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  1. Article ; Online: Growth, Biochemical Characteristics, Flesh Quality, and Gut Microbiota of the Pacific White Shrimp (

    Lin, Hongxing / Liang, Xiaolong / Han, Fenglu / Luo, Xiaolong / Li, Erchao

    Aquaculture nutrition

    2023  Volume 2023, Page(s) 8627246

    Abstract: This study evaluated the effects of defatted superworm ( ...

    Abstract This study evaluated the effects of defatted superworm (
    Language English
    Publishing date 2023-07-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 1235332-2
    ISSN 1365-2095 ; 1353-5773
    ISSN (online) 1365-2095
    ISSN 1353-5773
    DOI 10.1155/2023/8627246
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    In stock of ZB MED Bonn / Germany

    Z 6113: Show issues

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  2. Article ; Online: High-quality 3D printing of ethylene vinyl acetate with direct pellet-based FDM for medical applications: Mechanical analysis, energy absorption and recovery evaluation.

    Luo, Shengyang / Zhang, Xiaolong

    Journal of the mechanical behavior of biomedical materials

    2023  Volume 148, Page(s) 106231

    Abstract: Ethylene Vinyl Acetate (EVA) is a biocompatible and non-toxic copolymer known for its applications in medicine, drug delivery systems, and energy absorption. This paper presents a novel method for 3D printing EVA using the Fused Deposition Modeling (FDM) ...

    Abstract Ethylene Vinyl Acetate (EVA) is a biocompatible and non-toxic copolymer known for its applications in medicine, drug delivery systems, and energy absorption. This paper presents a novel method for 3D printing EVA using the Fused Deposition Modeling (FDM) technique. By directly utilizing pellet-form EVA material and employing pneumatic pressure for extrusion, we addressed the issue of filament buckling commonly encountered in traditional filament-based printing. A custom-made pellet printer enabled direct feeding of polymer pellets. The mechanical properties, microstructure of the printed EVA parts was analyzed to evaluate the suitability of the direct pellet printing technique for producing high-quality EVA components. The results showed acceptable printing quality and favorable mechanical properties (about 1000% elongation at break and 6.59 MPa tensile strength). Additionally, a cyclic compression test was conducted, subjecting specimens to various strains (30%,80% and 120%) and assessing their compressive and energy absorption properties undergoing significant deformations. Observations reveal a noticeable decline in the mechanical properties after the first compression cycle. The mechanical properties tend to stabilize and reach a steady state from the second cycle onwards until the sixth cycle. Furthermore, a compression cyclic test with various strain rates conducted, investigated the functional performance of the printed EVA components in engineering and biomedical applications, considering the impact of strain rate. Observations indicate that lower strain rates tend to enhance the material's ability to withstand deformation before yielding. This study contributes to expanding the potential of EVA in additive manufacturing, particularly in biomedical and energy absorption systems.
    MeSH term(s) Cytoskeleton ; Drug Delivery Systems ; Polymers ; Printing, Three-Dimensional ; Ethylenes
    Chemical Substances vinyl acetate (L9MK238N77) ; Polymers ; Ethylenes
    Language English
    Publishing date 2023-11-10
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2378381-3
    ISSN 1878-0180 ; 1751-6161
    ISSN (online) 1878-0180
    ISSN 1751-6161
    DOI 10.1016/j.jmbbm.2023.106231
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  3. Article: Genomic Analysis of the

    Yuan, Xiaolong / Li, Yunqing / Luo, Ting / Bi, Wei / Yu, Jiaojun / Wang, Yi

    Mycobiology

    2023  Volume 51, Issue 1, Page(s) 36–48

    Abstract: Xanthoria ... ...

    Abstract Xanthoria elegans
    Language English
    Publishing date 2023-02-15
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 2631580-4
    ISSN 2092-9323 ; 1229-8093
    ISSN (online) 2092-9323
    ISSN 1229-8093
    DOI 10.1080/12298093.2023.2175428
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  4. Article ; Online: Enhanced Capacity Retention of Li

    Peng, Shihao / Luo, Jiakun / Liu, Wenwen / He, Xiaolong / Xie, Fang

    Molecules (Basel, Switzerland)

    2023  Volume 28, Issue 13

    Abstract: ... ...

