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Article: Corrigendum: What is the role of the neutrophil extracellular traps in the cardiovascular disease burden associated with hemodialysis bioincompatibility?

Cristol, Jean-Paul / Thierry, Alain R / Bargnoux, Anne-Sophie / Morena-Carrere, Marion / Canaud, Bernard

2024 Volume 11, Page(s) 1393023

Abstract: This corrects the article DOI: 10.3389/fmed.2023.1268748.]. ...

Abstract	[This corrects the article DOI: 10.3389/fmed.2023.1268748.].
Language	English
Publishing date	2024-03-12
Publishing country	Switzerland
Document type	Published Erratum
ZDB-ID	2775999-4
ISSN	2296-858X
ISSN	2296-858X
DOI	10.3389/fmed.2024.1393023
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Article ; Online: Typical Sources and Locations of Marijuana among US Young Adults: Differences by Sexual Minority Status.

Yockey, R Andrew / Cristol, Benjamin A / Stryker, Shanna / Kline, Nolan

Substance use & misuse

2023 Volume 58, Issue 5, Page(s) 704–708

Abstract: ... ...

Abstract	Background
MeSH term(s)	Humans ; Female ; Young Adult ; Cannabis ; Sexual and Gender Minorities ; Bisexuality ; Sexual Behavior ; Heterosexuality
Language	English
Publishing date	2023-02-27
Publishing country	England
Document type	Journal Article
ZDB-ID	1310358-1
ISSN	1532-2491 ; 1082-6084
ISSN (online)	1532-2491
ISSN	1082-6084
DOI	10.1080/10826084.2023.2184204
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Article: What is the role of the neutrophil extracellular traps in the cardiovascular disease burden associated with hemodialysis bioincompatibility?

Cristol, Jean-Paul / Thierry, Alain R / Bargnoux, Anne-Sophie / Morena-Carrere, Marion / Canaud, Bernard

Frontiers in medicine

2023 Volume 10, Page(s) 1268748

Abstract: Despite significant progress in dialysis modalities, intermittent renal replacement therapy remains an "unphysiological" treatment that imperfectly corrects uremic disorders and may lead to low-grade chronic inflammation, neutrophil activation, and ... ...

Abstract	Despite significant progress in dialysis modalities, intermittent renal replacement therapy remains an "unphysiological" treatment that imperfectly corrects uremic disorders and may lead to low-grade chronic inflammation, neutrophil activation, and oxidative stress due to repetitive blood/membrane interactions contributing to the "remaining uremic syndrome" and cardiovascular disease burden of hemodialysis patients. Understanding dialysis bioincompatibility pathways still remains a clinical and biochemical challenge. Indeed, surrogate biomarkers of inflammation including C-reactive protein could not discriminate between all components involved in these complex pathways. A few examples may serve to illustrate the case. Cytokine release during dialysis sessions may be underestimated due to their removal using high-flux dialysis or hemodiafiltration modalities. Complement activation is recognized as a key event of bioincompatibility. However, it appears as an early and transient event with anaphylatoxin level normalization at the end of the dialysis session. Complement activation is generally assumed to trigger leukocyte stimulation leading to proinflammatory mediators' secretion and oxidative burst. In addition to being part of the innate immune response involved in eliminating physically and enzymatically microbes, the formation of Neutrophil Extracellular Traps (NETs), known as NETosis, has been recently identified as a major harmful component in a wide range of pathologies associated with inflammatory processes. NETs result from the neutrophil degranulation induced by reactive oxygen species overproduction via NADPH oxidase and consist of modified chromatin decorated with serine proteases, elastase, bactericidal proteins, and myeloperoxidase (MPO) that produces hypochlorite anion. Currently, NETosis remains poorly investigated as a sensitive and integrated marker of bioincompatibility in dialysis. Only scarce data could be found in the literature. Oxidative burst and NADPH oxidase activation are well-known events in the bioincompatibility phenomenon. NET byproducts such as elastase, MPO, and circulating DNA have been reported to be increased in dialysis patients more specifically during dialysis sessions, and were identified as predictors of poor outcomes. As NETs and MPO could be taken up by endothelium, NETs could be considered as a vascular memory of intermittent bioincompatibility phenomenon. In this working hypothesis article, we summarized the puzzle pieces showing the involvement of NET formation during hemodialysis and postulated that NETosis may act as a disease modifier and may contribute to the comorbid burden associated with dialysis bioincompatibility.
Language	English
Publishing date	2023-11-15
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2775999-4
ISSN	2296-858X
ISSN	2296-858X
DOI	10.3389/fmed.2023.1268748
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Article ; Online: Organic Brake Friction Composite Materials: Impact of Mixing Duration on Microstructure, Properties, Tribological Behavior and Wear Resistance.

