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  1. Article ; Online: Letter to the editor on "torsion of cryptorchidism was misdiagnosed as hernia".

    Yue, Feng / Qiao, Xuhua / Wang, Chunyan

    Asian journal of surgery

    2023  Volume 46, Issue 12, Page(s) 5893–5894

    MeSH term(s) Male ; Humans ; Cryptorchidism/diagnosis ; Cryptorchidism/surgery ; Hernia, Inguinal/diagnosis ; Hernia, Inguinal/surgery ; Diagnostic Errors
    Language English
    Publishing date 2023-09-14
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 1068461-x
    ISSN 0219-3108 ; 1015-9584
    ISSN (online) 0219-3108
    ISSN 1015-9584
    DOI 10.1016/j.asjsur.2023.08.200
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Targeting HDACs for diffuse large B-cell lymphoma therapy

    Chunyan Wu / Qiao Song / Sophie Gao / Shaoling Wu

    Scientific Reports, Vol 14, Iss 1, Pp 1-

    2024  Volume 11

    Abstract: Abstract Histone deacetylases (HDACs) are involved in tumorigenesis and progression, however, their role in diffuse large B-cell lymphoma (DLBCL) is not well understood. In this study, we examined the expression levels, mutations, and clinical ... ...

    Abstract Abstract Histone deacetylases (HDACs) are involved in tumorigenesis and progression, however, their role in diffuse large B-cell lymphoma (DLBCL) is not well understood. In this study, we examined the expression levels, mutations, and clinical significance of HDACs in DLBCL. Additionally, we investigated the therapeutic potential of Chidamide, a novel HDAC inhibitor, to provide scientific evidence for targeting HDACs in DLBCL patients. We extracted transcriptome data of DLBCLs––including 47 lymph node samples and 337 whole-blood-cell controls––from The Cancer Genome Atlas. Bioinformatic analyses of HDAC expression, mutation, and correlation with the clinical significance of DLBCL patients were performed with the Gene Expression Profiling Interactive Analysis, GENEMANIA, and web-based software including cBioPortal and WebGestalt. To examine the therapeutic effect of Chidamide, DLBCL cell lines (WSU-DLCL-2 and DB cells) were employed. Cell proliferation and apoptosis were analyzed with Cell Counting Kit-8 and flow cytometry assays. The impact of Chidamide treatment was also analyzed by RNA sequencing of treated DB cells. Western blot was used to explore the molecular mechanism of the cytotoxicity of Chidamide on DLBCL cell lines. The expression of some HDACs (HDAC1, 2, 3, 4, 6, 7, 8, and 9) were significantly higher in the lymph node samples of DLBCL than that in whole-blood-cell controls. Moreover, we found that the mutation rate of HDACs was also higher in DLBCL tissues, although the overall survival of DLBCL patients was not associated with HDAC expression. Chidamide was found to have a cytotoxic effect on DLBCL cells in a dose-dependent manner, while transcriptome analysis and western blot revealed that using it for treatment impacted several biological processes, including PI3K/AKT signaling, mTOR signaling, the cell cycle, and apoptosis pathways. Alterations of HDAC genes, including enhanced expression and mutations, are positively related to DLBCL. Targeting HDACs with specific inhibitors such as Chidamide ...
    Keywords Medicine ; R ; Science ; Q
    Subject code 616
    Language English
    Publishing date 2024-01-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Targeting HDACs for diffuse large B-cell lymphoma therapy.

    Wu, Chunyan / Song, Qiao / Gao, Sophie / Wu, Shaoling

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 289

    Abstract: Histone deacetylases (HDACs) are involved in tumorigenesis and progression, however, their role in diffuse large B-cell lymphoma (DLBCL) is not well understood. In this study, we examined the expression levels, mutations, and clinical significance of ... ...

