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  1. Article ; Online: Assessment of the impact of the vaccine pass policy on COVID-19 vaccine hesitancy and uptake among Chinese adults in Hong Kong.

    Wong, Irene O L / Wong, Cherry / Mak, Nelly / Dai, Alan / Xiao, Jingyi / Wu, Peng / Ni, Michael Y / Liao, Qiuyan / Cowling, Benjamin J

    Vaccine

    2024  

    Abstract: ... mortality in older ages in Hong Kong in early 2022 requiring three doses by June 2022. We did not identify ... vaccine uptake in adults in a Chinese population in Hong Kong.: Methods: We analysed patterns ... in Hong Kong in early 2022. Since the policy withdrawal the uptake of further booster doses has been very low ...

    Abstract Background: Recognising the importance of attaining high vaccine coverage to mitigate the COVID-19 impact, a Vaccine Pass scheme was implemented during and after the first large Omicron wave with high mortality in older ages in Hong Kong in early 2022 requiring three doses by June 2022. We did not identify any studies evaluating the policy impact of vaccination mandates with vaccine uptake over whole policy period of time in a Chinese population. We aim to evaluate the impact of the Vaccine Pass policy on COVID-19 vaccine uptake in adults in a Chinese population in Hong Kong.
    Methods: We analysed patterns in vaccine uptake and hesitancy using local data from population vaccine registry and 32 cross-sectional telephone surveys conducted from October 2021 to December 2022. The association of Vaccine Pass phases with vaccine uptake was examined using logistic regression analyses, taking into account covariates including self-risk perception, perceived self-efficacy in preventing COVID-19 and trust in government in pandemic control as well as physical distancing measures and demographics.
    Results: The uptake of primary series and third doses was positively significantly associated with the successive stages of Vaccine Pass implementation (adjusted odds ratios ranged from 2.41 to 7.81). Other statistically significant drivers of uptake included age group, chronic condition, higher perceived personal susceptibility to COVID-19, higher trust in government, and higher educational attainment.
    Conclusion: Vaccine uptake in older adults was observed to have increased by a greater extent after the policy annoucement and implementation, under the contextual changes during and after a large Omicron wave with high mortality in Hong Kong in early 2022. Since the policy withdrawal the uptake of further booster doses has been very low in all ages. We suggest that improving voluntary booster uptake in older adults should be prioritized.
    Language English
    Publishing date 2024-04-15
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 605674-x
    ISSN 1873-2518 ; 0264-410X
    ISSN (online) 1873-2518
    ISSN 0264-410X
    DOI 10.1016/j.vaccine.2024.04.035
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: The Tao Hong Si Wu Decoction ameliorates diabetes-associated cognitive dysfunction by inhibiting the formation of amyloid plaques.

    Cai, Ming / Chen, Zhen / Zhang, Mengling / Xia, Wenwen / Dai, Wentao / Zhao, Mengdie / Xie, Ruonan / Ji, Zhaojie / Han, Lan / Peng, Daiyin

    International journal of geriatric psychiatry

    2024  Volume 39, Issue 3, Page(s) e6076

    Abstract: Objectives: The herbs in Tao Hong Si Wu Decoction (THSWD) are beneficial in the treatment ...

