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Article ; Online: Antimony (V) Adsorption at the Hematite–Water Interface

Jerzy Mierzwa / Rose Mumbi / Avedananda Ray / Sudipta Rakshit / Michael E. Essington / Dibyendu Sarkar

Soil Systems, Vol 5, Iss 20, p

A Macroscopic and In Situ ATR-FTIR Study

2021 Volume 20

Abstract: ... Iron oxide minerals are considered major sinks for Sb. Among the different oxidation states of Sb, (+) V is ... found more commonly in a wide redox range. Despite many adsorption studies of Sb (V) with various ... iron oxide minerals, detailed research on the adsorption mechanism of Sb (V) on hematite using macroscopic ...

Abstract	The environmental mobility of antimony (Sb) is largely unexplored in geochemical environments. Iron oxide minerals are considered major sinks for Sb. Among the different oxidation states of Sb, (+) V is found more commonly in a wide redox range. Despite many adsorption studies of Sb (V) with various iron oxide minerals, detailed research on the adsorption mechanism of Sb (V) on hematite using macroscopic, spectroscopic, and surface complexation modeling is rare. Thus, the main objective of our study is to evaluate the surface complexation mechanism of Sb (V) on hematite under a range of solution properties using macroscopic, in situ attenuated total reflectance Fourier transform infrared (ATR-FTIR) spectroscopic, and surface complexation modeling. The results indicate that the Sb (V) adsorption on hematite was highest at pH 4–6. After pH 6, the adsorption decreased sharply and became negligible above pH 9. The effect of ionic strength was negligible from pH 4 to 6. The spectroscopic results confirmed the presence of inner- and outer-sphere surface complexes at lower pH values, and only outer-sphere-type surface complex at pH 8. Surface complexation models successfully predicted the Sb (V) adsorption envelope. Our research will improve the understanding of Sb (V) mobility in iron-oxide-rich environments.
Keywords	adsorption ; antimony ; hematite ; ATR-FTIR ; mechanism ; surface complexation modeling ; Physical geography ; GB3-5030 ; Chemistry ; QD1-999
Subject code	540
Language	English
Publishing date	2021-03-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Preliminary Validation and Feasibility of the Autism Detection in Early Childhood-Virtual (ADEC-V) for Autism Telehealth Evaluations in a Hospital Setting.

Kryszak, Elizabeth M / Albright, Charles M / Stephenson, Kevin G / Nevill, Rose E / Hedley, Darren / Burns, Claire O / Young, Robyn L / Butter, Eric M / Vargo, Kerrigan / Mulick, James A

Journal of autism and developmental disorders

2022 Volume 52, Issue 12, Page(s) 5139–5149

Abstract: ... V) for telehealth assessment of possible autism. Participants were 121 children (24.79% female) aged ... in the Midwestern United States between October 2020 and February 2021. The ADEC-V showed good sensitivity (0.82) and specificity ... sample including more children without ASD. This preliminary validation study identifies the ADEC-V ...

Abstract	This study provided preliminary validation of the Autism Detection in Early Childhood-Virtual (ADEC-V) for telehealth assessment of possible autism. Participants were 121 children (24.79% female) aged 18-47 months who completed telehealth evaluations at a large pediatric hospital in the Midwestern United States between October 2020 and February 2021. The ADEC-V showed good sensitivity (0.82) and specificity (0.78) and was significantly correlated with other ASD symptom measures (i.e., CARS-2, ADI-R). Internal consistency was acceptable (α = 0.77). These results need replication in a larger and broader sample including more children without ASD. This preliminary validation study identifies the ADEC-V as a promising measure for telehealth ASD assessments in young children.
MeSH term(s)	Child ; Child, Preschool ; Humans ; Female ; Male ; Autistic Disorder/diagnosis ; Autism Spectrum Disorder/diagnosis ; Feasibility Studies ; Telemedicine/methods ; Hospitals
Language	English
Publishing date	2022-02-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	391999-7
ISSN	1573-3432 ; 0162-3257
ISSN (online)	1573-3432
ISSN	0162-3257
DOI	10.1007/s10803-022-05433-1
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Article ; Online: III/V silicon hybrid laser based on a resonant Bragg structure.

