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Article ; Online: Occurrence of hyperoxia during iNO treatment for persistent pulmonary hypertension of the newborn: a cohort study.

de Jager, Justine / Brouwer, Fleur / Reijman, Jeroen / van der Palen, Roel L F / Steggerda, Sylke J / Visser, Remco / Te Pas, Arjan B / Dekker, Janneke

European journal of pediatrics

2024 Volume 183, Issue 5, Page(s) 2455–2461

Abstract: High concentrations of oxygen are often needed to optimize oxygenation in infants with persistent pulmonary hypertension (PPHN), but this can also increase the risk of hyperoxemia. We determined the occurrence of hyperoxemia in infants treated for PPHN. ... ...

Abstract	High concentrations of oxygen are often needed to optimize oxygenation in infants with persistent pulmonary hypertension (PPHN), but this can also increase the risk of hyperoxemia. We determined the occurrence of hyperoxemia in infants treated for PPHN. Medical records of infants ≥ 34 + 0 weeks gestational age (GA) who received inhaled nitric oxide (iNO) were retrospectively reviewed for oxygenation parameters during iNO therapy. Oxygen was manually titrated to target arterial oxygen tension (PaO
MeSH term(s)	Humans ; Infant, Newborn ; Hyperoxia/etiology ; Nitric Oxide/administration & dosage ; Retrospective Studies ; Persistent Fetal Circulation Syndrome/therapy ; Male ; Female ; Administration, Inhalation ; Oxygen/blood ; Oxygen/administration & dosage ; Oxygen Saturation ; Oxygen Inhalation Therapy/methods ; Hypoxia/etiology ; Hypoxia/therapy
Chemical Substances	Nitric Oxide (31C4KY9ESH) ; Oxygen (S88TT14065)
Language	English
Publishing date	2024-03-12
Publishing country	Germany
Document type	Journal Article
ZDB-ID	194196-3
ISSN	1432-1076 ; 0340-6199 ; 0943-9676
ISSN (online)	1432-1076
ISSN	0340-6199 ; 0943-9676
DOI	10.1007/s00431-024-05506-6
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Article ; Online: Surviving the first COVID-19 wave and learning lessons for the second.

de Brouwer, Remco / van Veldhuisen, Dirk J / de Boer, Rudolf A

European journal of heart failure

2020 Volume 22, Issue 6, Page(s) 975–977

MeSH term(s)	Angiotensin Receptor Antagonists ; Angiotensin-Converting Enzyme Inhibitors ; Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Heart Failure ; Humans ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2 ; United Kingdom
Chemical Substances	Angiotensin Receptor Antagonists ; Angiotensin-Converting Enzyme Inhibitors
Keywords	covid19
Language	English
Publishing date	2020-07-04
Publishing country	England
Document type	Editorial ; Comment
ZDB-ID	1483672-5
ISSN	1879-0844 ; 1388-9842
ISSN (online)	1879-0844
ISSN	1388-9842
DOI	10.1002/ejhf.1938
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Zs.A 5299: Show issues

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Article: Surviving the first COVID-19 wave and learning lessons for the second

de Brouwer, Remco / van Veldhuisen, Dirk J / de Boer, Rudolf A

Eur J Heart Fail

Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #609616
Database	COVID19

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Article: Exploring the Correlation Between Fibrosis Biomarkers and Clinical Disease Severity in PLN p.Arg14del Patients.

van der Voorn, Stephanie M / Bourfiss, Mimount / Te Riele, Anneline S J M / Taha, Karim / Vos, Marc A / de Brouwer, Remco / Verstraelen, Tom E / de Boer, Rudolf A / Remme, Carol Ann / van Veen, Toon A B

Frontiers in cardiovascular medicine

2022 Volume 8, Page(s) 802998

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2022-01-13
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2781496-8
ISSN	2297-055X
ISSN	2297-055X
DOI	10.3389/fcvm.2021.802998
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Article ; Online: Phenotypic and Genetic Factors Associated with Absence of Cardiomyopathy Symptoms in PLN:c.40_42delAGA Carriers.

Lopera-Maya, Esteban A / Li, Shuang / de Brouwer, Remco / Nolte, Ilja M / van Breen, Justin / Jongbloed, Jan D H / Swertz, Morris A / Snieder, Harold / Franke, Lude / Wijmenga, Cisca / de Boer, Rudolf A / Deelen, Patrick / van der Zwaag, Paul A / Sanna, Serena

Journal of cardiovascular translational research

2023 Volume 16, Issue 6, Page(s) 1251–1266

Abstract: The c.40_42delAGA variant in the phospholamban gene (PLN) has been associated with dilated and arrhythmogenic cardiomyopathy, with up to 70% of carriers experiencing a major cardiac event by age 70. However, there are carriers who remain asymptomatic at ... ...

