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Article ; Online: Dietary Vitamin K

Schultz, Carl J / Dalgaard, Frederik / Bellinge, Jamie W / Murray, Kevin / Sim, Marc / Connolly, Emma / Blekkenhorst, Lauren C / Bondonno, Catherine P / Lewis, Joshua R / Gislason, Gunnar H / Tjønneland, Anne / Overvad, Kim / Hodgson, Jonathan M / Bondonno, Nicola P

Arteriosclerosis, thrombosis, and vascular biology

2023 Volume 44, Issue 2, Page(s) 513–521

Abstract: ... of aortic valve stenosis. Vitamin K activates inhibitors of vascular calcification and may modulate inflammation and ... skeletal bone loss. Therefore, we aimed to determine whether higher dietary intakes of vitamin K: Methods ... frequency questionnaire at baseline, from which habitual intakes of vitamin K: Results: In 55 545 ...

Abstract	Background: Leaflet calcification contributes to the development and progression of aortic valve stenosis. Vitamin K activates inhibitors of vascular calcification and may modulate inflammation and skeletal bone loss. Therefore, we aimed to determine whether higher dietary intakes of vitamin K Methods: In the Danish Diet, Cancer and Health study, participants aged 50 to 64 years completed a 192-item food frequency questionnaire at baseline, from which habitual intakes of vitamin K Results: In 55 545 participants who were followed for a maximum of 21.5 years, 1085 were diagnosed with aortic stenosis and 615 were identified as having subsequent complications. Participants in the highest quintile of vitamin K Conclusions: In this study, a high intake of vitamin K
MeSH term(s)	Humans ; Vitamin K 1 ; Aortic Valve Stenosis/epidemiology ; Aortic Valve Stenosis/surgery ; Aortic Valve ; Vitamin K ; Eating ; Risk Factors ; Vitamin K 2
Chemical Substances	Vitamin K 1 (84-80-0) ; Vitamin K (12001-79-5) ; Vitamin K 2 (11032-49-8)
Language	English
Publishing date	2023-12-28
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1221433-4
ISSN	1524-4636 ; 1079-5642
ISSN (online)	1524-4636
ISSN	1079-5642
DOI	10.1161/ATVBAHA.123.320271
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Article ; Online: Association between vitamin K

Palmer, Claire R / Bellinge, Jamie W / Dalgaard, Frederik / Sim, Marc / Murray, Kevin / Connolly, Emma / Blekkenhorst, Lauren C / Bondonno, Catherine P / Croft, Kevin D / Gislason, Gunnar / Tjønneland, Anne / Overvad, Kim / Schultz, Carl / Lewis, Joshua R / Hodgson, Jonathan M / Bondonno, Nicola P

European journal of epidemiology

2021 Volume 36, Issue 10, Page(s) 1005–1014

Abstract: Reported associations between vitamin K ...

Abstract	Reported associations between vitamin K
MeSH term(s)	Cardiovascular Diseases/metabolism ; Cardiovascular Diseases/mortality ; Cardiovascular Diseases/prevention & control ; Cause of Death ; Denmark/epidemiology ; Female ; Humans ; Male ; Middle Aged ; Mortality ; Neoplasms/metabolism ; Neoplasms/mortality ; Neoplasms/prevention & control ; Nutrition Assessment ; Prospective Studies ; Risk Factors ; Surveys and Questionnaires ; Vitamin K/administration & dosage ; Vitamin K 1/administration & dosage ; Vitamin K 2/administration & dosage
Chemical Substances	Vitamin K 2 (11032-49-8) ; Vitamin K (12001-79-5) ; Vitamin K 1 (84-80-0)
Language	English
Publishing date	2021-09-30
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	632614-6
ISSN	1573-7284 ; 0393-2990
ISSN (online)	1573-7284
ISSN	0393-2990
DOI	10.1007/s10654-021-00806-9
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Article ; Online: The effect of Vitamin-K

Bellinge, Jamie W / Francis, Roslyn J / Lee, Sing Ching / Vickery, Alistair / Macdonald, William / Gan, Seng Khee / Chew, Gerard T / Phillips, Michael / Lewis, Joshua R / Watts, Gerald F / Schultz, Carl J

Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology

2021 Volume 29, Issue 4, Page(s) 1855–1866

Abstract: ... tomography (CT), were randomized to one of four treatment groups (placebo/placebo, vitamin-K: Results: 149 ... subjects completed follow-up (vitamin-K: Conclusions: In patients with type 2 diabetes, neither vitamin ... K: Clinical trial registration: ACTRN12616000024448. ...

