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  1. Article ; Online: Chimeric antigen receptor T-cell therapy in acute myeloid leukemia.

    Koedam, Jan / Wermke, Martin / Ehninger, Armin / Cartellieri, Marc / Ehninger, Gerhard

    Current opinion in hematology

    2022  Volume 29, Issue 2, Page(s) 74–83

    Abstract: Purpose of review: Treatment outcome of relapsed or refractory AML patients remains dismal and new treatment options are needed. Adoptive cell therapy using CAR-T cells is a potentially interesting approach in this.: Recent findings: Several ... ...

    Abstract Purpose of review: Treatment outcome of relapsed or refractory AML patients remains dismal and new treatment options are needed. Adoptive cell therapy using CAR-T cells is a potentially interesting approach in this.
    Recent findings: Several potentially interesting AML targets are being investigated with CAR-T therapy with over 60 clinical trials listed on clinicaltrials.gov. The first clinical data are only just emerging with mixed results, once more proving that further research is needed.
    Summary: Adoptive cell therapy using chimeric antigen receptor T cells is being investigated in AML through many clinical trials. So far, no AML-specific antigen has been identified, requiring additional strategies to mitigate on-target off-tumor toxicity and to increase efficacy. Focus point is to acquire control over the CAR T cells once administered. Strategies to do so include biodegradable CARs, inducible CARs, suicide-switch containing CARs and two-component modular CARs. Limited and mixed results are available, confirming the risk of lasting toxicity for nonswitchable CARs. Initial results of modular CARs suggest toxicity can be mitigated whilst maintaining CAR activity by the use of modular CAR concepts that allows for 'ON' and 'OFF' switching.
    MeSH term(s) Cell- and Tissue-Based Therapy ; Humans ; Immunotherapy, Adoptive/adverse effects ; Immunotherapy, Adoptive/methods ; Leukemia, Myeloid, Acute/pathology ; Receptors, Antigen, T-Cell/genetics ; Receptors, Antigen, T-Cell/therapeutic use ; Receptors, Chimeric Antigen
    Chemical Substances Receptors, Antigen, T-Cell ; Receptors, Chimeric Antigen
    Language English
    Publishing date 2022-01-10
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1153887-9
    ISSN 1531-7048 ; 1065-6251
    ISSN (online) 1531-7048
    ISSN 1065-6251
    DOI 10.1097/MOH.0000000000000703
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3703: Show issues Location:
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  2. Book ; Thesis: Die klinische Wertigkeit des FT 4 und des T4/TBG-Quotienten in der Schilddrüsen-Diagnostik

    Cartellieri, Maria

    1989  

    Author's details vorgelegt von Maria Cartellieri
    Size 1 Mikrofiche : 24x
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Freiburg (Breisgau), Univ., Diss., 1989
    Note Mikroreprod. e. Ms. 72 Bl.: Ill., graph. Darst.
    HBZ-ID HT003762210
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1991 MB 3193 order for loan Magazin

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  3. Book ; Thesis: Untersuchungen zum GAG- und Pol-Protein des prototypischen Foamyvirus (PFV)

    Cartellieri, Marc

    2005  

    Author's details Marc Cartellieri
    Language German
    Size 189 S., graph. Darst.
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Techn. Univ., Diss.--Dresden, 2006
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  4. Article ; Online: Proof of concept for a rapidly switchable universal CAR-T platform with UniCAR-T-CD123 in relapsed/refractory AML.

    Wermke, Martin / Kraus, Sabrina / Ehninger, Armin / Bargou, Ralf C / Goebeler, Maria-Elisabeth / Middeke, Jan Moritz / Kreissig, Carla / von Bonin, Malte / Koedam, Jan / Pehl, Michael / Bornhäuser, Martin / Einsele, Hermann / Ehninger, Gerhard / Cartellieri, Marc

    Blood

    2021  Volume 137, Issue 22, Page(s) 3145–3148

    MeSH term(s) Aged ; Aged, 80 and over ; Humans ; Immunotherapy, Adoptive ; Leukemia, Myeloid, Acute/therapy ; Male ; Middle Aged ; Proof of Concept Study ; Receptors, Chimeric Antigen/administration & dosage
    Chemical Substances Receptors, Chimeric Antigen
    Language English
    Publishing date 2021-02-18
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood.2020009759
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 364: Show issues

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  5. Article ; Online: Evaluation of switch-mediated costimulation in trans on universal CAR-T cells (UniCAR) targeting CD123-positive AML.

    Meyer, Jan-Erik / Loff, Simon / Dietrich, Josephine / Spehr, Johannes / Jurado Jiménez, Gabriel / von Bonin, Malte / Ehninger, Gerhard / Cartellieri, Marc / Ehninger, Armin

    Oncoimmunology

    2021  Volume 10, Issue 1, Page(s) 1945804

    Abstract: Chimeric antigen receptor T cells (CAR-T) targeting CD19 have achieved significant success in patients with B cell malignancies. To date, implementation of CAR-T in other indications remains challenging due to the lack of truly tumor-specific antigens as ...