Davis, Jordan A / Kim, Myun Sik / El Amili, Abdelkrim / Trotter, Douglas C / Starbuck, Andrew L / Dallo, Christina / Pomerene, Andrew T / DeRose, Christopher T / Lentine, Anthony L / Fainman, Yeshaiahu

Applied optics

2020 Volume 59, Issue 13, Page(s) 4158–4164

Abstract: We demonstrate a laser tunable in intensity with gigahertz tuning speed based on a III/V reflective ...

Abstract	We demonstrate a laser tunable in intensity with gigahertz tuning speed based on a III/V reflective semiconductor optical amplifier (RSOA) coupled to a silicon photonic chip. The silicon chip contains a Bragg-based Fabry-Perot resonator to form a passive bandpass filter within its stopband to enable single-mode operation of the laser. We observe a side mode suppression ratio of 43 dB, linewidth of 790 kHz, and an optical output power of 1.65 mW around 1530 nm. We also investigate using a micro-ball lens as an alternative coupling method between the RSOA and the silicon chip.
Language	English
Publishing date	2020-05-13
Publishing country	United States
Document type	Journal Article
ISSN	1539-4522
ISSN (online)	1539-4522
DOI	10.1364/AO.390522
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Article ; Online: Mechanisms and Regulation of Cardiac Ca V 1.2 Trafficking

Maartje Westhoff / Rose E. Dixon

International Journal of Molecular Sciences, Vol 22, Iss 5927, p

2021 Volume 5927

Abstract: ... at the ventricular myocardium triggers voltage-dependent L-type Ca 2+ (Ca V 1.2) channels in individual myocytes ... activity of functional Ca V 1.2 channels at the t-tubule dyads dictates the amplitude of the Ca 2+ influx ... have revealed the existence of internal reservoirs of preformed Ca V 1.2 channels that can be rapidly ...

Abstract	During cardiac excitation contraction coupling, the arrival of an action potential at the ventricular myocardium triggers voltage-dependent L-type Ca 2+ (Ca V 1.2) channels in individual myocytes to open briefly. The level of this Ca 2+ influx tunes the amplitude of Ca 2+ -induced Ca 2+ release from ryanodine receptors (RyR2) on the junctional sarcoplasmic reticulum and thus the magnitude of the elevation in intracellular Ca 2+ concentration and ultimately the downstream contraction. The number and activity of functional Ca V 1.2 channels at the t-tubule dyads dictates the amplitude of the Ca 2+ influx. Trafficking of these channels and their auxiliary subunits to the cell surface is thus tightly controlled and regulated to ensure adequate sarcolemmal expression to sustain this critical process. To that end, recent discoveries have revealed the existence of internal reservoirs of preformed Ca V 1.2 channels that can be rapidly mobilized to enhance sarcolemmal expression in times of acute stress when hemodynamic and metabolic demand increases. In this review, we provide an overview of the current thinking on Ca V 1.2 channel trafficking dynamics in the heart. We highlight the numerous points of control including the biosynthetic pathway, the endosomal recycling pathway, ubiquitination, and lysosomal and proteasomal degradation pathways, and discuss the effects of β-adrenergic and angiotensin receptor signaling cascades on this process.
Keywords	L-type calcium channels ; ion channel trafficking ; t-tubule ; caveolae ; calcium signaling ; β-adrenergic receptor ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Subject code	333
Language	English
Publishing date	2021-05-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
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Article ; Online: V-ATPase Inhibition Decreases Mutant Androgen Receptor Activity in Castrate-resistant Prostate Cancer.

Whitton, Bradleigh / Okamoto, Haruko / Rose-Zerilli, Matthew / Packham, Graham / Crabb, Simon J

Molecular cancer therapeutics

2021 Volume 20, Issue 4, Page(s) 739–748

Abstract: ... V-ATPase), a multiprotein complex that catalyzes proton transport across intracellular and ... plasma membranes, influences wild-type AR function, the effect of V-ATPase inhibition on variant AR function is ... unknown.Inhibition of V-ATPase reduced AR function in wild-type and mutant AR luciferase reporter models ...

