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  1. Article ; Online: First Total Synthesis of the Re-Type Lipopolysaccharide This work was supported by the Research for the Future Program (No. 97L00502) from the Japan Society for the Promotion of Science. H.Y. is grateful for a JSPS Research Fellowship for Young Scientists (No. 1241) from the Japan Society for the Promotion of Science. The authors are grateful to Mr. Seiji Adachi for his skillful measurement of NMR spectra.

    Yoshizaki, Hiroaki / Fukuda, Naohiro / Sato, Kenjiro / Oikawa, Masato / Fukase, Koichi / Suda, Yasuo / Kusumoto, Shoichi

    Angewandte Chemie (International ed. in English)

    2001  Volume 40, Issue 8, Page(s) 1475–1480

    Language English
    Publishing date 2001-04-17
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2011836-3
    ISSN 1521-3773 ; 1433-7851
    ISSN (online) 1521-3773
    ISSN 1433-7851
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  2. Article ; Online: Effect of extracellular matrix fiber cross-linkage on cancer cell motility and surrounding matrix deformation.

    Omata, Seiji / Fukuda, Keisuke / Sakai, Yurie / Ohuchida, Kenoki / Morita, Yasuyuki

    Biochemical and biophysical research communications

    2023  Volume 673, Page(s) 44–50

    Abstract: Cancer incidence is increasing annually, and the invasion of cancer into the stroma significantly affects cancer metastasis. The stroma primarily comprises an abundant extracellular matrix (ECM) that interacts closely with cancer cells. Cancer cells use ... ...

    Abstract Cancer incidence is increasing annually, and the invasion of cancer into the stroma significantly affects cancer metastasis. The stroma primarily comprises an abundant extracellular matrix (ECM) that interacts closely with cancer cells. Cancer cells use the ECM as a scaffold to migrate from a tumor via mechanical actions such as pushing and pulling the fibers. The purpose of this study is to clarify the effects of elastic modulus differences on cell migration behavior based on the same ECM fiber structure. We observe temporal changes in the morphology of cancer cells and the surrounding ECM to elucidate the relationship between changes in the mechanical properties of the ECM and the invasive behavior of cancer cells. We analyze the shape and migration distance of cancer cells and the displacement field of the ECM by varying the fiber elastic modulus but fixing the ECM density. Increasing the elastic modulus results in a protruding cell shape, which indicates the maximum displacement of the ECM around the cell. Additionally, differences in cell migration speed and dispersion based on the elastic modulus are observed. The behavior of cells with increasing elasticity is classified via cluster analysis. Owing to the chemical cross-linking of the fibers, some cells cannot deform the surrounding tissue. This is attributable to the gel state of the ECM and microscopic fluctuations in the fiber density around the cells. We successfully assessed the effect of changes in the ECM modulus on cell mortality and morphology to reveal the mechanism of cancer invasion.
    MeSH term(s) Humans ; Extracellular Matrix ; Neoplasms ; Elasticity ; Elastic Modulus ; Cell Movement
    Language English
    Publishing date 2023-06-20
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 205723-2
    ISSN 1090-2104 ; 0006-291X ; 0006-291X
    ISSN (online) 1090-2104 ; 0006-291X
    ISSN 0006-291X
    DOI 10.1016/j.bbrc.2023.06.019
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    Zs.A 116: Show issues Location:
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  3. Article ; Online: Viscosity increase/gelation of therapeutic IgG monoclonal antibodies induced by Zn

    Fukuda, Masakazu / Yamazaki, Tadao / Ueno, Seiji / Koga, Akiko / Yamanaka, Yuji

    European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V

    2022  Volume 178, Page(s) 179–186

    Abstract: We investigated the elution of zinc ions ( ... ...

