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  1. Article ; Online: Cox (1972): recollections and reflections.

    Oakes, David

    Lifetime data analysis

    2023  Volume 29, Issue 4, Page(s) 699–708

    Abstract: I present some personal memories and thoughts on Cox's 1972 paper "Regression Models and Life-Tables". ...

    Abstract I present some personal memories and thoughts on Cox's 1972 paper "Regression Models and Life-Tables".
    MeSH term(s) Humans ; Life Tables ; Regression Analysis
    Language English
    Publishing date 2023-09-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1479719-7
    ISSN 1572-9249 ; 1380-7870
    ISSN (online) 1572-9249
    ISSN 1380-7870
    DOI 10.1007/s10985-023-09609-4
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  2. Book ; Online ; E-Book: Statistical Modeling for Biological Systems

    Almudevar, Anthony / Oakes, David / Hall, Jack

    In Memory of Andrei Yakovlev

    2020  

    Abstract: This book commemorates the scientific contributions of distinguished statistician, Andrei Yakovlev. It reflects upon Dr. Yakovlev’s many research interests including stochastic modeling and the analysis of micro-array data and throughout the book it ... ...

    Author's details edited by Anthony Almudevar, David Oakes, Jack Hall
    Abstract This book commemorates the scientific contributions of distinguished statistician, Andrei Yakovlev. It reflects upon Dr. Yakovlev’s many research interests including stochastic modeling and the analysis of micro-array data and throughout the book it emphasizes applications of the theory in biology, medicine and public health. The contributions to this volume are divided into two parts. Part A consists of original research articles, which can be roughly grouped into four thematic areas, (i) branching processes, especially as models for cell kinetics, (ii) multiple testing issues as they arise in the analysis of biologic data, (iii) applications of mathematical models and of new inferential techniques in epidemiology, and (iv) contributions to statistical methodology, with an emphasis on the modeling and analysis of survival time data. Part B consists of methodological research reported as a short communication, ending with some personal reflections on research fields associated with Andrei and on his approach to science. The Appendix contains an abbreviated vitae and a list of Andrei’s publications, complete as far as we know. The contributions in this book are written by Dr. Yakovlev’s collaborators and notable statisticians including former Presidents of the Institute of Mathematical Statistics and of the Statistics Section of the AAAS. Dr. Yakovlev’s research appeared in four books and almost 200 scientific papers, in mathematics, statistics, biomathematics and biology journals. Ultimately this book offers a tribute to Dr. Yakovlev’s work and recognizes the legacy of his contributions in the biostatistics community.
    Keywords Statistics  ; Biostatistics ; Biomedical engineering ; Statistics for Life Sciences, Medicine, Health Sciences ; Biomedical Engineering/Biotechnology
    Subject code 610.28
    Language English
    Size 1 online resource (XXII, 354 p. 34 illus.)
    Edition 1st ed. 2020.
    Publisher Springer International Publishing ; Imprint: Springer
    Publishing place Cham
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 3-030-34675-7 ; 3-030-34674-9 ; 978-3-030-34675-1 ; 978-3-030-34674-4
    DOI 10.1007/978-3-030-34675-1
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Book ; Online ; E-Book: The independent neuropsychological evaluation

    Oakes, Howard J. / Lovejoy, David W. / Bush, Shane S.

    (Oxford workshop series)

    2017  

    Author's details Howard J. Oakes, David W. Lovejoy, Shane S. Bush
    Series title Oxford workshop series
    Keywords Neuropsychology / organization & administration ; Neuropsychological Tests
    Language English
    Size 1 Online-Ressource (xii, 138 Seiten)
    Publisher Oxford University Press
    Publishing place New York, NY
    Publishing country United States
    Document type Book ; Online ; E-Book
    Note Includes bibliographical references and index
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT020133777
    ISBN 978-0-19-068204-0 ; 9780199828326 ; 0-19-068204-3 ; 0199828326
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  4. Article ; Online: Survival models and health sequences: discussion.

    Oakes, David

    Lifetime data analysis

    2018  Volume 24, Issue 4, Page(s) 592–594

    Language English
    Publishing date 2018-07-11
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 1479719-7
    ISSN 1572-9249 ; 1380-7870
    ISSN (online) 1572-9249
    ISSN 1380-7870
    DOI 10.1007/s10985-018-9441-8
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  5. Article ; Online: Recommending swimming to people with low back pain: A scoping review.

    Oakes, Helen / de Vivo, Marlize / Mills, Hayley / Stephensen, David

    Journal of bodywork and movement therapies

    2023  Volume 36, Page(s) 274–281

    Abstract: Background: It is common practice for health professionals to recommend swimming to people with low back pain (LBP) despite limited evidence. The aim of this review was to gain an understanding of the current evidence base supporting the recommendation ... ...