    Abstract Li
    MeSH term(s) Lithium ; Ionic Liquids ; Silicon Dioxide ; Electrolytes ; Ions ; Electrodes
    Chemical Substances Lithium (9FN79X2M3F) ; Ionic Liquids ; Silicon Dioxide (7631-86-9) ; Electrolytes ; Ions
    Language English
    Publishing date 2023-06-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules28134896
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    In stock of ZB MED Cologne/Königswinter

    Zs.MO 81: Show issues

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  5. Article ; Online: An ethynyl-modified interpenetrated metal-organic framework for highly efficient selective gas adsorption.

    Yu, Xueyue / Huang, Ziyang / Krishna, Rajamani / Luo, Xiaolong / Liu, Yunling

    Dalton transactions (Cambridge, England : 2003)

    2023  Volume 52, Issue 41, Page(s) 15101–15106

    Abstract: An ethynyl-modified interpenetrated MOF material ... ...

    Abstract An ethynyl-modified interpenetrated MOF material with
    Language English
    Publishing date 2023-10-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 1472887-4
    ISSN 1477-9234 ; 1364-5447 ; 0300-9246 ; 1477-9226
    ISSN (online) 1477-9234 ; 1364-5447
    ISSN 0300-9246 ; 1477-9226
    DOI 10.1039/d3dt02834h
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  6. Article ; Online: Genetic correction of induced pluripotent stem cells from a DFNA36 patient results in morphologic and functional recovery of derived hair cell-like cells.

    Luo, Yi / Wu, Kaiwen / Zhang, Xiaolong / Wang, Hongyang / Wang, Qiuju

    Stem cell research & therapy

    2024  Volume 15, Issue 1, Page(s) 4

    Abstract: Background: TMC1 is one of the most common deafness genes causing DFNA36. Patient-derived human induced pluripotent stem cells (iPSCs) provide an opportunity to modelling diseases. TMC1 p.M418K mutation in human is orthologous to Beethoven mice. Here, ... ...

    Abstract Background: TMC1 is one of the most common deafness genes causing DFNA36. Patient-derived human induced pluripotent stem cells (iPSCs) provide an opportunity to modelling diseases. TMC1 p.M418K mutation in human is orthologous to Beethoven mice. Here, we investigated the differentiation, morphology and electrophysiological properties of hair cell-like cells (HC-like cells) derived from DFNA36 patient.
    Methods: Inner ear HC-like cells were induced from iPSCs derived from DFNA36 (TMC1 p.M418K) patient (M
    Results: In this study we successfully generated HC-like cells from iPSCs with three different genotypes. HC-like cells from M
    Conclusions: Our results indicate that TMC1 p.M418K mutation didn't influence inner ear hair cell differentiation but the morphology of microvilli and electrophysiological properties and gene correction induced recovery. CRISPR/Cas9 gene therapy is feasible in human patient with TMC1 p.M418K mutation.
    MeSH term(s) Humans ; Animals ; Mice ; Induced Pluripotent Stem Cells ; Hair Cells, Auditory/physiology ; Hearing Loss, Sensorineural/genetics ; Mutation/genetics ; Hair ; Membrane Proteins/genetics
    Chemical Substances TMC1 protein, mouse ; Membrane Proteins
    Language English
    Publishing date 2024-01-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 2548671-8
    ISSN 1757-6512 ; 1757-6512
    ISSN (online) 1757-6512
    ISSN 1757-6512
    DOI 10.1186/s13287-023-03617-9
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  7. Article ; Online: Effect of serum inflammatory factors in predicting co-infection with influenza viruses and Omicron.

    Zhang, Chengli / Wang, Wei / Luo, Xianglin / Yin, Minggang / Guo, Xiaolong

    Immunity, inflammation and disease

    2024  Volume 12, Issue 1, Page(s) e1158

    Abstract: Objectives: To identify the key differences in laboratory indicators between mono-infection and co-infection by influenza viruses and Omicron to facilitate timely adjustments in patient treatment strategies.: Methods: Prealbumin and C-reactive ... ...