    Abstract We investigated the elution of zinc ions (Zn
    MeSH term(s) Antibodies, Monoclonal/chemistry ; Elastomers ; Immunoglobulin G/chemistry ; Scattering, Small Angle ; Syringes ; Viscosity ; X-Ray Diffraction ; Zinc
    Chemical Substances Antibodies, Monoclonal ; Elastomers ; Immunoglobulin G ; Zinc (J41CSQ7QDS)
    Language English
    Publishing date 2022-08-25
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1065368-5
    ISSN 1873-3441 ; 0939-6411
    ISSN (online) 1873-3441
    ISSN 0939-6411
    DOI 10.1016/j.ejpb.2022.08.008
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  4. Article ; Online: Correction to: Effectiveness and safety of sarilumab in patients with rheumatoid arthritis: A multicenter, retrospective, inverse probability of treatment-weighted analysis based on the FRAB-registry.

    Harada, Hiroshi / Kondo, Masakazu / Maeyama, Akira / Fukuda, Takaaki / Ikemura, Satoshi / Shono, Eisuke / Tsuru, Tomomi / Inoue, Yasushi / Yoshizawa, Seiji / Niiro, Hiroaki / Nakashima, Yasuharu

    Clinical rheumatology

    2024  Volume 43, Issue 5, Page(s) 1787–1791

    Language English
    Publishing date 2024-03-15
    Publishing country Germany
    Document type Published Erratum
    ZDB-ID 604755-5
    ISSN 1434-9949 ; 0770-3198
    ISSN (online) 1434-9949
    ISSN 0770-3198
    DOI 10.1007/s10067-024-06907-6
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  5. Article: Exercise prescription using an insertable cardiac monitor in a patient with catecholaminergic polymorphic ventricular tachycardia.

    Momoi, Mizuki / Katsumata, Yoshinori / Kataoka, Masaharu / Yamagishi, Hiroyuki / Fukuda, Keiichi / Takatsuki, Seiji

    HeartRhythm case reports

    2021  Volume 8, Issue 1, Page(s) 17–21

    Language English
    Publishing date 2021-10-21
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2834871-0
    ISSN 2214-0271
    ISSN 2214-0271
    DOI 10.1016/j.hrcr.2021.10.004
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  6. Article ; Online: Dual functional catalysis of [Nb

    Kikkawa, Soichi / Fukuda, Shoji / Hirayama, Jun / Shirai, Naoki / Takahata, Ryo / Suzuki, Kosuke / Yamaguchi, Kazuya / Teranishi, Toshiharu / Yamazoe, Seiji

    Chemical communications (Cambridge, England)

    2022  Volume 58, Issue 64, Page(s) 9018–9021

    Abstract: A catalyst prepared by modifying the surface of Au nanoparticles (NPs) on ... ...

    Abstract A catalyst prepared by modifying the surface of Au nanoparticles (NPs) on Al
    Language English
    Publishing date 2022-08-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 1472881-3
    ISSN 1364-548X ; 1359-7345 ; 0009-241X
    ISSN (online) 1364-548X
    ISSN 1359-7345 ; 0009-241X
    DOI 10.1039/d2cc02472a
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  7. Article: Kocuria kristinae infection associated with short bowel syndrome: A case report.

    Namba, Yosuke / Fujisaki, Seiji / Fukuda, Toshikatsu

    International journal of surgery case reports

    2020  Volume 77, Page(s) 276–278

    Abstract: Introduction: Only a few cases of K. kristinae infection have been reported in the literature. Patients with short bowel syndrome have an increased risk of opportunistic infections due to decreased bowel immunity and the long-term central venous ... ...