    Abstract Chimeric antigen receptor T cells (CAR-T) targeting CD19 have achieved significant success in patients with B cell malignancies. To date, implementation of CAR-T in other indications remains challenging due to the lack of truly tumor-specific antigens as well as control of CAR-T activity in patients. CD123 is highly expressed in acute myeloid leukemia (AML) blasts including leukemia-initiating cells making it an attractive immunotherapeutic target. However, CD123 expression in normal hematopoietic progenitor cells and endothelia bears the risk of severe toxicities and may limit CAR-T applications lacking fine-tuned control mechanisms. Therefore, we recently developed a rapidly switchable universal CAR-T platform (UniCAR), in which CAR-T activity depends on the presence of a soluble adapter called targeting module (TM), and confirmed clinical proof-of-concept for targeting CD123 in AML with improved safety. As costimulation via 4-1BB ligand (4-1BBL) can enhance CAR-T expansion, persistence, and effector functions, a novel CD123-specific TM variant (TM123-4-1BBL) comprising trimeric single-chain 4-1BBL was developed for transient costimulation of UniCAR-T cells (UniCAR-T) at the leukemic site
    MeSH term(s) Antigens, Neoplasm ; Humans ; Immunotherapy, Adoptive ; Interleukin-3 Receptor alpha Subunit ; Leukemia, Myeloid, Acute/drug therapy ; T-Lymphocytes
    Chemical Substances Antigens, Neoplasm ; Interleukin-3 Receptor alpha Subunit
    Language English
    Publishing date 2021-07-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2645309-5
    ISSN 2162-402X ; 2162-4011
    ISSN (online) 2162-402X
    ISSN 2162-4011
    DOI 10.1080/2162402X.2021.1945804
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Der Einfluß des Internets auf die Marktforschung

    Cartellieri, Maximilian

    Planung & Analyse : Zeitschrift für Marktforschung und Marketing , No. 2 , p. 34-38

    vom Stiefkind zum Zukunftspartner des Managements?

    2002  , Issue 2, Page(s) 34–38

    Author's details Maximilian Cartellieri
    Keywords Marktforschung ; Internet
    Language German
    Size graph. Darst
    Publisher Dt. Fachverl.
    Publishing place Frankfurt, M.
    Document type Article
    Note Zsfassung in engl. Sprache
    ZDB-ID 721476-5
    Database ECONomics Information System

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  7. Article: Rapidly Switchable Universal CAR-T Cells for Treatment of CD123-Positive Leukemia.

    Loff, Simon / Dietrich, Josephine / Meyer, Jan-Erik / Riewaldt, Julia / Spehr, Johannes / von Bonin, Malte / Gründer, Cordula / Swayampakula, Mridula / Franke, Kristin / Feldmann, Anja / Bachmann, Michael / Ehninger, Gerhard / Ehninger, Armin / Cartellieri, Marc

    Molecular therapy oncolytics

    2020  Volume 17, Page(s) 408–420

    Abstract: Chimeric antigen receptor T cells (CAR-T) targeting CD19 or B cell maturation antigen (BCMA) are highly effective against B cell malignancies. However, application of CAR-T to less differentially expressed targets remains a challenge due to lack of tumor- ...

    Abstract Chimeric antigen receptor T cells (CAR-T) targeting CD19 or B cell maturation antigen (BCMA) are highly effective against B cell malignancies. However, application of CAR-T to less differentially expressed targets remains a challenge due to lack of tumor-specific antigens and CAR-T controllability. CD123, a highly promising leukemia target, is expressed not only by leukemic and leukemia-initiating cells, but also by myeloid, hematopoietic progenitor, and certain endothelial cells. Thus, CAR-T lacking fine-tuned control mechanisms pose a high toxicity risk. To extend the CAR-T target landscape and widen the therapeutic window, we adapted our rapidly switchable universal CAR-T platform (UniCAR) to target CD123. UniCAR-T efficiently eradicated CD123
    Language English
    Publishing date 2020-04-29
    Publishing country United States
    Document type Journal Article
    ISSN 2372-7705
    ISSN 2372-7705
    DOI 10.1016/j.omto.2020.04.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Silver staining techniques of polyacrylamide gels.

    Bartsch, Holger / Arndt, Claudia / Koristka, Stefanie / Cartellieri, Marc / Bachmann, Michael

    Methods in molecular biology (Clifton, N.J.)

    2012  Volume 869, Page(s) 481–486

    Abstract: Although the main application for polyacrylamide gels is the separation and subsequent blotting of proteins for immunodetection, there are tasks that need staining of proteins in the polyacrylamide gel. Several different staining techniques exist for ... ...

