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Article ; Online: Gut microbiota-derived butyrate promotes coronavirus TGEV infection through impairing RIG-I-triggered local type I interferon responses via class I HDAC inhibition.

Yin, Lingdan / Liu, Xiang / Yao, Yao / Yuan, Mengqi / Luo, Yi / Zhang, Guozhong / Pu, Juan / Liu, Pinghuang

2024 Volume 98, Issue 2, Page(s) e0137723

Abstract: Gut microbiota-derived metabolites are important for the replication and pathogenesis of many viruses. However, the roles of bacterial metabolites in swine enteric coronavirus (SECoV) infection remain poorly understood. Recent studies show that SECoVs ... ...

Abstract	Gut microbiota-derived metabolites are important for the replication and pathogenesis of many viruses. However, the roles of bacterial metabolites in swine enteric coronavirus (SECoV) infection remain poorly understood. Recent studies show that SECoVs infection
MeSH term(s)	Animals ; Butyrates/metabolism ; Coronavirus/physiology ; Coronavirus Infections/immunology ; Coronavirus Infections/veterinary ; Coronavirus Infections/virology ; Gastrointestinal Microbiome ; Interferon Type I/immunology ; RNA, Viral ; Swine ; Transmissible gastroenteritis virus/physiology ; Swine Diseases/immunology ; Swine Diseases/virology
Chemical Substances	Butyrates ; Interferon Type I ; RNA, Viral
Language	English
Publishing date	2024-01-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	80174-4
ISSN	1098-5514 ; 0022-538X
ISSN (online)	1098-5514
ISSN	0022-538X
DOI	10.1128/jvi.01377-23
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: A study on the psychological needs of nurses caring for patients with coronavirus disease 2019 from the perspective of the existence, relatedness, and growth theory

Xue Yin / Lingdan Zeng

International Journal of Nursing Sciences, Vol 7, Iss 2, Pp 157-

2020 Volume 160

Abstract: Objective: This study aimed to explore the psychological needs of nurses caring for patients with coronavirus disease 2019(COVID-19) and to propose corresponding interventions. Methods: In-depth interviews were conducted with 10 nurses who cared for ... ...

Abstract	Objective: This study aimed to explore the psychological needs of nurses caring for patients with coronavirus disease 2019(COVID-19) and to propose corresponding interventions. Methods: In-depth interviews were conducted with 10 nurses who cared for patients with COVID-19. Interview data were analyzed by category analysis from the perspective of the existence, relatedness, and growth theory (ERG). Results: The existence needs were mainly reflected in health and security needs, whereas the relatedness needs consisting mainly of interpersonal needs, humanistic concern needs, and family needs; further, the growth needs were mainly reflected as a strong need for knowledge. Existence needs were the main needs during the epidemic, with health and security needs influencing each other. Humanistic concern needs were the most important of the relatedness needs; interpersonal and family needs were also growing. Conclusion: It is found that the existence, relatedness, and growth needs coexist in clinical nurses. It is helpful to take effective interventions to meet their needs if the needs of nurses caring for COVID-19 patients could be perceived well.
Keywords	COVID-19 ; Nursing staff ; Psychological needs ; The existence ; relatedness and growth theory ; Nursing ; RT1-120 ; covid19
Subject code	306
Language	English
Publishing date	2020-04-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: A study on the psychological needs of nurses caring for patients with coronavirus disease 2019 from the perspective of the existence, relatedness, and growth theory.

Yin, Xue / Zeng, Lingdan

International journal of nursing sciences

2020 Volume 7, Issue 2, Page(s) 157–160

Abstract: Objective: This study aimed to explore the psychological needs of nurses caring for patients with coronavirus disease 2019(COVID-19) and to propose corresponding interventions.: Methods: In-depth interviews were conducted with 10 nurses who cared for ...

Abstract	Objective: This study aimed to explore the psychological needs of nurses caring for patients with coronavirus disease 2019(COVID-19) and to propose corresponding interventions. Methods: In-depth interviews were conducted with 10 nurses who cared for patients with COVID-19. Interview data were analyzed by category analysis from the perspective of the existence, relatedness, and growth theory (ERG). Results: The existence needs were mainly reflected in health and security needs, whereas the relatedness needs consisting mainly of interpersonal needs, humanistic concern needs, and family needs; further, the growth needs were mainly reflected as a strong need for knowledge. Existence needs were the main needs during the epidemic, with health and security needs influencing each other. Humanistic concern needs were the most important of the relatedness needs; interpersonal and family needs were also growing. Conclusion: It is found that the existence, relatedness, and growth needs coexist in clinical nurses. It is helpful to take effective interventions to meet their needs if the needs of nurses caring for COVID-19 patients could be perceived well.
Keywords	covid19
Language	English
Publishing date	2020-04-04
Publishing country	China
Document type	Journal Article
ZDB-ID	2800296-9
ISSN	2352-0132 ; 2352-0132
ISSN (online)	2352-0132
ISSN	2352-0132
DOI	10.1016/j.ijnss.2020.04.002
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Erratum: Targeting cysteine-rich angiogenic inducer-61 by antibody immunotherapy suppresses growth and migration of non-small cell lung cancer.

