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Article ; Online: Digital Twin applications toward Industry 4.0

Mohd Javaid / Abid Haleem / Rajiv Suman

Cognitive Robotics, Vol 3, Iss , Pp 71-

A Review

2023 Volume 92

Abstract: Digital Twin is a virtual representation of objects, processes, and systems that exist in real-time. While Digital Twin can represent digital objects, they are often used to connect the physical and digital worlds. This technology plays a vital role in ... ...

Abstract	Digital Twin is a virtual representation of objects, processes, and systems that exist in real-time. While Digital Twin can represent digital objects, they are often used to connect the physical and digital worlds. This technology plays a vital role in fulfilling various requirements of Industry 4.0. It gives a digital image of a factory's operations, a communications network's activities, or the movement of items through a logistics system. This paper studies Digital Twin and its need in Industry 4.0. Then the process and supportive features of Digital Twin for Industry 4.0 are diagrammatically discussed, and finally, the major applications of Digital Twin for Industry 4.0 are identified. Digital Twin sophistication depends on the process or product represented and the data available. Manufacturers can learn how assets will behave in real-time, in the physical world, by putting sensors on particular assets, gathering data, creating digital duplicates, and employing machine intelligence. They can confidently make wise judgments, which helps improve company performance. Digital Twin assesses material usage to save costs, discover inefficiencies, replicate tool tracking systems, and do other things. Manufacturers construct a digital clone for specific equipment and tools, exclusive products or systems, entire procedures, or anything else they want to improve on the factory floor. Sensors and other equipment that collect real-time data on the state of the process or product collect this information, which on the other hand, must be handled and processed appropriately. It is made feasible by IoT sensors, which collect data from the physical environment and transmit it to be virtually recreated. This information comprises design and engineering details that explain the asset's shape, materials, components, and behaviour or performance.
Keywords	Digital Twin ; Applications ; Industry 4.0 ; Virtual ; Digital representation ; Features ; Electronic computers. Computer science ; QA75.5-76.95
Subject code	670
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	KeAi Communications Co. Ltd.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Target product profile: aerosolized surfactant for neonatal respiratory distress.

Rao, Suman / Edmond, Karen / Bahl, Rajiv

Bulletin of the World Health Organization

2023 Volume 101, Issue 5, Page(s) 341–345

Abstract: Treatment with surfactant has been found to improve the survival rate of neonates with respiratory distress syndrome, particularly preterm infants. However, surfactant is usually administered by endotracheal intubation and generally only in level-3 ... ...

Abstract	Treatment with surfactant has been found to improve the survival rate of neonates with respiratory distress syndrome, particularly preterm infants. However, surfactant is usually administered by endotracheal intubation and generally only in level-3 neonatal intensive care units. Recent improvements in aerosolization technology have raised the possibility that aerosolized surfactant could now be given in wider range of settings, including resource-poor settings. Consequently, the World Health Organization has developed a target product profile for product developers that describes the optimal and minimal characteristics of an aerosolized surfactant for treating neonates with respiratory distress syndrome in low- and middle-income countries. Development of the target product profile involved a scoping review of systematic reviews and target product profiles of aerosolized surfactant, the constitution of an international expert advisory group, consultations with medical professionals from a wide range of countries and a public consultation. The resulting target product profile specifies that the surfactant and its associated aerosolization device should ideally, among other characteristics: (i) be at least as safe and effective as current intratracheal surfactant; (ii) produce a rapid clinical improvement; (iii) be easy to transport and use (e.g. by nurses in level-2 health-care facilities in low- and middle-income countries); (iv) be affordable for low- and middle-income countries; and (v) be stable when stored in hot and humid conditions. In addition, the aerosolization device should be capable of daily use for many years. The introduction of an effective aerosolized surfactant globally could substantially reduce neonatal mortality due to respiratory distress syndrome.
MeSH term(s)	Infant ; Infant, Newborn ; Humans ; Surface-Active Agents/therapeutic use ; Infant, Premature ; Systematic Reviews as Topic ; Pulmonary Surfactants/therapeutic use ; Respiratory Distress Syndrome, Newborn/drug therapy
Chemical Substances	Surface-Active Agents ; Pulmonary Surfactants
Language	English
Publishing date	2023-03-02
Publishing country	Switzerland
Document type	Review ; Journal Article
ZDB-ID	80213-x
ISSN	1564-0604 ; 0042-9686 ; 0366-4996 ; 0510-8659
ISSN (online)	1564-0604
ISSN	0042-9686 ; 0366-4996 ; 0510-8659
DOI	10.2471/BLT.23.289727
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Journal ; Article ; Online: Target product profile

Rao, Suman / Edmond, Karen / Bahl, Rajiv

aerosolized surfactant for neonatal respiratory distress

2023

Abstract: ... 341 ... ...

