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Article: The Association Between the Patient Self-Report Survey for the Assessment of Fibromyalgia with Pain Sensitivity and Psychological Factors in Individuals with Musculoskeletal Pain.

Wilson, Abigail T / Razzell, Charlotte / Hanney, William J

2023 Volume 16, Page(s) 3297–3308

Abstract: Purpose: The Patient Self-Report Survey for the Assessment of Fibromyalgia may potentially be a method for subgrouping patients with musculoskeletal pain who have a nociplastic pain presentation. Limited research has explored the convergent validity of ... ...

Abstract	Purpose: The Patient Self-Report Survey for the Assessment of Fibromyalgia may potentially be a method for subgrouping patients with musculoskeletal pain who have a nociplastic pain presentation. Limited research has explored the convergent validity of this questionnaire against psychophysical measures of pain sensitivity and psychological factors in individuals with musculoskeletal pain. Therefore, the purpose of this study is to examine the strength of the association between total scores on the Patient Self-Report Survey for the Assessment of Fibromyalgia with clinical, pain sensitivity, and psychological factors. Patients and methods: As a secondary analysis of a cross-sectional study, participants with shoulder (n = 20) or low back pain (n = 20) completed Quantitative Sensory Testing (QST), pain-related psychological questionnaires, and the Patient Self-Report Survey for the Assessment of Fibromyalgia. A Spearman correlation determined the association between total scores on the Patient Self Report Survey for the Assessment of Fibromyalgia with psychological factors and pain sensitivity behaviorally assessed with QST. Results: Negative psychological factors demonstrate moderate to strong positive associations with the Patient Self-Report Survey for the Assessment of Fibromyalgia (rho range = 0.36-0.80), suggesting greater negative psychological factors were observed in patients with higher severity of fibromyalgia symptoms. Pain sensitivity factors demonstrated weak to moderate negative associations with The Patient Self-Report Survey for the Assessment of Fibromyalgia (PPT rho range=-0.36- -0.41), suggesting that elevated pain sensitivity was observed in individuals with higher severity of nociplastic pain symptoms. Conclusion: Collectively, this supports the convergent validity of the Patient Self-Report Survey for the Assessment of Fibromyalgia with psychological and pain sensitivity factors in patients with musculoskeletal pain.
Language	English
Publishing date	2023-09-28
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2495284-9
ISSN	1178-7090
ISSN	1178-7090
DOI	10.2147/JPR.S425687
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The force-sensitive protein Ajuba regulates cell adhesion during epithelial morphogenesis.

Razzell, William / Bustillo, Maria E / Zallen, Jennifer A

The Journal of cell biology

2018 Volume 217, Issue 10, Page(s) 3715–3730

Abstract: The reorganization of cells in response to mechanical forces converts simple epithelial sheets into complex tissues of various shapes and dimensions. Epithelial integrity is maintained throughout tissue remodeling, but the mechanisms that regulate ... ...

Abstract	The reorganization of cells in response to mechanical forces converts simple epithelial sheets into complex tissues of various shapes and dimensions. Epithelial integrity is maintained throughout tissue remodeling, but the mechanisms that regulate dynamic changes in cell adhesion under tension are not well understood. In
MeSH term(s)	Actomyosin/genetics ; Actomyosin/metabolism ; Adherens Junctions/genetics ; Adherens Junctions/metabolism ; Animals ; Cell Adhesion/genetics ; Drosophila Proteins/genetics ; Drosophila Proteins/metabolism ; Drosophila melanogaster ; Epithelium/embryology ; LIM Domain Proteins/genetics ; LIM Domain Proteins/metabolism ; Morphogenesis/physiology ; Protein Domains
Chemical Substances	Drosophila Proteins ; LIM Domain Proteins ; jub protein, Drosophila ; Actomyosin (9013-26-7)
Language	English
Publishing date	2018-07-13
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	218154-x
ISSN	1540-8140 ; 0021-9525
ISSN (online)	1540-8140
ISSN	0021-9525
DOI	10.1083/jcb.201801171
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Article ; Online: A Deep Ultraviolet Raman and Fluorescence Spectral Library of 51 Organic Compounds for the SHERLOC Instrument Onboard Mars 2020.

Razzell Hollis, Joseph / Sharma, Sunanda / Abbey, William / Bhartia, Rohit / Beegle, Luther / Fries, Marc / Hein, Jeffrey D / Monacelli, Brian / Nordman, Austin D

Astrobiology

2022 Volume 23, Issue 1, Page(s) 1–23

Abstract: We report deep ultraviolet (DUV) Raman and Fluorescence spectra obtained on a SHERLOC (Scanning Habitable Environments with Raman and Luminescence for Organics and Chemicals) analog instrument for 51 pure organic compounds, including 5 carboxylic acids, ... ...

