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Article ; Online: The genetic polymorphisms at the promoter region of

Saify, Khyber

Molecular biology research communications

2023 Volume 12, Issue 1, Page(s) 51–55

Abstract: Human leukocyte antigen-DQB1 (HLA-DQB1, OMIM: 604305) is the human major histocompatibility complex (MHC) system. HLA genes are classified into three classes (I, II, and III). The HLA-DQB1 belongs to class II, is mainly involved in the actions of the ... ...

Abstract	Human leukocyte antigen-DQB1 (HLA-DQB1, OMIM: 604305) is the human major histocompatibility complex (MHC) system. HLA genes are classified into three classes (I, II, and III). The HLA-DQB1 belongs to class II, is mainly involved in the actions of the human immune system and plays a fundamental role in donor-recipient matching in transplantation and can be associated with most autoimmune diseases. In this study, the potential influence(s) of the G-71C (rs71542466) and T-80C (rs9274529) genetic polymorphisms were investigated. These polymorphisms, located in the
Language	English
Publishing date	2023-04-11
Publishing country	Iran
Document type	Journal Article
ISSN	2345-2005
ISSN (online)	2345-2005
DOI	10.22099/mbrc.2023.46890.1813
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Article: Genetic polymorphisms in the promoter region of catalase gene, creates new potential PAX-6 and STAT4 response elements.

Saify, Khyber

Molecular biology research communications

2016 Volume 5, Issue 2, Page(s) 97–100

Abstract: Catalase ( ...

Abstract	Catalase (
Language	English
Publishing date	2016-11-14
Publishing country	Iran
Document type	Journal Article
ZDB-ID	2687523-8
ISSN	2322-181X
ISSN	2322-181X
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Article ; Online: Genetic polymorphisms in the promoter region of catalase gene, creates new potential PAX-6 and STAT4 response elements

Khyber Saify

Molecular Biology Research Communications, Vol 5, Iss 2, Pp 97-

2016 Volume 100

Abstract: Catalase (CAT, OMIM: 115500) is an endogenous antioxidant enzyme and genetic variations in the regulatory regions of the CAT gene may alter the CAT enzyme activity and subsequently may alter the risk of oxidative stress related disease. In this study, ... ...

Abstract	Catalase (CAT, OMIM: 115500) is an endogenous antioxidant enzyme and genetic variations in the regulatory regions of the CAT gene may alter the CAT enzyme activity and subsequently may alter the risk of oxidative stress related disease. In this study, potential influence(s) of the A-21T (rs7943316) and C-262T (rs1001179) genetic polymorphisms in the CAT promoter region, using the ALGGEN-PROMO.v8.3 online software were analyzed. Our findings show that the A allele at the -21 position creates a new potential binding site for PAX-6 and the T allele at the -262 position changes the TFII-I binding site into STAT4 response element. The PAX-6 and STAT4 are the multifunctional and enhancing transcription factors.
Keywords	Keywords: Catalase; PAX-6; STAT4; Transcription factors ; Biology (General) ; QH301-705.5 ; Science ; Q
Language	English
Publishing date	2016-06-01T00:00:00Z
Publisher	Shiraz University Press
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Susceptibility to the novel coronavirus disease (COVID-19) is associated with ABO and Rh blood groups: a case-control study from Afghanistan.

Saify, Khyber / Alborz, Mohammad Sarwar / Saadat, Mostafa

The Egyptian journal of medical human genetics

2021 Volume 22, Issue 1, Page(s) 1

Abstract: Background: There are preliminary studies about the association between COVID-19 and ABO phenotypes and the results are controversial. There are only two studies which investigated the association of Rh blood groups in addition to ABO with COVID-19; ... ...

Abstract	Background: There are preliminary studies about the association between COVID-19 and ABO phenotypes and the results are controversial. There are only two studies which investigated the association of Rh blood groups in addition to ABO with COVID-19; however, in the statistical analysis ABO and Rh blood groups have been considered separately. Therefore, the present case-control study was performed to determine the association of COVID-19 with ABO blood groups considering the Rh blood groups simultaneously. The study was conducted in Kunduz COVID-19 treatment specific center, Spin-Zar Hospital (Kunduz Province, North East Afghanistan). A total of 301 confirmed COVID-19 cases and 1039 healthy blood donors as control group were included in the study. Results: The Rh Conclusion: These findings indicate that susceptibility to COVID-19 is strongly associated with A
Language	English
Publishing date	2021-01-05
Publishing country	Egypt
Document type	Journal Article
ZDB-ID	2515357-2
ISSN	2090-2441 ; 2090-2441
ISSN (online)	2090-2441
ISSN	2090-2441
DOI	10.1186/s43042-020-00124-x
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Article ; Online: Susceptibility to the novel coronavirus disease (COVID-19) is associated with ABO and Rh blood groups

