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Article ; Online: Correction to: Reply to Letter: Evaluation of macular blood flow after intermittent intravenous infusion of high‑dose corticosteroids (pulse therapy) in patients with thyroid‑associated orbitopathy (TAO) using angio‑OCT.

Del Noce, Chiara / Desideri, Lorenzo Ferro / Roda, Matilde / Vagge, Aldo

Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie

2022 Volume 260, Issue 12, Page(s) 4029

Language	English
Publishing date	2022-09-27
Publishing country	Germany
Document type	Published Erratum
ZDB-ID	8435-9
ISSN	1435-702X ; 0721-832X
ISSN (online)	1435-702X
ISSN	0721-832X
DOI	10.1007/s00417-022-05838-9
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Article ; Online: Reply to Letter: Evaluation of macular blood flow after intermittent intravenous infusion of high-dose corticosteroids (pulse therapy) in patients with thyroid-associated orbitopathy (TAO) using angio-OCT.

Del Noce, Chiara / Desideri, Lorenzo Ferro / Roda, Matilde / Vagge, Aldo

Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie

2022 Volume 260, Issue 12, Page(s) 4027

MeSH term(s)	Humans ; Graves Ophthalmopathy/complications ; Graves Ophthalmopathy/diagnosis ; Graves Ophthalmopathy/drug therapy ; Infusions, Intravenous ; Tomography, Optical Coherence ; Hemodynamics ; Adrenal Cortex Hormones
Chemical Substances	Adrenal Cortex Hormones
Language	English
Publishing date	2022-06-06
Publishing country	Germany
Document type	Letter ; Comment
ZDB-ID	8435-9
ISSN	1435-702X ; 0721-832X
ISSN (online)	1435-702X
ISSN	0721-832X
DOI	10.1007/s00417-022-05715-5
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Article ; Online: Bleb Needling with Mitomycin C as Adjunctive Therapy in Failing Blebs: A Retrospective Study.

Del Noce, Chiara / Vagge, Aldo / Traverso, Carlo Enrico

Ophthalmic research

2019 Volume 62, Issue 1, Page(s) 55–60

Abstract: Purpose: To evaluate the effects and complications related to use of mitomycin C (MMC) as an adjunctive therapy in bleb needling.: Methods: Retrospective review of the records of patients affected by open-angle glaucoma who underwent a bleb revision ... ...

Abstract	Purpose: To evaluate the effects and complications related to use of mitomycin C (MMC) as an adjunctive therapy in bleb needling. Methods: Retrospective review of the records of patients affected by open-angle glaucoma who underwent a bleb revision as a treatment for failed trabeculectomy. All subjects underwent surgery with a fornix-based approach to incision. Full baseline data for each patient included a comprehensive ocular and medical history, the patient's Snellen visual acuity test results, and Goldmann applanation tonometry test results. Data were reported following observations occurring at 6, 12, 18, 24, and 30 months. In addition, the number and timing of needling with or without MMC subconjunctival injections and any short- and long-term complications were observed. Results: We included 101 patients, 56 (55.4%) male and 45 (44.6%) female. The mean age was 69.81 ± 16.19 years (range 28-92). Statistically significant effects of needling and needling and MMC (p values <0.05) in the decrease in intraocular pressure were observed. Three (2.9%) patients presented hypotony at the last follow-up visit. No other complications were observed. Conclusions: Needling bleb revision augmented with the use of MMC appears to be a more useful tool in the management of failing bleb.
MeSH term(s)	Aged ; Aged, 80 and over ; Alkylating Agents/administration & dosage ; Conjunctival Diseases/prevention & control ; Female ; Glaucoma, Open-Angle/surgery ; Humans ; Intraocular Pressure ; Male ; Middle Aged ; Mitomycin/administration & dosage ; Needles ; Punctures/methods ; Retrospective Studies ; Trabeculectomy/methods
Chemical Substances	Alkylating Agents ; Mitomycin (50SG953SK6)
Language	English
Publishing date	2019-05-09
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	205708-6
ISSN	1423-0259 ; 0030-3747
ISSN (online)	1423-0259
ISSN	0030-3747
DOI	10.1159/000499129
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Article ; Online: Blue light filtering ophthalmic lenses: A systematic review.