Abstract	The c.40_42delAGA variant in the phospholamban gene (PLN) has been associated with dilated and arrhythmogenic cardiomyopathy, with up to 70% of carriers experiencing a major cardiac event by age 70. However, there are carriers who remain asymptomatic at older ages. To understand the mechanisms behind this incomplete penetrance, we evaluated potential phenotypic and genetic modifiers in 74 PLN:c.40_42delAGA carriers identified in 36,339 participants of the Lifelines population cohort. Asymptomatic carriers (N = 48) showed shorter QRS duration (- 5.73 ms, q value = 0.001) compared to asymptomatic non-carriers, an effect we could replicate in two different independent cohorts. Furthermore, symptomatic carriers showed a higher correlation (r
MeSH term(s)	Humans ; Aged ; Mutation ; Cardiomyopathies/diagnosis ; Cardiomyopathies/genetics ; Calcium-Binding Proteins/genetics ; Genotype
Chemical Substances	phospholamban ; Calcium-Binding Proteins
Language	English
Publishing date	2023-01-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	2422411-X
ISSN	1937-5395 ; 1937-5387
ISSN (online)	1937-5395
ISSN	1937-5387
DOI	10.1007/s12265-022-10347-5
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Article ; Online: A randomized controlled trial of eplerenone in asymptomatic phospholamban p.Arg14del carriers.

de Brouwer, Remco / Te Rijdt, Wouter P / Hoorntje, Edgar T / Amin, Ahmad / Asselbergs, Folkert W / Cox, Moniek G P J / van der Heijden, Jeroen F / Hillege, Hans / Karper, Jacco C / Mahmoud, Belend / van der Meer, Peter / Oomen, Anton / Te Riele, Anneline S J M / Silljé, Herman H W / Tan, Hanno L / van Tintelen, Jan Peter / van Veldhuisen, Dirk J / Westenbrink, Berend Daan / Wiesfeld, Ans C P /

Willems, Tineke P / van der Zwaag, Paul A / Wilde, Arthur A M / de Boer, Rudolf A / van den Berg, Maarten P

European heart journal

2023 Volume 44, Issue 40, Page(s) 4284–4287

Language	English
Publishing date	2023-05-18
Publishing country	England
Document type	Journal Article
ZDB-ID	603098-1
ISSN	1522-9645 ; 0195-668X
ISSN (online)	1522-9645
ISSN	0195-668X
DOI	10.1093/eurheartj/ehad292
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Zs.A 1563: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 640: Show issues

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Article ; Online: Value of genetic testing in the diagnosis and risk stratification of arrhythmogenic right ventricular cardiomyopathy.

de Brouwer, Remco / Bosman, Laurens P / Gripenstedt, Sophia / Wilde, Arthur A M / van den Berg, Maarten P / Peter van Tintelen, J / de Boer, Rudolf A / Te Riele, Anneline S J M

Heart rhythm

2022 Volume 19, Issue 10, Page(s) 1659–1665

Abstract: Background: Arrhythmogenic right ventricular cardiomyopathy (ARVC) is characterized by risk of malignant ventricular arrhythmia (VA). ARVC is diagnosed using an array of clinical tests in the consensus-based Task Force Criteria (TFC), one of which is ... ...

Abstract	Background: Arrhythmogenic right ventricular cardiomyopathy (ARVC) is characterized by risk of malignant ventricular arrhythmia (VA). ARVC is diagnosed using an array of clinical tests in the consensus-based Task Force Criteria (TFC), one of which is genetic testing. Objective: The purpose of this study was to investigate the value of genetic testing in diagnosing ARVC and its relation to the occurrence of first malignant VA. Methods: A multicenter cohort of patients with ARVC was scored using the revised 2010 TFC with and without genetic criterion, analyzing any resulting loss or delay of diagnosis. Malignant VA was defined as sustained VA (≥30-second duration at ≥100 beats/min or requiring intervention). Results: We included 402 subjects (221 [55%] male; 216 [54%] proband; 40 [27-51] years old at presentation) who were diagnosed with definite ARVC. A total of 232 subjects (58%) fulfilled genetic testing criteria. Removing the genetic criterion caused loss of diagnosis in 18 patients (4%) (11 of 216 probands [5%] and 7 of 186 relatives [4%]) and delay of diagnosis by ≥30 days in 22 patients (5%) (21 of 216 probands [10%] and 1 of 186 relative [0.5%]). A first malignant VA occurred in no patients who lost diagnosis and in 3 patients (3 of 216 probands [1%] and no relatives) during their diagnosis delay, none fatal. Time-to-event analysis showed no significant difference in time from diagnosis to malignant VA between pathogenic variant carriers and noncarriers. Conclusion: Disregarding the genetic criterion of the TFC caused loss or delay of diagnosis in 10% of patients with ARVC (40 of 402). Malignant VA occurred in 1% of cases with lost or delayed diagnosis (3 of 402), none fatal.
MeSH term(s)	Adult ; Arrhythmias, Cardiac/genetics ; Arrhythmogenic Right Ventricular Dysplasia/diagnosis ; Arrhythmogenic Right Ventricular Dysplasia/genetics ; Electrocardiography ; Female ; Genetic Testing ; Humans ; Male ; Middle Aged ; Risk Assessment
Language	English
Publishing date	2022-06-07
Publishing country	United States
Document type	Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
ZDB-ID	2229357-7
ISSN	1556-3871 ; 1547-5271
ISSN (online)	1556-3871
ISSN	1547-5271
DOI	10.1016/j.hrthm.2022.05.038
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Zs.A 6278: Show issues