Khyber Saify / Mohammad Sarwar Alborz / Mostafa Saadat

Egyptian Journal of Medical Human Genetics, Vol 22, Iss 1, Pp 1-

a case-control study from Afghanistan

2021 Volume 5

Abstract: Abstract Background There are preliminary studies about the association between COVID-19 and ABO phenotypes and the results are controversial. There are only two studies which investigated the association of Rh blood groups in addition to ABO with COVID- ... ...

Abstract	Abstract Background There are preliminary studies about the association between COVID-19 and ABO phenotypes and the results are controversial. There are only two studies which investigated the association of Rh blood groups in addition to ABO with COVID-19; however, in the statistical analysis ABO and Rh blood groups have been considered separately. Therefore, the present case-control study was performed to determine the association of COVID-19 with ABO blood groups considering the Rh blood groups simultaneously. The study was conducted in Kunduz COVID-19 treatment specific center, Spin-Zar Hospital (Kunduz Province, North East Afghanistan). A total of 301 confirmed COVID-19 cases and 1039 healthy blood donors as control group were included in the study. Results The Rh− phenotype strongly increased the risk of COVID-19 (OR = 2.97, 95% CI 1.86–3.89, P < 0.001). Although blood group A increased the risk of developing COVID-19, the association did not reach statistical significance. In analysis of the combination phenotypes, the A− blood group remarkably increased the risk of COVID-19 (OR = 7.24, 95% CI 3.62–14.4, P < 0.001). Multivariate analysis revealed that the interaction of Rh and ABO is significant (P < 0.013). Conclusion These findings indicate that susceptibility to COVID-19 is strongly associated with A− blood group.
Keywords	COVID-19 ; Susceptibility ; ABO ; Rh ; Blood groups ; Medicine (General) ; R5-920 ; Genetics ; QH426-470
Subject code	610
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	SpringerOpen
Document type	Article ; Online
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Article ; Online: Association Between a 50bp Ins/Del Genetic Variation at Promoter of the Superoxide Dismutase-1 (SOD1) and the Risk of Dependency to Opium and Methamphetamine

Khyber Saify / Mostafa Saadat

Acta Medica Iranica, Vol 56, Iss

2019 Volume 10

Abstract: Superoxide dismutase-1 (SOD1, OMIM: 147450, copper-zinc superoxide dismutase) is one of the major antioxidant enzymes, which plays an important role in clearance of reactive oxygen species. A common genetic polymorphism of 50 bp insertion/deletion (Ins/ ... ...

Abstract	Superoxide dismutase-1 (SOD1, OMIM: 147450, copper-zinc superoxide dismutase) is one of the major antioxidant enzymes, which plays an important role in clearance of reactive oxygen species. A common genetic polymorphism of 50 bp insertion/deletion (Ins/Del) in the promoter region of the SOD1 has been reported. The purpose of the present study was to investigate the association between this polymorphism and the risk of opium (OD) and methamphetamine (MD) dependency. The present report was consisted of two case-control studies. The first study consisted of 143 OD subjects and 570 healthy controls. The second study consisted of 65 cases with MD and 635 controls. The controls were selected randomly from the healthy blood donors. Genotyping were carried out using PCR based method. Statistical analysis indicated that neither the Ins/Del (OR=1.06, 95% CI: 0.69-1.62, P=0.788) nor the Del/Del (OR=0.57, 95% CI: 0.13-2.55, P=0.464) genotypes were associated with the risk of OD. Although the frequency of the Ins/Del genotype was lower among methamphetamine-dependent persons compared to healthy control subjects, there was no significant association between the Ins/Del polymorphism and the risk of MD (OR=0.82, 95% CI: 0.44-1.53, P=0.547). The present findings demonstrated that the SOD1 50bp Ins/Del polymorphism is not associated with the risk of OD and MD.
Keywords	Drug-dependent ; Ins/Del ; Polymorphism ; SOD1 ; Medicine (General) ; R5-920
Subject code	610
Language	English
Publishing date	2019-01-01T00:00:00Z
Publisher	Tehran University of Medical Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Influence of a 50bp Ins/Del polymorphism at promoter of the superoxide dismutase-1 on gene expression and risk of heroin dependency.