    Abstract Objectives: The herbs in Tao Hong Si Wu Decoction (THSWD) are beneficial in the treatment of cognitive impairment. However, the underlying mechanisms of THSWD in treating diabetes-associated cognitive dysfunction (DACD) are not entirely explored. This study is aimed to investigate the therapeutic effects of THSWD in DACD model rats and the underlying mechanism.
    Methods: Ultra-high-phase liquid chromatography was employed to identify the main compounds contained in the THSWD extract. DACD rat model was induced by feeding with a high-sugar and high-fat diet and injecting streptozotocin (35 mg/kg). DACD rats were gavaged with THSWD for 1 week. The learning and memory abilities of the rats were measured by using the Morris water maze. Western blotting was used to detect the changes in DACD rat targets. Statistical methods were used to evaluate the correlation between proteins.
    Results: The results show that THSWD effectively reduced the escape latency, hippocampal neuron damage, glycosylated hemoglobin, type A1C, and blood lipid levels in DACD rats. Furthermore, DACD rats showed significantly increased amyloid precursor protein, β-secretase, Aβ
    Conclusions: THSWD can improve the learning and memory abilities of DACD rats by inhibiting the expression of AEGs-AGE receptors pathway, which provides an experimental basis for the clinical application of THSWD. In addition, the experiment combines pharmacological and statistical methods, which offers a new perspective for the study of Chinese herbal medicine.
    MeSH term(s) Humans ; Rats ; Animals ; Drugs, Chinese Herbal/therapeutic use ; Drugs, Chinese Herbal/pharmacology ; Plaque, Amyloid ; Cognitive Dysfunction/drug therapy ; Cognitive Dysfunction/etiology ; Diabetes Mellitus
    Chemical Substances Taohong Siwu decoction II ; Drugs, Chinese Herbal
    Language English
    Publishing date 2024-03-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 806736-3
    ISSN 1099-1166 ; 0885-6230
    ISSN (online) 1099-1166
    ISSN 0885-6230
    DOI 10.1002/gps.6076
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Women in respiratory medicine: Perspectives from China Mainland and Hong Kong.

    Ip, Mary S M / Dai, Huaping

    Respirology (Carlton, Vic.)

    2022  Volume 27, Issue 7, Page(s) 549–552

    MeSH term(s) China ; Female ; Hong Kong ; Humans ; Pulmonary Medicine
    Language English
    Publishing date 2022-04-07
    Publishing country Australia
    Document type Letter
    ZDB-ID 1435849-9
    ISSN 1440-1843 ; 1323-7799
    ISSN (online) 1440-1843
    ISSN 1323-7799
    DOI 10.1111/resp.14252
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Building demolition waste management through smart BIM: A case study in Hong Kong.

    Kang, Kai / Besklubova, Svetlana / Dai, Yaqi / Zhong, Ray Y

    Waste management (New York, N.Y.)

    2022  Volume 143, Page(s) 69–83

    Abstract: Hong Kong's construction industry, known for its massive building infrastructure, produces ... remains a concern for stakeholders and exert pressure on the limited capacity of Hong Kong's landfills ...

    Abstract Hong Kong's construction industry, known for its massive building infrastructure, produces an enormous amount of waste every year, the vast majority of which is disposed for landfills. Therefore, some effective operational measures and waste management policies have been implemented. However, enormous waste remains a concern for stakeholders and exert pressure on the limited capacity of Hong Kong's landfills. Though previous research discusses Building Information Modelling (BIM) application for construction waste management enhancement, the BIM model has not been widely implemented for building demolition with waste management. Hence, as a response to the aforementioned shortcomings, this paper develops a conceptual framework that allows collecting, maintaining, and analyzing comprehensive information through Smart BIM that uses advanced technologies such as Internet of Things (IoT) and capable of reacting to user activities such as waste quantitative assessment, demolition process planning, optimal disposal route selection, and waste management strategy are executed. The advantages of the proposed framework are shown in a case study benefit-cost analysis based on three planned reuse and recycling-rate scenarios that explain on- and off-site recycling methods. The results show that the proposed framework will pave the way for generating sustainable waste disposal practices by providing technical and decision-making support functionalities to engineers and planners in the construction industry.
    MeSH term(s) Construction Industry ; Construction Materials ; Hong Kong ; Industrial Waste ; Recycling ; Waste Management
    Chemical Substances Industrial Waste
    Language English
    Publishing date 2022-02-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2001471-5
    ISSN 1879-2456 ; 0956-053X
    ISSN (online) 1879-2456
    ISSN 0956-053X
    DOI 10.1016/j.wasman.2022.02.027
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Applicability of the Global Lung Function Initiative prediction equations in Hong Kong Chinese children.

