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  1. Article ; Online: Devices-based treatment of hypertension: the position of the European Society of Hypertension (ESH) 2023 guidelines.

    Grassi, Guido

    Expert review of medical devices

    2024  Volume 21, Issue 4, Page(s) 265–267

    Language English
    Publishing date 2024-04-08
    Publishing country England
    Document type Editorial
    ZDB-ID 2250857-0
    ISSN 1745-2422 ; 1743-4440
    ISSN (online) 1745-2422
    ISSN 1743-4440
    DOI 10.1080/17434440.2024.2339414
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6424: Show issues Location:
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  2. Article ; Online: Heart failure related central sympathetic activation: debunking the 'holy grail'?

    Grassi, Guido

    European journal of heart failure

    2023  Volume 25, Issue 2, Page(s) 211–212

    MeSH term(s) Humans ; Heart Failure ; Sympathetic Nervous System
    Language English
    Publishing date 2023-01-11
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 1483672-5
    ISSN 1879-0844 ; 1388-9842
    ISSN (online) 1879-0844
    ISSN 1388-9842
    DOI 10.1002/ejhf.2764
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5299: Show issues Location:
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  3. Article ; Online: Response to the Letter regarding article "Heart rate threshold for cardiovascular risk and sympathetic activation in metabolic syndrome".

    Grassi, Guido

    Acta diabetologica

    2023  Volume 60, Issue 8, Page(s) 1115–1116

    MeSH term(s) Humans ; Metabolic Syndrome/epidemiology ; Cardiovascular Diseases/epidemiology ; Cardiovascular Diseases/etiology ; Heart Rate/physiology ; Risk Factors ; Heart Disease Risk Factors
    Language English
    Publishing date 2023-05-20
    Publishing country Germany
    Document type Letter ; Comment
    ZDB-ID 1097676-0
    ISSN 1432-5233 ; 0940-5429
    ISSN (online) 1432-5233
    ISSN 0940-5429
    DOI 10.1007/s00592-023-02106-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 611: Show issues Location:
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  4. Article ; Online: Sympathetic modulation as a goal of antihypertensive treatment: from drugs to devices.

    Grassi, Guido

    Journal of hypertension

    2023  Volume 41, Issue 11, Page(s) 1688–1695

    Abstract: The present study aims to examine the effects of nonpharmacological, pharmacological and devices-based treatment on hypertension-related sympathetic overactivity. This will be done by analyzing the results of different published studies, in which ... ...

    Abstract The present study aims to examine the effects of nonpharmacological, pharmacological and devices-based treatment on hypertension-related sympathetic overactivity. This will be done by analyzing the results of different published studies, in which sympathetic activity has been assessed via indirect or direct techniques. After examining the rationale for sympathomodulatory interventions in antihypertensive treatment, the study will discuss the methodological intrinsic limitations of the studies aimed at assessing different therapeutic interventions. The core of the study will be then focused on the effects of nonpharmacological (dietary restriction of sodium intake, physical exercise training, weight reduction), pharmacological (monotherapy, combination drug treatment, new drugs such as sodium glucose co-transport protein-2 inhibitors and angiotensin receptor neprilysin inhibitors), as well as devices-based interventions (renal sympathetic nerves ablation and carotid baroreceptor activation therapy) on the hypertension-related sympathetic overdrive. Finally, the areas worthy of future research as well as the debated issues in the field will be highlighted.
    Language English
    Publishing date 2023-09-04
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 605532-1
    ISSN 1473-5598 ; 0263-6352 ; 0952-1178
    ISSN (online) 1473-5598
    ISSN 0263-6352 ; 0952-1178
    DOI 10.1097/HJH.0000000000003538
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 614: Show issues

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  5. Article ; Online: The role of β-blockers in medical treatment.

    Kjeldsen, Sverre E / Grassi, Guido

    Current medical research and opinion

    2024  Volume 40, Issue sup1, Page(s) 1–2

    MeSH term(s) Humans ; Adrenergic beta-Antagonists/therapeutic use
    Chemical Substances Adrenergic beta-Antagonists
    Language English
    Publishing date 2024-04-10
    Publishing country England
    Document type Editorial
    ZDB-ID 80296-7
    ISSN 1473-4877 ; 0300-7995
    ISSN (online) 1473-4877
    ISSN 0300-7995
    DOI 10.1080/03007995.2024.2324138
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 955: Show issues Location:
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  6. Article ; Online: Sympathetic overactivity, hypertension and cardiovascular disease: state of the art.

    Grassi, Guido / Drager, Luciano F

    Current medical research and opinion

    2024  Volume 40, Issue sup1, Page(s) 5–13

    Abstract: Cardiovascular disease (CVD) remains the most prevalent cause of premature death worldwide. It had been suspected for decades that increased activity of the sympathetic nervous system (SNS) might play a pathogenetic role in the development and ... ...

