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Article ; Online: Re: positive surgical margins in robot-assisted partial nephrectomy: a multi-institutional analysis of oncologic outcomes (leave no tumor behind): A. Khalifeh, J. H. Kaouk, S. Bhayani, C. Rogers, m. Stifelman, Y. S. Tanagho, R. Kumar, M. A. Gorin, G. Sivarajan, D. Samarasekera and M. E. Allaf J Urol 2013;190:1674-1679.

Goldfarb, Robert / Adejoro, Oluwakayode / Lane, Brian / Kim, Simon P / Weight, Christopher

2014 Volume 192, Issue 1, Page(s) 278–279

MeSH term(s)	Female ; Humans ; Kidney Neoplasms/pathology ; Kidney Neoplasms/surgery ; Male ; Nephrectomy/methods ; Robotics
Language	English
Publishing date	2014-07
Publishing country	United States
Document type	Comment ; Letter
ZDB-ID	3176-8
ISSN	1527-3792 ; 0022-5347
ISSN (online)	1527-3792
ISSN	0022-5347
DOI	10.1016/j.juro.2013.12.055
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Article ; Online: Rationale and Design of the TARGET-EFT Trial: Multicomponent Intervention for Frail and Pre-frail Patients Hospitalized with Acute Cardiac Conditions.

Fountotos, R / Munir, H / Ahmad, F / Goldfarb, M / Afilalo, J

The journal of nutrition, health & aging

2022 Volume 26, Issue 3, Page(s) 282–289

Abstract: Background: With the aging population and rising rates of cardiovascular disease (CVD), cardiologists and cardiac surgeons are encountering a growing number of frail older patients that have complex cardiac and non-cardiac issues. Measuring frailty ... ...

Abstract	Background: With the aging population and rising rates of cardiovascular disease (CVD), cardiologists and cardiac surgeons are encountering a growing number of frail older patients that have complex cardiac and non-cardiac issues. Measuring frailty provides valuable prognostic information to help personalize treatment decisions. However, there is minimal evidence on multicomponent frailty interventions in this setting. The TARGET-EFT (The MulTicomponent Acute Intervention in FRail GEriatric PaTients with cardiovascular disease using the Essential Frailty Toolset) trial aims to target physical and non-physical frailty deficits to improve health-related quality of life and hospital-acquired disability in frail patients hospitalized with CVD. Methods: The TARGET-EFT trial is a single-center parallel-group randomized clinical trial in frail and pre-frail older adults ≥65 years admitted to the cardiovascular unit (CVU) at the Jewish General Hospital, Montreal, Quebec. The trial will compare usual inpatient care to a multicomponent intervention targeting physical weakness, cognitive impairment, malnutrition, and anemia. Outcomes of interest in both groups will be assessed at three time points: (1) study enrollment, (2) discharge from the CVU, and (3) 30 days after hospital discharge. Conclusions: The overarching goal is to treat patients' frailty in parallel with their CVD, and in doing so, optimize patient functional losses while in-hospital and shortly thereafter. The results of this trial will inform best practices for patient-centered care in this vulnerable patient group.
MeSH term(s)	Acute Disease ; Aged ; Cardiovascular Diseases/complications ; Cognitive Dysfunction ; Frail Elderly/psychology ; Frailty/complications ; Frailty/therapy ; Geriatric Assessment ; Heart Diseases ; Humans ; Quality of Life/psychology
Language	English
Publishing date	2022-03-17
Publishing country	France
Document type	Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	2081921-3
ISSN	1760-4788 ; 1279-7707
ISSN (online)	1760-4788
ISSN	1279-7707
DOI	10.1007/s12603-022-1759-y
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Article ; Online: Effect of a high-citrate beverage on urine chemistry in patients with calcium kidney stones.

Goldfarb, David S / Modersitzki, Frank / Asplin, John R / Nazzal, Lama

Urolithiasis

2023 Volume 51, Issue 1, Page(s) 96

Abstract: ... in an increase in mean 24-h urine citrate and urine pH, and a decrease in supersaturation of calcium oxalate ...