Abstract	Background: There is currently no treatment for attenuating progression of arterial calcification. Methods: 154 patients with diabetes mellitus and coronary calcification, as detected using computed tomography (CT), were randomized to one of four treatment groups (placebo/placebo, vitamin-K Results: 149 subjects completed follow-up (vitamin-K Conclusions: In patients with type 2 diabetes, neither vitamin-K Clinical trial registration: ACTRN12616000024448.
MeSH term(s)	Colchicine/therapeutic use ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/drug therapy ; Double-Blind Method ; Humans ; Positron Emission Tomography Computed Tomography ; Sodium Fluoride ; Vascular Calcification/diagnostic imaging ; Vascular Calcification/drug therapy ; Vitamin K 1 ; Vitamins
Chemical Substances	Vitamins ; Vitamin K 1 (84-80-0) ; Sodium Fluoride (8ZYQ1474W7) ; Colchicine (SML2Y3J35T)
Language	English
Publishing date	2021-04-06
Publishing country	United States
Document type	Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	1212505-2
ISSN	1532-6551 ; 1071-3581
ISSN (online)	1532-6551
ISSN	1071-3581
DOI	10.1007/s12350-021-02589-8
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Article ; Online: Modulation of Neutrophil Function by Recombinant Human IgG1 Fc Hexamer in the Endogenous K/BxN Mouse Model of Rheumatoid Arthritis.

Almizraq, Ruqayyah J / Frias Boligan, Kayluz / Lewis, Bonnie J B / Cen, Selena / Whetstone, Heather / Spirig, Rolf / Käsermann, Fabian / Campbell, Ian K / von Gunten, Stephan / Branch, Donald R

Pharmacology

2023 Volume 108, Issue 2, Page(s) 176–187

Abstract: Introduction: Neutrophils are a pivotal cell type in the K/BxN mouse model of rheumatoid arthritis ... the potential anti-inflammatory effect of a recombinant IgG1 Fc hexamer (rFc-µTP-L309C) on neutrophils in the K ... L309C, but not HSA, was able to significantly ameliorate the arthritis in the K/BxN mice. Significant ...

Abstract	Introduction: Neutrophils are a pivotal cell type in the K/BxN mouse model of rheumatoid arthritis and play an essential role in the progression of the arthritis. They are readily activated by immune complexes (ICs) via their FcγRs to release IL-1β in addition to other cytokines, which are inducing cartilage destruction. Neutrophils also release neutrophil-active chemokines to recruit themselves in an autocrine manner to perpetuate tissue destruction. FcγR-expression on neutrophils is of crucial importance for the recognition of ICs. Methods: In this study, due to its high avidity for binding to FcγRs, we investigated the potential anti-inflammatory effect of a recombinant IgG1 Fc hexamer (rFc-µTP-L309C) on neutrophils in the K/BxN mouse model of endogenously generated chronic arthritis. 200 mg/kg rFc-µTP-L309C and human serum albumin (HSA), used as controls, were administered subcutaneously every other day. Mouse ankle joints were monitored daily to generate a clinical score. Immunohistology was used to evaluate neutrophil infiltration and TUNEL to assess apoptosis. ELISA was used to measure IL-1β. Results: Treatment with rFc-µTP-L309C, but not HSA, was able to significantly ameliorate the arthritis in the K/BxN mice. Significant neutrophil infiltration into the ankle joint was found, but treatment with rFc-µTP-L309C resulted in significantly less neutrophil infiltration. There was no significant influence of rFc-µTP-L309C on neutrophil death or apoptosis. Less neutrophil infiltration could not be correlated to chemokine-mediated migration. Significantly less IL-1β was measured in mice treated with rFc-µTP-L309C. Conclusion: In the endogenous K/BxN mouse model of rheumatoid arthritis, amelioration can be explained in part by inhibition of neutrophil infiltration into the joints as well as inhibition of IL-1β production. Given the observed inhibitory properties on neutrophils, rFc-µTP-L309C may be a potential therapeutic candidate to treat autoimmune and inflammatory conditions in which neutrophils are the predominant cell type involved in pathogenesis.
MeSH term(s)	Humans ; Mice ; Animals ; Immunoglobulin G/metabolism ; Neutrophils/metabolism ; Neutrophils/pathology ; Uridine Triphosphate/metabolism ; Arthritis, Rheumatoid/pathology ; Disease Models, Animal ; Immunologic Factors ; Arthritis, Experimental ; Mice, Inbred C57BL
Chemical Substances	Immunoglobulin G ; Uridine Triphosphate (UT0S826Z60) ; Immunologic Factors
Language	English
Publishing date	2023-01-25
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	206671-3
ISSN	1423-0313 ; 0031-7012
ISSN (online)	1423-0313
ISSN	0031-7012
DOI	10.1159/000528780
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Article ; Online: Search for the Lepton Flavor Violating Decays B^{+}→K^{+}τ^{±}ℓ^{∓} (ℓ=e, μ) at Belle.