Abstract	We report deep ultraviolet (DUV) Raman and Fluorescence spectra obtained on a SHERLOC (Scanning Habitable Environments with Raman and Luminescence for Organics and Chemicals) analog instrument for 51 pure organic compounds, including 5 carboxylic acids, 10 polycyclic aromatic hydrocarbons, 24 amino acids, 6 nucleobases, and 6 different grades of macromolecular carbon from humic acid to graphite. Organic mixtures were not investigated. We discuss how the DUV fluorescence and Raman spectra exhibited by different organic compounds allow for detection, classification, and identification of organics by SHERLOC. We find that 1- and 2-ring aromatic compounds produce detectable fluorescence within SHERLOC's spectral range (250-355 nm), but fluorescence spectra are not unique enough to enable easy identification of particular compounds. However, both aromatic and aliphatic compounds can be identified by their Raman spectra, with the number of Raman peaks and their positions being highly specific to chemical structure, within SHERLOC's reported spectral uncertainty of ±5 cm
MeSH term(s)	Fluorescence ; Organic Chemicals ; Carboxylic Acids ; Carbon ; Graphite ; Mars ; Spectrum Analysis, Raman
Chemical Substances	Organic Chemicals ; Carboxylic Acids ; Carbon (7440-44-0) ; Graphite (7782-42-5)
Language	English
Publishing date	2022-11-11
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	2047736-3
ISSN	1557-8070 ; 1531-1074
ISSN (online)	1557-8070
ISSN	1531-1074
DOI	10.1089/ast.2022.0023
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Article ; Online: Detection and Degradation of Adenosine Monophosphate in Perchlorate-Spiked Martian Regolith Analog, by Deep-Ultraviolet Spectroscopy.

Razzell Hollis, Joseph / Fornaro, Teresa / Rapin, William / Wade, Jessica / Vicente-Retortillo, Álvaro / Steele, Andrew / Bhartia, Rohit / Beegle, Luther W

Astrobiology

2021 Volume 21, Issue 5, Page(s) 511–525

Abstract: The search for organic biosignatures on Mars will depend on finding material protected from the destructive ambient radiation. Solar ultraviolet can induce photochemical degradation of organic compounds, but certain clays have been shown to preserve ... ...

Abstract	The search for organic biosignatures on Mars will depend on finding material protected from the destructive ambient radiation. Solar ultraviolet can induce photochemical degradation of organic compounds, but certain clays have been shown to preserve organic material. We examine how the SHERLOC instrument on the upcoming
MeSH term(s)	Adenosine Monophosphate ; Extraterrestrial Environment ; Mars ; Perchlorates ; Spectrometry, Fluorescence ; Ultraviolet Rays
Chemical Substances	Perchlorates ; Adenosine Monophosphate (415SHH325A)
Language	English
Publishing date	2021-01-25
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	2047736-3
ISSN	1557-8070 ; 1531-1074
ISSN (online)	1557-8070
ISSN	1531-1074
DOI	10.1089/ast.2020.2362
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Article ; Online: Cell biology. Embryonic clutch control.

Razzell, William / Martin, Paul

Science (New York, N.Y.)

2012 Volume 335, Issue 6073, Page(s) 1181–1182

MeSH term(s)	Actomyosin/physiology ; Animals ; Caenorhabditis elegans/cytology ; Caenorhabditis elegans/embryology ; Cell Shape ; Drosophila melanogaster/cytology ; Drosophila melanogaster/embryology ; Gastrulation
Chemical Substances	Actomyosin (9013-26-7)
Language	English
Publishing date	2012-03-09
Publishing country	United States
Document type	Comment ; Journal Article
ZDB-ID	128410-1
ISSN	1095-9203 ; 0036-8075
ISSN (online)	1095-9203
ISSN	0036-8075
DOI	10.1126/science.1220388
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Article ; Online: Recapitulation of morphogenetic cell shape changes enables wound re-epithelialisation.

Razzell, William / Wood, Will / Martin, Paul

Development (Cambridge, England)

2014 Volume 141, Issue 9, Page(s) 1814–1820

Abstract: Wound repair is a fundamental, conserved mechanism for maintaining tissue homeostasis and shares many parallels with embryonic morphogenesis. Small wounds in simple epithelia rapidly assemble a contractile actomyosin cable at their leading edge, as well ... ...