Abstract	A well-accepted strategy to prevent kidney stones is to increase urine volume by increasing oral intake of fluids, especially water, to lower supersaturation of the relevant, relatively insoluble salts, and thereby lower the risk of precipitation. Randomized controlled trials have shown that this strategy works. It is inexpensive, safe, and intuitively attractive to patients. However, although any beverage can increase urine volume, and citrus juices can increase urine citrate content and pH, no beverage other than water has been clearly shown by randomized controlled trial to prevent kidney stones. We designed an innovative, palatable, low-calorie, high alkali citrate beverage to prevent kidney stones, called Moonstone. One packet of Moonstone powder, mixed in 500 ml of water, contains 24.5 meq of alkali citrate. We administered one packet twice a day to ten calcium stone formers. Moonstone resulted in an increase in mean 24-h urine citrate and urine pH, and a decrease in supersaturation of calcium oxalate in calcium stone formers compared to an equal volume of water. These changes, comparable to those seen in a prior study of a similar amount of (potassium-magnesium) citrate, will likely be associated with a clinically meaningful reduction in kidney stone burden in patients with calcium stones. The effect to increase urine pH would also be expected to benefit patients with uric acid and cystine stones, groups that we hope to study in a subsequent study. The study preparation was well tolerated and was selected as a preferred preventative strategy by about half the participants. Moonstone is an alternative, over-the-counter therapy for kidney stone prevention.
MeSH term(s)	Humans ; Citric Acid/adverse effects ; Calcium ; Kidney Calculi/etiology ; Kidney Calculi/prevention & control ; Kidney Calculi/chemistry ; Citrates ; Water
Chemical Substances	Citric Acid (2968PHW8QP) ; Calcium (SY7Q814VUP) ; Citrates ; Water (059QF0KO0R)
Language	English
Publishing date	2023-07-21
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2703553-0
ISSN	2194-7236 ; 2194-7228
ISSN (online)	2194-7236
ISSN	2194-7228
DOI	10.1007/s00240-023-01468-w
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Article ; Online: Efficacy of memory protocols in 9- to 89-year-olds' memory for prior contacts.

Goldfarb, Deborah / Chae, Hana / Dawson, Haley R / Evans, Jacqueline R / Fisher, Ronald P / Daneshbodi, Ariana / Meissner, Christian A

Scientific reports

2024 Volume 14, Issue 1, Page(s) 5775

Abstract: Memory for prior contacts has several important applied implications, including contact tracing (for communicable diseases). Incomplete episodic memory reports, which occur across the developmental lifespan but are particularly relevant for children and ... ...

Abstract	Memory for prior contacts has several important applied implications, including contact tracing (for communicable diseases). Incomplete episodic memory reports, which occur across the developmental lifespan but are particularly relevant for children and older adults, may hamper such efforts. Prior research has shown that cognitively informed memory techniques may bolster recall of contacts in adults, but that work has not addressed the developmental efficacy of these techniques. Here we evaluated the effectiveness of such techniques for familiar and unfamiliar contacts within a sample of 9- to 89-year-olds in the context of an ongoing pandemic. The tested memory techniques bolstered recall across the lifespan, irrespective of whether the interview was conducted live with an interviewer or via a self-led interview. Children, emerging adults, and adults did not reveal any differences in memory productivity, however, older adults recalled fewer contacts. Implications for theory and application are discussed.
MeSH term(s)	Child ; Humans ; Aged ; Mental Recall ; Memory, Episodic
Language	English
Publishing date	2024-03-09
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-55267-3
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Article: Predictors of Acute Kidney Injury (AKI) among COVID-19 Patients at the US Department of Veterans Affairs: The Important Role of COVID-19 Vaccinations.

Lukowsky, Lilia R / Der-Martirosian, Claudia / Northcraft, Heather / Kalantar-Zadeh, Kamyar / Goldfarb, David S / Dobalian, Aram

Vaccines

2024 Volume 12, Issue 2

Abstract: Background: There are knowledge gaps about factors associated with acute kidney injury (AKI) among COVID-19 patients. To examine AKI predictors among COVID-19 patients, a retrospective longitudinal cohort study was conducted between January 2020 and ... ...