Watanuki, S / de Marino, G / Trabelsi, K / Adachi, I / Aihara, H / Asner, D M / Atmacan, H / Aulchenko, V / Aushev, T / Ayad, R / Babu, V / Banerjee, Sw / Bauer, M / Behera, P / Belous, K / Bessner, M / Bhardwaj, V / Bhuyan, B / Biswas, D /

Bodrov, D / Bonvicini, G / Borah, J / Bozek, A / Bračko, M / Branchini, P / Browder, T E / Budano, A / Campajola, M / Cao, L / Červenkov, D / Chang, M-C / Cheon, B G / Chilikin, K / Cho, K / Cho, S-J / Choi, S-K / Choi, Y / Choudhury, S / Cinabro, D / Das, S / De Nardo, G / De Pietro, G / Dhamija, R / Di Capua, F / Dong, T V / Epifanov, D / Ferber, T / Ferlewicz, D / Fulsom, B G / Garg, R / Gaur, V / Garmash, A / Giri, A / Goldenzweig, P / Graziani, E / Gu, T / Guan, Y / Gudkova, K / Hadjivasiliou, C / Halder, S / Han, X / Hara, T / Hayasaka, K / Hayashii, H / Herrmann, D / Hou, W-S / Hsu, C-L / Inami, K / Inguglia, G / Ipsita, N / Ishikawa, A / Itoh, R / Iwasaki, M / Jacobs, W W / Ji, Q P / Jia, S / Jin, Y / Joo, K K / Kaliyar, A B / Kichimi, H / Kim, C H / Kim, D Y / Kim, K-H / Kim, Y-K / Kinoshita, K / Kodyš, P / Korobov, A / Korpar, S / Kovalenko, E / Križan, P / Krokovny, P / Kuhr, T / Kumar, M / Kumara, K / Kuzmin, A / Kwon, Y-J / Lange, J S / Laurenza, M / Lee, S C / Lewis, P / Li, L K / Li, Y / Li Gioi, L / Libby, J / Lin, Y-R / Liventsev, D / Matsuda, T / Maurya, S K / Meier, F / Merola, M / Metzner, F / Miyabayashi, K / Mizuk, R / Mohanty, G B / Nakao, M / Nayak, L / Nayak, M / Nisar, N K / Nishida, S / Ono, H / Oskin, P / Pakhlova, G / Pardi, S / Park, H / Park, J / Park, S-H / Passeri, A / Pedlar, T K / Pestotnik, R / Piilonen, L E / Podobnik, T / Prencipe, E / Prim, M T / Röhrken, M / Rout, N / Russo, G / Sandilya, S / Sangal, A / Santelj, L / Savinov, V / Schnell, G / Schwanda, C / Seino, Y / Senyo, K / Sevior, M E / Shan, W / Shapkin, M / Shiu, J-G / Shwartz, B / Simon, F / Solovieva, E / Starič, M / Sumihama, M / Sumiyoshi, T / Takizawa, M / Tanida, K / Tenchini, F / Uchida, M / Uglov, T / Unno, Y / Uno, K / Uno, S / van Tonder, R / Varner, G / Varvell, K E / Wang, D / Wang, E / Wang, M-Z / Won, E / Xu, X / Yabsley, B D / Yan, W / Yang, S B / Yelton, J / Yusa, Y / Zhang, Z P / Zhilich, V / Zhukova, V

Physical review letters

2023 Volume 130, Issue 26, Page(s) 261802

Abstract: We present a search for the lepton flavor violating decays B^{+}→K^{+}τ^{±}ℓ^{∓}, with ℓ=(e,μ ... in a hadronic decay mode. We find no evidence for B^{±}→K^{±}τℓ decays and set upper limits on their branching ...