Saify, Khyber / Saadat, Mostafa

Environmental health and preventive medicine

2017 Volume 22, Issue 1, Page(s) 4

Abstract: Objective: Superoxide dismutase-1 (SOD1, OMIM: 147450) is one of the major antioxidant enzymes, which plays a vital role in clearance of reactive oxygen species. A genetic polymorphism of 50 bp insertion/deletion (Ins/Del) in the promoter region of the ... ...

Abstract	Objective: Superoxide dismutase-1 (SOD1, OMIM: 147450) is one of the major antioxidant enzymes, which plays a vital role in clearance of reactive oxygen species. A genetic polymorphism of 50 bp insertion/deletion (Ins/Del) in the promoter region of the SOD1 was reported. The aims of the present study are to evaluate the influence of this polymorphism on the SOD1 mRNA levels in human peripheral blood cells and its association with risk of heroin dependency. Methods: The present study consisted of 47 healthy students of Shiraz University (south-west Iran) for investigating the association between the Ins/Del polymorphism on expression level of SOD1, also a total of 442 heroin dependent and 799 healthy controls were included in a case-control study investigating the association between the study polymorphism and risk of dependency to heroin. The quantitative SOD1 mRNA expression levels were investigated using quantitative real-time PCR. Results: Statistical analysis revealed a significant difference between the study genotypes (t = 5.17; df = 45; P < 0.001). The Del allele of the study polymorphism decreased approximately 33% of the SOD1 mRNA levels of the gene in the heterozygote individuals. Statistical analysis indicating that in both genders, neither the Ins/Del nor the Del/Del genotypes was associated with the risk of heroin addiction. Conclusions: The present study indicating that although the Ins/Del polymorphism of SOD1 is associated with the SOD1 expression levels, this polymorphism is not associated with the risk of dependency to heroin.
MeSH term(s)	Adult ; Female ; Gene Expression ; Heroin ; Heroin Dependence/genetics ; Humans ; INDEL Mutation ; Iran ; Male ; Polymorphism, Genetic ; Promoter Regions, Genetic ; Superoxide Dismutase-1/genetics ; Superoxide Dismutase-1/metabolism ; Young Adult
Chemical Substances	SOD1 protein, human ; Heroin (70D95007SX) ; Superoxide Dismutase-1 (EC 1.15.1.1)
Language	English
Publishing date	2017-03-15
Publishing country	England
Document type	Journal Article
ZDB-ID	2018758-0
ISSN	1347-4715 ; 1342-078X
ISSN (online)	1347-4715
ISSN	1342-078X
DOI	10.1186/s12199-017-0617-8
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Article ; Online: Association between variable number of tandem repeats (VNTR) polymorphism in the promoter region of monoamine oxidase A (MAOA) gene and susceptibility to heroin dependence.

Saify, Khyber / Saadat, Mostafa

Psychiatry research

2015 Volume 229, Issue 3, Page(s) 1055–1056

Language	English
Publishing date	2015-10-30
Publishing country	Ireland
Document type	Letter ; Research Support, Non-U.S. Gov't
ZDB-ID	445361-x
ISSN	1872-7123 ; 1872-7506 ; 0925-4927 ; 0165-1781
ISSN (online)	1872-7123 ; 1872-7506
ISSN	0925-4927 ; 0165-1781
DOI	10.1016/j.psychres.2015.08.017
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Article ; Online: Expression levels of OPRM1 and PDYN in human SH-SY5Y cells treated with morphine and methadone.

Saify, Khyber / Saadat, Mostafa

Life sciences

2016 Volume 150, Page(s) 39–41

Abstract: Aims: The opioid receptor mu-1 (OPRM1, site of action for methadone and morphine, OMIM: 600018) and prodynorphin (PDYN, OMIM: 131340) genes are belonging to the endogenous opioid family. There is no data on alterations of mRNA levels of PDYN and OPRM1 ... ...