    Chan, Kate C / Zhu, Huichen / Yu, Michelle / Yuen, Hoi-Man / Dai, Siyu / Chin, Hui-Yen / Choy, Jonathan / Chan, Jeffrey / Tsoi, Dana / Siu, Brian / Au, Chun T / Li, Albert M

    Pediatric pulmonology

    2023  Volume 58, Issue 11, Page(s) 3235–3245

    Abstract: ... Initiative (GLI) prediction equations for spirometry in Hong Kong children and to develop prediction ... prediction equations in Hong Kong Chinese children. The GLI-2012 equations may underestimate FEV ...

    Abstract Background and objective: This study aimed to assess the applicability of the Global Lung Function Initiative (GLI) prediction equations for spirometry in Hong Kong children and to develop prediction equations based on the Generalized Additive Models for Location, Scale, and Shape (GAMLSS) modeling.
    Methods: Healthy Chinese children and adolescents aged 6-17 years old were recruited from randomly selected schools to undergo spirometry. The measurements were transformed to z-score according to the GLI-2012 equations for South East (SE) Asians and the GLI-2022 global race-neutral equations. Prediction equations for spirometric indices were developed with GAMLSS modeling to identify predictors.
    Results: A total of 886 children (477 boys) with a mean age of 12.5 years (standard deviation [SD] 3.3 years) were included. By the GLI-2012 SE Asian equations, positive mean z-scores were observed in forced expiratory volume in 1 s (FEV
    Conclusion: Our study provided data supporting the applicability of the GLI prediction equations in Hong Kong Chinese children. The GLI-2012 equations may underestimate FEV
    MeSH term(s) Male ; Female ; Adolescent ; Humans ; Child ; East Asian People ; Hong Kong/epidemiology ; Reference Values ; Forced Expiratory Volume/physiology ; Spirometry ; Vital Capacity/physiology ; Lung/physiology
    Language English
    Publishing date 2023-08-29
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 632784-9
    ISSN 1099-0496 ; 8755-6863
    ISSN (online) 1099-0496
    ISSN 8755-6863
    DOI 10.1002/ppul.26649
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Egg residue and depletion of meloxicam in Jing Hong laying hens following multiple oral doses.

    Shao, Hao-Tian / Gao, Liang / Li, Hao-Tian / Zhang, Mei / Chen, Jun-Cheng / Duan, Ming-Hui / Li, Ze-En / Dai, Yan / Li, Xing-Ping / Yang, Fan

    Poultry science

    2023  Volume 102, Issue 8, Page(s) 102761

    Abstract: ... enriched the study on the residue of meloxicam in domestic Jing Hong laying hens and provided WDIs to help ...

    Abstract Meloxicam is a nonsteroidal anti-inflammatory drug (NSAID) commonly used in an extra-label manner in commercial laying hens for the treatment of foot lesions, which are a common issue in this species. The present study aimed to determine the depletion profiles of meloxicam in eggs with multiple oral administration under 2 different dosing regimens and to further recommend reasonable withdrawal intervals (WDIs). Meloxicam (1 mg/kg) was administered orally to laying hens under 2 dosing schedules: 10 doses at 24-h intervals and 15 doses at 12-h intervals. Eggs were collected daily after the first dosing, and meloxicam concentrations in both yolk and white were determined by a high-performance liquid chromatography (HPLC) method. The weight ratio of white to yolk in the whole egg was 1.54 (the mean of 20 eggs with repeated tests), and this value combined with the meloxicam concentrations in white and yolk were used to calculate the drug concentrations in whole eggs. Meloxicam was quickly eliminated from egg white, and its concentrations could only be quantified at 2 time points during the elimination phase. The elimination half-lives in yolk and whole egg were 3.07 ± 1.00 and 2.98 ± 0.88 d, respectively, after 10 repeated doses. And the corresponding elimination half-lives were 2.30 ± 0.83 and 2.18 ± 0.67 d, respectively, after repeated 15 doses. Considering the time when meloxicam was not detectable in eggs with the time of ovum development and maturation, a withdrawal interval (WDI) was suggested as 17 d for both dosing schedules. The current results enriched the study on the residue of meloxicam in domestic Jing Hong laying hens and provided WDIs to help ensure animal-derived food safety.
    MeSH term(s) Animals ; Female ; Meloxicam/analysis ; Egg Yolk/chemistry ; Chickens ; Drug Residues/analysis ; Ovum/chemistry ; Administration, Oral ; Eggs/analysis
    Chemical Substances Meloxicam (VG2QF83CGL)
    Language English
    Publishing date 2023-04-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 242586-5
    ISSN 1525-3171 ; 0032-5791
    ISSN (online) 1525-3171
    ISSN 0032-5791
    DOI 10.1016/j.psj.2023.102761
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Age-dependent effect of ambient ozone on emergency asthma hospitalizations in Hong Kong.