Vagge, Aldo / Ferro Desideri, Lorenzo / Del Noce, Chiara / Di Mola, Ilaria / Sindaco, Daniele / Traverso, Carlo E

Seminars in ophthalmology

2021 Volume 36, Issue 7, Page(s) 541–548

Abstract: ... ...

Abstract	Background
MeSH term(s)	Animals ; Cataract Extraction ; Humans ; Lens, Crystalline ; Lenses, Intraocular ; Light ; Macular Degeneration
Language	English
Publishing date	2021-03-18
Publishing country	England
Document type	Journal Article ; Systematic Review
ZDB-ID	632820-9
ISSN	1744-5205 ; 0882-0538
ISSN (online)	1744-5205
ISSN	0882-0538
DOI	10.1080/08820538.2021.1900283
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Article ; Online: Evaluation of choroidal thickness and choroidal vascular blood flow in patients with thyroid-associated orbitopathy (TAO) using SD-OCT and Angio-OCT.

Del Noce, Chiara / Vagge, Aldo / Nicolò, Massimo / Traverso, Carlo Enrico

Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie

2020 Volume 258, Issue 5, Page(s) 1103–1107

Abstract: Purpose: The aim of this study was to evaluate changes in choroidal thickness and in choroidal vascular blood flow in patients with thyroid-associated orbitopathy (TAO) and their relationship with clinical features and disease activity using spectral ... ...

Abstract	Purpose: The aim of this study was to evaluate changes in choroidal thickness and in choroidal vascular blood flow in patients with thyroid-associated orbitopathy (TAO) and their relationship with clinical features and disease activity using spectral domain optical coherence tomography (SD-OCT) and Angio-OCT technology. Methods: Eighteen patients and control subjects underwent a complete eye examination, OCT, and Angio-OCT. We also obtained angiographic scans at 3 different consecutive levels (L1, L2, and L3) below the choriocapillary. Results: The subfoveal choroid was significantly thicker in TAO patients than the control eyes (285.6275 ± 32.5 μm compared with 135.89 ± 19.8 μm, respectively, p = 0.0089). The correlation analysis in the TAO group showed a significant correlation between the choroidal thickness and EUGOGO clinical score (r = 0.84, p = 8.44032E-07). Vascular flow of choriocapillary was markedly reduced in subjects with TAO compared with healthy subjects (49.78 ± 4.5 vs. 53.36 ± 1.07; p = 2.5105E-07) and vascular flow of the deeper layer L3 resulted higher in subjects with TAO than in healthy subjects (46.9 ± 20.23 and 41.475 ± 3.06; p = 0.01168). Conclusions: Subfoveal choroidal thickness and choroidal blood flow were significantly different in patients with TAO compared with healthy subjects.
MeSH term(s)	Adult ; Aged ; Choroid/blood supply ; Choroid/diagnostic imaging ; Choroid/pathology ; Ciliary Arteries/physiology ; Cross-Sectional Studies ; Female ; Fluorescein Angiography ; Graves Ophthalmopathy/diagnostic imaging ; Graves Ophthalmopathy/physiopathology ; Humans ; Intraocular Pressure ; Male ; Middle Aged ; Ophthalmoscopy ; Orbital Diseases/diagnostic imaging ; Orbital Diseases/physiopathology ; Organ Size ; Tomography, Optical Coherence ; Visual Acuity/physiology ; Young Adult
Language	English
Publishing date	2020-02-06
Publishing country	Germany
Document type	Journal Article
ZDB-ID	8435-9
ISSN	1435-702X ; 0721-832X
ISSN (online)	1435-702X
ISSN	0721-832X
DOI	10.1007/s00417-020-04616-9
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Evaluation of macular blood flow after intermittent intravenous infusion of high-dose corticosteroids (pulse therapy) in patients with thyroid-associated orbitopathy (TAO) using angio-OCT.