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Article ; Online: ECG-only explainable deep learning algorithm predicts the risk for malignant ventricular arrhythmia in phospholamban cardiomyopathy.

van de Leur, Rutger R / de Brouwer, Remco / Bleijendaal, Hidde / Verstraelen, Tom E / Mahmoud, Belend / Perez-Matos, Ana / Dickhoff, Cathelijne / Schoonderwoerd, Bas A / Germans, Tjeerd / Houweling, Arjan / van der Zwaag, Paul A / Cox, Moniek G P J / Peter van Tintelen, J / Te Riele, Anneline S J M / van den Berg, Maarten P / Wilde, Arthur A M / Doevendans, Pieter A / de Boer, Rudolf A / van Es, René

Heart rhythm

2024

Abstract: Background: Phospholamban (PLN) p.(Arg14del) variant carriers are at risk for development of malignant ventricular arrhythmia (MVA). Accurate risk stratification allows timely implantation of intracardiac defibrillators and is currently performed with a ...

Abstract	Background: Phospholamban (PLN) p.(Arg14del) variant carriers are at risk for development of malignant ventricular arrhythmia (MVA). Accurate risk stratification allows timely implantation of intracardiac defibrillators and is currently performed with a multimodality prediction model. Objective: This study aimed to investigate whether an explainable deep learning-based approach allows risk prediction with only electrocardiogram (ECG) data. Methods: A total of 679 PLN p.(Arg14del) carriers without MVA at baseline were identified. A deep learning-based variational auto-encoder, trained on 1.1 million ECGs, was used to convert the 12-lead baseline ECG into its FactorECG, a compressed version of the ECG that summarizes it into 32 explainable factors. Prediction models were developed by Cox regression. Results: The deep learning-based ECG-only approach was able to predict MVA with a C statistic of 0.79 (95% CI, 0.76-0.83), comparable to the current prediction model (C statistic, 0.83 [95% CI, 0.79-0.88]; P = .054) and outperforming a model based on conventional ECG parameters (low-voltage ECG and negative T waves; C statistic, 0.65 [95% CI, 0.58-0.73]; P < .001). Clinical simulations showed that a 2-step approach, with ECG-only screening followed by a full workup, resulted in 60% less additional diagnostics while outperforming the multimodal prediction model in all patients. A visualization tool was created to provide interactive visualizations (https://pln.ecgx.ai). Conclusion: Our deep learning-based algorithm based on ECG data only accurately predicts the occurrence of MVA in PLN p.(Arg14del) carriers, enabling more efficient stratification of patients who need additional diagnostic testing and follow-up.
Language	English
Publishing date	2024-02-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	2229357-7
ISSN	1556-3871 ; 1547-5271
ISSN (online)	1556-3871
ISSN	1547-5271
DOI	10.1016/j.hrthm.2024.02.038
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Zs.A 6278: Show issues

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Article ; Online: Long-term reliability of the phospholamban (PLN) p.(Arg14del) risk model in predicting major ventricular arrhythmia: a landmark study.

van der Heide, Myrthe Y C / Verstraelen, Tom E / van Lint, Freyja H M / Bosman, Laurens P / de Brouwer, Remco / Proost, Virginnio M / van Drie, Esmée / Taha, Karim / Zwinderman, Aeilko H / Dickhoff, Cathelijne / Schoonderwoerd, Bas A / Germans, Tjeerd / Houweling, Arjan C / Gimeno-Blanes, Juan R / van der Zwaag, Paul A / de Boer, Rudolf A / Cox, Moniek G P J / van Tintelen, J Peter / Wilde, Arthur A M

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology

2024 Volume 26, Issue 4

Abstract: Aims: Recently, a genetic variant-specific prediction model for phospholamban (PLN) p.(Arg14del)-positive individuals was developed to predict individual major ventricular arrhythmia (VA) risk to support decision-making for primary prevention ... ...