Abstract	Wound repair is a fundamental, conserved mechanism for maintaining tissue homeostasis and shares many parallels with embryonic morphogenesis. Small wounds in simple epithelia rapidly assemble a contractile actomyosin cable at their leading edge, as well as dynamic filopodia that finally knit the wound edges together. Most studies of wound re-epithelialisation have focused on the actin machineries that assemble in the leading edge of front row cells and that resemble the contractile mechanisms that drive morphogenetic episodes, including Drosophila dorsal closure, but, clearly, multiple cell rows back must also contribute for efficient repair of the wound. Here, we examine the role of cells back from the wound edge and show that they also stretch towards the wound and cells anterior-posterior to the wound edge rearrange their junctions with neighbours to drive cell intercalation events. This process in anterior-posterior cells is active and dependent on pulses of actomyosin that lead to ratcheted shrinkage of junctions; the actomyosin pulses are targeted to breaks in the cell polarity protein Par3 at cell vertices. Inhibiting actomyosin dynamics back from the leading edge prevents junction shrinkage and inhibits the wound edge from advancing. These events recapitulate cell rearrangements that occur during germband extension, in which intercalation events drive the elongation of tissues.
MeSH term(s)	Animals ; Cell Polarity ; Cell Shape ; Drosophila melanogaster/cytology ; Drosophila melanogaster/embryology ; Embryo, Nonmammalian/cytology ; Epithelium/embryology ; Epithelium/pathology ; Intercellular Junctions/metabolism ; Morphogenesis ; Myosins/metabolism ; Wound Healing
Chemical Substances	Myosins (EC 3.6.4.1)
Language	English
Publishing date	2014-04-09
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	90607-4
ISSN	1477-9129 ; 0950-1991
ISSN (online)	1477-9129
ISSN	0950-1991
DOI	10.1242/dev.107045
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Article ; Online: Swatting flies: modelling wound healing and inflammation in Drosophila.

Razzell, William / Wood, Will / Martin, Paul

Disease models & mechanisms

2011 Volume 4, Issue 5, Page(s) 569–574

Abstract: Aberrant wound healing can lead to a variety of human pathologies, from non-healing chronic wounds that can become dangerously infected, to exuberant fibrotic healing in which repair is accompanied by excessive inflammation. To guide therapeutic ... ...

Abstract	Aberrant wound healing can lead to a variety of human pathologies, from non-healing chronic wounds that can become dangerously infected, to exuberant fibrotic healing in which repair is accompanied by excessive inflammation. To guide therapeutic intervention, we need a better understanding of the fundamental mechanisms driving tissue repair; this will require complementary wound-healing studies in several model organisms. Drosophila has been used to model genetic aspects of numerous human pathologies, and is being used increasingly to gain insight into the molecular and genetic aspects of tissue repair and inflammation, which have classically been modelled in mice or cultured cells. This review discusses the advantages and disadvantages of Drosophila as a wound-healing model, as well as some exciting new research opportunities that will be enabled by its use.
MeSH term(s)	Animals ; Disease Models, Animal ; Drosophila/genetics ; Drosophila/immunology ; Drosophila/metabolism ; Epithelium/metabolism ; Epithelium/pathology ; Inflammation/pathology ; Signal Transduction/genetics ; Wound Healing/genetics
Language	English
Publishing date	2011-08-02
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2451104-3
ISSN	1754-8411 ; 1754-8403
ISSN (online)	1754-8411
ISSN	1754-8403
DOI	10.1242/dmm.006825
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Article ; Online: 'White wave' analysis of epithelial scratch wound healing reveals how cells mobilise back from the leading edge in a myosin-II-dependent fashion.

Matsubayashi, Yutaka / Razzell, William / Martin, Paul

Journal of cell science

2011 Volume 124, Issue Pt 7, Page(s) 1017–1021

Abstract: Collective cell migration is absolutely essential for a wide variety of physiological episodes including the re-epithelialisation component of tissue repair. However, the investigation of such processes has been frustrated by difficulties in ... ...

Abstract	Collective cell migration is absolutely essential for a wide variety of physiological episodes including the re-epithelialisation component of tissue repair. However, the investigation of such processes has been frustrated by difficulties in quantitatively analysing the behaviours of a large body of cells within a migrating epithelial sheet, which previously required manually tracking a large number of individual cells, or using advanced computational techniques. Here, we describe a novel and simpler image subtraction method with which we can visualise and quantify collective cell mobilisation as a 'white wave' that propagates back from the leading edge of a scratch-wounded monolayer of cultured epithelial cells. Using this technique, we show that actomyosin constriction negatively regulates cell mobilisation and that the advancement of cell sheets and the mobilisation of rows of cells behind their leading edges are independently regulated. We also show that there is a finite limit to the number of rows of cells mobilised after wounding. Moreover, our data suggest that enhancing cell mobilisation, by release from myosin II contractility, accelerates the healing of large wounds in the long term, thus raising the possibility that the cell mobilisation 'wave' we reveal here might be a therapeutic target for improving wound healing.
MeSH term(s)	Animals ; Cell Movement ; Cells, Cultured ; Epithelial Cells/cytology ; Epithelial Cells/metabolism ; Mice ; Myosin Type II/genetics ; Myosin Type II/metabolism ; Wound Healing
Chemical Substances	Myosin Type II (EC 3.6.1.-)
Language	English
Publishing date	2011-03-14
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2993-2
ISSN	1477-9137 ; 0021-9533
ISSN (online)	1477-9137
ISSN	0021-9533
DOI	10.1242/jcs.080853
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Article ; Online: Calcium flashes orchestrate the wound inflammatory response through DUOX activation and hydrogen peroxide release.