    Dai, Yuanrong / Qiu, Hong / Sun, Shengzhi / Yang, Yang / Lin, Hualiang / Tian, Linwei

    The Journal of allergy and clinical immunology

    2018  Volume 141, Issue 4, Page(s) 1532–1534.e5

    MeSH term(s) Adolescent ; Adult ; Aged ; Air Pollutants/adverse effects ; Air Pollution/adverse effects ; Asthma/etiology ; Child ; Female ; Hong Kong ; Hospitalization ; Humans ; Male ; Middle Aged ; Ozone/adverse effects ; Young Adult
    Chemical Substances Air Pollutants ; Ozone (66H7ZZK23N)
    Language English
    Publishing date 2018-01-31
    Publishing country United States
    Document type Letter
    ZDB-ID 121011-7
    ISSN 1097-6825 ; 1085-8725 ; 0091-6749
    ISSN (online) 1097-6825 ; 1085-8725
    ISSN 0091-6749
    DOI 10.1016/j.jaci.2018.01.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Comparison of the immunogenicity of BNT162b2 and CoronaVac COVID-19 vaccines in Hong Kong.

    Mok, Chris Ka Pun / Cohen, Carolyn A / Cheng, Samuel M S / Chen, Chunke / Kwok, Kin-On / Yiu, Karen / Chan, Tat-On / Bull, Maireid / Ling, Kwun Cheung / Dai, Zixi / Ng, Susanna S / Lui, Grace Chung-Yan / Wu, Chao / Amarasinghe, Gaya K / Leung, Daisy W / Wong, Samuel Yeung Shan / Valkenburg, Sophie A / Peiris, Malik / Hui, David S

    Respirology (Carlton, Vic.)

    2021  Volume 27, Issue 4, Page(s) 301–310

    Abstract: ... receiving either two doses of BNT162b2 (n = 366) or CoronaVac (n = 360) vaccines in Hong Kong were ...

    Abstract Background and objective: Few head-to-head evaluations of immune responses to different vaccines have been reported.
    Methods: Surrogate virus neutralization test (sVNT) antibody levels of adults receiving either two doses of BNT162b2 (n = 366) or CoronaVac (n = 360) vaccines in Hong Kong were determined. An age-matched subgroup (BNT162b2 [n = 49] vs. CoronaVac [n = 49]) was tested for plaque reduction neutralization (PRNT) and spike-binding antibody and T-cell reactivity in peripheral blood mononuclear cells.
    Results: One month after the second dose of vaccine, BNT162b2 elicited significantly higher PRNT
    Conclusion: Vaccination with BNT162b2 induces stronger humoral responses than CoronaVac. CoronaVac induces higher CD4
    MeSH term(s) Adult ; BNT162 Vaccine ; COVID-19/prevention & control ; COVID-19 Vaccines ; Hong Kong ; Humans ; Leukocytes, Mononuclear ; SARS-CoV-2
    Chemical Substances COVID-19 Vaccines ; BNT162 Vaccine (N38TVC63NU)
    Language English
    Publishing date 2021-11-24
    Publishing country Australia
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1435849-9
    ISSN 1440-1843 ; 1323-7799
    ISSN (online) 1440-1843
    ISSN 1323-7799
    DOI 10.1111/resp.14191
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Hong Kong’s water security: a governance perspective

    Wang, Raymond Yu / Dai, Liping

    International Journal of Water Resources Development. 2021 Jan. 02, v. 37, no. 1 p.48-66

    2021  

    Abstract: Traditional concerns regarding Hong Kong’s water security have centred on water quantity, quality ... sensitive insights into Hong Kong’s water security, which will be subject to the restructuring of the water ...