    Abstract Histone deacetylases (HDACs) are involved in tumorigenesis and progression, however, their role in diffuse large B-cell lymphoma (DLBCL) is not well understood. In this study, we examined the expression levels, mutations, and clinical significance of HDACs in DLBCL. Additionally, we investigated the therapeutic potential of Chidamide, a novel HDAC inhibitor, to provide scientific evidence for targeting HDACs in DLBCL patients. We extracted transcriptome data of DLBCLs--including 47 lymph node samples and 337 whole-blood-cell controls--from The Cancer Genome Atlas. Bioinformatic analyses of HDAC expression, mutation, and correlation with the clinical significance of DLBCL patients were performed with the Gene Expression Profiling Interactive Analysis, GENEMANIA, and web-based software including cBioPortal and WebGestalt. To examine the therapeutic effect of Chidamide, DLBCL cell lines (WSU-DLCL-2 and DB cells) were employed. Cell proliferation and apoptosis were analyzed with Cell Counting Kit-8 and flow cytometry assays. The impact of Chidamide treatment was also analyzed by RNA sequencing of treated DB cells. Western blot was used to explore the molecular mechanism of the cytotoxicity of Chidamide on DLBCL cell lines. The expression of some HDACs (HDAC1, 2, 3, 4, 6, 7, 8, and 9) were significantly higher in the lymph node samples of DLBCL than that in whole-blood-cell controls. Moreover, we found that the mutation rate of HDACs was also higher in DLBCL tissues, although the overall survival of DLBCL patients was not associated with HDAC expression. Chidamide was found to have a cytotoxic effect on DLBCL cells in a dose-dependent manner, while transcriptome analysis and western blot revealed that using it for treatment impacted several biological processes, including PI3K/AKT signaling, mTOR signaling, the cell cycle, and apoptosis pathways. Alterations of HDAC genes, including enhanced expression and mutations, are positively related to DLBCL. Targeting HDACs with specific inhibitors such as Chidamide may represent a potential therapeutic approach for DLBCL patients.
    MeSH term(s) Humans ; Histone Deacetylases/metabolism ; Phosphatidylinositol 3-Kinases/metabolism ; Aminopyridines/pharmacology ; Lymphoma, Large B-Cell, Diffuse/drug therapy ; Lymphoma, Large B-Cell, Diffuse/genetics ; Lymphoma, Large B-Cell, Diffuse/pathology ; Cell Proliferation ; Cell Line, Tumor ; Apoptosis/genetics
    Chemical Substances N-(2-amino-5-fluorobenzyl)-4-(N-(pyridine-3-acrylyl)aminomethyl)benzamide (87CIC980Y0) ; Histone Deacetylases (EC 3.5.1.98) ; Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; Aminopyridines
    Language English
    Publishing date 2024-01-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-50956-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Statistical Measurements and Club Effects of High-Quality Development in Chinese Manufacturing.

    Lin, Chunyan / Qiao, Wen

    International journal of environmental research and public health

    2022  Volume 19, Issue 23

    Abstract: Advanced manufacturing is the pillar for building a modern economic system. We measured the level of high-quality development of manufacturing (HQDM) in China, and found that it has gone through the three stages of expansion, cultivation, and promotion. ... ...

    Abstract Advanced manufacturing is the pillar for building a modern economic system. We measured the level of high-quality development of manufacturing (HQDM) in China, and found that it has gone through the three stages of expansion, cultivation, and promotion. Spatially, it is characterized as "high in the east, low in the west" and "fast in the west, slow in the east", and presents non-equilibrium characteristics. To overcome the subjective bias introduced by artificially set clubs, we utilize a data-driven nonlinear time-varying factor model for clustering into four convergent clubs, where provinces with higher intensity of environmental regulation and environmental preference tend to move closer to the clubs with a higher level of HQDM. We reveal the convergence patterns and regional differences in HQDM, which provides a new perspective for determining the trends of high-quality manufacturing development, thus allowing for policy recommendations targeted at narrowing the manufacturing development gap.
    Language English
    Publishing date 2022-12-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2175195-X
    ISSN 1660-4601 ; 1661-7827
    ISSN (online) 1660-4601
    ISSN 1661-7827
    DOI 10.3390/ijerph192316228
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Research progress of traditional Chinese medicine compound "Xiaochaihu Decoction" in the treatment of depression.

    Sun, Chunyan / Gao, Mingzhou / Qiao, Mingqi

    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

    2023  Volume 159, Page(s) 114249

    Abstract: Depression is a common psychiatric disorder under the category of depression syndrome in Traditional Chinese Medicine (TCM) theory. Meanwhile, Xiaochaihu Decoction is a classical TCM formulation regulating Qi, resolving and dissipating stagnation. ... ...