Abstract	We present a search for the lepton flavor violating decays B^{+}→K^{+}τ^{±}ℓ^{∓}, with ℓ=(e,μ), using the full data sample of 772×10^{6} BB[over ¯] pairs recorded by the Belle detector at the KEKB asymmetric-energy e^{+}e^{-} collider. We use events in which one B meson is fully reconstructed in a hadronic decay mode. We find no evidence for B^{±}→K^{±}τℓ decays and set upper limits on their branching fractions at the 90% confidence level in the (1-3)×10^{-5} range. The obtained limits are the world's best results.
Language	English
Publishing date	2023-01-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	208853-8
ISSN	1079-7114 ; 0031-9007
ISSN (online)	1079-7114
ISSN	0031-9007
DOI	10.1103/PhysRevLett.130.261802
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Article ; Online: First Observation of Λπ^{+} and Λπ^{-} Signals near the K[over ¯]N(I=1) Mass Threshold in Λ_{c}^{+}→Λπ^{+}π^{+}π^{-} Decay.

Ma, Y / Yelton, J / Tanida, K / Adachi, I / Ahn, J K / Aihara, H / Al Said, S / Asner, D M / Atmacan, H / Aushev, T / Ayad, R / Babu, V / Bahinipati, S / Banerjee, Sw / Behera, P / Belous, K / Bennett, J / Bessner, M / Bhuyan, B /

Bilka, T / Biswas, D / Bobrov, A / Bodrov, D / Borah, J / Bozek, A / Bračko, M / Branchini, P / Browder, T E / Budano, A / Campajola, M / Červenkov, D / Chang, M-C / Chen, A / Cheon, B G / Chilikin, K / Cho, H E / Cho, K / Cho, S-J / Choi, S-K / Choi, Y / Choudhury, S / Cinabro, D / Das, S / De Nardo, G / De Pietro, G / Dhamija, R / Di Capua, F / Dingfelder, J / Doležal, Z / Dong, T V / Epifanov, D / Ferber, T / Ferlewicz, D / Fulsom, B G / Garg, R / Gaur, V / Garmash, A / Giri, A / Goldenzweig, P / Golob, B / Graziani, E / Gudkova, K / Hadjivasiliou, C / Halder, S / Hayasaka, K / Hayashii, H / Hedges, M T / Hou, W-S / Hsu, C-L / Inami, K / Ipsita, N / Ishikawa, A / Itoh, R / Iwasaki, M / Jacobs, W W / Jang, E-J / Jia, S / Jin, Y / Kaliyar, A B / Kang, K H / Kawasaki, T / Kiesling, C / Kim, C H / Kim, D Y / Kim, Y-K / Kinoshita, K / Kodyš, P / Korobov, A / Korpar, S / Kovalenko, E / Križan, P / Krokovny, P / Kumar, R / Kumara, K / Kwon, Y-J / Lam, T / Lange, J S / Lee, S C / Lewis, P / Li, L K / Li, Y / Li Gioi, L / Libby, J / Lieret, K / Lin, Y-R / Liventsev, D / Luo, T / Masuda, M / Matsuda, T / Matvienko, D / Maurya, S K / Meier, F / Merola, M / Metzner, F / Miyabayashi, K / Mohanty, G B / Mussa, R / Nakamura, I / Nakano, T / Nakao, M / Natkaniec, Z / Natochii, A / Nayak, L / Nayak, M / Nisar, N K / Nishida, S / Ogawa, S / Ono, H / Oskin, P / Pakhlov, P / Pakhlova, G / Pardi, S / Park, H / Park, J / Patra, S / Paul, S / Pestotnik, R / Piilonen, L E / Podobnik, T / Prencipe, E / Prim, M T / Rostomyan, A / Rout, N / Russo, G / Sandilya, S / Santelj, L / Savinov, V / Schnell, G / Schueler, J / Schwanda, C / Seino, Y / Senyo, K / Sevior, M E / Shan, W / Shapkin, M / Sharma, C / Shen, C P / Shiu, J-G / Simon, F / Sokolov, A / Solovieva, E / Starič, M / Sumihama, M / Sumiyoshi, T / Sutcliffe, W / Takizawa, M / Tamponi, U / Tenchini, F / Uchida, M / Uehara, S / Uglov, T / Unno, Y / Uno, K / Uno, S / Urquijo, P / Usov, Y / Vahsen, S E / van Tonder, R / Varner, G / Vinokurova, A / Vossen, A / Wang, D / Wang, M-Z / Watanabe, M / Watanuki, S / Werbycka, O / Won, E / Xu, X / Yabsley, B D / Yan, W / Yang, S B / Yin, J H / Yuan, C Z / Yuan, L / Zhang, Z P / Zhilich, V / Zhukova, V