    Abstract Cardiovascular disease (CVD) remains the most prevalent cause of premature death worldwide. It had been suspected for decades that increased activity of the sympathetic nervous system (SNS) might play a pathogenetic role in the development and progression of hypertension, heart failure (HF) and CVD. The use of microneurographic techniques to directly assess the SNS has allowed this field to advance considerably in recent years. We now have compelling evidence for a key role of sympathetic overactivity in the pathogenesis and progression of hypertension and associated hypertension-mediated organ damage (such as endothelial dysfunction, arterial stiffness and left ventricular hypertrophy), HF (with or without reduced left ventricular ejection fraction). Sympathetic overactivity also drives increased cardiovascular risk in the settings of obesity, metabolic syndrome, chronic kidney disease and obstructive sleep apnoea, among other conditions. Thus, sympathetic overactivity is an important factor that drives patients through the CVD continuum, from the early appearance of cardiovascular risk factors, to impairments of the structure and function of components of the heart and arteries, to established CVD, and ultimately to a life-threatening cardiovascular event. A deeper understanding of the role of sympathetic overactivity in the pathogenesis of CVD and HF will support the optimization of therapeutic interventions for these conditions.
    MeSH term(s) Humans ; Cardiovascular Diseases/etiology ; Cardiovascular Diseases/complications ; Stroke Volume ; Ventricular Function, Left ; Hypertension/drug therapy ; Heart Failure ; Sympathetic Nervous System
    Language English
    Publishing date 2024-04-10
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 80296-7
    ISSN 1473-4877 ; 0300-7995
    ISSN (online) 1473-4877
    ISSN 0300-7995
    DOI 10.1080/03007995.2024.2305248
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 955: Show issues Location:
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  7. Article ; Online: The Sympathetic Nervous System in Hypertension: Roadmap Update of a Long Journey.

    Grassi, Guido

    American journal of hypertension

    2021  Volume 34, Issue 12, Page(s) 1247–1254

    Abstract: The present paper will provide an update on the role of sympathetic neural factors in the development and progression of essential hypertension by reviewing data collected in the past 10 years. This will be done by discussing the results of the published ...

    Abstract The present paper will provide an update on the role of sympathetic neural factors in the development and progression of essential hypertension by reviewing data collected in the past 10 years. This will be done by discussing the results of the published studies in which sympathetic neural function in essential hypertension and related disease has been investigated via sophisticated and highly sensitive techniques, such as microneurographic recording of sympathetic nerve traffic and regional norepinephrine spillover. First, the relevance of the pathophysiological background of the neurogenic alterations will be discussed. It will be then examined the behavior of the sympathetic neural function in specific clinical phenotypes, such as resistant hypertension, pseudoresistant hypertension, and hypertensive states displaying elevated resting heart values. This will be followed by a discussion of the main results of the meta-analytic studies examining the behavior of sympathetic nerve traffic in essential hypertension, obesity, metabolic syndrome, and chronic renal failure. The sympathetic effects of renal denervation and carotid baroreceptor stimulation as well as the possible involvement of sympathetic neural factors in the determination of the so-called "residual risk" of the treated hypertensive patients will be finally discussed.
    MeSH term(s) Blood Pressure/physiology ; Humans ; Hypertension/drug therapy ; Hypertension/therapy ; Kidney ; Norepinephrine/metabolism ; Pressoreceptors ; Sympathetic Nervous System
    Chemical Substances Norepinephrine (X4W3ENH1CV)
    Language English
    Publishing date 2021-08-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 639383-4
    ISSN 1941-7225 ; 1879-1905 ; 0895-7061
    ISSN (online) 1941-7225 ; 1879-1905
    ISSN 0895-7061
    DOI 10.1093/ajh/hpab124
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2329: Show issues Location:
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  8. Article ; Online: Baroreceptors as a target of device-based neuromodulation in heart failure: Long-term outcomes.

    Grassi, Guido / Dell'Oro, Raffaella / Quarti-Trevano, Fosca

    European journal of heart failure

    2024  

    Language English
    Publishing date 2024-04-25
    Publishing country England
    Document type Editorial
    ZDB-ID 1483672-5
    ISSN 1879-0844 ; 1388-9842
    ISSN (online) 1879-0844
    ISSN 1388-9842
    DOI 10.1002/ejhf.3258
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  9. Article ; Online: Impact of heart rate on arterial stiffness: virtual vs. real assessment.

    Grassi, Guido

    Journal of hypertension

    2020  Volume 38, Issue 12, Page(s) 2382–2383

    MeSH term(s) Blood Pressure ; Heart Rate ; Humans ; Pulse Wave Analysis ; Vascular Stiffness
    Language English
    Publishing date 2020-10-24
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 605532-1
    ISSN 1473-5598 ; 0263-6352 ; 0952-1178
    ISSN (online) 1473-5598
    ISSN 0263-6352 ; 0952-1178
    DOI 10.1097/HJH.0000000000002603
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  10. Article ; Online: New European Guidelines 2023 for Hypertension: When and Why Should We Think About Sleep Apnea?

    Grassi, Guido / Mancia, Giuseppe

    Archivos de bronconeumologia

    2023  Volume 60, Issue 2, Page(s) 73–74

    MeSH term(s) Humans ; Sleep Apnea Syndromes/complications ; Sleep Apnea Syndromes/therapy ; Hypertension/complications
    Language Spanish
    Publishing date 2023-11-10
    Publishing country Spain
    Document type Editorial
    ZDB-ID 733126-5
    ISSN 1579-2129 ; 0300-2896
    ISSN (online) 1579-2129
    ISSN 0300-2896
    DOI 10.1016/j.arbres.2023.11.005
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