Del Noce, Chiara / Roda, Matilde / Ferro Desideri, Lorenzo / Traverso, Carlo E / Vagge, Aldo

Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie

2021 Volume 260, Issue 2, Page(s) 571–576

Abstract: Purpose: The aim of this study is to evaluate the changes in macular blood flow index (BFI) in patients with moderate to severe thyroid-associated orbitopathy (TAO) before and after pulse therapy and their relationship with clinical features and disease ...

Abstract	Purpose: The aim of this study is to evaluate the changes in macular blood flow index (BFI) in patients with moderate to severe thyroid-associated orbitopathy (TAO) before and after pulse therapy and their relationship with clinical features and disease activity using angio-OCT technology. Methods: We analyzed twenty-four eyes. Every patient underwent a complete eye examination and angio-OCT analysis (OCT Topcon ImageNet 6; DRI OCT Triton, Topcon Corporation) before (T0) and two months (T2) after pulse therapy. We analyzed macular vascular blood flow in four angiographic levels: superficial plexus (SP), deep plexus (DP), external retina (ER), and choriocapillaris (CC). We used the clinical activity score (CAS) score to define TAO as moderate or severe. Results: Macular BFI significantly increased at T2 in the DP, ER, and CC (p < 0.01). CAS score (5.8 ± 0.8 vs. 3.9 ± 0.9, p < 0.01) and Hertel exophthalmometry values (22.6 ± 2.3 mm vs. 21.2 ± 2,5 mm, p < 0.01) improved for all patients at T2 compared T0. Mean IOP increased from 13.3 ± 2.8 mmHg to 14.3 ± 2.1 mmHg (p < 0.01). No correlation was found between CAS score and macular BFI in all the analyzed levels. Conclusions: Pulse therapy treatment can change macular BFI. In particular, two months alter pulse therapy, all the patients show an increase in macular vascular blood flow in each angiographic level. According to our results, angio-OCT analysis of the macular BFI may be a useful tool in the follow-up of TAO patients after pulse therapy.
MeSH term(s)	Adrenal Cortex Hormones ; Choroid ; Fluorescein Angiography ; Graves Ophthalmopathy/diagnosis ; Graves Ophthalmopathy/drug therapy ; Humans ; Infusions, Intravenous ; Tomography, Optical Coherence
Chemical Substances	Adrenal Cortex Hormones
Language	English
Publishing date	2021-09-01
Publishing country	Germany
Document type	Journal Article
ZDB-ID	8435-9
ISSN	1435-702X ; 0721-832X
ISSN (online)	1435-702X
ISSN	0721-832X
DOI	10.1007/s00417-021-05336-4
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Article ; Online: Evaluation of peripapillary vascular flow in patients with Thyroid-Associated Ophthalmopathy (TAO) by OCT Angiography.

Del Noce, Chiara / Roda, Matilde / Valsecchi, Nicola / Guandalini, Sofia / Di Geronimo, Natalie / Schiavi, Costantino / Traverso, Carlo Enrico / Vagge, Aldo

Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie

2022 Volume 260, Issue 8, Page(s) 2711–2716

Abstract: Purpose: To evaluate changes in peripapillary vascular blood flow indices (PVBFI) in patients with thyroid-associated ophthalmopathy (TAO) using OCT angiography (OCTA) technology.: Methods: Patients with TAO and control subjects matched for age and ... ...