Physical review letters

2023 Volume 130, Issue 15, Page(s) 151903

Abstract: ... with a significance of 7.5σ (6.2σ). As these two signals are very close to the K[over ¯]N threshold, we also ... investigate the possibility of a K[over ¯]N cusp, and find that we cannot discriminate between these two ...

Abstract	Using the data sample of 980 fb^{-1} collected with the Belle detector operating at the KEKB asymmetric-energy e^{+}e^{-} collider, we present the results of an investigation of the Λπ^{+} and Λπ^{-} invariant mass distributions looking for substructure in the decay Λ_{c}^{+}→Λπ^{+}π^{+}π^{-}. We find a significant signal in each mass distribution. When interpreted as resonances, we find for the Λπ^{+} (Λπ^{-}) combination a mass of 1434.3±0.6(stat)±0.9(syst) MeV/c^{2} [1438.5±0.9(stat)±2.5(syst) MeV/c^{2}], an intrinsic width of 11.5±2.8(stat)±5.3(syst) MeV/c^{2} [33.0±7.5(stat)±23.6(syst) MeV/c^{2}] with a significance of 7.5σ (6.2σ). As these two signals are very close to the K[over ¯]N threshold, we also investigate the possibility of a K[over ¯]N cusp, and find that we cannot discriminate between these two interpretations due to the limited size of the data sample.
Language	English
Publishing date	2023-04-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	208853-8
ISSN	1079-7114 ; 0031-9007
ISSN (online)	1079-7114
ISSN	0031-9007
DOI	10.1103/PhysRevLett.130.151903
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Article: Constitutive and Stress-Induced Psychomotor Cortical Responses to Compound K Supplementation.

Flanagan, Shawn D / Proessl, Felix / Dunn-Lewis, Courtenay / Canino, Maria C / Sterczala, Adam J / Connaboy, Chris / DuPont, William H / Caldwell, Lydia K / Kraemer, William J

Frontiers in neuroscience

2020 Volume 14, Page(s) 315

Abstract: Isolated ginsenoside metabolites such as Compound K (CK) are of increasing interest to consumer and ...

Abstract	Isolated ginsenoside metabolites such as Compound K (CK) are of increasing interest to consumer and clinical populations as safe and non-pharmacological means to enhance psychomotor performance constitutively and in response to physical or cognitive stress. Nevertheless, the influence of CK on behavioral performance and EEG measures of cortical activity in humans is undetermined. In this double-blinded, placebo-controlled, counterbalanced within-group study, dose-dependent responses to CK (placebo, 160 and 960 mg) were assessed after 2 weeks of supplementation in nineteen healthy men and women (age: 39.9 ± 7.9 year, height 170.2 ± 8.6 cm, weight 79.7 ± 11.9 kg). Performance on upper- and lower-body choice reaction tests (CRTs) was tested before and after intense lower-body anaerobic exercise. Treatment- and stress-related changes in brain activity were measured with high-density EEG based on event-related potentials, oscillations, and source activity. Upper- (-12.3 ± 3.5 ms,
Language	English
Publishing date	2020-04-08
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2411902-7
ISSN	1662-453X ; 1662-4548
ISSN (online)	1662-453X
ISSN	1662-4548
DOI	10.3389/fnins.2020.00315
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Article ; Online: Higher Dietary Vitamin K Intake is Associated with Better Physical Function and Lower Long-Term Injurious Falls Risk in Community-Dwelling Older Women.