Abstract	341 345
Keywords	Policy & Practice
Publisher	World Health Organization
Document type	Journal ; Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Successful T replete haploidentical HSCT with post-transplant cyclophosphamide in two patients with Wiskott-Aldrich syndrome.

Kapoor, Rajan / Yanamandra, Uday / Kumar, Rajiv / Pramanik, Suman Kumar

Medical journal, Armed Forces India

2023 Volume 79, Issue 6, Page(s) 722–725

Abstract: We describe two young patients with Wiskott-Aldrich Syndrome (WAS) who were treated by T-replete hematopoietic stem cell transplantation (HSCT) from the HLA haploidentical father according to a modified Baltimore protocol. Whereas similar protocols have ... ...

Abstract	We describe two young patients with Wiskott-Aldrich Syndrome (WAS) who were treated by T-replete hematopoietic stem cell transplantation (HSCT) from the HLA haploidentical father according to a modified Baltimore protocol. Whereas similar protocols have been successfully used in various malignant and non-malignant diseases, this is the first report for this particular disease. The data being presented pertains to the report about two successful haploidentical transplants with post transplant cyclophosphamide (PTCY) after busulfan-based conditioning.
Language	English
Publishing date	2023-09-12
Publishing country	India
Document type	Case Reports
ZDB-ID	196342-9
ISSN	0377-1237
ISSN	0377-1237
DOI	10.1016/j.mjafi.2023.08.015
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Article ; Online: Exploring the capabilities of modern technologies for health care

Abid Haleem / Mohd Javaid / Rajiv Suman / Raju Vaishya

Apollo Medicine, Vol 19, Iss 1, Pp 37-

2022 Volume 40

Abstract: Modern technologies offer several new applications and have several benefits in health-care delivery. These technologies include the Internet of things, artificial intelligence, wearable devices, telemedicine, virtual reality, and robotics. These enable ... ...

Abstract	Modern technologies offer several new applications and have several benefits in health-care delivery. These technologies include the Internet of things, artificial intelligence, wearable devices, telemedicine, virtual reality, and robotics. These enable targeted personalized health and well-being services. At present, the pharmaceutical industry is confronted with considerable hurdles and financial burdens related to clinical trial, retention, and adherence. Modern technologies allow participation in clinical studies from the comfort of home or any other location as per requirement. In the present digital era, patients can regularly expect more information about their health by using these technologies. These also reduce the chances of errors and precisely evaluate the amount of data and better analysis. Therefore, health-care service providers are now taking a proactive approach by adopting in wearable technology that can enable real-time monitoring of high-risk patients to predict the possibility of a catastrophic health crisis. Telecommunication equipment is more user-friendly and has been utilized by a large population all over the world, which is helpful to reduce the communication gap. In this review, we aimed to identify and discuss the significant capabilities of modern technologies for health-care delivery.
Keywords	digital health care ; health-care capabilities ; medical ; modern technologies ; Medicine ; R
Subject code	360
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	Wolters Kluwer Medknow Publications
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Intratumoural metastasis of primary lung adenocarcinoma to non-invasive follicular thyroid neoplasm with papillary-like nuclear features.

Yadav, Subhash / Ankathi, Suman Kumar / Patil, Asawari / Kaushal, Rajiv

Pathologica

2023 Volume 115, Issue 3, Page(s) 186–191

Abstract: Metastasis to the thyroid gland is very uncommon with an incidence of 2-3% of all thyroid malignancies. A higher incidence is noted in autopsy studies indicating incidental detection. However, tumour-to-tumour metastasis is extremely uncommon with a ... ...