    Abstract Depression is a common psychiatric disorder under the category of depression syndrome in Traditional Chinese Medicine (TCM) theory. Meanwhile, Xiaochaihu Decoction is a classical TCM formulation regulating Qi, resolving and dissipating stagnation. Clinically, the formulation has long been adopted to treat Shaoyang stagnation syndrome for depression syndrome. In this review, potential targets of action and the corresponding pathways of Xiaochaihu Decoction are explored for depression treatment via network pharmacology. The article also systematically summarizes the active components and pharmacological mechanisms of seven Chinese herbal medicine components in Xiaochaihu Decoction and guides the future study direction of Xiaochaihu Decoction, which may serve a promising treatment for depression.
    MeSH term(s) Humans ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/therapeutic use ; Medicine, Chinese Traditional ; Depression/drug therapy ; Mental Disorders/drug therapy
    Chemical Substances xiaochaihu ; Drugs, Chinese Herbal
    Language English
    Publishing date 2023-01-20
    Publishing country France
    Document type Journal Article ; Review
    ZDB-ID 392415-4
    ISSN 1950-6007 ; 0753-3322 ; 0300-0893
    ISSN (online) 1950-6007
    ISSN 0753-3322 ; 0300-0893
    DOI 10.1016/j.biopha.2023.114249
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Statistical Measurements and Club Effects of High-Quality Development in Chinese Manufacturing

    Chunyan Lin / Wen Qiao

    International Journal of Environmental Research and Public Health, Vol 19, Iss 16228, p

    2022  Volume 16228

    Abstract: Advanced manufacturing is the pillar for building a modern economic system. We measured the level of high-quality development of manufacturing (HQDM) in China, and found that it has gone through the three stages of expansion, cultivation, and promotion. ... ...

    Abstract Advanced manufacturing is the pillar for building a modern economic system. We measured the level of high-quality development of manufacturing (HQDM) in China, and found that it has gone through the three stages of expansion, cultivation, and promotion. Spatially, it is characterized as “high in the east, low in the west” and “fast in the west, slow in the east”, and presents non-equilibrium characteristics. To overcome the subjective bias introduced by artificially set clubs, we utilize a data-driven nonlinear time-varying factor model for clustering into four convergent clubs, where provinces with higher intensity of environmental regulation and environmental preference tend to move closer to the clubs with a higher level of HQDM. We reveal the convergence patterns and regional differences in HQDM, which provides a new perspective for determining the trends of high-quality manufacturing development, thus allowing for policy recommendations targeted at narrowing the manufacturing development gap.
    Keywords high-quality development of manufacturing ; club convergence ; nonlinear time-varying factor model ; ordered logit model ; Medicine ; R
    Language English
    Publishing date 2022-12-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Comparative analysis of the effectiveness difference of SARS-COV-2 mRNA vaccine in different populations in the real world: A review.

    Cai, Sihui / Chang, Chunyan / Zhang, Xiuhong / Qiao, Weizhen

    Medicine

    2023  Volume 102, Issue 34, Page(s) e34805

    Abstract: Coronavirus disease 2019 (COVID-19) has ravaged the world since December 2019. Up to now, it is still prevalent around the world. Vaccines are an important means to prevent the spread of COVID-19 and reduce severe disease and mortality. Currently, ... ...

    Abstract Coronavirus disease 2019 (COVID-19) has ravaged the world since December 2019. Up to now, it is still prevalent around the world. Vaccines are an important means to prevent the spread of COVID-19 and reduce severe disease and mortality. Currently, different types of novel coronavirus vaccines are still being developed and improved, and the relevant vaccines that have been approved for marketing have been widely vaccinated around the world. As vaccination coverage continues to grow, concerns about the efficacy and safety of vaccines after real-world use have grown. Some clinical studies have shown that vaccine effectiveness is closely related to antibody response after vaccination. Among them, the advantages of COVID-19 messenger ribonucleic acid (mRNA) vaccine, such as better adaptability to variant strains and better immune response ability, have attracted great attention. However, different populations with different genders, ages, previous COVID-19 infection history, underlying diseases and treatments will show different antibody responses after mRNA vaccination, which will affect the protection of the vaccine. Based on this, this paper reviews the reports related severe acute respiratory syndrome Coronavirus 2 mRNA vaccines, and summarizes the effectiveness of vaccines in different populations and different disease states and looked forward to the precise vaccination strategy of the vaccine in the future.
    MeSH term(s) Female ; Male ; Humans ; COVID-19 Vaccines ; SARS-CoV-2 ; COVID-19/prevention & control ; RNA, Messenger ; mRNA Vaccines
    Chemical Substances COVID-19 Vaccines ; RNA, Messenger ; mRNA Vaccines
    Language English
    Publishing date 2023-01-26
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 80184-7
    ISSN 1536-5964 ; 0025-7974
    ISSN (online) 1536-5964
    ISSN 0025-7974
    DOI 10.1097/MD.0000000000034805
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Case report: A rare case of acute hemolysis in advanced rectal cancer after XELOX and nivolumab treatment: analysis of drug-dependent antibodies.