Abstract	Prostate cancer is critically dependent on androgen receptor (AR) signaling. Despite initial responsiveness to androgen deprivation, most patients with advanced prostate cancer subsequently progress to a clinically aggressive castrate-resistant prostate cancer (CRPC) phenotype, typically associated with expression of splice-variant or mutant AR forms. Although current evidence suggests that the vacuolar-ATPase (V-ATPase), a multiprotein complex that catalyzes proton transport across intracellular and plasma membranes, influences wild-type AR function, the effect of V-ATPase inhibition on variant AR function is unknown.Inhibition of V-ATPase reduced AR function in wild-type and mutant AR luciferase reporter models. In hormone-sensitive prostate cancer cell lines (LNCaP, DuCaP) and mutant AR CRPC cell lines (22Rv1, LNCaP-F877L/T878A), V-ATPase inhibition using bafilomycin-A1 and concanamycin-A reduced AR expression, and expression of AR target genes, at mRNA and protein levels. Furthermore, combining chemical V-ATPase inhibition with the AR antagonist enzalutamide resulted in a greater reduction in AR downstream target expression than enzalutamide alone in LNCaP cells. To investigate the role of individual subunit isoforms, siRNA and CRISPR-Cas9 were used to target the V
MeSH term(s)	Humans ; Male ; Prostatic Neoplasms, Castration-Resistant/drug therapy ; Receptors, Androgen/drug effects ; Transfection ; Vacuolar Proton-Translocating ATPases/antagonists & inhibitors
Chemical Substances	AR protein, human ; Receptors, Androgen ; Vacuolar Proton-Translocating ATPases (EC 3.6.1.-)
Language	English
Publishing date	2021-02-09
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2063563-1
ISSN	1538-8514 ; 1535-7163
ISSN (online)	1538-8514
ISSN	1535-7163
DOI	10.1158/1535-7163.MCT-20-0662
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Article: Primary exposure to SARS-CoV-2 variants elicits convergent epitope specificities, immunoglobulin V gene usage and public B cell clones.

Lima, Noemia S / Musayev, Maryam / Johnston, Timothy S / Wagner, Danielle A / Henry, Amy R / Wang, Lingshu / Yang, Eun Sung / Zhang, Yi / Birungi, Kevina / Black, Walker P / O'Dell, Sijy / Schmidt, Stephen D / Moon, Damee / Lorang, Cynthia G / Zhao, Bingchun / Chen, Man / Boswell, Kristin L / Roberts-Torres, Jesmine / Davis, Rachel L /

Peyton, Lowrey / Narpala, Sandeep R / O'Connell, Sarah / Wang, Jennifer / Schrager, Alexander / Talana, Chloe Adrienna / Leung, Kwanyee / Shi, Wei / Khashab, Rawan / Biber, Asaf / Zilberman, Tal / Rhein, Joshua / Vetter, Sara / Ahmed, Afeefa / Novik, Laura / Widge, Alicia / Gordon, Ingelise / Guech, Mercy / Teng, I-Ting / Phung, Emily / Ruckwardt, Tracy J / Pegu, Amarendra / Misasi, John / Doria-Rose, Nicole A / Gaudinski, Martin / Koup, Richard A / Kwong, Peter D / McDermott, Adrian B / Amit, Sharon / Schacker, Timothy W / Levy, Itzchak / Mascola, John R / Sullivan, Nancy J / Schramm, Chaim A / Douek, Daniel C

bioRxiv : the preprint server for biology

2022

Abstract: ... of epitope immunodominance. Furthermore, convergent V gene usage and similar public B cell clones were ...

Abstract	An important consequence of infection with a SARS-CoV-2 variant is protective humoral immunity against other variants. The basis for such cross-protection at the molecular level is incompletely understood. Here we characterized the repertoire and epitope specificity of antibodies elicited by Beta, Gamma and ancestral variant infection and assessed their cross-reactivity to these and the more recent Delta and Omicron variants. We developed a high-throughput approach to obtain immunoglobulin sequences and produce monoclonal antibodies for functional assessment from single B cells. Infection with any variant elicited similar cross-binding antibody responses exhibiting a remarkably conserved hierarchy of epitope immunodominance. Furthermore, convergent V gene usage and similar public B cell clones were elicited regardless of infecting variant. These convergent responses despite antigenic variation may represent a general immunological principle that accounts for the continued efficacy of vaccines based on a single ancestral variant.
Language	English
Publishing date	2022-06-30
Publishing country	United States
Document type	Preprint
DOI	10.1101/2022.03.28.486152
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Primary exposure to SARS-CoV-2 variants elicits convergent epitope specificities, immunoglobulin V gene usage and public B cell clones.