Makni, Fatma / Cristol, Anne-Lise / Elleuch, Riadh / Desplanques, Yannick

Polymers

2022 Volume 14, Issue 9

Abstract: The lack of knowledge on the link between the manufacturing process and performance constitutes a major issue in brake lining development. The manufacturing process of organic brake friction composite materials includes several steps (mixing, preforming, ...

Abstract	The lack of knowledge on the link between the manufacturing process and performance constitutes a major issue in brake lining development. The manufacturing process of organic brake friction composite materials includes several steps (mixing, preforming, hot molding and post-curing), which define their final microstructure, properties and performances. This study focuses on the effect of mixing duration on the microstructure, properties and tribological behavior of organic friction composite materials. The adopted methodology is based on simplified formulations effective in limiting synergistic effects by reducing the number and size distribution of constituents. Two simplified materials are here developed according to the mixing duration of the constituent introduction sequence. The microstructural characteristics are studied using 2D and 3D analyses, and then correlated with the thermophysical and mechanical properties. Wear mechanisms and tribological behavior are studied in relation to the microstructure and properties of the materials. The results show the effect of mixing duration as regards particle distribution and fiber arrangement. The distribution and size of fiber entanglements contribute to the formation of carbonaceous particle clusters, which create bulk bridges improving thermal conductivity. Moreover, the arrangement of rock fibers affects density, porosity and thermo-physical properties. In addition, the mixing disrupts the cohesion of fiber bundles with the matrix, affecting compressive modulus and wear behavior. This microstructural defect also fosters abundant third-body source flow, which disturbs the tribological circuit and behavior. Porosities induced by fiber entanglements, having a large and irregular size and distribution on the frictional surface, result in low wear resistance and alter the frictional stability.
Language	English
Publishing date	2022-04-21
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527146-5
ISSN	2073-4360 ; 2073-4360
ISSN (online)	2073-4360
ISSN	2073-4360
DOI	10.3390/polym14091692
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Article: Friction Performance Improvement of Phenolic/Rockwool Fibre Composites: Influence of Fibre Morphology and Distribution.

Makni, Fatma / Cristol, Anne-Lise / Desplanques, Yannick / Elleuch, Riadh

Materials (Basel, Switzerland)

2022 Volume 15, Issue 15

Abstract: The size and morphology of reinforcing fibres have a great influence on organic brake friction composite material properties and performance. This research aims to establish the link between friction material microstructure heterogeneity induced by ... ...

Abstract	The size and morphology of reinforcing fibres have a great influence on organic brake friction composite material properties and performance. This research aims to establish the link between friction material microstructure heterogeneity induced by rockwool fibre morphology and distribution and the resulting tribological behaviour. The adopted approach is based on simplified formulations designed to limit synergistic effects by reducing the number and size distribution of constituents. Two simplified materials are developed with different rockwool fibre size and morphology. The first material is elaborated with calibrated fibre balls, and the second one is performed with separated fibres. Friction and wear behaviour are correlated with thermal phenomena in order to reveal wear mechanisms and thus understand the link between microstructural characteristics and the resulting tribological behaviour. It was found that a regular size and distribution of rockwool fibre balls induce better tribological behaviour and enhance wear resistance. Indeed, a homogeneously distributed porosity, which is induced by fibre balls, favours the development and preservation of the load-bearing plateaus in the contact. This, consequently guarantees a stable friction and a reduced wear rate. Consequently, reducing microstructural heterogeneity, resulting from rockwool fibre morphology and distribution, improves the performance of composite friction material.
Language	English
Publishing date	2022-08-04
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2487261-1
ISSN	1996-1944
ISSN	1996-1944
DOI	10.3390/ma15155381
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Article: Analytical Performances of the Novel i-STAT Alinity Point-of-Care Analyzer.

Larcher, Romaric / Lottelier, Maxence / Badiou, Stephanie / Dupuy, Anne-Marie / Bargnoux, Anne-Sophie / Cristol, Jean-Paul

Diagnostics (Basel, Switzerland)

2023 Volume 13, Issue 2

Abstract: Many Point-of-Care devices have been released over the past decade. However, data regarding their analytical performances in real-world situations remains scarce. Herein, we aimed to assess the analytical performances of the i-STAT Alinity system. We ... ...