Sim, M / Smith, C / Bondonno, N P / Radavelli-Bagatini, S / Blekkenhorst, L C / Dalla Via, J / McCormick, R / Zhu, K / Hodgson, J M / Prince, R L / Lewis, J R

The journal of nutrition, health & aging

2023 Volume 27, Issue 1, Page(s) 38–45

Abstract: Background: In recent years, a potential beneficial role of Vitamin K in neuromuscular function ... has been recognised. However, the optimal dietary intake of Vitamin K to support muscle function ... Measurements: A new Australian Vitamin K nutrient database, supplemented with published data, was used ...

Abstract	Background: In recent years, a potential beneficial role of Vitamin K in neuromuscular function has been recognised. However, the optimal dietary intake of Vitamin K to support muscle function in the context of falls prevention remains unknown. Objective: To examine the relationship of dietary Vitamin K1 and K2 with muscle function and long-term injurious fall-related hospitalisations in older women. Design: Cohort study. Participants: 1347 community-dwelling older Australian women ≥70 years. Measurements: A new Australian Vitamin K nutrient database, supplemented with published data, was used to calculate Vitamin K1 and K2 intake from a validated food frequency questionnaire at baseline (1998). Muscle function (grip strength and timed-up-and-go; TUG) as well plasma Vitamin D status (25OHD) were also assessed at baseline. Fall-related hospitalisations over 14.5 years were obtained from linked health records. Multivariable-adjusted logistic regression and Cox-proportional hazard models were used to analyse the data. Results: Over 14.5 years of follow-up (14,774 person-years), 535 (39.7%) women experienced a fall-related hospitalisation. Compared to women with the lowest Vitamin K1 intake (Quartile 1, median 49 µg/d), those with the highest intake (Quartile 4, median 120 µg/d) had 29% lower odds (OR 0.71 95%CI 0.52-0.97) for slow TUG performance (>10.2 s), and 26% lower relative hazards of a fall-related hospitalisation (HR 0.74 95%CI 0.59-0.93) after multivariable adjustment. These associations were non-linear and plateaued at moderate intakes of ~70-100 µg/d. There was no relation to grip strength. Vitamin K2 intakes were not associated with muscle function or falls. Conclusion: A higher habitual Vitamin K1 intake was associated with better physical function and lower long-term injurious falls risk in community-dwelling older women. In the context of musculoskeletal health, Vitamin K1 found abundantly in green leafy vegetables should be promoted.
MeSH term(s)	Humans ; Female ; Aged ; Male ; Cohort Studies ; Vitamin K 1 ; Independent Living ; Australia ; Vitamin K
Chemical Substances	Vitamin K 1 (84-80-0) ; Vitamin K (12001-79-5)
Language	English
Publishing date	2023-01-10
Publishing country	France
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2081921-3
ISSN	1760-4788 ; 1279-7707
ISSN (online)	1760-4788
ISSN	1279-7707
DOI	10.1007/s12603-022-1866-9
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Article ; Online: Vitamin K Intake and Atherosclerotic Cardiovascular Disease in the Danish Diet Cancer and Health Study.

Bellinge, Jamie W / Dalgaard, Frederik / Murray, Kevin / Connolly, Emma / Blekkenhorst, Lauren C / Bondonno, Catherine P / Lewis, Joshua R / Sim, Marc / Croft, Kevin D / Gislason, Gunnar / Torp-Pedersen, Christian / Tjønneland, Anne / Overvad, Kim / Hodgson, Jonathan M / Schultz, Carl / Bondonno, Nicola P

Journal of the American Heart Association

2021 Volume 10, Issue 16, Page(s) e020551

Abstract: Background Dietary vitamin K (K ...