    Abstract Introduction: Only a few cases of K. kristinae infection have been reported in the literature. Patients with short bowel syndrome have an increased risk of opportunistic infections due to decreased bowel immunity and the long-term central venous catheter placement. We report a rare case of K. kristinae infection associated with SBS requiring long-term central venous access port placement.
    Presentation of case: A 70-year-old woman presented with fever of approximately 39 °C to our hospital for examination. She has undergone total hysterectomy and radiation therapy for cervical cancer 36 years ago. Five years ago, she developed multiple small bowel perforations, and a jejunostomy was constructed at the oral end of the perforation and approximately 110 cm from the ligament of Treitz because of the difficulty in dissecting the adhesion. She developed short bowel syndrome, and the central venous port was constructed four years ago due to poor enteral nutrition. K. kristinae was detected in the central venous catheter tip and in two blood cultures. We administered intravenous vancomycin. After seven days of antibiotic treatment, both fever and inflammatory reaction improved, and the blood culture was negative. After 16 days of antibiotic treatment, we performed central venous port construction on the side opposite to the previous site.
    Conclusion: Patients with short bowel syndrome have an increased risk of K. kristinae infections due to decreased bowel immunity and the long-term central venous port, and therefore, these patients should be followed up carefully.
    Language English
    Publishing date 2020-11-05
    Publishing country Netherlands
    Document type Case Reports
    ISSN 2210-2612
    ISSN 2210-2612
    DOI 10.1016/j.ijscr.2020.11.006
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  8. Article ; Online: Kangaroo mother care alters chromogranin A and perfusion index in preterm babies.

    Endo, Tomohiro / Sampei, Mari / Fukuda, Seiji

    Pediatrics international : official journal of the Japan Pediatric Society

    2020  Volume 63, Issue 1, Page(s) 53–59

    Abstract: Background: While providing various benefits, concerns about the potential risks of kangaroo mother care, or skin-to-skin contact (SSC), between mother and her preterm infant hinder its widespread implementation in some resource- rich countries. In ... ...

    Abstract Background: While providing various benefits, concerns about the potential risks of kangaroo mother care, or skin-to-skin contact (SSC), between mother and her preterm infant hinder its widespread implementation in some resource- rich countries. In neonates, salivary chromogranin A (s-CgA) is elevated upon exposure to stress, whereas the perfusion index (PI) is associated with hemodynamics and peripheral perfusion. Here, we investigated the effects of SSC on s-CgA and the PI in preterm infants.
    Methods: Twelve infants were enrolled in the study. Factors associated with baseline s-CgA were analyzed. Baseline s-CgA and the level after SSC were compared. Secreted IgA in the saliva was compared as the control. The PI before, throughout, and after SSC were compared.
    Results: Baseline s-CgA was significantly lower in infants who were supplemented with baby formula milk in addition to breast milk before SSC (n = 2) compared with those fed with their mother's breast milk alone (n = 10, P = 0.03). SSC significantly decreased s-CgA in babies who were fed breast milk only before SSC (n = 10, P = 0.01) but not in those supplemented with formula milk before SSC (n = 2). Secreted IgA in saliva was not affected by SSC. The PI was significantly elevated during SSC (P = .01).
    Conclusion: Our data indicate that SSC can reduce s-CgA levels when combined with mother's breast milk and increase the PI in preterm infants, thereby providing additional evidence of the benefit of SSC.
    MeSH term(s) Child ; Chromogranin A/blood ; Humans ; Infant, Low Birth Weight ; Infant, Newborn ; Infant, Premature ; Kangaroo-Mother Care Method ; Perfusion Index
    Chemical Substances Chromogranin A
    Language English
    Publishing date 2020-12-05
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 1470376-2
    ISSN 1442-200X ; 1328-8067
    ISSN (online) 1442-200X
    ISSN 1328-8067
    DOI 10.1111/ped.14350
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    Zs.A 848: Show issues Location:
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  9. Article ; Online: Patient concern regarding bleeding side effects from oral anticoagulation therapy for atrial fibrillation: An analysis from the multicenter KiCS-AF registry.

    Ueda, Ikuko / Kohsaka, Shun / Ikemura, Nobuhiro / Kimura, Takehiro / Katsumata, Yoshinori / Takemura, Ryo / Suzuki, Masahiro / Takatsuki, Seiji / Koide, Daisuke / Fukuda, Keiichi

    European journal of cardiovascular nursing

    2023  

    Abstract: Aims: The purpose of this study is to utilize PROs to determine the percentage of patients concerned about mild to moderate bleeding side effects of anticoagulants.: Methods and results: We consecutively enrolled 3,312 newly diagnosed or referred ... ...