Li, Xinpeng / Yuan, Naxin / Lin, Lingdan / Yin, Lixia / Qu, Yiqing

Experimental and therapeutic medicine

2022 Volume 24, Issue 1, Page(s) 438

Abstract: This corrects the article DOI: 10.3892/etm.2018.6274.]. ...

Abstract	[This corrects the article DOI: 10.3892/etm.2018.6274.].
Language	English
Publishing date	2022-05-11
Publishing country	Greece
Document type	Published Erratum
ZDB-ID	2683844-8
ISSN	1792-1015 ; 1792-0981
ISSN (online)	1792-1015
ISSN	1792-0981
DOI	10.3892/etm.2022.11365
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Swine Enteric Coronaviruses (PEDV, TGEV, and PDCoV) Induce Divergent Interferon-Stimulated Gene Responses and Antigen Presentation in Porcine Intestinal Enteroids.

Yin, Lingdan / Liu, Xiang / Hu, Dongmei / Luo, Yi / Zhang, Guozhong / Liu, Pinghuang

Frontiers in immunology

2022 Volume 12, Page(s) 826882

Abstract: Swine enteric coronaviruses (SECoVs) including porcine epidemic diarrhea virus (PEDV), transmissible gastroenteritis virus (TGEV), and porcine deltacoronavirus (PDCoV), account for the majority of lethal watery diarrhea in neonatal pigs and pose ... ...

Abstract	Swine enteric coronaviruses (SECoVs) including porcine epidemic diarrhea virus (PEDV), transmissible gastroenteritis virus (TGEV), and porcine deltacoronavirus (PDCoV), account for the majority of lethal watery diarrhea in neonatal pigs and pose significant economic and public health burdens in the world. While the three SECoVs primarily infect intestinal epithelia
MeSH term(s)	Animals ; Antigen Presentation/immunology ; Coronavirus Infections/veterinary ; Gastroenteritis, Transmissible, of Swine/etiology ; Gastroenteritis, Transmissible, of Swine/metabolism ; Gastroenteritis, Transmissible, of Swine/pathology ; Gene Expression Profiling ; Gene Expression Regulation ; Host-Pathogen Interactions/genetics ; Host-Pathogen Interactions/immunology ; Interferons/metabolism ; Porcine epidemic diarrhea virus/physiology ; Swine ; Swine Diseases/etiology ; Swine Diseases/metabolism ; Swine Diseases/pathology ; Transmissible gastroenteritis virus
Chemical Substances	Interferons (9008-11-1)
Language	English
Publishing date	2022-01-20
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2021.826882
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: A study on the psychological needs of nurses caring for patients with coronavirus disease 2019 from the perspective of the existence, relatedness, and growth theory

Yin, Xue / Zeng, Lingdan

Abstract	Objective: This study aimed to explore the psychological needs of nurses caring for patients with coronavirus disease 2019(COVID-19) and to propose corresponding interventions. Methods: In-depth interviews were conducted with 10 nurses who cared for patients with COVID-19. Interview data were analyzed by category analysis from the perspective of the existence, relatedness, and growth theory (ERG). Results: The existence needs were mainly reflected in health and security needs, whereas the relatedness needs consisted mainly of interpersonal needs, humanistic concern needs, and family needs; further, the growth needs were mainly reflected as a strong need for knowledge. Existence needs were the main needs during the epidemic, with health and security needs influencing each other. Humanistic concern needs were the most important of the relatedness needs; interpersonal and family needs were also growing. Conclusion: It is found that the existence, relatedness, and growth needs coexist in clinical nurses. It is helpful to take effective interventions to meet their needs if the needs of nurses caring for COVID-19 patients could be perceived well.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #30973
Database	COVID19

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Article ; Online: Coronavirus Porcine Deltacoronavirus Upregulates MHC Class I Expression through RIG-I/IRF1-Mediated NLRC5 Induction.