Peyton, Lowrey / Narpala, Sandeep R / O'Connell, Sarah / Serebryannyy, Leonid / Wang, Jennifer / Schrager, Alexander / Talana, Chloe Adrienna / Shimberg, Geoffrey / Leung, Kwanyee / Shi, Wei / Khashab, Rawan / Biber, Asaf / Zilberman, Tal / Rhein, Joshua / Vetter, Sara / Ahmed, Afeefa / Novik, Laura / Widge, Alicia / Gordon, Ingelise / Guech, Mercy / Teng, I-Ting / Phung, Emily / Ruckwardt, Tracy J / Pegu, Amarendra / Misasi, John / Doria-Rose, Nicole A / Gaudinski, Martin / Koup, Richard A / Kwong, Peter D / McDermott, Adrian B / Amit, Sharon / Schacker, Timothy W / Levy, Itzchak / Mascola, John R / Sullivan, Nancy J / Schramm, Chaim A / Douek, Daniel C

Nature communications

2022 Volume 13, Issue 1, Page(s) 7733

Abstract: ... antibody responses exhibiting a conserved hierarchy of epitope immunodominance. Furthermore, convergent V gene usage ...

Abstract	An important consequence of infection with a SARS-CoV-2 variant is protective humoral immunity against other variants. However, the basis for such cross-protection at the molecular level is incompletely understood. Here, we characterized the repertoire and epitope specificity of antibodies elicited by infection with the Beta, Gamma and WA1 ancestral variants and assessed their cross-reactivity to these and the more recent Delta and Omicron variants. We developed a method to obtain immunoglobulin sequences with concurrent rapid production and functional assessment of monoclonal antibodies from hundreds of single B cells sorted by flow cytometry. Infection with any variant elicited similar cross-binding antibody responses exhibiting a conserved hierarchy of epitope immunodominance. Furthermore, convergent V gene usage and similar public B cell clones were elicited regardless of infecting variant. These convergent responses despite antigenic variation may account for the continued efficacy of vaccines based on a single ancestral variant.
MeSH term(s)	Humans ; Immunoglobulin Variable Region ; Epitopes/genetics ; SARS-CoV-2/genetics ; COVID-19 ; Clone Cells ; Antibodies, Monoclonal ; Antibodies, Neutralizing ; Antibodies, Viral ; Spike Glycoprotein, Coronavirus/genetics
Chemical Substances	Immunoglobulin Variable Region ; Epitopes ; Antibodies, Monoclonal ; Antibodies, Neutralizing ; Antibodies, Viral ; Spike Glycoprotein, Coronavirus ; spike protein, SARS-CoV-2
Language	English
Publishing date	2022-12-14
Publishing country	England
Document type	Journal Article
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-022-35456-2
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Article ; Online: Lig v 1 structure and the inflammatory response to the Ole e 1 protein family.

Robledo Retana, Tania / Bradley-Clarke, Jack / Croll, Tristan / Rose, Ruth / Hoti, Inva / Stagg, Andrew J / Villalba, Mayte / Pickersgill, Richard W

Allergy

2020 Volume 75, Issue 9, Page(s) 2395–2398

MeSH term(s)	Allergens ; Antigens, Plant ; Humans ; Olea ; Plant Proteins ; Pollen
Chemical Substances	Allergens ; Antigens, Plant ; Plant Proteins
Language	English
Publishing date	2020-06-09
Publishing country	Denmark
Document type	Letter ; Research Support, Non-U.S. Gov't
ZDB-ID	391933-x
ISSN	1398-9995 ; 0105-4538
ISSN (online)	1398-9995
ISSN	0105-4538
DOI	10.1111/all.14351
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Article ; Online: Convergent epitope specificities, V gene usage and public clones elicited by primary exposure to SARS-CoV-2 variants