    Abstract Background: It is common practice for health professionals to recommend swimming to people with low back pain (LBP) despite limited evidence. The aim of this review was to gain an understanding of the current evidence base supporting the recommendation of swimming to people with LBP.
    Methods: A scoping review was conducted searching five electronic databases, CINAHL, MEDLINE, PEDro, PubMed, and SPORTdiscus using the keywords back pain AND swim*. The studies were grouped by study design and the following uncertainties were considered; the impact of swimming on the spine and LBP, evidence of swimming increasing or reducing the risk of LBP and the use of swimming in LBP rehabilitation programmes.
    Results: 25 studies met the eligibility criteria; including sixteen observational studies exploring the relationship between swimming and LBP, three biomechanical studies investigating the impact of swimming on the spine, and five interventional studies of which four integrated swimming into a rehabilitation programme and one used swimming to modify lumbar lordosis.
    Conclusion: The review confirmed there is limited research and only low-level evidence to support the recommendation of swimming to people with LBP. Observational studies make up the greater proportion of research undertaken in the field; the data indicates that swimming is a low-risk form of exercise but not without risk. The findings from biomechanical research suggest that lumbar lordosis does not increase excessively when swimming breaststroke, but certain swimming techniques could negatively impact LBP and interventional trials illustrate that there are various ways to integrate swimming into a rehabilitation programme.
    MeSH term(s) Humans ; Low Back Pain/rehabilitation ; Lordosis ; Swimming ; Lumbar Vertebrae
    Language English
    Publishing date 2023-08-25
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2029441-4
    ISSN 1532-9283 ; 1360-8592
    ISSN (online) 1532-9283
    ISSN 1360-8592
    DOI 10.1016/j.jbmt.2023.05.012
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5620: Show issues Location:
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  6. Article: Military culture and collaborative decision-making in mental healthcare: cultural, communication and policy considerations.

    Treichler, Emily B H / Reznik, Samantha J / Oakes, David / Girard, Vanessa / Zisman-Ilani, Yaara

    BJPsych open

    2023  Volume 9, Issue 5, Page(s) e154

    Abstract: Military culture relies on hierarchy and obedience, which contradict the implementation and use of collaborative care models. In this commentary, a team of lived experience, clinical and research experts discuss, for the first time, cultural, ... ...

    Abstract Military culture relies on hierarchy and obedience, which contradict the implementation and use of collaborative care models. In this commentary, a team of lived experience, clinical and research experts discuss, for the first time, cultural, communication and policy considerations for implementing collaborative care models in military mental healthcare settings.
    Language English
    Publishing date 2023-08-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 2829557-2
    ISSN 2056-4724
    ISSN 2056-4724
    DOI 10.1192/bjo.2023.516
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  7. Article ; Online: MGMT, a risk factor for both genetic and environmental forms of dementia.

    Kisby, Glen E / Oakes, Heaton / Beckett, David / Spencer, Peter S

    Alzheimer's & dementia : the journal of the Alzheimer's Association

    2022  Volume 19, Issue 5, Page(s) 2208–2210

    Abstract: MGMT, the gene coding for the DNA-repair protein ... ...

    Abstract MGMT, the gene coding for the DNA-repair protein O
    MeSH term(s) Female ; Humans ; Alzheimer Disease/complications ; Alzheimer Disease/epidemiology ; Alzheimer Disease/genetics ; Amyotrophic Lateral Sclerosis/epidemiology ; Amyotrophic Lateral Sclerosis/genetics ; DNA ; DNA Modification Methylases ; DNA Repair Enzymes/genetics ; Parkinsonian Disorders/epidemiology ; Parkinsonian Disorders/genetics ; Risk Factors ; Tumor Suppressor Proteins
    Chemical Substances DNA (9007-49-2) ; DNA Modification Methylases (EC 2.1.1.-) ; DNA Repair Enzymes (EC 6.5.1.-) ; MGMT protein, human (EC 2.1.1.63) ; Tumor Suppressor Proteins
    Language English
    Publishing date 2022-12-30
    Publishing country United States
    Document type Letter ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 2211627-8
    ISSN 1552-5279 ; 1552-5260
    ISSN (online) 1552-5279
    ISSN 1552-5260
    DOI 10.1002/alz.12900
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    Zs.A 6316: Show issues Location:
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    Zs.MO 540: Show issues

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  8. Article: T cells Use Focal Adhesions to Pull Themselves Through Confined Environments.

    Caillier, Alexia / Oleksyn, David / Fowell, Deborah J / Miller, Jim / Oakes, Patrick W

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Immune cells are highly dynamic and able to migrate through environments with diverse biochemical and mechanical composition. Their migration has classically been defined as amoeboid under the assumption that it is integrin-independent. Here we show that ...