Abstract	Background: There are knowledge gaps about factors associated with acute kidney injury (AKI) among COVID-19 patients. To examine AKI predictors among COVID-19 patients, a retrospective longitudinal cohort study was conducted between January 2020 and December 2022. Logistic regression models were used to examine predictors of AKI, and survival analysis was performed to examine mortality in COVID-19 patients. Results: A total of 742,799 veterans diagnosed with COVID-19 were included and 95,573 were hospitalized within 60 days following COVID-19 diagnosis. A total of 45,754 developed AKI and 28,573 AKI patients were hospitalized. Use of vasopressors (OR = 14.73; 95% CL 13.96-15.53), history of AKI (OR = 2.22; CL 2.15-2.29), male gender (OR = 1.90; CL 1.75-2.05), Black race (OR = 1.62; CL 1.57-1.65), and age 65+ (OR = 1.57; CL 1.50-1.63) were associated with AKI. Patients who were vaccinated twice and boosted were least likely to develop AKI (OR = 0.51; CL 0.49-0.53) compared to unvaccinated COVID-19 patients. Patients receiving two doses (OR = 0.77; CL = 0.72-0.81), or a single dose (OR = 0.88; CL = 0.81-0.95) were also less likely to develop AKI compared to the unvaccinated. AKI patients exhibited four times higher mortality compared to those without AKI (HR = 4.35; CL 4.23-4.50). Vaccinated and boosted patients had the lowest mortality risk compared to the unvaccinated (HR = 0.30; CL 0.28-0.31). Conclusion: Use of vasopressors, being unvaccinated, older age, male gender, and Black race were associated with post COVID-19 AKI. Whether COVID-19 vaccination, including boosters, decreases the risk of developing AKI warrants additional studies.
Language	English
Publishing date	2024-01-30
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2703319-3
ISSN	2076-393X
ISSN	2076-393X
DOI	10.3390/vaccines12020146
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Article: Kinetic Evidence for an Induced Fit Mechanism in the Binding of the Substrate Camphor by Cytochrome P450

Guengerich, F Peter / Child, Stella A / Barckhausen, Ian R / Goldfarb, Margo H

ACS catalysis

2020 Volume 11, Issue 2, Page(s) 639–649

Abstract: Bacterial cytochrome P450 (P450) 101A1 ( ... ...

Abstract	Bacterial cytochrome P450 (P450) 101A1 (P450
Language	English
Publishing date	2020-12-29
Publishing country	United States
Document type	Journal Article
ISSN	2155-5435
ISSN	2155-5435
DOI	10.1021/acscatal.0c04455
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Article ; Online: A qualitative analysis of child protection professionals' challenges during the COVID-19 pandemic.

Priolo Filho, Sidnei R / Chae, Hana / Bhakta, Ayesha / Moura, Bárbara Renata / Correia, Bianca Borges / Santos, Jackeline da Silva / Sieben, Thaisy Luana / Goldfarb, Deborah

Child abuse & neglect

2023 Volume 143, Page(s) 106229

Abstract: Purpose: Child Protection Professionals (CPPs) play a key role in providing insights into the child protection system and how it can best support children's right to personal security, particularly during trying times like the COVID-19 pandemic. ... ...

Abstract	Purpose: Child Protection Professionals (CPPs) play a key role in providing insights into the child protection system and how it can best support children's right to personal security, particularly during trying times like the COVID-19 pandemic. Qualitative research provides one potential tool to tap into this knowledge and awareness. This research thus expanded earlier qualitative work on CPPs' perceptions of the impact of COVID-19 on their work, including potential struggles and barriers, into the context of a developing country. Methods: A total of 309 CPPs from all five regions in Brazil answered demographics, pandemic-related resilient behaviors, and open-ended questions regarding their profession during the pandemic. Results: Data went through a three-step process of analysis: (1) pre-analysis; (2) category creation; and (3) coding of responses. Five categories emerged from the analysis: the Pandemic's Impact on CPPs' Work; the Impact of the Pandemic on CPP-Involved Families; Occupational Concerns during the Pandemic; Politics and the Pandemic; and Vulnerability due to the Pandemic. Conclusions: Our qualitative analyses showed the pandemic resulted in increased challenges for CPPs across several fronts within their workplace. Although each of these categories is discussed separately, they all influenced one another. This highlights the need to continue efforts to support CPPs.
MeSH term(s)	Humans ; Child ; COVID-19/epidemiology ; Pandemics/prevention & control ; Brazil/epidemiology
Language	English
Publishing date	2023-05-05
Publishing country	England
Document type	Journal Article
ZDB-ID	799143-5
ISSN	1873-7757 ; 0145-2134
ISSN (online)	1873-7757
ISSN	0145-2134
DOI	10.1016/j.chiabu.2023.106229
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Article ; Online: Enhancing access to early intervention by including parent navigators with lived experience in a pediatric medical home.

