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  1. Article ; Online: Development of low-temperature and ultrahigh-vacuum photoinduced force microscopy.

    Yamamoto, Tatsuya / Sugawara, Yasuhiro

    The Review of scientific instruments

    2023  Volume 94, Issue 3, Page(s) 33702

    Abstract: In this paper, we develop optical and electronic systems for photoinduced force microscopy (PiFM) that can measure photoinduced forces under low temperature and ultrahigh vacuum (LT-UHV) without artifacts. For our LT-UHV PiFM, light is irradiated from ... ...

    Abstract In this paper, we develop optical and electronic systems for photoinduced force microscopy (PiFM) that can measure photoinduced forces under low temperature and ultrahigh vacuum (LT-UHV) without artifacts. For our LT-UHV PiFM, light is irradiated from the side on the tip-sample junction, which can be adjusted through the combination of an objective lens inside the vacuum chamber and a 90° mirror outside the vacuum chamber. We measured photoinduced forces due to the electric field enhancement between the tip and the Ag surface, and confirmed that photoinduced force mapping and measurement of photoinduced force curves were possible using the PiFM that we developed. The Ag surface was used to measure the photoinduced force with high sensitivity, and it is effective in enhancing the electric field using the plasmon gap mode between the metal tip and the metal surface. Additionally, we confirmed the necessity of Kelvin feedback during the measurement of photoinduced forces, to avoid artifacts due to electrostatic forces, by measuring photoinduced forces on organic thin films. The PiFM, operating under low temperature and ultrahigh vacuum developed here, is a promising tool to investigate the optical properties of various materials with very high spatial resolution.
    Language English
    Publishing date 2023-04-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 209865-9
    ISSN 1089-7623 ; 0034-6748
    ISSN (online) 1089-7623
    ISSN 0034-6748
    DOI 10.1063/5.0132166
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 4' 46/112: Show issues

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  2. Article ; Online: Trpv4-mediated apoptosis of Leydig cells induced by high temperature regulates sperm development and motility in zebrafish.

    Yamamoto, Yasuhiro / Hishikawa, Daisuke / Ono, Fumihito

    Communications biology

    2024  Volume 7, Issue 1, Page(s) 96

    Abstract: Exposure of testes to high-temperature environment results in defective spermatogenesis. Zebrafish exposed to high temperature exhibited apoptosis not only in germ cells but also in Leydig cells, as expected from studies using mice or salmon. However, ... ...

    Abstract Exposure of testes to high-temperature environment results in defective spermatogenesis. Zebrafish exposed to high temperature exhibited apoptosis not only in germ cells but also in Leydig cells, as expected from studies using mice or salmon. However, the role of testicular somatic cells in spermatogenesis defects remains unclear. We found that in Leydig cells the Trpv4 gene encoding the temperature sensitive ion channel was specifically upregulated in high temperature. High temperature also reduced hormone synthesis in Leydig cells and led to a prompt downregulation of sperm motility. In the Trpv4 null mutant, neither Leydig cell-specific apoptosis nor decreased sperm motility was observed under high temperature. These results indicate that Leydig cell specific-apoptosis is induced via Trpv4 by high temperature. Notably this Trpv4-dependent mechanism was specific to Leydig cells and did not operate in germ cells. Because sperm exposed to high temperature exhibited compromised genome stability, we propose that temperature sensing leading to apoptosis in Leydig cells evolved to actively suppress generation of offspring with unstable genome.
    MeSH term(s) Animals ; Male ; Mice ; Apoptosis/physiology ; Leydig Cells/physiology ; Semen ; Sperm Motility ; Spermatozoa ; Temperature ; Zebrafish/genetics
    Chemical Substances TRPV4 protein, zebrafish
    Language English
    Publishing date 2024-01-13
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2399-3642
    ISSN (online) 2399-3642
    DOI 10.1038/s42003-023-05740-y
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  3. Article ; Online: Trpv4-mediated apoptosis of Leydig cells induced by high temperature regulates sperm development and motility in zebrafish

    Yasuhiro Yamamoto / Daisuke Hishikawa / Fumihito Ono

    Communications Biology, Vol 7, Iss 1, Pp 1-

    2024  Volume 11

    Abstract: Abstract Exposure of testes to high-temperature environment results in defective spermatogenesis. Zebrafish exposed to high temperature exhibited apoptosis not only in germ cells but also in Leydig cells, as expected from studies using mice or salmon. ... ...