Lima, Noemia S / Mukhamedova, Maryam / Johnston, Timothy S / Wagner, Danielle A / Henry, Amy R / Wang, Lingshu / Yang, Eun Sung / Zhang, Yi / Birungi, Kevina / Black, Walker P / O'Dell, Sijy / Schmidt, Stephen D / Moon, Damee / Lorang, Cynthia G / Zhao, Bingchun / Chen, Man / Boswell, Kristin / Roberts-Torres, Jesmine / Davis, Rachel L /

Peyton, Lowrey / Narpala, Sandeep R / O'Connell, Sarah / Wang, Jennifer / Schrager, Alexander / Talana, Chloe Adrienna / Leung, Kwanyee / Shi, Wei / Khashab, Rawan / Biber, Asaf / Zilberman, Tal / Rhein, Joshua / Vetter, Sara / Ahmed, Afeefa / Novik, Laura / Widge, Alicia / Gordon, Ingelise / Guech, Mercy / Teng, I-Ting / Phung, Emily / Ruckwardt, Tracy / Pegu, Amarendra / Misasi, John / Doria-Rose, Nicole A / Gaudinski, Martin / Koup, Richard A / Kwong, Peter D / McDermott, Adrian B / Amit, Sharon / Schacker, Timothy W / Levy, Itzchak / Mascola, John R / Sullivan, Nancy J / Schramm, Chaim A / Douek, Daniel C

bioRxiv

Abstract: ... immunodominance for RBD and convergent V gene usage when compared to ancestral virus infection. Additionally ...

Abstract	While humoral immune responses to infection or vaccination with ancestral SARS-CoV-2 have been well-characterized, responses elicited by infection with variants are less understood. Here we characterized the repertoire, epitope specificity, and cross-reactivity of antibodies elicited by Beta and Gamma variant infection compared to ancestral virus. We developed a high-throughput approach to obtain single-cell immunoglobulin sequences and isolate monoclonal antibodies for functional assessment. Spike-, RBD- and NTD-specific antibodies elicited by Beta- or Gamma-infection exhibited a remarkably similar hierarchy of epitope immunodominance for RBD and convergent V gene usage when compared to ancestral virus infection. Additionally, similar public B cell clones were elicited regardless of infecting variant. These convergent responses may account for the broad cross-reactivity and continued efficacy of vaccines based on a single ancestral variant.
Keywords	covid19
Language	English
Publishing date	2022-03-29
Publisher	Cold Spring Harbor Laboratory
Document type	Article ; Online
DOI	10.1101/2022.03.28.486152
Database	COVID19

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Article ; Online: Siderophore production in Azotobacter vinelandii in response to Fe-, Mo- and V-limitation.

McRose, Darcy L / Baars, Oliver / Morel, François M M / Kraepiel, Anne M L

Environmental microbiology

2017 Volume 19, Issue 9, Page(s) 3595–3605

Abstract: ... for the acquisition of the nitrogenase co-factors Mo and V. However, regulation of siderophore production by Mo- and V ...

Abstract	Azotobacter vinelandii is a terrestrial diazotroph well studied for its siderophore production capacity and its role as a model nitrogen fixer. In addition to Fe, A. vinelandii siderophores are used for the acquisition of the nitrogenase co-factors Mo and V. However, regulation of siderophore production by Mo- and V-limitation has been difficult to confirm and knowledge of the full suite of siderophores synthesized by this organism has only recently become available. Using this new information, we conducted an extensive study of siderophore production in N
MeSH term(s)	Azotobacter vinelandii/metabolism ; Catechols/metabolism ; Citrates/biosynthesis ; Iron/metabolism ; Molybdenum/metabolism ; Nitrogen/metabolism ; Nitrogen Fixation ; Nitrogenase/metabolism ; Pyrrolidinones ; Siderophores/biosynthesis ; Vanadium/metabolism
Chemical Substances	Catechols ; Citrates ; Pyrrolidinones ; Siderophores ; Vanadium (00J9J9XKDE) ; vibrioferrin (157568-17-7) ; Molybdenum (81AH48963U) ; Iron (E1UOL152H7) ; Nitrogenase (EC 1.18.6.1) ; catechol (LF3AJ089DQ) ; Nitrogen (N762921K75)
Language	English
Publishing date	2017-08-14
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	2020213-1
ISSN	1462-2920 ; 1462-2912
ISSN (online)	1462-2920
ISSN	1462-2912
DOI	10.1111/1462-2920.13857
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