    Zhao, Dengke / Song, Qiao / Wu, Chunyan / Wang, Shuye

    Frontiers in medicine

    2023  Volume 10, Page(s) 1167759

    Abstract: Objective: To investigate the mechanism, : Methods: We encountered a male patient with stage IV rectal cancer who experienced acute hemolysis during the ninth cycle of treatment with XELOX combined with nivolumab and cetuximab. The patient's blood ... ...

    Abstract Objective: To investigate the mechanism,
    Methods: We encountered a male patient with stage IV rectal cancer who experienced acute hemolysis during the ninth cycle of treatment with XELOX combined with nivolumab and cetuximab. The patient's blood samples were collected and tested for the presence of oxaliplatin or nivolumab antibodies on red blood cells.
    Results: Direct antiglobulin testing of red blood cells incubated with oxaliplatin was strongly positive, whereas cells incubated with nivolumab were negative, which suggested that oxaliplatin was responsible for the hemolysis. After short-term highdose glucocorticoid treatment, human normal immunoglobulin infusion, and other symptomatic treatments, the patient's condition rapidly improved, and he continued to receive nivolumab treatment without further hemolysis.
    Conclusion: Attention should be paid to the possibility of acute hemolysis when using oxaliplatin and nivolumab, and it is important to recognize and manage this adverse event early. We detected oxaliplatin-related antibodies on the surface of red blood cells
    Language English
    Publishing date 2023-05-25
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2023.1167759
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Role of NF-κB in cardiac changes of obstructive sleep apnoea rabbits treated by mandibular advancement device.

    Kang, Wenjing / Zhu, Dechao / Zhang, Shilong / Qiao, Xing / Liu, Jie / Liu, Chunyan / Lu, Haiyan

    Journal of oral rehabilitation

    2024  

    Abstract: Background: Obstructive sleep apnoea (OSA) is an independent risk factor for cardiovascular diseases. We aimed to investigate the role of nuclear factor-kappa B (NF-κB) in the changes of cardiac structures in OSA rabbits treated by mandibular ... ...

    Abstract Background: Obstructive sleep apnoea (OSA) is an independent risk factor for cardiovascular diseases. We aimed to investigate the role of nuclear factor-kappa B (NF-κB) in the changes of cardiac structures in OSA rabbits treated by mandibular advancement device (MAD).
    Methods: Eighteen male New Zealand white rabbits aged 6 months were randomly divided into three groups: control group, group OSA and group MAD. Hyaluronate gel was injected into the soft palate of the rabbits in group OSA and group MAD to induce OSA. The cone beam computer tomography (CBCT) of the upper airway and polysomnography (PSG) was performed to ensure successful modelling. CBCT and PSG were applied again to detect the effects of MAD treatment. All animals were induced to sleep in a supine position for 4-6 h a day for 8 weeks. Then the levels of NF-κB, Interleukin 6 (IL-6), Interleukin 10 (IL-10) and the proportion of myocardial fibrosis (MF) were detected.
    Results: The higher activation of NF-κB, IL-6 and IL-10 were found in the OSA group than in the control group, leading to the increase of collagen fibres compared with the control group. Furthermore, the apnoea-hypopnea index (AHI) was positively correlated with the above factors. There were no significant differences between group MAD and the control group.
    Conclusion: The NF-κB pathway was activated in the myocardium of OSA rabbits, which accelerated the development of MF. Early application of MAD could reduce the activation of NF-κB in the myocardium and prevent the development of MF.
    Language English
    Publishing date 2024-02-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 187079-8
    ISSN 1365-2842 ; 0305-182X
    ISSN (online) 1365-2842
    ISSN 0305-182X
    DOI 10.1111/joor.13666
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: IFNγ-Producing B Cells Play a Regulating Role in Infection-Mediated Inhibition of Allergy.

    Qiao, Sai / Peng, Ying / Zhang, Chunyan / Thomas, Rony / Wang, Shuhe / Yang, Xi

    Biology

    2023  Volume 12, Issue 9

    Abstract: The hygiene hypothesis suggests that some infections may inhibit the development of allergic diseases, but the mechanism remains unclear. Our previous study has shown that ... ...

    Abstract The hygiene hypothesis suggests that some infections may inhibit the development of allergic diseases, but the mechanism remains unclear. Our previous study has shown that Chlamydia
    Language English
    Publishing date 2023-09-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2661517-4
    ISSN 2079-7737
    ISSN 2079-7737
    DOI 10.3390/biology12091259
    Database MEDical Literature Analysis and Retrieval System OnLINE

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