    Abstract Abstract Exposure of testes to high-temperature environment results in defective spermatogenesis. Zebrafish exposed to high temperature exhibited apoptosis not only in germ cells but also in Leydig cells, as expected from studies using mice or salmon. However, the role of testicular somatic cells in spermatogenesis defects remains unclear. We found that in Leydig cells the Trpv4 gene encoding the temperature sensitive ion channel was specifically upregulated in high temperature. High temperature also reduced hormone synthesis in Leydig cells and led to a prompt downregulation of sperm motility. In the Trpv4 null mutant, neither Leydig cell-specific apoptosis nor decreased sperm motility was observed under high temperature. These results indicate that Leydig cell specific-apoptosis is induced via Trpv4 by high temperature. Notably this Trpv4-dependent mechanism was specific to Leydig cells and did not operate in germ cells. Because sperm exposed to high temperature exhibited compromised genome stability, we propose that temperature sensing leading to apoptosis in Leydig cells evolved to actively suppress generation of offspring with unstable genome.
    Keywords Biology (General) ; QH301-705.5
    Language English
    Publishing date 2024-01-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article: Biofilm-associated candidal thrombophlebitis.

    Fukushima, Shinnosuke / Yamamoto, Koichiro / Nakano, Yasuhiro / Hagiya, Hideharu / Otsuka, Fumio

    IDCases

    2023  Volume 31, Page(s) e01733

    Language English
    Publishing date 2023-02-28
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2745454-X
    ISSN 2214-2509
    ISSN 2214-2509
    DOI 10.1016/j.idcr.2023.e01733
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  5. Article ; Online: Hyoro-zeme in the Battle for Tottori Castle: The first description of refeeding syndrome in Japan.

    Kano, Yasuhiro / Aoyama, Sayaka / Yamamoto, Ryuichiro

    The American journal of the medical sciences

    2023  Volume 366, Issue 6, Page(s) 397–403

    Abstract: Eating after a period of starvation can cause refeeding syndrome, a fatal condition caused by a shift in fluids and electrolytes that can result in sudden death. The Battle for Tottori Castle (1581) during the Warring States Period of Japan, which ... ...

    Abstract Eating after a period of starvation can cause refeeding syndrome, a fatal condition caused by a shift in fluids and electrolytes that can result in sudden death. The Battle for Tottori Castle (1581) during the Warring States Period of Japan, which witnessed the use of hyoro-zeme, the tactic of intentionally starving a besieged enemy, was followed by a dramatic episode of mass death among starving soldiers not from fighting but from eating; accounts from the period relate that many of the besieged soldiers survived the hyoro-zeme only to die soon afterwards when they were fed immediately after surrendering. We herein reviewed the Japanese historical records of the Battle for Tottori Castle and hypothesized that the hyoro-zeme episode they recount is possibly the oldest description of refeeding syndrome to be documented in Japan. Our investigation revealed sufficient evidence that refeeding syndrome was the cause of the mass deaths reported after the famous battle.
    MeSH term(s) Humans ; Refeeding Syndrome/etiology ; Japan ; Starvation/complications
    Language English
    Publishing date 2023-09-09
    Publishing country United States
    Document type Editorial
    ZDB-ID 82078-7
    ISSN 1538-2990 ; 0002-9629
    ISSN (online) 1538-2990
    ISSN 0002-9629
    DOI 10.1016/j.amjms.2023.08.015
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    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.2/10: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  6. Article: Overlapping Myocarditis and Postural Orthostatic Tachycardia Syndrome After COVID-19 Messenger RNA Vaccination: A Case Report.

    Sanada, Yuichi / Azuma, Junji / Hirano, Yasuhiro / Hasegawa, Yasuhiro / Yamamoto, Takehisa

    Cureus

    2022  Volume 14, Issue 11, Page(s) e31006

    Abstract: The worldwide spread of the coronavirus disease 2019 (COVID-19) pandemic and the significant morbidity and mortality rate associated with it led to the rapid development of several COVID-19 vaccines. While serious side effects related to the vaccines are ...