Liu, Xiang / Yin, Lingdan / Xue, Mei / Chen, Jianfei / Li, Liang / Fu, Fang / Feng, Li / Liu, Pinghuang

Journal of virology

2022 Volume 96, Issue 7, Page(s) e0015822

Abstract: Major histocompatibility complex class I (MHC-I) and MHC-II molecules, mainly being responsible for the processing and presentation of intracellular or extracellular antigen, respectively, are critical for antiviral immunity. Here, we reported that ... ...

Abstract	Major histocompatibility complex class I (MHC-I) and MHC-II molecules, mainly being responsible for the processing and presentation of intracellular or extracellular antigen, respectively, are critical for antiviral immunity. Here, we reported that porcine deltacoronavirus (PDCoV) with the zoonotic potential and potential spillover from pigs to humans, upregulated the expressions of porcine MHC-I (swine leukocyte antigen class I, SLA-I) molecules and SLA-I antigen presentation associated genes instead of porcine MHC-II (SLA-II) molecules both in primary porcine enteroids and swine testicular (ST) cells at the late stage of infection, and this finding was verified
MeSH term(s)	Animals ; Coronavirus Infections/immunology ; Deltacoronavirus/immunology ; Gene Expression Regulation/immunology ; Histocompatibility Antigens Class I/genetics ; Histocompatibility Antigens Class I/immunology ; Interferon Regulatory Factor-1/genetics ; Interferon Regulatory Factor-1/metabolism ; Swine
Chemical Substances	Histocompatibility Antigens Class I ; Interferon Regulatory Factor-1
Language	English
Publishing date	2022-03-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	80174-4
ISSN	1098-5514 ; 0022-538X
ISSN (online)	1098-5514
ISSN	0022-538X
DOI	10.1128/jvi.00158-22
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 609: Show issues

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Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Aminopeptidase N Expression, Not Interferon Responses, Determines the Intestinal Segmental Tropism of Porcine Deltacoronavirus.

Yin, Lingdan / Chen, Jianfei / Li, Liang / Guo, Shanshan / Xue, Mei / Zhang, Jialin / Liu, Xiang / Feng, Li / Liu, Pinghuang

Journal of virology

2020 Volume 94, Issue 14

Abstract: Porcine deltacoronavirus (PDCoV) is an economically important enteropathogen of swine with worldwide distribution. PDCoV primarily infects the small intestine instead of the large ... ...

Abstract	Porcine deltacoronavirus (PDCoV) is an economically important enteropathogen of swine with worldwide distribution. PDCoV primarily infects the small intestine instead of the large intestine
MeSH term(s)	Animals ; CD13 Antigens/genetics ; Coronavirus/physiology ; Coronavirus Infections/veterinary ; Enterocolitis/metabolism ; Enterocolitis/pathology ; Enterocolitis/virology ; Gene Expression Regulation, Viral ; Host-Pathogen Interactions ; Interferons/metabolism ; Intestinal Mucosa/metabolism ; Intestinal Mucosa/pathology ; Intestinal Mucosa/virology ; Swine ; Swine Diseases/metabolism ; Swine Diseases/pathology ; Swine Diseases/virology ; Viral Tropism ; Virus Replication
Chemical Substances	Interferons (9008-11-1) ; CD13 Antigens (EC 3.4.11.2)
Keywords	covid19
Language	English
Publishing date	2020-07-01
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80174-4
ISSN	1098-5514 ; 0022-538X
ISSN (online)	1098-5514
ISSN	0022-538X
DOI	10.1128/JVI.00480-20
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 609: Show issues

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ab Jg. 2022: Lesesaal (EG)

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Article ; Online: IFN-Lambda 3 Mediates Antiviral Protection Against Porcine Epidemic Diarrhea Virus by Inducing a Distinct Antiviral Transcript Profile in Porcine Intestinal Epithelia.

Li, Liang / Xue, Mei / Fu, Fang / Yin, Lingdan / Feng, Li / Liu, Pinghuang

Frontiers in immunology

2019 Volume 10, Page(s) 2394

Abstract: Type III interferon-lambda (IFN-λ) plays a critical role against infection, particularly in mucosal infection in the respiratory and gastrointestinal tract. Our study and other previous studies have shown that porcine IFN-λ more efficiently curtails the ... ...