Abstract	Metastasis to the thyroid gland is very uncommon with an incidence of 2-3% of all thyroid malignancies. A higher incidence is noted in autopsy studies indicating incidental detection. However, tumour-to-tumour metastasis is extremely uncommon with a handful of cases published in the literature to date. Also, non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFT-P) is a rare neoplasm; diagnosis requires meticulous sampling of the entire capsule and fulfilment of other diagnostic criteria. We report a case of primary adenocarcinoma of lung in a 57-year-old female who additionally had a left thyroid nodule which appeared suspicious on ultrasonography. Histology of lung tumour was conventional papillary adenocarcinoma while aspiration cytology from the thyroid raised suspicion of metastatic adenocarcinoma. On hemithyroidectomy, the thyroid nodule showed metastatic adenocarcinoma in the centre of the nodule, while the peripheral portion showed non-invasive follicular thyroid neoplasm with papillary-like nuclear features; the diagnosis of which was confirmed with complete sampling of the thyroid capsule. The immunoprofile also supported the above dual histology. This is an extremely uncommon occurrence and metastasis within a NIFT-P has not been reported to the best of our knowledge.
MeSH term(s)	Female ; Humans ; Middle Aged ; Thyroid Nodule/pathology ; Adenocarcinoma, Follicular/diagnostic imaging ; Adenocarcinoma, Follicular/surgery ; Thyroid Cancer, Papillary/pathology ; Thyroid Neoplasms/diagnosis ; Thyroid Neoplasms/surgery ; Thyroid Neoplasms/pathology ; Adenocarcinoma of Lung ; Lung Neoplasms/diagnosis
Language	English
Publishing date	2023-05-22
Publishing country	Italy
Document type	Case Reports
ZDB-ID	418229-7
ISSN	1591-951X ; 0031-2983
ISSN (online)	1591-951X
ISSN	0031-2983
DOI	10.32074/1591-951X-780
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Article ; Online: 3D printing applications for healthcare research and development

Mohd Javaid / Abid Haleem / Ravi Pratap Singh / Rajiv Suman

Global Health Journal, Vol 6, Iss 4, Pp 217-

2022 Volume 226

Abstract: There is a growing demand for customised, biocompatible, and sterilisable components in the medical business. 3D Printing is a disruptive technology for healthcare and provides significant research and development avenues. Simple 3D printing service ... ...

Abstract	There is a growing demand for customised, biocompatible, and sterilisable components in the medical business. 3D Printing is a disruptive technology for healthcare and provides significant research and development avenues. Simple 3D printing service gives patients low-cost individualised prostheses, implants, and gadgets, enabling surgeons to operate more effectively with customised equipment and models; and assisting medical device manufacturers in developing new and faster goods. 3D printed tissue pieces can overcome various challenges and may eventually allow medication companies to streamline research and development. In the long run, it may also assist in lowering prices and making medicines more accessible and effective for everybody. There is a growing corpus of research on the advantages of employing 3D printed anatomic models in teaching and training. The capacity to 3D printing individual anatomical diseases for practical learning is one of the fundamental contrasts between utilising 3D and regular anatomical models. 3D printing is very appealing for producing patient-specific implants. This literature review-based paper explores the role of 3D printing and 3D bioprinting in healthcare. It briefs the need and progressive steps for implementing 3D printing in healthcare and presented various facilities and enablers of 3D printing for the healthcare sector. Finally, this paper identifies and discusses the significant applications of 3D printing for healthcare research and development. 3D printing services can be deployed to easily construct complex geometries in plastic or metal with good precision. This results in improved prototypes, lower costs, and lower part processing times. They can now physically create with natural materials, previously unattainable with prior technologies. Every hospital should have 3D printers in the future, allowing new organs/parts to be developed in-house.
Keywords	3D printing ; Healthcare ; Medical ; Research ; Development ; Medicine ; R
Subject code	670
Language	English
Publishing date	2022-12-01T00:00:00Z
Publisher	KeAi Communications Co., Ltd.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Global newborn health research priorities identified in 2014

Shuchita Gupta / Suman PN Rao / Sachiyo Yoshida / Rajiv Bahl

EClinicalMedicine, Vol 52, Iss , Pp 101599- (2022)

A review to evaluate the uptake

2022

Abstract: Summary: Background: In 2014, World Health Organization published global research priorities for newborn health till 2025. We conducted this review to summarize completed or ongoing research on the twenty priorities. Methods: We conducted searches for ... ...