Abstract	Aims: The opioid receptor mu-1 (OPRM1, site of action for methadone and morphine, OMIM: 600018) and prodynorphin (PDYN, OMIM: 131340) genes are belonging to the endogenous opioid family. There is no data on alterations of mRNA levels of PDYN and OPRM1 in cells exposed to methadone. Therefore, the present study was carried out. Main methods: Here we have investigated the alterations of the expression levels of OPRM1 and PDYN genes in response to methadone (final concentrations 1, 2.5, 5, 7.5, 10 μM) and morphine (final concentrations 1, 5, 10 μM) in human SH-SY5Y cells (at 1h, 24h, 72 h, 18 days of exposure times). Key findings: The most important findings are summaries as follow: 1) In the cells treated with morphine, the mRNA level of OPRM1 significantly decreased from 1h to 72 h in a dose dependent manner, but it is increased when the cells treated for 18 days by high concentrations of morphine; 2) Although the PDYN mRNA level is increased at 1 and 24h (for 5 and 10 μM morphine), it is decreased at 72 h and 18 days; 3) The mRNA level of OPRM1 negatively is associated with a methadone dose dependent and exposure time dependent manner; 4) In overall, the PDYN mRNA level is increased in the treated cells without any obvious trend by dose of methadone or exposure time. Significance: Decreasing the PDYN mRNA levels in cells exposed to morphine for long period times, and increasing the level of PDYN mRNA in methadone treated cells, can interpret why heroine-dependent persons, easily accept methadone therapy.
MeSH term(s)	Analgesics, Opioid/pharmacology ; Cell Line ; Dose-Response Relationship, Drug ; Enkephalins/biosynthesis ; Enkephalins/genetics ; Humans ; Methadone/pharmacology ; Morphine/pharmacology ; Protein Precursors/biosynthesis ; Protein Precursors/genetics ; RNA, Messenger/biosynthesis ; RNA, Messenger/genetics ; Receptors, Opioid, mu/biosynthesis ; Receptors, Opioid, mu/genetics
Chemical Substances	Analgesics, Opioid ; Enkephalins ; OPRM1 protein, human ; Protein Precursors ; RNA, Messenger ; Receptors, Opioid, mu ; Morphine (76I7G6D29C) ; preproenkephalin (93443-35-7) ; Methadone (UC6VBE7V1Z)
Language	English
Publishing date	2016-04-01
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	3378-9
ISSN	1879-0631 ; 0024-3205
ISSN (online)	1879-0631
ISSN	0024-3205
DOI	10.1016/j.lfs.2016.02.078
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Article ; Online: Susceptibility to methamphetamine dependence associated with high transcriptional activity alleles of VNTR polymorphism in the promoter region of monoamine oxidase A (MAOA)

Khyber Saify / Mostafa Saadat

Egyptian Journal of Medical Human Genetics, Vol 17, Iss 1, Pp 111-

2016 Volume 114

Abstract: Background and purpose: Monoamine oxidase A (MAOA, Xp11.3; OMIM: 309850) can modulate the level of neurotransmitters in the central nervous system. A 30 bp variable number of tandem repeat (VNTR) genetic polymorphism on the promoter region of the MAOA ... ...

Abstract	Background and purpose: Monoamine oxidase A (MAOA, Xp11.3; OMIM: 309850) can modulate the level of neurotransmitters in the central nervous system. A 30 bp variable number of tandem repeat (VNTR) genetic polymorphism on the promoter region of the MAOA can modulate the transcriptional activity of the gene. Association between this polymorphism and dependency to methamphetamine was investigated. Subjects and methods: A total of 65 methamphetamine abusers (52 males and 13 females) and 635 healthy controls (525 males and 110 females) were included in the present case–control study. Genotypic analysis for the MAOA VNTR polymorphism was determined by conventional PCR. Based on transcriptional activity of the VNTR alleles, the alleles were categorized into two classes: L allele (2R and 3R alleles) and H allele (3.5R, 4R and 5R alleles), which have low and high transcriptional activities, respectively. Results: Our data show that the H allele significantly increases the risk of methamphetamine dependence in males (OR = 2.03, 95% CI: 1.04–3.67, P = 0.037). The H allele seems positively associated with the risk of dependency to methamphetamine among females, but the observed OR did not reach the significance level, probability due to small sample size of the patients. Conclusion: The present study supports the role of the VNTR polymorphism on the promoter region of the MAOA on methamphetamine dependence.
Keywords	Methamphetamine dependence ; Monoamine oxidase A ; MAOA ; Polymorphism ; VNTR ; Medicine (General) ; R5-920 ; Genetics ; QH426-470
Subject code	590
Language	English
Publishing date	2016-01-01T00:00:00Z
Publisher	SpringerOpen
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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