    Abstract Objectives: To identify the key differences in laboratory indicators between mono-infection and co-infection by influenza viruses and Omicron to facilitate timely adjustments in patient treatment strategies.
    Methods: Prealbumin and C-reactive protein (CRP) levels were analyzed in 161 COVID-19 cases infected by SARS-CoV-2 (wild type), 299 cases infected by Omicron, 95 cases infected by influenza virus A/B (Flu A/B) and 133 co-infection cases infected with Flu A/B and Omicron. The receiver operating characteristic (ROC) curve and logistic regression equation were used to analyze the clinical predictive capacity of prealbumin and CRP in coinfected patients.
    Results: The co-infected and wild-type infected patients had significantly different CRP and prealbumin levels compared to mono-infected patients with Omicron or Flu A/B (p < .001). The ROC curve results indicated that prealbumin was more efficient than CRP in identifying co-infection from Omicron (AUC: 0.867 vs. 0.724) or Flu A/B (AUC: 0.797 vs. 0.730), and joint prediction significantly improved the diagnostic ability to discriminate co-infection from mono-infection (AUC: 0.934 and 0.887).
    Conclusion: The findings suggest that prealbumin is a valuable indicator that can warn of co-infection and guide timely treatment decisions. Joint prediction may offer an even more effective diagnostic tool for discriminating co-infection from mono-infection.
    MeSH term(s) Humans ; Coinfection ; Prealbumin ; COVID-19 ; Inflammation ; Orthomyxoviridae
    Chemical Substances Prealbumin
    Language English
    Publishing date 2024-01-25
    Publishing country England
    Document type Journal Article
    ZDB-ID 2740382-8
    ISSN 2050-4527 ; 2050-4527
    ISSN (online) 2050-4527
    ISSN 2050-4527
    DOI 10.1002/iid3.1158
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  8. Article ; Online: Spatial distribution of two acaricides and five neonicotinoids in beehives and surrounding environments in China.

    Shi, Jingliang / Wang, Xiaolong / Chen, Zeyou / Mao, Daqing / Luo, Yi

    Journal of hazardous materials

    2024  Volume 469, Page(s) 133892

    Abstract: Managed bees commonly suffer from cross-contamination with acaricides and neonicotinoids, posing robust threats to bee population health. However, their residual characteristics and spatial distribution in beehives and surrounding environments are poorly ...

    Abstract Managed bees commonly suffer from cross-contamination with acaricides and neonicotinoids, posing robust threats to bee population health. However, their residual characteristics and spatial distribution in beehives and surrounding environments are poorly understood. This study detected two common acaricides and five neonicotinoids in 240 beehive samples and 44 surrounding environmental samples collected from 25 Chinese provinces. The results showed that 40.0% of the honey samples contained acaricides and 83.1% contained neonicotinoids. Neonicotinoid concentrations in honey were geographically distinguished by the "Hu Huanyong line", and concentrations of neonicotinoids in honey from eastern areas were 2.65-fold higher than those in honey from western areas. Compared to the approved acaricide amitraz, the banned acaricide coumaphos was detected more frequently in honey and was positively correlated with that quantified in the paired pollen samples. Although coumaphos was identified in only three soil samples, lower coumaphos residues in honey might be associated with persistent pollution in the surrounding environment. Conversely, neonicotinoids were detected at higher levels in honey than in the pollen and soil, demonstrating that the neonicotinoid residues in honey have a cumulative effect. This study contributes to a better understanding of the pesticide contamination scenarios that underlie the exposure risks of bees.
    MeSH term(s) Bees ; Animals ; Acaricides/toxicity ; Neonicotinoids ; Coumaphos ; Pesticides ; Soil ; Insecticides/analysis
    Chemical Substances Acaricides ; Neonicotinoids ; Coumaphos (L08SZ5Z5JC) ; Pesticides ; Soil ; Insecticides
    Language English
    Publishing date 2024-02-28
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1491302-1
    ISSN 1873-3336 ; 0304-3894
    ISSN (online) 1873-3336
    ISSN 0304-3894
    DOI 10.1016/j.jhazmat.2024.133892
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  9. Article ; Online: Genetic correction of induced pluripotent stem cells from a DFNA36 patient results in morphologic and functional recovery of derived hair cell-like cells

    Yi Luo / Kaiwen Wu / Xiaolong Zhang / Hongyang Wang / Qiuju Wang

    Stem Cell Research & Therapy, Vol 15, Iss 1, Pp 1-

    2024  Volume 13

    Abstract: Abstract Background TMC1 is one of the most common deafness genes causing DFNA36. Patient-derived human induced pluripotent stem cells (iPSCs) provide an opportunity to modelling diseases. TMC1 p.M418K mutation in human is orthologous to Beethoven mice. ... ...