Abstract	Aims: Recently, a genetic variant-specific prediction model for phospholamban (PLN) p.(Arg14del)-positive individuals was developed to predict individual major ventricular arrhythmia (VA) risk to support decision-making for primary prevention implantable cardioverter defibrillator (ICD) implantation. This model predicts major VA risk from baseline data, but iterative evaluation of major VA risk may be warranted considering that the risk factors for major VA are progressive. Our aim is to evaluate the diagnostic performance of the PLN p.(Arg14del) risk model at 3-year follow-up. Methods and results: We performed a landmark analysis 3 years after presentation and selected only patients with no prior major VA. Data were collected of 268 PLN p.(Arg14del)-positive subjects, aged 43.5 ± 16.3 years, 38.9% male. After the 3 years landmark, subjects had a mean follow-up of 4.0 years (± 3.5 years) and 28 (10%) subjects experienced major VA with an annual event rate of 2.6% [95% confidence interval (CI) 1.6-3.6], defined as sustained VA, appropriate ICD intervention, or (aborted) sudden cardiac death. The PLN p.(Arg14del) risk score yielded good discrimination in the 3 years landmark cohort with a C-statistic of 0.83 (95% CI 0.79-0.87) and calibration slope of 0.97. Conclusion: The PLN p.(Arg14del) risk model has sustained good model performance up to 3 years follow-up in PLN p.(Arg14del)-positive subjects with no history of major VA. It may therefore be used to support decision-making for primary prevention ICD implantation not merely at presentation but also up to at least 3 years of follow-up.
MeSH term(s)	Female ; Humans ; Male ; Arrhythmias, Cardiac/diagnosis ; Arrhythmias, Cardiac/genetics ; Arrhythmias, Cardiac/therapy ; Calcium-Binding Proteins/genetics ; Death, Sudden, Cardiac/etiology ; Death, Sudden, Cardiac/prevention & control ; Defibrillators, Implantable ; Reproducibility of Results ; Risk Factors ; Adult ; Middle Aged
Chemical Substances	Calcium-Binding Proteins ; phospholamban
Language	English
Publishing date	2024-04-01
Publishing country	England
Document type	Journal Article
ZDB-ID	1449879-0
ISSN	1532-2092 ; 1099-5129
ISSN (online)	1532-2092
ISSN	1099-5129
DOI	10.1093/europace/euae069
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Zs.A 5434: Show issues

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Article ; Online: The experience of non-conveyance following emergency medical service triage from the perspective of patients and their relatives: A qualitative study.

van Doorn, Silvie C M / Verhalle, Ruud C / Ebben, Remco H A / Frost, Donna M / Vloet, Lilian C M / de Brouwer, Carin P M

International emergency nursing

2020 Volume 54, Page(s) 100952

Abstract: Background: As many as 25% of all Dutch ambulance emergency service assignments result in non-conveyance of the patient to the hospital. Little is known about how patients and their relatives experience being left at home by an ambulance nurse after an ... ...

Abstract	Background: As many as 25% of all Dutch ambulance emergency service assignments result in non-conveyance of the patient to the hospital. Little is known about how patients and their relatives experience being left at home by an ambulance nurse after an acute request for medical help. Aim: To gain insight into the experience of patients and their relatives with a high urgency request for ambulance assistance that results in non-conveyance, with the ultimate goal of offering adequate follow-up. Method: A qualitative design based on semi-structured interviews with fifteen patients and seven relatives, conducted between September and November 2018. Results: Four themes emerged from the thematic analysis: Fear as the prominent emotion, four components of confidence in decision-making, different consequences and coping between patient and relative(s) over time and the perceived need for evaluation afterwards. Conclusion: The experience after non-conveyance has several phases in which fear, reassurance, confirmation (for relatives) and shame (for patients) follow each other throughout the care process. Complex interpersonal skills of ambulance nurses congruent with the concept of person-centred care can modulate this impact. These findings offer starting points for the optimisation of training programmes within the ambulance care sector.
MeSH term(s)	Adaptation, Psychological ; Aged ; Aged, 80 and over ; Ambulances ; Decision Making ; Emergency Medical Services/organization & administration ; Family/psychology ; Fear ; Female ; Humans ; Male ; Middle Aged ; Netherlands ; Patient Selection ; Patients/psychology ; Qualitative Research ; Triage
Language	English
Publishing date	2020-12-28
Publishing country	England
Document type	Journal Article
ZDB-ID	2420747-0
ISSN	1878-013X ; 1755-599X
ISSN (online)	1878-013X
ISSN	1755-599X
DOI	10.1016/j.ienj.2020.100952
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