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  1. Article: Sieben Fragen an Dr. Manuela Funke-Chambour

    Funke-Chambour, Manuela

    Karger Kompass Pneumologie

    2018  Volume 6, Issue 1, Page(s) 44–45

    Language English
    Publishing date 2018-02-08
    Publisher S. Karger GmbH
    Publishing place Freiburg, Germany
    Document type Article
    Note Steckbrief Forschung
    ZDB-ID 3052384-9
    ISSN 2296-0317 ; 2296-0368
    ISSN (online) 2296-0317
    ISSN 2296-0368
    DOI 10.1159/000486438
    Database Karger publisher's database

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  2. Article ; Online: Registries for Idiopathic Pulmonary Fibrosis: When Is It Time to Go Global?

    Funke-Chambour, Manuela

    Annals of the American Thoracic Society

    2020  Volume 17, Issue 11, Page(s) 1378–1379

    MeSH term(s) Humans ; Idiopathic Pulmonary Fibrosis/diagnosis ; Idiopathic Pulmonary Fibrosis/epidemiology ; Registries ; Substance-Related Disorders
    Language English
    Publishing date 2020-10-30
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2717461-X
    ISSN 2325-6621 ; 1943-5665 ; 2325-6621
    ISSN (online) 2325-6621 ; 1943-5665
    ISSN 2325-6621
    DOI 10.1513/AnnalsATS.202007-835ED
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Ziritaxestat and Lung Function in Idiopathic Pulmonary Fibrosis.

    Kawano-Dourado, Leticia / Funke-Chambour, Manuela / Wells, Athol U

    JAMA

    2023  Volume 330, Issue 10, Page(s) 973

    MeSH term(s) Humans ; Idiopathic Pulmonary Fibrosis/drug therapy ; Idiopathic Pulmonary Fibrosis/physiopathology ; Lung/diagnostic imaging ; Lung/physiopathology ; Respiratory Physiological Phenomena ; Imidazoles/therapeutic use
    Chemical Substances GLPG1690 ; Imidazoles
    Language English
    Publishing date 2023-09-12
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2958-0
    ISSN 1538-3598 ; 0254-9077 ; 0002-9955 ; 0098-7484
    ISSN (online) 1538-3598
    ISSN 0254-9077 ; 0002-9955 ; 0098-7484
    DOI 10.1001/jama.2023.12637
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Pulmonary fibrosis: from pathogenesis to clinical decision-making.

    Koudstaal, Thomas / Funke-Chambour, Manuela / Kreuter, Michael / Molyneaux, Philip L / Wijsenbeek, Marlies S

    Trends in molecular medicine

    2023  Volume 29, Issue 12, Page(s) 1076–1087

    Abstract: Pulmonary fibrosis (PF) encompasses a spectrum of chronic lung diseases that progressively impact the interstitium, resulting in compromised gas exchange, breathlessness, diminished quality of life (QoL), and ultimately respiratory failure and mortality. ...

    Abstract Pulmonary fibrosis (PF) encompasses a spectrum of chronic lung diseases that progressively impact the interstitium, resulting in compromised gas exchange, breathlessness, diminished quality of life (QoL), and ultimately respiratory failure and mortality. Various diseases can cause PF, with their underlying causes primarily affecting the lung interstitium, leading to their referral as interstitial lung diseases (ILDs). The current understanding is that PF arises from abnormal wound healing processes triggered by various factors specific to each disease, leading to excessive inflammation and fibrosis. While significant progress has been made in understanding the molecular mechanisms of PF, its pathogenesis remains elusive. This review provides an in-depth exploration of the latest insights into PF pathophysiology, diagnosis, treatment, and future perspectives.
    MeSH term(s) Humans ; Pulmonary Fibrosis/diagnosis ; Pulmonary Fibrosis/etiology ; Pulmonary Fibrosis/therapy ; Quality of Life ; Lung Diseases, Interstitial/diagnosis ; Lung Diseases, Interstitial/etiology ; Lung Diseases, Interstitial/therapy ; Lung ; Fibrosis ; Clinical Decision-Making
    Language English
    Publishing date 2023-09-14
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2036490-8
    ISSN 1471-499X ; 1471-4914
    ISSN (online) 1471-499X
    ISSN 1471-4914
    DOI 10.1016/j.molmed.2023.08.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Diagnostik interstitieller Lungenerkrankungen im multidisziplinären Team.

    Berezowska, Sabina / Pöllinger, Alexander / Funke-Chambour, Manuela

    Therapeutische Umschau. Revue therapeutique

    2020  Volume 76, Issue 7, Page(s) 375–381

    Abstract: Diagnostics of interstitial lung diseases in the multidisciplinary ... ...