Mirzaian, Christine B / Solomon, Olga / Setaghiyan, Helen / Hudson, Sharon / Goldfarb, Fran / Eaton, Guadalupe Lorena / Vasquez, Rita / Babb, Lucia / Yin, Larry

Families, systems & health : the journal of collaborative family healthcare

2023

Abstract: Introduction: A growing number of children have developmental delay (DD) or intellectual and developmental disabilities (IDD), and early intervention (EI) can improve their developmental trajectory. However, access to EI is fraught with disparities. ... ...

Abstract	Introduction: A growing number of children have developmental delay (DD) or intellectual and developmental disabilities (IDD), and early intervention (EI) can improve their developmental trajectory. However, access to EI is fraught with disparities. This article describes the development of Parent Navigator (PN) program that placed three parents with lived experience in a pediatric medical home to serve as community health workers to provide support to families with a child with DD or IDD to access EI and other needed resources. Method: We used a mixed-methods approach to program evaluation that included (a) documenting the number of referrals to the EI programs made by the PNs; (b) documenting referral outcomes; (c) conducting a physician satisfaction survey; and (d) interviewing the PNs to reflect on their experiences assisting families. Results: From July 2018 to September 2020, our PNs facilitated 623 referrals to EI due to significant developmental concerns found during a pediatric visit. Rates of successful connection to EI were 71%. Survey results indicated that pediatricians felt the PNs were a valuable part of the healthcare team and helped reduce their own job stress. The PNs provided multiple examples of their methods of addressing barriers to EI access by relating to families with their own lived experience and by "meeting families where they are at." Discussion: The PN program might be a successful approach to addressing disparities in EI access for families in need by using an innovative method of employing individuals with lived experience in the pediatric primary care setting. (PsycInfo Database Record (c) 2024 APA, all rights reserved).
Language	English
Publishing date	2023-12-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	1326859-4
ISSN	1939-0602 ; 1091-7527 ; 0736-1718
ISSN (online)	1939-0602
ISSN	1091-7527 ; 0736-1718
DOI	10.1037/fsh0000864
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Article ; Online: Multicomponent intervention for frail and pre-frail older adults with acute cardiovascular conditions: The TARGET-EFT randomized clinical trial.

Fountotos, Rosie / Ahmad, Fayeza / Bharaj, Neetika / Munir, Haroon / Marsala, John / Rudski, Lawrence G / Goldfarb, Michael / Afilalo, Jonathan

Journal of the American Geriatrics Society

2023 Volume 71, Issue 5, Page(s) 1406–1415

Abstract: Background: Hospitalization for cardiovascular disease (CVD) may be complicated by hospital-acquired disability (HAD) and subsequently poor health-related quality of life (HRQOL). While frailty has been shown to be a risk factor, it has yet to be ... ...