    Abstract Traditional concerns regarding Hong Kong’s water security have centred on water quantity, quality and pricing. In contrast, this article embraces an integrative conceptualization of water security from a governance perspective. A technocratic and supply-oriented water system may overlook challenges stemming from scalar mismatches at the territorial, institutional and discursive levels, as well as at the science–policy interface. Resilience thinking could identify new areas of concern and provide contextually sensitive insights into Hong Kong’s water security, which will be subject to the restructuring of the water governance system, which concerns changing discourses, power relations and institutional mechanisms.
    Keywords governance ; water ; water quantity ; water security ; China ; scalar mismatch ; resilience ; Hong Kong
    Language English
    Dates of publication 2021-0102
    Size p. 48-66.
    Publishing place Routledge
    Document type Article ; Online
    Note NAL-AP-2-clean
    ZDB-ID 2016525-0
    ISSN 1360-0648 ; 0790-0627
    ISSN (online) 1360-0648
    ISSN 0790-0627
    DOI 10.1080/07900627.2019.1688647
    Database NAL-Catalogue (AGRICOLA)

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  10. Article ; Online: Construction of Influenza Early Warning Model Based on Combinatorial Judgment Classifier: A Case Study of Seasonal Influenza in Hong Kong.

    Wang, Zi-Xiao / Ntambara, James / Lu, Yan / Dai, Wei / Meng, Rui-Jun / Qian, Dan-Min

    Current medical science

    2022  Volume 42, Issue 1, Page(s) 226–236

    Abstract: ... increasingly become a major public health problem in some areas, such as Hong Kong (China). Therefore, based ... on a variety of machine learning methods, and considering the seasonal influenza in Hong Kong, the study aims ... performance. In the present study, the epidemic situation and meteorological data of Hong Kong in recent years ...

    Abstract Objective: The annual influenza epidemic is a heavy burden on the health care system, and has increasingly become a major public health problem in some areas, such as Hong Kong (China). Therefore, based on a variety of machine learning methods, and considering the seasonal influenza in Hong Kong, the study aims to establish a Combinatorial Judgment Classifier (CJC) model to classify the epidemic trend and improve the accuracy of influenza epidemic early warning.
    Methods: The characteristic variables were selected using the single-factor statistical method to establish the influencing factor system of an influenza outbreak. On this basis, the CJC model was proposed to provide an early warning for an influenza outbreak. The characteristic variables in the final model included atmospheric pressure, absolute maximum temperature, mean temperature, absolute minimum temperature, mean dew point temperature, the number of positive detections of seasonal influenza viruses, the positive percentage among all respiratory specimens, and the admission rates in public hospitals with a principal diagnosis of influenza.
    Results: The accuracy of the CJC model for the influenza outbreak trend reached 96.47%, the sensitivity and specificity change rates of this model were lower than those of other models. Hence, the CJC model has a more stable prediction performance. In the present study, the epidemic situation and meteorological data of Hong Kong in recent years were used as the research objects for the construction of the model index system, and a lag correlation was found between the influencing factors and influenza outbreak. However, some potential risk factors, such as geographical nature and human factors, were not incorporated, which ideally affected the prediction performance to some extent.
    Conclusion: In general, the CJC model exhibits a statistically better performance, when compared to some classical early warning algorithms, such as Support Vector Machine, Discriminant Analysis, and Ensemble Classfiers, which improves the performance of the early warning of seasonal influenza.
    MeSH term(s) Epidemiological Models ; Epidemiological Monitoring ; Hong Kong ; Humans ; Influenza, Human/epidemiology ; Machine Learning ; Models, Statistical
    Language English
    Publishing date 2022-01-04
    Publishing country China
    Document type Journal Article
    ZDB-ID 2931065-9
    ISSN 2523-899X ; 2096-5230
    ISSN (online) 2523-899X
    ISSN 2096-5230
    DOI 10.1007/s11596-021-2493-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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