Abstract	Many Point-of-Care devices have been released over the past decade. However, data regarding their analytical performances in real-world situations remains scarce. Herein, we aimed to assess the analytical performances of the i-STAT Alinity system. We conducted an analytical performances study with the i-STAT Alinity device using cartridges CG4+ (pH, Pco2, Po2, lactate, bicarbonate and base excess); CHEM8+ (Na, K, Cl, ionized Ca, urea, creatinine, glucose, hematocrit and hemoglobin) and PT/INR (prothrombin time and international normalized ratio). We assessed the imprecision and compared the results to those obtained on existing instruments in the central laboratory. We found that the within-lab coefficients of variation (CV) were very low (<2%) or low (2−5%), except for creatinine and PT (CV = 5.2% and CV = 6.3%, respectively). For almost all the parameters, the results were strongly (R2 = 90−95%) or very strongly (R2 > 95%) correlated with those of the existing laboratory instruments, and the biases were very low (<2%) or low (2−5%). However, correlations of the PT and INR measurements with existing instruments were lower (R2 = 86.0% and 89.7%), and biases in the Po2 (7.9%), creatinine (5.4%) and PT (−6.6%) measurements were higher. The i-STAT Alinity appeared as a convenient device for measurements of numerous parameters. However, clinicians should interpret Po2, creatinine and PT results with caution.
Language	English
Publishing date	2023-01-13
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662336-5
ISSN	2075-4418
ISSN	2075-4418
DOI	10.3390/diagnostics13020297
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Article: Evaluation of a new automated immunoassay for the quantification of anti-Müllerian hormone.

Lotierzo, Manuela / Urbain, Victor / Dupuy, Anne-Marie / Cristol, Jean-Paul

Practical laboratory medicine

2021 Volume 25, Page(s) e00220

Abstract: ... with a coefficient of determination (r: Conclusions: The performance of Lumipulse G AMH system was highly ...

Abstract	Objectives: A newly developed fully automated Lumipulse G AMH method (Fujirebio Diagnostics) was recently introduced in clinical laboratories for quantitative determination of anti-Müllerian hormone (AMH) level in human serum or plasma. AMH has emerged as value-added biomarker in the assessment of ovarian reserve, in diagnosis of granulosa cells cancer and in the investigation of gonadal disorders. We compared Lumipulse G AMH assay performances with other methods largely applied for AMH measurements. Design and methods: The Lumipulse G AMH method based on two-step sandwich chemiluminescence enzyme immunoassay was assessed on Lumipulse G600II analyzer. The evaluation study included imprecisions, sensitivity and linearity whereas a comparison study was performed on a heterogeneous population of 114 patients by using the Elecsys AMH Plus assay on COBAS 8000 e602 module (Roche Diagnostics). Results: Lumipulse G AMH system showed good repeatability (within-run imprecision) with CV values below 1% (0.5% and 0.9% for high and low serum pools). Similarly within-laboratory imprecision was assessed with CV values of 2.5% and 1.6% for high and low level controls respectively. A linearity regression formula of 1.0119x-0.067 with a coefficient of determination (r Conclusions: The performance of Lumipulse G AMH system was highly comparable with that of Roche Elecsys AMH Plus assay although approximately 10% higher values of AMH levels were observed for Lumipulse AMH system at all range of concentrations. Nevertheless the Lumipulse G system seems to be largely suitable for quantitative determination of AMH level in small-scale laboratory because of the reduced size and the use of single cartridge per test assuring flexibility and easy handling.
Language	English
Publishing date	2021-04-14
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2834973-8
ISSN	2352-5517
ISSN	2352-5517
DOI	10.1016/j.plabm.2021.e00220
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Article ; Online: Environmentally relevant methylmercury exposure reduces the metabolic scope of a model songbird.

Gerson, Alexander R / Cristol, Daniel A / Seewagen, Chad L

Environmental pollution (Barking, Essex : 1987)

2018 Volume 246, Page(s) 790–796

Abstract: For most birds, energy efficiency and conservation are paramount to balancing the competing demands of self-maintenance, reproduction, and other demanding life history stages. Yet the ability to maximize energy output for behaviors like predator escape ... ...