    Abstract Although the main application for polyacrylamide gels is the separation and subsequent blotting of proteins for immunodetection, there are tasks that need staining of proteins in the polyacrylamide gel. Several different staining techniques exist for protein staining in SDS gels that differ in their sensitivity, their expenditure of time, and other aspects. Still, silver staining is the most sensitive and reliable staining technique. Because this technique was developed in the 1970s, a huge number of variations exist. Therefore, we will provide herein three methods, which are robust and easy to perform.
    MeSH term(s) Acrylic Resins/chemistry ; Animals ; Cattle ; Electrophoresis, Polyacrylamide Gel/methods ; Limit of Detection ; Serum Albumin, Bovine/chemistry ; Serum Albumin, Bovine/isolation & purification ; Silver Staining/methods
    Chemical Substances Acrylic Resins ; polyacrylamide gels ; Serum Albumin, Bovine (27432CM55Q)
    Language English
    Publishing date 2012
    Publishing country United States
    Document type Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-61779-821-4_42
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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  9. Article ; Online: Tonic Signaling and Its Effects on Lymphopoiesis of CAR-Armed Hematopoietic Stem and Progenitor Cells.

    Albert, Susann / Koristka, Stefanie / Gerbaulet, Alexander / Cartellieri, Marc / Arndt, Claudia / Feldmann, Anja / Berndt, Nicole / Loureiro, Liliana R / von Bonin, Malte / Ehninger, Gerhard / Eugster, Anne / Bonifacio, Ezio / Bornhäuser, Martin / Bachmann, Michael P / Ehninger, Armin

    Journal of immunology (Baltimore, Md. : 1950)

    2019  Volume 202, Issue 6, Page(s) 1735–1746

    Abstract: Long-term survival of adoptively transferred chimeric Ag receptor (CAR) T cells is often limited. Transplantation of hematopoietic stem cells (HSCs) transduced to express CARs could help to overcome this problem as CAR-armed HSCs can continuously deliver ...

    Abstract Long-term survival of adoptively transferred chimeric Ag receptor (CAR) T cells is often limited. Transplantation of hematopoietic stem cells (HSCs) transduced to express CARs could help to overcome this problem as CAR-armed HSCs can continuously deliver CAR
    MeSH term(s) Adoptive Transfer ; Animals ; Cell Differentiation/physiology ; Hematopoietic Stem Cell Transplantation/methods ; Hematopoietic Stem Cells/metabolism ; Humans ; Lymphocyte Activation/physiology ; Lymphopoiesis/physiology ; Mice ; Mice, Inbred C57BL ; Receptors, Chimeric Antigen/metabolism ; Signal Transduction/physiology
    Chemical Substances Receptors, Chimeric Antigen
    Language English
    Publishing date 2019-02-06
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 3056-9
    ISSN 1550-6606 ; 0022-1767 ; 1048-3233 ; 1047-7381
    ISSN (online) 1550-6606
    ISSN 0022-1767 ; 1048-3233 ; 1047-7381
    DOI 10.4049/jimmunol.1801004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ud II Zs.37: Show issues Location:
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    Zs.MG 28: Show issues

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  10. Article: TraFo-CRISPR: Enhanced Genome Engineering by Transient Foamy Virus Vector-Mediated Delivery of CRISPR/Cas9 Components.

    Lindel, Fabian / Dodt, Carolin R / Weidner, Niklas / Noll, Monique / Bergemann, Fabian / Behrendt, Rayk / Fischer, Sarah / Dietrich, Josephine / Cartellieri, Marc / Hamann, Martin V / Lindemann, Dirk

    Molecular therapy. Nucleic acids

    2019  Volume 18, Page(s) 708–726

    Abstract: The adaptation of CRISPR/Cas technology for use in mammals has revolutionized genome engineering. In particular with regard to clinical application, efficient expression of Cas9 within a narrow time frame is highly desirable to minimize the accumulation ... ...

    Abstract The adaptation of CRISPR/Cas technology for use in mammals has revolutionized genome engineering. In particular with regard to clinical application, efficient expression of Cas9 within a narrow time frame is highly desirable to minimize the accumulation of off-target editing. We developed an effective, aptamer-independent retroviral delivery system for Cas9 mRNAs that takes advantage of a unique foamy virus (FV) capability: the efficient encapsidation and transfer of non-viral RNAs. This enabled us to create a FV vector toolbox for efficient, transient delivery (TraFo) of CRISPR/Cas9 components into different target tissues. Co-delivery of Cas9 mRNA by TraFo-Cas9 vectors in combination with retroviral, integration-deficient single guide RNA (sgRNA) expression enhanced efficacy and specificity of gene-inactivation compared with CRISPR/Cas9 lentiviral vector systems. Furthermore, separate TraFo-Cas9 delivery allowed the optional inclusion of a repair matrix for efficient gene correction or tagging as well as the addition of fluorescent negative selection markers for easy identification of off-target editing or incorrect repair events. Thus, the TraFo CRISPR toolbox represents an interesting alternative technology for gene inactivation and gene editing.
    Language English
    Publishing date 2019-10-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2662631-7
    ISSN 2162-2531
    ISSN 2162-2531
    DOI 10.1016/j.omtn.2019.10.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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