    Abstract Aims: The purpose of this study is to utilize PROs to determine the percentage of patients concerned about mild to moderate bleeding side effects of anticoagulants.
    Methods and results: We consecutively enrolled 3,312 newly diagnosed or referred patients for atrial fibrillation (AF) management from 11 sites within the Keio interhospital Cardiovascular Studies-Atrial Fibrillation Registry between September 2012 and May 2018. Of these patients, 2,636 (79.5%) were taking oral anticoagulants at enrollment. Using the Atrial Fibrillation Effect on Quality-of-life questionnaire (AFEQT), the patients who responded "1: not at all bothered" or "2: hardly bothered" on the seven-point scale regarding bleeding side effects were classified as the "no OAC concern" group while those responding "3: a little bothered" to "7: extremely bothered" were classified as the "OAC concern" group. On baseline analysis, 29.3% (n = 772) were "concerned" about bleeding side effects. The proportion of women and patients with AF-related symptoms was higher in the OAC concern vs. no OAC concern group (36.9% vs. 29.8%, p < 0.0004 and 66.2% vs. 56.7%, p < 0.0001, respectively). The CHADS2 scores ≥ 2 were comparable between groups. Of the 430 patients in the 1-year follow-up analysis, the proportion of the continued OAC concern group (1 year from enrollment) was 41.6%.The dabigatran, rivaroxaban, and apixaban usage rates were comparable between the two groups in baseline and 1-year follow-up analysis.
    Conclusion: Approximately one-third of all patients with AF on anticoagulant therapy were concerned regarding bleeding from short-and long-term anticoagulant use.
    Language English
    Publishing date 2023-09-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 2151245-0
    ISSN 1873-1953 ; 1474-5151
    ISSN (online) 1873-1953
    ISSN 1474-5151
    DOI 10.1093/eurjcn/zvad094
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  10. Article ; Online: Association between daily breakfast habit during pregnancy and neurodevelopment in 3-year-old offspring: The Japan Environment and Children's Study.

    Imaizumi, Karin / Murata, Tsuyoshi / Isogami, Hirotaka / Fukuda, Toma / Kyozuka, Hyo / Yasuda, Shun / Yamaguchi, Akiko / Sato, Akiko / Ogata, Yuka / Shinoki, Kosei / Hosoya, Mitsuaki / Yasumura, Seiji / Hashimoto, Koichi / Fujimori, Keiya / Nishigori, Hidekazu

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 6337

    Abstract: The association between daily breakfast habits during pregnancy and offspring neurodevelopment remains unknown. We evaluated the association between breakfast habits during pregnancy and offspring neurodevelopment. Data of 72,260 women with singleton ... ...

    Abstract The association between daily breakfast habits during pregnancy and offspring neurodevelopment remains unknown. We evaluated the association between breakfast habits during pregnancy and offspring neurodevelopment. Data of 72,260 women with singleton deliveries at and after 37 weeks of gestation enrolled during 2011-2014 in the Japan Environment and Children's Study were analysed. Offspring neurodevelopmental delays at 3 years of age were evaluated using the Ages and Stages Questionnaire, Third Edition (ASQ-3). Participants were stratified by tertiles of maternal daily energy intake (DEI) (Groups 1, 2, and 3:< 1400, 1400-1799, and ≥ 1800 kcal, respectively) during pregnancy and by offspring sex. The adjusted odds ratio (aOR) for abnormality in communication among participants with daily breakfast consumption habit was 0.87 (95% confidence interval, 0.80-0.96). A stratified analysis based on total DEI showed no significant differences in the neurodevelopment of Group 1 offspring. The aOR for abnormality in communication was 0.80 (95% confidence interval, 0.68-0.94) in Group 2. The aOR for abnormality in personal-social characteristics was 0.84 (95% confidence interval, 0.71-0.99) in Group 3. Maternal daily breakfast habits are associated with offspring neurodevelopment at 3 years of age, with the association influenced by maternal DEI and offspring sex.
    MeSH term(s) Child ; Pregnancy ; Humans ; Female ; Child, Preschool ; Japan/epidemiology ; Breakfast ; Family ; Surveys and Questionnaires
    Language English
    Publishing date 2024-03-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-55912-x
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