Abstract	Purpose: To evaluate changes in peripapillary vascular blood flow indices (PVBFI) in patients with thyroid-associated ophthalmopathy (TAO) using OCT angiography (OCTA) technology. Methods: Patients with TAO and control subjects matched for age and sex were included in the study. Eye examination, Clinical Activity Score (CAS) evaluation and OCTA scan analysis (Topcon ImageNet 6; DRI OCT Triton, Topcon Corporation) were performed. In particular, PVBFI of the superficial capillary plexus (SCP), deep capillary plexus (DCP), outer retina (OR) and choriocapillaris (CC) layers were obtained by OCTA and extracted from 8-bit greyscale OCT images using the ImageJ software package. Results: Twenty-six patients with TAO (19 females, mean age 54.7 ± 5.2 and 7 males, mean age 51.4 ± 16.3) were compared with 26 healthy subjects (15 females, mean age 48.2 ± 14.1 and 11 males, mean age 53.1 ± 15.2). Both DCP-PVBF and CC-PVBFI were significantly reduced in TAO patients compared to control eyes (28.6 ± 2.1 vs. 29.7 ± 0.93, p = 0.002; 46.5 ± 1.72 vs. 47.2 ± 1.2, p = 0.019 respectively); on the other hand, no statistically significant differences were found in SCP-PVBFI and OR-PVBFI in TAO patients compared to healthy subjects (p > 0.05). Also, CC-PVBFI was associated with elevated values of CAS (p = 0.018) and ROC curve showed that patients with elevated CC-PVBFI were correlated with active TAO (CAS > 3) (p = 0.012). Conclusions: TAO disease may be associated with changes in DCP-PVBFI and CC-PVBFI; also, CC-PVBFI seems to correlate with disease activity.
MeSH term(s)	Adult ; Aged ; Choroid ; Female ; Fluorescein Angiography/methods ; Graves Ophthalmopathy/diagnosis ; Humans ; Male ; Middle Aged ; Retina ; Retinal Vessels ; Tomography, Optical Coherence/methods
Language	English
Publishing date	2022-02-12
Publishing country	Germany
Document type	Journal Article
ZDB-ID	8435-9
ISSN	1435-702X ; 0721-832X
ISSN (online)	1435-702X
ISSN	0721-832X
DOI	10.1007/s00417-022-05551-7
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Article: Effect of Liposomal-Lactoferrin-Based Eye Drops on the Conjunctival Microflora of Patients Undergoing Cataract Surgery.

Giannaccare, Giuseppe / Comis, Sofia / Jannuzzi, Virginia / Camposampiero, Davide / Ponzin, Diego / Cambria, Sergio / Santocono, Marcello / Pallozzi Lavorante, Nicola / Del Noce, Chiara / Scorcia, Vincenzo / Traverso, Carlo E / Vagge, Aldo

Ophthalmology and therapy

2023 Volume 12, Issue 2, Page(s) 1315–1326

Abstract: Introduction: Postoperative endophthalmitis is typically caused by the patient's conjunctival bacterial flora. Povidone iodine solution (5%) is used perioperatively to obtain periocular and ocular antisepsis. However, an adjunctive prophylaxis procedure ...

Abstract	Introduction: Postoperative endophthalmitis is typically caused by the patient's conjunctival bacterial flora. Povidone iodine solution (5%) is used perioperatively to obtain periocular and ocular antisepsis. However, an adjunctive prophylaxis procedure could further help control the conjunctival microbial load. Considering the increase in antibiotic resistance, a progressive shift toward alternative methods would be desirable. Somilux Methods: LF-based eye drops or a vehicle solution (water solution) were instilled 4 times a day starting 3 days before cataract surgery. Before the therapy (T0) and at the time of surgery (T1), a conjunctival swab was performed in both eyes and processed to detect microbial growth, microbiological isolation, and species identification. The outcome was the quantification and characterization of the local microbial flora before and after using LF-based or vehicle-based eye drops. Safety of the treatments was also evaluated. Results: 88 eyes of 44 patients (mean [± SD] age 75 [± 12.6] years) were enrolled. At baseline, 54 conjunctival swabs showed only saprophytic flora, 27 showed only potential pathogenic flora, and seven showed both of them. LF-based eye drops reduced the proportion of potentially pathogenic bacteria (36% at T0 vs. 9% at T1, p = 0.008) compared with the vehicle (41% at T0 vs. 55% at T1, p = 0.302) without altering the physiological ocular microbial composition. No adverse events have been reported. Conclusion: Our findings provide a novel contribution to the scientific knowledge on the role of LF in the ophthalmic field, supporting the use of LF-based eye drops as a safe and selective treatment to improve the ocular surface physiological defenses and control the bacterial ocular surface contamination prior to cataract surgery.
Language	English
Publishing date	2023-02-24
Publishing country	England
Document type	Journal Article
ISSN	2193-8245
ISSN	2193-8245
DOI	10.1007/s40123-023-00673-5
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Article: Is Spectral-Domain Optical Coherence Tomography Always Able to Detect the Anti-Vascular Endothelial Growth Factor Action on Neovascular Membrane?