    Abstract Immune cells are highly dynamic and able to migrate through environments with diverse biochemical and mechanical composition. Their migration has classically been defined as amoeboid under the assumption that it is integrin-independent. Here we show that activated primary Th1 T cells require both confinement and extracellular matrix protein to migrate efficiently. This migration is mediated through small and dynamic focal adhesions that are composed of the same proteins associated with canonical mesenchymal focal adhesions, such as integrins, talin, and vinculin. These focal adhesions, furthermore, localize to sites of contractile traction stresses, enabling T cells to pull themselves through confined spaces. Finally, we show that Th1 T cell preferentially follows tracks of other T cells, suggesting that these adhesions are modifying the extracellular matrix to provide additional environmental guidance cues. These results demonstrate not only that the boundaries between amoeboid and mesenchymal migration modes are ambiguous, but that integrin-mediated adhesions play a key role in T cell motility.
    Language English
    Publishing date 2023-10-19
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.10.16.562587
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  9. Article ; Online: Accelerated cascade melanoma therapy using enzyme-nanozyme-integrated dissolvable polymeric microneedles.

    Singh, Parbeen / Chen, Yongli / Youden, Brian / Oakley, David / Carrier, Andrew / Oakes, Ken / Servos, Mark / Jiang, Runqing / Zhang, Xu

    International journal of pharmaceutics

    2024  Volume 652, Page(s) 123814

    Abstract: Dissolvable polymeric microneedles (DPMNs) have emerged as a powerful technology for the localized treatment of diseases, such as melanoma. Herein, we fabricated a DPMN patch containing a potent enzyme-nanozyme composite that transforms the upregulated ... ...

    Abstract Dissolvable polymeric microneedles (DPMNs) have emerged as a powerful technology for the localized treatment of diseases, such as melanoma. Herein, we fabricated a DPMN patch containing a potent enzyme-nanozyme composite that transforms the upregulated glucose consumption of cancerous cells into lethal reactive oxygen species via a cascade reaction accelerated by endogenous chloride ions and external near-infrared (NIR) irradiation. This was accomplished by combining glucose oxidase (Gox) with a NIR-responsive chloroperoxidase-like copper sulfide (CuS) nanozyme. In contrast with subcutaneous injection, the microneedle system highly localizes the treatment, enhancing nanomedicine uptake by the tumor and reducing its systemic exposure to the kidneys and spleen. NIR irradiation further controls the potency and toxicity of the formulation by thermally disabling Gox. In a mouse melanoma model, this unique combination of photothermal, starvation, and chemodynamic therapies resulted in complete tumor eradication (99.2 ± 0.8 % reduction in tumor volume within 10 d) without producing signs of systemic toxicity. By comparison, other treatment combinations only resulted in a 42-76.5 % reduction in tumor growth. The microneedle patch design is therefore not only highly potent but also with regulated toxicity and improved safety.
    MeSH term(s) Animals ; Mice ; Melanoma ; Glucose Oxidase ; Biological Transport ; Chlorides ; Copper ; Disease Models, Animal ; Neoplasms ; Hydrogen Peroxide ; Cell Line, Tumor ; Tumor Microenvironment
    Chemical Substances Glucose Oxidase (EC 1.1.3.4) ; Chlorides ; Copper (789U1901C5) ; Hydrogen Peroxide (BBX060AN9V)
    Language English
    Publishing date 2024-01-26
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 428962-6
    ISSN 1873-3476 ; 0378-5173
    ISSN (online) 1873-3476
    ISSN 0378-5173
    DOI 10.1016/j.ijpharm.2024.123814
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    Zs.A 1409: Show issues Location:
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  10. Article ; Online: An introduction to survival models: in honor of Ross Prentice.

    Oakes, David

    Lifetime data analysis

    2013  Volume 19, Issue 4, Page(s) 442–462

    Abstract: I review some key ideas and models in survival analysis with emphasis on modeling the effects of covariates on survival times. I focus on the proportional hazards model of Cox (J R Stat Soc B 34:187-220, 1972), its extensions and alternatives, including ... ...

    Abstract I review some key ideas and models in survival analysis with emphasis on modeling the effects of covariates on survival times. I focus on the proportional hazards model of Cox (J R Stat Soc B 34:187-220, 1972), its extensions and alternatives, including the accelerated life model. I briefly describe some models for competing risks data, multiple and repeated event-time data and multivariate survival data.
    MeSH term(s) Biostatistics/history ; History, 20th Century ; History, 21st Century ; Humans ; Models, Statistical ; Multivariate Analysis ; Proportional Hazards Models ; Risk ; Survival Analysis
    Language English
    Publishing date 2013-07-06
    Publishing country United States
    Document type Biography ; Historical Article ; Introductory Journal Article
    ZDB-ID 1479719-7
    ISSN 1572-9249 ; 1380-7870
    ISSN (online) 1572-9249
    ISSN 1380-7870
    DOI 10.1007/s10985-013-9276-2
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