    Title translation Diagnostics of interstitial lung diseases in the multidisciplinary team.
    Abstract Diagnostics of interstitial lung diseases in the multidisciplinary team
    MeSH term(s) Biopsy ; Humans ; Lung/pathology ; Lung Diseases, Interstitial/diagnosis ; Patient Care Team ; Surgical Instruments
    Language German
    Publishing date 2020-01-08
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 82044-1
    ISSN 1664-2864 ; 0040-5930
    ISSN (online) 1664-2864
    ISSN 0040-5930
    DOI 10.1024/0040-5930/a001105
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Idiopathische Lungenfibrose – Epidemiologie, Ursachen und klinischer Verlauf.

    Schäfer, Stephan C / Funke-Chambour, Manuela / Berezowska, Sabina

    Der Pathologe

    2020  Volume 41, Issue 1, Page(s) 46–51

    Abstract: Idiopathic pulmonary fibrosis (IPF) plays a special role within the group of interstitial lung diseases (ILDs) due to its inexorable progression and its specific medical treatment. With a median survival of only 2-3 years from the time of diagnosis, the ... ...

    Title translation Idiopathic pulmonary fibrosis-epidemiology, causes, and clinical course.
    Abstract Idiopathic pulmonary fibrosis (IPF) plays a special role within the group of interstitial lung diseases (ILDs) due to its inexorable progression and its specific medical treatment. With a median survival of only 2-3 years from the time of diagnosis, the prognosis is worse than many carcinomas.In contrast to other ILDs, IPF does not respond to anti-inflammatory treatment with corticosteroids but rather demands a specific medical therapy. Even though this cannot cure the disease, it can prolong survival. Lung transplantation is the only cure for progressive lung fibrosis. The clinical course is individual and difficult to predict. Acute exacerbations accelerate the clinical course and lead to high mortality.The underlying pathomechanisms of IPF, with its complex immunological and inflammatory processes and external impacts, have been the focus of recent research. Lifestyle and environmental influences are held responsible for much of its natural history. Smoking, pneumotoxic medications, and inhalation of dusts are well-known risk factors. Likewise, genetic and hereditary factors play a crucial role.This short review focuses on the peculiarities of IPF within the group of ILDs, especially in relation to its underlying mechanisms and clinical progression.
    MeSH term(s) Disease Progression ; Humans ; Idiopathic Pulmonary Fibrosis/diagnosis ; Idiopathic Pulmonary Fibrosis/epidemiology ; Idiopathic Pulmonary Fibrosis/etiology ; Idiopathic Pulmonary Fibrosis/pathology ; Lung Diseases, Interstitial/diagnosis ; Lung Diseases, Interstitial/epidemiology ; Lung Diseases, Interstitial/etiology ; Lung Diseases, Interstitial/pathology ; Prognosis ; Risk Factors
    Language German
    Publishing date 2020-01-28
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 135954-x
    ISSN 1432-1963 ; 0172-8113
    ISSN (online) 1432-1963
    ISSN 0172-8113
    DOI 10.1007/s00292-019-00747-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Reply to: Pharmacotherapy for lung cancer with comorbid interstitial pneumonia: limited evidence requires appropriate evaluation.

    Funke-Chambour, Manuela / Kewalramani, Namrata / Machahua, Carlos / Poletti, Venerino / Wells, Athol U / Cadranel, Jacques

    ERJ open research

    2022  Volume 8, Issue 4

    Abstract: The divergent views on lung cancer treatments in fibrosing lung patients reflect differences due to variable side-effect incidences in different countries and among ethnicities. International efforts are needed to better define treatment approaches. ...

    Abstract The divergent views on lung cancer treatments in fibrosing lung patients reflect differences due to variable side-effect incidences in different countries and among ethnicities. International efforts are needed to better define treatment approaches.
    Language English
    Publishing date 2022-12-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 2827830-6
    ISSN 2312-0541
    ISSN 2312-0541
    DOI 10.1183/23120541.00469-2022
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Lung cancer in patients with fibrosing interstitial lung diseases: an overview of current knowledge and challenges.

    Kewalramani, Namrata / Machahua, Carlos / Poletti, Venerino / Cadranel, Jacques / Wells, Athol U / Funke-Chambour, Manuela

    ERJ open research

    2022  Volume 8, Issue 2

    Abstract: Patients with progressive fibrosing interstitial lung diseases (fILD) have increased morbidity and mortality. Lung fibrosis can be associated with lung cancer. The pathogenesis of both diseases shows similarities, although not all mechanisms are ... ...

