostic imaging
    Language English
    Publishing date 2021-04-16
    Publishing country Italy
    Document type Case Reports ; Journal Article
    ZDB-ID 127315-2
    ISSN 2240-2993 ; 0300-9009
    ISSN (online) 2240-2993
    ISSN 0300-9009
    DOI 10.1007/s13760-021-01668-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Disposable aluminum covering for electrodes during nerve conduction studies in COVID-19 patients.

    Takata, Tadayuki / Kobara, Hideki / Deguchi, Kazushi / Masaki, Tsutomu

    Clinical neurology and neurosurgery

    2020  Volume 195, Page(s) 106064

    MeSH term(s) Aluminum/administration & dosage ; Betacoronavirus ; COVID-19 ; Coronavirus Infections/diagnosis ; Coronavirus Infections/physiopathology ; Electric Stimulation/instrumentation ; Electric Stimulation/methods ; Electrodes ; Humans ; Neural Conduction/physiology ; Pandemics ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/physiopathology ; SARS-CoV-2
    Chemical Substances Aluminum (CPD4NFA903)
    Keywords covid19
    Language English
    Publishing date 2020-07-03
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 193107-6
    ISSN 1872-6968 ; 0303-8467
    ISSN (online) 1872-6968
    ISSN 0303-8467
    DOI 10.1016/j.clineuro.2020.106064
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ui I Zs.53: Show issues Location:
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  8. Article: Factors controlling dissolved 137Cs activities in coastal waters on the eastern and western sides of Honshu, Japan

    Takata, Hyoe / Wada, Toshihiro / Aono, Tatsuo / Inoue, Mutsuo / Kanasashi, Tsutomu / Suzuki, Shotaro / Amano, Yosuke

    Science of the total environment. 2022 Feb. 01, v. 806

    2022  

    Abstract: The distributions of dissolved ¹³⁷Cs in river, nearshore, and offshore waters on the east and west coasts of the Japanese island of Honshu were studied in 2018–2021, 7–10 years after the Fukushima Dai-ichi Nuclear Power Plant (FDNPP) accident. On the ... ...

    Abstract The distributions of dissolved ¹³⁷Cs in river, nearshore, and offshore waters on the east and west coasts of the Japanese island of Honshu were studied in 2018–2021, 7–10 years after the Fukushima Dai-ichi Nuclear Power Plant (FDNPP) accident. On the east side along the north western North Pacific (Fukushima Prefecture), estuarine processes, including desorption from riverine particles and dissolution into pore water from riverine particles that had settled to the seafloor, contributed to the maintenance of high dissolved ¹³⁷Cs activities in nearshore and offshore waters. A survey and mass-balance calculation in a semi-enclosed estuarine area, the Matsukawa-ura, in the northern part of Fukushima, provided convincing evidence that rivers contributed to the influx of ¹³⁷Cs to coastal waters. In contrast, the extremely low activities of dissolved and particulate ¹³⁷Cs in the Tedori River of Ishikawa Prefecture on the western side of Japan along the Japan Sea suggested that inputs of riverine ¹³⁷Cs made a negligible contribution to the increase of dissolved ¹³⁷Cs activities in the nearshore and offshore waters. The relatively high dissolved ¹³⁷Cs activities observed in the offshore waters of the Japan Sea were due to movement of FDNPP-derived ¹³⁷Cs into the Japan Sea via the Tsushima Warm Current. Mechanisms controlling the distributions of ¹³⁷Cs activities in coastal waters of the eastern and western sides of Japan therefore differ.
    Keywords Japan ; accidents ; cesium radioisotopes ; desorption ; environment ; estuaries ; nuclear power ; power plants ; riparian areas ; rivers ; surveys
    Language English
    Dates of publication 2022-0201
    Publishing place Elsevier B.V.
    Document type Article
    ZDB-ID 121506-1
    ISSN 1879-1026 ; 0048-9697
    ISSN (online) 1879-1026
    ISSN 0048-9697
    DOI 10.1016/j.scitotenv.2021.151216
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 74/341: Show issues

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  9. Article ; Online: 5-Aminolevulinic Acid Attenuates Glucose-Regulated Protein 78 Expression and Hepatocyte Lipoapoptosis via Heme Oxygenase-1 Induction.

    Hashimoto, Takaaki / Sugihara, Takaaki / Kanda, Tsutomu / Takata, Tomoaki / Isomoto, Hajime

    International journal of molecular sciences

    2021  Volume 22, Issue 21

    Abstract: Endoplasmic reticulum (ER) stress plays a pivotal role in the progression of steatohepatitis. 5-aminolevulinic acid (5-ALA), a precursor in the heme biosynthetic pathway, has recently been reported to induce heme oxygenase (HO)-1. HO-1 exerts important ... ...