Abstract	Background: Hospitalization for cardiovascular disease (CVD) may be complicated by hospital-acquired disability (HAD) and subsequently poor health-related quality of life (HRQOL). While frailty has been shown to be a risk factor, it has yet to be studied as a therapeutic target to improve outcomes. Objectives: This trial sought to determine the effects of an in-hospital multicomponent intervention targeting physical weakness, cognitive impairment, malnutrition, and anemia on patient-centered outcomes compared to usual care. Methods: A single-center parallel-group randomized clinical trial was conducted in older patients with acute CVD and evidence of frailty or pre-frailty as measured by the Essential Frailty Toolset (EFT). Patients were randomized to usual care or a multicomponent intervention. Outcomes were HRQOL (EQ-5D-5L score) and disability (Older Americans Resources and Services score) at 30 days post-discharge and mood disturbances (Hospital Anxiety and Depression Scale) at discharge. Results: The trial cohort consisted of 142 patients with a mean age of 79.5 years and 55% females. The primary diagnosis was heart failure in 29%, valvular heart disease in 28%, ischemic heart disease in 14%, arrhythmia in 11%, and other CVDs in 18%. The intervention improved HRQOL scores (coefficient 0.08; 95% CI 0.01, 0.15; p = 0.03) and mood scores (coefficient -1.95; 95% CI -3.82, -0.09; p = 0.04) but not disability scores (coefficient 0.18; 95% CI -1.44, 1.81; p = 0.82). There were no intervention-related adverse events. Conclusion: In frail older patients hospitalized for acute CVDs, an in-hospital multicomponent intervention targeted to frailty was safe and led to modest yet clinically meaningful improvements in HRQOL and mental well-being. The downstream impact of these effects on event-free survival and functional status remains to be evaluated in future research, as does the generalizability to other healthcare systems. Clinical registration number: NCT04291690.
MeSH term(s)	Female ; Aged ; Humans ; Male ; Frail Elderly/psychology ; Frailty/complications ; Frailty/therapy ; Frailty/psychology ; Quality of Life/psychology ; Aftercare ; Patient Discharge ; Heart Failure
Language	English
Publishing date	2023-01-16
Publishing country	United States
Document type	Randomized Controlled Trial ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80363-7
ISSN	1532-5415 ; 0002-8614
ISSN (online)	1532-5415
ISSN	0002-8614
DOI	10.1111/jgs.18228
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Article: Rationale and Design of the TARGET-EFT Trial: Multicomponent Intervention for Frail and Pre-frail Patients Hospitalized with Acute Cardiac Conditions

Fountotos, R. / Munir, H. / Ahmad, F. / Goldfarb, M. / Afilalo, Jonathan

journal of nutrition, health & aging. 2022 Mar., v. 26, no. 3

2022

Abstract: BACKGROUND: With the aging population and rising rates of cardiovascular disease (CVD), cardiologists and cardiac surgeons are encountering a growing number of frail older patients that have complex cardiac and non-cardiac issues. Measuring frailty ... ...

Abstract	BACKGROUND: With the aging population and rising rates of cardiovascular disease (CVD), cardiologists and cardiac surgeons are encountering a growing number of frail older patients that have complex cardiac and non-cardiac issues. Measuring frailty provides valuable prognostic information to help personalize treatment decisions. However, there is minimal evidence on multicomponent frailty interventions in this setting. The TARGET-EFT (The MulTicomponent Acute Intervention in FRail GEriatric PaTients with cardiovascular disease using the Essential Frailty Toolset) trial aims to target physical and non-physical frailty deficits to improve health-related quality of life and hospital-acquired disability in frail patients hospitalized with CVD. METHODS: The TARGET-EFT trial is a single-center parallel-group randomized clinical trial in frail and pre-frail older adults ≥65 years admitted to the cardiovascular unit (CVU) at the Jewish General Hospital, Montreal, Quebec. The trial will compare usual inpatient care to a multicomponent intervention targeting physical weakness, cognitive impairment, malnutrition, and anemia. Outcomes of interest in both groups will be assessed at three time points: (1) study enrollment, (2) discharge from the CVU, and (3) 30 days after hospital discharge. CONCLUSIONS: The overarching goal is to treat patients’ frailty in parallel with their CVD, and in doing so, optimize patient functional losses while in-hospital and shortly thereafter. The results of this trial will inform best practices for patient-centered care in this vulnerable patient group.
Keywords	Jews ; anemia ; cardiovascular diseases ; cognitive disorders ; hospitals ; malnutrition ; nutrition ; patients ; quality of life ; Quebec
Language	English
Dates of publication	2022-03
Size	p. 282-289.
Publishing place	Springer Paris
Document type	Article
ZDB-ID	2081921-3
ISSN	1760-4788 ; 1279-7707
ISSN (online)	1760-4788
ISSN	1279-7707
DOI	10.1007/s12603-022-1759-y
Database	NAL-Catalogue (AGRICOLA)

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