Abstract	Summary: Background: In 2014, World Health Organization published global research priorities for newborn health till 2025. We conducted this review to summarize completed or ongoing research on the twenty priorities. Methods: We conducted searches for twenty questions on MEDLINE via PubMed, Cochrane CENTRAL, Web of Science, clinical trial registries, and funder websites between July 2014 and May 2022. Studies addressing research questions using adequate design were included. Adequacy of uptake of a priority was assessed based on predefined criteria. Findings: The uptake of research priorities was high for 8 (40%), moderate for 11 (55%), and one priority, effectiveness of training community health workers (CHWs) to treat neonatal sepsis at home remains unaddressed. Priorities with moderate uptake include effectiveness of simplified neonatal resuscitation programme, simple clinical algorithms for CHWs to neonatal infection, CHWs training in basic neonatal resuscitation, community-initiated kangaroo mother care, perinatal audits, and novel tocolytic agents, scaling-up chlorhexidine cord application, stable surfactant with simpler administration, accurate, affordable methods to diagnose fetal distress, strategies for prevention and treatment of intrauterine growth retardation, and causal pathways for antenatal stillbirths. Interpretation: Adequate research was undertaken on pressing global concerns in newborn health. Funders and researchers should reflect on and address less researched areas. Funding: None.
Keywords	Medicine (General) ; R5-920
Subject code	306
Language	English
Publishing date	2022-10-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Cross-sectional imaging review of common to uncommon lung cancer mimickers in a tertiary care oncology center.

Patnam, Nandakumar / Trivedi, Kamaxi / Janu, Amit / Kaushal, Rajiv Kumar / Kulkarni, Suyash / Ankathi, Suman Kumar

Acta radiologica (Stockholm, Sweden : 1987)

2023 Volume 64, Issue 10, Page(s) 2731–2747

Abstract: Lung cancer is the most diagnosed cancer worldwide. Many non-malignant pulmonary lesions, such as tuberculosis, fungal infection, organizing pneumonia, inflammatory myofibroblastic tumor, and IgG4 disease, can mimic lung cancer due to their overlapping ... ...

Abstract	Lung cancer is the most diagnosed cancer worldwide. Many non-malignant pulmonary lesions, such as tuberculosis, fungal infection, organizing pneumonia, inflammatory myofibroblastic tumor, and IgG4 disease, can mimic lung cancer due to their overlapping morphological appearance on imaging. These benign entities with minor differentiating imaging clues may go unnoticed in a high-volume cancer institution, leading to over-investigation that may result in repeated biopsies, pointless wedge resections, and related morbidities. However, with a thorough medical history, laboratory diagnostic work-up, and careful analysis of imaging findings, one can occasionally restrict the range of possible diagnoses or arrive at a definitive conclusion. When imaging features overlap, image-guided lung sampling is crucial since histopathological analysis is the gold standard.
MeSH term(s)	Humans ; Tertiary Healthcare ; Tomography, X-Ray Computed ; Lung Neoplasms/pathology ; Lung/pathology ; Pneumonia/pathology
Language	English
Publishing date	2023-08-18
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	105-3
ISSN	1600-0455 ; 0284-1851 ; 0349-652X
ISSN (online)	1600-0455
ISSN	0284-1851 ; 0349-652X
DOI	10.1177/02841851231191987
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Article: 3D Printing Applications for Radiology: An Overview.

Haleem, Abid / Javaid, Mohd / Suman, Rajiv / Singh, Ravi Pratap

The Indian journal of radiology & imaging

2021 Volume 31, Issue 1, Page(s) 10–17

Abstract: Three-dimensional (3D) printing technologies are part of additive manufacturing processes and are used to manufacture a 3D physical model from a digital computer-aided design model as per the required shape and size. These technologies are now used for ... ...

Abstract	Three-dimensional (3D) printing technologies are part of additive manufacturing processes and are used to manufacture a 3D physical model from a digital computer-aided design model as per the required shape and size. These technologies are now used for advanced radiology applications by providing all information through 3D physical model. It provides innovation in radiology for clinical applications, treatment planning, procedural simulation, medical and patient education. Radiological advancements have been made in diagnosis and communication through medical digital imaging techniques like computed tomography, magnetic resonance imaging. These images are converted into Digital Imaging and Communications in Medicine in Standard Triangulate Language file format, easily printable in 3D printing technologies. This 3D model provides in-depth information about pathologic and anatomic states. It is useful to create new opportunities related to patient care. This article discusses the potential of 3D printing technology in radiology. The steps involved in 3D printing for radiology are discussed diagrammatically, and finally identified 12 significant applications of 3D printing technology for radiology with a brief description. A radiologist can incorporate this technology to fulfil different challenges such as training, planning, guidelines, and better communications.
Language	English
Publishing date	2021-06-01
Publishing country	India
Document type	Journal Article ; Review
ZDB-ID	605869-3
ISSN	0971-3026 ; 0970-2016
ISSN	0971-3026 ; 0970-2016
DOI	10.1055/s-0041-1729129
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