Abstract	Type III interferon-lambda (IFN-λ) plays a critical role against infection, particularly in mucosal infection in the respiratory and gastrointestinal tract. Our study and other previous studies have shown that porcine IFN-λ more efficiently curtails the infection of porcine epidemic diarrhea virus (PEDV) in the intestine epithelia than type I IFN, whereas IFN-λ3 exerts a more potent effect than IFN-λ1. However, the underlying mechanism remains elusive, and in particular, the transcriptional profile induced by IFN-λ3 has not been reported. Here, to resolve the mechanism responsible for the disparity between IFN-λ3 and type I IFN in anti-mucosal virus infection, we compared the transcription profiles induced by the two IFNs in porcine intestinal epithelial (IPEC-J2) cells by RNA-Seq. Our results showed that the pretreatment of IPEC-J2 cells with IFN-λ3 resulted in the differential expression of 983 genes. In contrast, IFN-α only modified the expression of 134 genes, and 110 of these genes were also observed in the response to IFN-λ3. A transcriptional enrichment analysis indicated that IFN-λ3 or IFN-α regulates multiple cellular processes and that IFN-λ3 activates more robust signaling pathways, particularly the antiviral Jak-STAT signaling pathway, than IFN-α. Furthermore, we verified the RNA-Seq results through an RT-qPCR analysis of IPEC-J2 cells and porcine enteroids. Moreover, transient expression of the porcine
MeSH term(s)	Animals ; Cell Line ; Coronavirus Infections/immunology ; Coronavirus Infections/pathology ; Interferons/immunology ; Intestinal Mucosa/immunology ; Intestinal Mucosa/pathology ; Porcine epidemic diarrhea virus/immunology ; Signal Transduction/immunology ; Swine ; Transcription, Genetic/immunology
Chemical Substances	Interferons (9008-11-1)
Keywords	covid19
Language	English
Publishing date	2019-10-17
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2019.02394
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Targeting cysteine-rich angiogenic inducer-61 by antibody immunotherapy suppresses growth and migration of non-small cell lung cancer.

Li, Xinpeng / Yuan, Naxin / Lin, Lingdan / Yin, Lixia / Qu, Yiqing

Experimental and therapeutic medicine

2018 Volume 16, Issue 2, Page(s) 730–738

Abstract: Non-small cell lung cancer (NSCLC) is the most frequent type of human lung cancer; lung cancer is responsible for the highest rates of cancer-associated mortality in the world. Cysteine-rich angiogenic inducer-61 (CYR-61) has been identified as a ... ...

Abstract	Non-small cell lung cancer (NSCLC) is the most frequent type of human lung cancer; lung cancer is responsible for the highest rates of cancer-associated mortality in the world. Cysteine-rich angiogenic inducer-61 (CYR-61) has been identified as a tumorigenesis-, development- and metastasis-related gene, and is reported to enhance proliferation, migration and invasion through hepatocyte growth factor (HGF)-induced scattering and the metastasis-inducing HGF/Met signaling pathway in tumor cells and xenograft models. CYR-61 is a protein that promotes human lung cancer cell metastasis and is closely related to the patient's prognosis in NSCLC. The purpose of the present study was to investigate whether CYR-61 may serve as a dual potential target for gene therapy of human NSCLC. In the present study, an antibody targeted against CYR-61 (anti-CYR-61) was constructed and the therapeutic effects and underlying mechanism of this antibody in NSCLC cells and mice with NSCLC was investigated. It was observed that NSCLC cell viability, migration and invasion were inhibited while cell apoptosis was induced by the neutralization of CYR-61 protein by anti-CYR-61. Western blotting demonstrated that extracellular signal-regulated kinase (ERK) and protein kinase B (AKT) expression levels in NSCLC cells were decreased following treatment with anti-CYR-61. In addition, it was observed that inhibition of NSCLC cell viability was achieved by the suppression of the epithelial-mesenchymal transition signaling pathway. ERK and AKT phosphorylation levels were downregulated in NSCLC cells and tumors following anti-CYR-61 treatment. Analysis of a murine model indicated that tumor growth was inhibited and tumor metastasis was significantly suppressed (P<0.01) following anti-CYR-61 treatment for CYR-61. In conclusion, CYR-61 may serve as a potential target for gene therapy for the treatment of human NSCLC.
Language	English
Publishing date	2018-06-08
Publishing country	Greece
Document type	Journal Article
ZDB-ID	2683844-8
ISSN	1792-1015 ; 1792-0981
ISSN (online)	1792-1015
ISSN	1792-0981
DOI	10.3892/etm.2018.6274
Database	MEDical Literature Analysis and Retrieval System OnLINE

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