    Abstract Abstract Background TMC1 is one of the most common deafness genes causing DFNA36. Patient-derived human induced pluripotent stem cells (iPSCs) provide an opportunity to modelling diseases. TMC1 p.M418K mutation in human is orthologous to Beethoven mice. Here, we investigated the differentiation, morphology and electrophysiological properties of hair cell-like cells (HC-like cells) derived from DFNA36 patient. Methods Inner ear HC-like cells were induced from iPSCs derived from DFNA36 (TMC1 p.M418K) patient (M+/−), normal control (M+/+) and genetic corrected iPSCs (M+/C). Immunofluorescence, scanning electron microscopy and whole-cell patch-clamp were used to study the mechanism and influence of TMC1 p.M418K mutation. Results In this study we successfully generated HC-like cells from iPSCs with three different genotypes. HC-like cells from M+/− showed defected morphology of microvilli and physiological properties compared to M+/+. HC-like cells from M+/C showed recovery in morphology of microvilli and physiological properties. Conclusions Our results indicate that TMC1 p.M418K mutation didn’t influence inner ear hair cell differentiation but the morphology of microvilli and electrophysiological properties and gene correction induced recovery. CRISPR/Cas9 gene therapy is feasible in human patient with TMC1 p.M418K mutation.
    Keywords Induced pluripotent stem cells ; TMC1 ; Hair cells ; Differentiation ; Whole-cell patch-clamp ; Medicine (General) ; R5-920 ; Biochemistry ; QD415-436
    Language English
    Publishing date 2024-01-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
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  10. Article ; Online: NaClO Co-selects antibiotic and disinfectant resistance in Klebsiella pneumonia: Implications for the potential risk of extensive disinfectant use during COVID-19 pandemic.

    Chen, Zeyou / Zhang, Yulin / Mao, Daqing / Wang, Xiaolong / Luo, Yi

    Journal of hazardous materials

    2024  Volume 470, Page(s) 134102

    Abstract: The inappropriate use of antibiotics is widely recognized as the primary driver of bacterial antibiotic resistance. However, less attention has been given to the potential induction of multidrug-resistant bacteria through exposure to disinfectants. In ... ...

    Abstract The inappropriate use of antibiotics is widely recognized as the primary driver of bacterial antibiotic resistance. However, less attention has been given to the potential induction of multidrug-resistant bacteria through exposure to disinfectants. In this study, Klebsiella pneumonia, an opportunistic pathogen commonly associated with hospital and community-acquired infection, was experimentally exposed to NaClO at both minimum inhibitory concentration (MIC) and sub-MIC levels over a period of 60 days. The result demonstrated that NaClO exposure led to enhanced resistance of K. pneumonia to both NaClO itself and five antibiotics (erythromycin, polymyxin B, gentamicin, tetracycline, and ciprofloxacin). Concurrently, the evolved resistant strains exhibited fitness costs, as evidenced by decreased growth rates. Whole population sequencing revealed that both concentrations of NaClO exposure caused genetic mutations in the genome of K. pneumonia. Some of these mutations were known to be associated with antibiotic resistance, while others had not previously been identified as such. In addition, 11 identified mutations were located in the virulence factors, demonstrating that NaClO exposure may also impact the pathogenicity of K. pneumoniae. Overall, this study highlights the potential for the widespread use of NaClO-containing disinfectants during the COVID-19 pandemic to contribute to the emergence of antibiotic-resistant bacteria. ENVIRONMENTAL IMPLICATION: Considering the potential hazardous effects of disinfectant residues on environment, organisms and biodiversity, the sharp rise in use of disinfectants during COVID-19 pandemic has been considered highly likely to cause worldwide secondary disasters in ecosystems and human health. This study demonstrated that NaClO exposure enhanced the resistance of K. pneumonia to both NaClO and five antibiotics (erythromycin, polymyxin B, gentamicin, tetracycline, and ciprofloxacin), highlighting the widespread use of NaClO-containing disinfectants during the COVID-19 pandemic may increase the emergence of antibiotic-resistant bacteria in the environment.
    MeSH term(s) Klebsiella pneumoniae/drug effects ; Klebsiella pneumoniae/genetics ; Disinfectants ; COVID-19 ; Anti-Bacterial Agents/pharmacology ; Humans ; Microbial Sensitivity Tests ; Sodium Hypochlorite/pharmacology ; Drug Resistance, Bacterial ; SARS-CoV-2/drug effects ; Mutation ; Drug Resistance, Multiple, Bacterial ; Klebsiella Infections/drug therapy
    Chemical Substances Disinfectants ; Anti-Bacterial Agents ; Sodium Hypochlorite (DY38VHM5OD)
    Language English
    Publishing date 2024-03-27
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1491302-1
    ISSN 1873-3336 ; 0304-3894
    ISSN (online) 1873-3336
    ISSN 0304-3894
    DOI 10.1016/j.jhazmat.2024.134102
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