Abstract	Background Dietary vitamin K (K
MeSH term(s)	Atherosclerosis/diagnosis ; Atherosclerosis/epidemiology ; Atherosclerosis/prevention & control ; Cardiovascular Diseases/diagnosis ; Cardiovascular Diseases/epidemiology ; Cardiovascular Diseases/prevention & control ; Denmark/epidemiology ; Diet ; Female ; Hospitalization ; Humans ; Incidence ; Male ; Middle Aged ; Nutrition Surveys ; Nutritive Value ; Prospective Studies ; Protective Factors ; Recommended Dietary Allowances ; Risk Assessment ; Risk Factors ; Time Factors ; Vitamin K 1/administration & dosage ; Vitamin K 2/administration & dosage
Chemical Substances	Vitamin K 2 (11032-49-8) ; Vitamin K 1 (84-80-0)
Language	English
Publishing date	2021-08-07
Publishing country	England
Document type	Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't
ZDB-ID	2653953-6
ISSN	2047-9980 ; 2047-9980
ISSN (online)	2047-9980
ISSN	2047-9980
DOI	10.1161/JAHA.120.020551
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Article ; Online: SARS-CoV-2 Incidence in K-12 School Districts with Mask-Required Versus Mask-Optional Policies - Arkansas, August-October 2021.

Donovan, Catherine V / Rose, Charles / Lewis, Kanna N / Vang, Kristyn / Stanley, Nichole / Motley, Michael / Brown, Clare C / Gray, Franklin John / Thompson, Joseph W / Amick, Benjamin C / Williams, Mark L / Thomas, Ebony / Neatherlin, John / Zohoori, Namvar / Porter, Austin / Cima, Mike

MMWR. Morbidity and mortality weekly report

2022 Volume 71, Issue 10, Page(s) 384–389

Abstract: ... in kindergarten through grade 12 (K-12). To identify any association between mask policies and COVID-19 incidence ... community levels, masks are an important part of a multicomponent prevention strategy in K-12 settings (5). ...

Abstract	Masks are effective at limiting transmission of SARS-CoV-2, the virus that causes COVID-19 (1), but the impact of policies requiring masks in school settings has not been widely evaluated (2-4). During fall 2021, some school districts in Arkansas implemented policies requiring masks for students in kindergarten through grade 12 (K-12). To identify any association between mask policies and COVID-19 incidence, weekly school-associated COVID-19 incidence in school districts with full or partial mask requirements was compared with incidence in districts without mask requirements during August 23-October 16, 2021. Three analyses were performed: 1) incidence rate ratios (IRRs) were calculated comparing districts with full mask requirements (universal mask requirement for all students and staff members) or partial mask requirements (e.g., masks required in certain settings, among certain populations, or if specific criteria could not be met) with school districts with no mask requirement; 2) ratios of observed-to-expected numbers of cases, by district were calculated; and 3) incidence in districts that switched from no mask requirement to any mask requirement were compared before and after implementation of the mask policy. Mean weekly district-level attack rates were 92-359 per 100,000 persons in the community* and 137-745 per 100,000 among students and staff members; mean student and staff member vaccination coverage ranged from 13.5% to 18.6%. Multivariable adjusted IRRs, which included adjustment for vaccination coverage, indicated that districts with full mask requirements had 23% lower COVID-19 incidence among students and staff members compared with school districts with no mask requirements. Observed-to-expected ratios for full and partial mask policies were lower than ratios for districts with no mask policy but were slightly higher for districts with partial policies than for those with full mask policies. Among districts that switched from no mask requirement to any mask requirement (full or partial), incidence among students and staff members decreased by 479.7 per 100,000 (p<0.01) upon implementation of the mask policy. In areas with high COVID-19 community levels, masks are an important part of a multicomponent prevention strategy in K-12 settings (5).
MeSH term(s)	Arkansas/epidemiology ; COVID-19/epidemiology ; COVID-19/prevention & control ; Health Policy ; Humans ; Incidence ; Masks ; SARS-CoV-2 ; Schools
Language	English
Publishing date	2022-03-11
Publishing country	United States
Document type	Technical Report
ZDB-ID	412775-4
ISSN	1545-861X ; 0149-2195
ISSN (online)	1545-861X
ISSN	0149-2195
DOI	10.15585/mmwr.mm7110e1
Database	MEDical Literature Analysis and Retrieval System OnLINE

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