Borgia, Luigi / Del Noce, Chiara / Iester, Michele

Case reports in ophthalmology

2016 Volume 7, Issue 2, Page(s) 309–314

Abstract: Purpose: To show the presence of an active neovascular membrane in age-related macular degeneration even if optical coherence tomography (OCT) does not detect intra- or subretinal edema.: Methods: This is a retrospective case report. During the ... ...

Abstract	Purpose: To show the presence of an active neovascular membrane in age-related macular degeneration even if optical coherence tomography (OCT) does not detect intra- or subretinal edema. Methods: This is a retrospective case report. During the follow-up after the intravitreal injection, 3 patients showed no intraretinal or subretinal edema by OCT; however, there was a progressive reduction in their visual acuity; thus, a fluorangiography (FA) examination was performed. Results: In these 3 cases, FA showed an active neovascular network. Conclusion: OCT could show a real reduction in the edema, but it is not always able to detect neovessel presence. Intravitreal injection could improve the vessel permeability without care and delete the neovascular network.
Language	English
Publishing date	2016-06-13
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	2577666-6
ISSN	1663-2699
ISSN	1663-2699
DOI	10.1159/000446512
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Article: Bleb Needling with Mitomycin C as Adjunctive Therapy in Failing Blebs: A Retrospective Study

Del Noce, Chiara / Vagge, Aldo / Traverso, Carlo Enrico

Ophthalmic Research

2019 Volume 62, Issue 1, Page(s) 55–60

Abstract: Purpose: To evaluate the effects and complications related to use of mitomycin C (MMC) as an adjunctive therapy in bleb needling. Methods: Retrospective review of the records of patients affected by open-angle glaucoma who underwent a bleb revision as a ... ...

Institution	Eye Clinic of Genoa, Policlinic Hospital, IRCCS Ospedale Policlinico San Martino, Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), University of Genoa, Genoa, Italy
Abstract	Purpose: To evaluate the effects and complications related to use of mitomycin C (MMC) as an adjunctive therapy in bleb needling. Methods: Retrospective review of the records of patients affected by open-angle glaucoma who underwent a bleb revision as a treatment for failed trabeculectomy. All subjects underwent surgery with a fornix-based approach to incision. Full baseline data for each patient included a comprehensive ocular and medical history, the patient’s Snellen visual acuity test results, and Goldmann applanation tonometry test results. Data were reported following observations occurring at 6, 12, 18, 24, and 30 months. In addition, the number and timing of needling with or without MMC subconjunctival injections and any short- and long-term complications were observed. Results: We included 101 patients, 56 (55.4%) male and 45 (44.6%) female. The mean age was 69.81 ± 16.19 years (range 28–92). Statistically significant effects of needling and needling and MMC (p values <0.05) in the decrease in intraocular pressure were observed. Three (2.9%) patients presented hypotony at the last follow-up visit. No other complications were observed. Conclusions: Needling bleb revision augmented with the use of MMC appears to be a more useful tool in the management of failing bleb.
Keywords	Mitomycin C ; Intraocular pressure ; Trabeculectomy ; Bleb needling
Language	English
Publishing date	2019-05-09
Publisher	S. Karger AG
Publishing place	Basel, Switzerland
Document type	Article
Note	Research Article
ZDB-ID	205708-6
ISSN	1423-0259 ; 0030-3747
ISSN (online)	1423-0259
ISSN	0030-3747
DOI	10.1159/000499129
Database	Karger publisher's database

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