    Abstract Endoplasmic reticulum (ER) stress plays a pivotal role in the progression of steatohepatitis. 5-aminolevulinic acid (5-ALA), a precursor in the heme biosynthetic pathway, has recently been reported to induce heme oxygenase (HO)-1. HO-1 exerts important cytoprotective actions. In this study, we aimed to explore the therapeutic potential of 5-ALA on palmitate-induced ER stress and lipoapoptosis. Huh-7 cells were treated with palmitic acid (PA) (800 μM) to induce steatosis for eight hours. Steatosis was evaluated by Lipi-green staining. 5-ALA (200 μM) was added with PA. The gene expression levels of the nuclear factor erythroid 2-related factor 2 (
    MeSH term(s) Activating Transcription Factor 6/metabolism ; Aminolevulinic Acid/metabolism ; Aminolevulinic Acid/pharmacology ; Apoptosis/drug effects ; Caspase 3/metabolism ; Cell Line, Tumor ; Endoplasmic Reticulum Chaperone BiP/genetics ; Endoplasmic Reticulum Chaperone BiP/metabolism ; Endoplasmic Reticulum Stress/drug effects ; Endoplasmic Reticulum Stress/physiology ; Fatty Liver/metabolism ; Fatty Liver/physiopathology ; Heme Oxygenase-1/metabolism ; Hepatocytes/drug effects ; Hepatocytes/metabolism ; Humans ; Lipid Metabolism/drug effects ; NF-E2-Related Factor 2/metabolism ; Palmitic Acid/pharmacology ; Transcription Factor CHOP/metabolism
    Chemical Substances ATF6 protein, human ; Activating Transcription Factor 6 ; DDIT3 protein, human ; Endoplasmic Reticulum Chaperone BiP ; HSPA5 protein, human ; NF-E2-Related Factor 2 ; NFE2L2 protein, human ; Transcription Factor CHOP (147336-12-7) ; Palmitic Acid (2V16EO95H1) ; Aminolevulinic Acid (88755TAZ87) ; HMOX1 protein, human (EC 1.14.14.18) ; Heme Oxygenase-1 (EC 1.14.14.18) ; CASP3 protein, human (EC 3.4.22.-) ; Caspase 3 (EC 3.4.22.-)
    Language English
    Publishing date 2021-10-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms222111405
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Temporal expression profiles of microRNAs associated with acute phase of brain ischemia in gerbil hippocampus.

    Hamada, Yasuhiro / Takata, Tadayuki / Iwama, Hisakazu / Kawakita, Rie / Nonaka, Wakako / Deguchi, Kazushi / Kobara, Hideki / Morishita, Asahiro / Miyamoto, Osamu / Nakamura, Takehiro / Itano, Toshifumi / Masaki, Tsutomu

    Heliyon

    2024  Volume 10, Issue 7, Page(s) e28875

    Abstract: Neuroprotective therapeutic potential for restoring dysregulated microRNA (miRNA) expression has previously been demonstrated in a gerbil cerebral infarction model. However, since temporal changes in miRNA expression profiles following stroke onset are ... ...

    Abstract Neuroprotective therapeutic potential for restoring dysregulated microRNA (miRNA) expression has previously been demonstrated in a gerbil cerebral infarction model. However, since temporal changes in miRNA expression profiles following stroke onset are unknown, miRNAs proving to be useful therapeutic targets have yet to be identified. We evaluated cognitive function, hippocampal neuronal cell death, and microarray-based miRNA expression profiles at 5, 9, 18, 36, and 72 h after 5-min whole brain ischemia in gerbils. A decline in cognitive function occurred in parallel with increased neuronal cell death 36-72 h after ischemia. The Jonckheere-Terpstra test was used to analyze miRNA expression trends 5-72 h after ischemia. The expression levels of 63 miRNAs were significantly upregulated, whereas 32 miRNAs were significantly downregulated, monotonically. Of the 32 monotonically downregulated miRNAs, 18 showed the largest decrease in expression 5-9 h after ischemia. A subset of these dysregulated miRNAs (miR-378a-5p, miR-204-5p, miR-34c-5p, miR-211-5p, miR-34b-3p, and miR-199b-3p) could be associated with brain ischemia and neuropsychiatric disorders.
    Language English
    Publishing date 2024-03-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2024.e28875
    Database MEDical Literature Analysis and Retrieval System OnLINE

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