Razzell, William / Evans, Iwan Robert / Martin, Paul / Wood, Will

Current biology : CB

2013 Volume 23, Issue 5, Page(s) 424–429

Abstract: A crucial early wound response is the recruitment of inflammatory cells drawn by danger cues released by the damaged tissue. Hydrogen peroxide (H2O2) has recently been identified as the earliest wound attractant in Drosophila embryos and zebrafish larvae. ...

Abstract	A crucial early wound response is the recruitment of inflammatory cells drawn by danger cues released by the damaged tissue. Hydrogen peroxide (H2O2) has recently been identified as the earliest wound attractant in Drosophila embryos and zebrafish larvae. The H2O2 signal is generated by activation of an NADPH oxidase, DUOX, and as a consequence, the first inflammatory cells are recruited to the wound within minutes. To date, nothing is known about how wounding activates DUOX. Here, we show that laser wounding of the Drosophila embryo epidermis triggers an instantaneous calcium flash, which travels as a wave via gap junctions several cell rows back from the wound edge. Blocking this calcium flash inhibits H2O2 release at the wound site and leads to a reduction in the number of immune cells migrating to the wound. We suggest that the wound-induced calcium flash activates DUOX via an EF hand calcium-binding motif and thus triggers the production of the attractant damage cue H2O2. Therefore, calcium represents the earliest signal in the wound inflammatory response.
MeSH term(s)	Animals ; Calcium Signaling ; Carrier Proteins/metabolism ; Drosophila ; Drosophila Proteins/metabolism ; Hemocytes/physiology ; Hydrogen Peroxide/metabolism ; Inflammation/metabolism ; NADPH Oxidases/metabolism ; Wound Healing
Chemical Substances	Carrier Proteins ; Drosophila Proteins ; mol protein, Drosophila ; Hydrogen Peroxide (BBX060AN9V) ; NADPH Oxidases (EC 1.6.3.-)
Language	English
Publishing date	2013-02-07
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1071731-6
ISSN	1879-0445 ; 0960-9822
ISSN (online)	1879-0445
ISSN	0960-9822
DOI	10.1016/j.cub.2013.01.058
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Article: Calcium Flashes Orchestrate the Wound Inflammatory Response through DUOX Activation and Hydrogen Peroxide Release

Razzell, William / Evans, Iwan Robert / Martin, Paul / Wood, Will

Current biology. 2013 Mar. 4, v. 23, no. 5

2013

Abstract: A crucial early wound response is the recruitment of inflammatory cells drawn by danger cues released by the damaged tissue. Hydrogen peroxide (H₂O₂) has recently been identified as the earliest wound attractant in Drosophila embryos and zebrafish larvae ...

Abstract	A crucial early wound response is the recruitment of inflammatory cells drawn by danger cues released by the damaged tissue. Hydrogen peroxide (H₂O₂) has recently been identified as the earliest wound attractant in Drosophila embryos and zebrafish larvae [1, 2]. The H₂O₂ signal is generated by activation of an NADPH oxidase, DUOX, and as a consequence, the first inflammatory cells are recruited to the wound within minutes. To date, nothing is known about how wounding activates DUOX. Here, we show that laser wounding of the Drosophila embryo epidermis triggers an instantaneous calcium flash, which travels as a wave via gap junctions several cell rows back from the wound edge. Blocking this calcium flash inhibits H₂O₂ release at the wound site and leads to a reduction in the number of immune cells migrating to the wound. We suggest that the wound-induced calcium flash activates DUOX via an EF hand calcium-binding motif and thus triggers the production of the attractant damage cue H₂O₂. Therefore, calcium represents the earliest signal in the wound inflammatory response.
Keywords	Danio rerio ; Drosophila ; calcium ; gap junctions ; hydrogen peroxide ; inflammation ; larvae
Language	English
Dates of publication	2013-0304
Size	p. 424-429.
Publishing place	Elsevier Inc.
Document type	Article
ZDB-ID	1071731-6
ISSN	1879-0445 ; 0960-9822
ISSN (online)	1879-0445
ISSN	0960-9822
DOI	10.1016/j.cub.2013.01.058
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