    Abstract Patients with progressive fibrosing interstitial lung diseases (fILD) have increased morbidity and mortality. Lung fibrosis can be associated with lung cancer. The pathogenesis of both diseases shows similarities, although not all mechanisms are understood. The combination of the diseases is challenging, due to the amplified risk of mortality, and also because lung cancer treatment carries additional risks in patients with underlying lung fibrosis. Acute exacerbations in fILD patients are linked to increased mortality, and the risk of acute exacerbations is increased after lung cancer treatment with surgery, chemotherapy or radiotherapy. Careful selection of treatment modalities is crucial to improve survival while maintaining acceptable quality of life in patients with combined lung cancer and fILD. This overview of epidemiology, pathogenesis, treatment and a possible role for antifibrotic drugs in patients with lung cancer and fILD is the summary of a session presented during the virtual European Respiratory Society Congress in 2021. The review summarises current knowledge and identifies areas of uncertainty. Most current data relate to patients with combined idiopathic pulmonary fibrosis and lung cancer. There is a pressing need for additional prospective studies, required for the formulation of a consensus statement or guideline on the optimal care of patients with lung cancer and fILD.
    Language English
    Publishing date 2022-06-20
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2827830-6
    ISSN 2312-0541
    ISSN 2312-0541
    DOI 10.1183/23120541.00115-2022
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Anti-Fibrotika als neue Therapie der idiopathischen Lungenfibrose.

    Funke-Chambour, Manuela / Geiser, Thomas

    Therapeutische Umschau. Revue therapeutique

    2016  Volume 73, Issue 1, Page(s) 25–29

    Abstract: Recent studies have shown efficacy to slow the decrease of forced vital capacity in patients with idiopathic pulmonary fibrosis. This summary refers to recent anti-fibrotic medications and describes current studies, indication for treatment and side ... ...

    Title translation Anti-fibrotics as novel therapy for idiopathic pulmonary fibrosis.
    Abstract Recent studies have shown efficacy to slow the decrease of forced vital capacity in patients with idiopathic pulmonary fibrosis. This summary refers to recent anti-fibrotic medications and describes current studies, indication for treatment and side effects, as well as discusses open questions of treatment.
    MeSH term(s) Anti-Inflammatory Agents, Non-Steroidal/administration & dosage ; Anti-Inflammatory Agents, Non-Steroidal/adverse effects ; Evidence-Based Medicine ; Fibrinolytic Agents/administration & dosage ; Fibrinolytic Agents/adverse effects ; Humans ; Idiopathic Pulmonary Fibrosis/diagnosis ; Idiopathic Pulmonary Fibrosis/drug therapy ; Indoles/administration & dosage ; Indoles/adverse effects ; Kidney Diseases/chemically induced ; Kidney Diseases/prevention & control ; Pyridones/administration & dosage ; Pyridones/adverse effects ; Respiratory System Agents/administration & dosage ; Respiratory System Agents/adverse effects ; Treatment Outcome
    Chemical Substances Anti-Inflammatory Agents, Non-Steroidal ; Fibrinolytic Agents ; Indoles ; Pyridones ; Respiratory System Agents ; pirfenidone (D7NLD2JX7U) ; nintedanib (G6HRD2P839)
    Language German
    Publishing date 2016
    Publishing country Switzerland
    Document type English Abstract ; Journal Article ; Review
    ZDB-ID 82044-1
    ISSN 1664-2864 ; 0040-5930
    ISSN (online) 1664-2864
    ISSN 0040-5930
    DOI 10.1024/0040-5930/a000751
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Autochthonous Case of Pulmonary Histoplasmosis, Switzerland.

    Schmiedel, Yvonne / Büchi, Annina E / Berezowska, Sabina / Pöllinger, Alexander / Mühlethaler, Konrad / Funke-Chambour, Manuela

    Emerging infectious diseases

    2021  Volume 27, Issue 3, Page(s) 966–969

    Abstract: In Europe, pulmonary histoplasmosis is rarely diagnosed except in travelers. We report a probable autochthonous case of severe chronic pulmonary histoplasmosis in an immunocompetent man in Switzerland without travel history outside of Europe. Diagnosis ... ...

    Abstract In Europe, pulmonary histoplasmosis is rarely diagnosed except in travelers. We report a probable autochthonous case of severe chronic pulmonary histoplasmosis in an immunocompetent man in Switzerland without travel history outside of Europe. Diagnosis was achieved by histopathology, fungal culture, and serology, but the source of the infection remains speculative.
    MeSH term(s) Europe ; Histoplasma ; Histoplasmosis ; Humans ; Lung Diseases, Fungal ; Male ; Switzerland
    Language English
    Publishing date 2021-02-23
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 1380686-5
    ISSN 1080-6059 ; 1080-6040
    ISSN (online) 1080-6059
    ISSN 1080-6040
    DOI 10.3201/eid2703.191831
    Database MEDical Literature Analysis and Retrieval System OnLINE

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