Abstract	For most birds, energy efficiency and conservation are paramount to balancing the competing demands of self-maintenance, reproduction, and other demanding life history stages. Yet the ability to maximize energy output for behaviors like predator escape and migration is often also critical. Environmental perturbations that affect energy metabolism may therefore have important consequences for fitness and survival. Methylmercury (MeHg) is a global pollutant that has wide-ranging impacts on physiological systems, but its effects on the metabolism of birds and other vertebrates are poorly understood. We investigated dose-dependent effects of dietary MeHg on the body composition, basal and peak metabolic rates (BMR, PMR), and respiratory quotients (RQ) of zebra finches (Taeniopygia guttata). Dietary exposure levels (0.0, 0.1, or 0.6 ppm wet weight) were intended to reflect a range of mercury concentrations found in invertebrate prey of songbirds in areas contaminated by atmospheric deposition or point-source pollution. We found adiposity increased with MeHg exposure. BMR also increased with exposure while PMR decreased, together resulting in reduced metabolic scope in both MeHg-exposed treatments. There were differences in RQ among treatments that suggested a compromised ability of exposed birds to rapidly metabolize carbohydrates during exercise in a hop-hover wheel. The elevated BMR of exposed birds may have been due to energetic costs of depurating MeHg, whereas the reduced PMR could have been due to reduced oxygen carrying capacity and/or reduced glycolytic capacity. Our results suggest that environmentally relevant mercury exposure is capable of compromising the ability of songbirds to both budget and rapidly exert energy.
MeSH term(s)	Animals ; Dietary Exposure/adverse effects ; Environmental Exposure/adverse effects ; Environmental Pollutants/metabolism ; Finches/metabolism ; Methylmercury Compounds/metabolism ; Reproduction/drug effects
Chemical Substances	Environmental Pollutants ; Methylmercury Compounds
Language	English
Publishing date	2018-12-29
Publishing country	England
Document type	Journal Article
ZDB-ID	280652-6
ISSN	1873-6424 ; 0013-9327 ; 0269-7491
ISSN (online)	1873-6424
ISSN	0013-9327 ; 0269-7491
DOI	10.1016/j.envpol.2018.12.072
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Article ; Online: Discrepant post-filter ionized calcium concentrations by 2 common gas analyzers in continuous renal replacement therapy using regional citrate anticoagulation: another piece of the puzzle.

Larcher, Romaric / Kuster, Nils / Bargnoux, Anne-Sophie / Klouche, Kada / Pieroni, Laurence / Cristol, Jean-Paul

Kidney international

2021 Volume 99, Issue 1, Page(s) 268–269

MeSH term(s)	Anticoagulants/adverse effects ; Calcium ; Citrates/adverse effects ; Citric Acid ; Continuous Renal Replacement Therapy ; Renal Replacement Therapy
Chemical Substances	Anticoagulants ; Citrates ; Citric Acid (2968PHW8QP) ; Calcium (SY7Q814VUP)
Language	English
Publishing date	2021-01-03
Publishing country	United States
Document type	Letter
ZDB-ID	120573-0
ISSN	1523-1755 ; 0085-2538
ISSN (online)	1523-1755
ISSN	0085-2538
DOI	10.1016/j.kint.2020.09.021
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Article ; Online: Feasibility and early effects of bed-cycling eccentric training: Potential clinical applications.

Pavlin, Laura / Fernandez, Florian / Lowgreen, Rauhiti / Ohresser, Isabelle / Cristol, Jean-Paul / Turc-Baron, Cécile / Bernardi, Henri / Candau, Robin

Clinical physiology and functional imaging

2022 Volume 43, Issue 3, Page(s) 154–164

Abstract: Purpose: This study aimed to evaluate feasibility and early effects of moderate intensity bed-cycling eccentric training on healthy individuals, and establish whether this training modality could be implemented into bedridden patients' routine care.: ... ...

Abstract	Purpose: This study aimed to evaluate feasibility and early effects of moderate intensity bed-cycling eccentric training on healthy individuals, and establish whether this training modality could be implemented into bedridden patients' routine care. Methods: Longitudinal study with prepost exercise intervention measurements. The development of a bed-adapted eccentric ergometer allowed to conduct five training sessions during 3 weeks at increasing intensity on 11 healthy individuals. Force-speed relationship, maximal voluntary knee extension force and neural activation of subjects were evaluated before and after the programme. Results: Five training sessions were sufficient to decrease the rate of perceived exertion whereas eccentric power output increased (+40%). After training, maximal voluntary isometric contraction force measured during knee extension had significantly improved in all subjects, with a mean increase of 17%. Maximal cycling power was also significantly higher (+7%) after the training programme. Conclusion: Taken together, these results show that moderate load eccentric bed cycling (i) was feasible and efficient, (ii) did not generate excessive individual perception of effort during exercise nor develop major muscular or joint pain after training and (iii) allowed early force and power gains in healthy subjects.
MeSH term(s)	Humans ; Feasibility Studies ; Longitudinal Studies ; Exercise/physiology ; Isometric Contraction ; Muscle, Skeletal/physiology ; Muscle Contraction/physiology
Language	English
Publishing date	2022-12-19
Publishing country	England
Document type	Journal Article
ZDB-ID	2071203-0
ISSN	1475-097X ; 1475-0961
ISSN (online)	1475-097X
ISSN	1475-0961
DOI	10.1111/cpf.12805
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