    Abstract The worldwide spread of the coronavirus disease 2019 (COVID-19) pandemic and the significant morbidity and mortality rate associated with it led to the rapid development of several COVID-19 vaccines. While serious side effects related to the vaccines are rare, various adverse events have been reported to occur after COVID-19 messenger RNA (mRNA) vaccination, including myocarditis, Guillain-Barré syndrome, and thrombosis. Postural orthostatic tachycardia syndrome (POTS) is a chronic cardiovascular dysautonomia among young and middle-aged individuals. Although the pathophysiology of POTS is thought to be heterogeneous, vaccine-induced immune-mediated autonomic dysfunction is hypothesized to be one cause of the syndrome. In this report, we present a case of myocarditis and POTS occurring in a 13-year-old male following COVID-19 mRNA vaccination. He presented with persistent severe fatigue and headache. The patient's symptoms improved after intravenous immunoglobulin for myocarditis, non-pharmacologic interventions, and multiple medications for POTS.
    Language English
    Publishing date 2022-11-02
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.31006
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  7. Article: Isolated unilateral absence of adult pulmonary artery.

    Yamamoto, Koichiro / Nakano, Yasuhiro / Otsuka, Fumio

    Clinical case reports

    2022  Volume 10, Issue 11, Page(s) e6652

    Abstract: Isolated unilateral absence of pulmonary artery (UAPA) is a rare congenital malformation. We describe a 26-year-old woman with isolated UAPA who presented with hemoptysis. Since massive hemoptysis may mandate selective embolization of collaterals or ... ...

    Abstract Isolated unilateral absence of pulmonary artery (UAPA) is a rare congenital malformation. We describe a 26-year-old woman with isolated UAPA who presented with hemoptysis. Since massive hemoptysis may mandate selective embolization of collaterals or surgical treatment, early diagnosis of UAPA is pivotal.
    Language English
    Publishing date 2022-11-27
    Publishing country England
    Document type Case Reports
    ZDB-ID 2740234-4
    ISSN 2050-0904
    ISSN 2050-0904
    DOI 10.1002/ccr3.6652
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  8. Article ; Online: Retrospective Analysis of the Incidence of Drug-Induced Interstitial Lung Disease by Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors and Survival in Patients Aged 75 Years or Older with Lung Cancer.

    Ishibashi, Masayuki / Nakagawa, Yoshiko / Shimizu, Tetsuo / Gon, Yasuhiro / Yamamoto, Hiroshi

    JMA journal

    2023  Volume 6, Issue 2, Page(s) 182–187

    Abstract: Introduction: To date, the appropriate epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) for patients aged ≥75 years with advanced : Methods: This study included a total of 89 patients aged ≥75 years who were diagnosed with : ... ...

    Abstract Introduction: To date, the appropriate epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) for patients aged ≥75 years with advanced
    Methods: This study included a total of 89 patients aged ≥75 years who were diagnosed with
    Results: No significant differences in the overall survival and progression-free survival were observed among the groups. However, a significantly higher incidence of drug-induced interstitial lung disease (ILD) was detected with osimertinib than with the first-generation EGFR-TKIs (p = 0.008).
    Conclusions: In older patients with
    Language English
    Publishing date 2023-04-10
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 3053329-6
    ISSN 2433-3298 ; 2433-328X
    ISSN (online) 2433-3298
    ISSN 2433-328X
    DOI 10.31662/jmaj.2022-0211
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  9. Article ; Online: Autophagy and Ciliogenesis.

    Yamamoto, Yasuhiro / Mizushima, Noboru

    JMA journal

    2021  Volume 4, Issue 3, Page(s) 207–215

    Abstract: Autophagy is a major intracellular degradation system and plays important roles in various physiological processes such as metabolic adaptation and intracellular homeostasis. It degrades intracellular components both randomly and selectively. Autophagic ... ...

    Abstract Autophagy is a major intracellular degradation system and plays important roles in various physiological processes such as metabolic adaptation and intracellular homeostasis. It degrades intracellular components both randomly and selectively. Autophagic activity is tightly regulated primarily by nutrient availability, but also by other extracellular and intracellular signals. Growing evidence suggests that there are multiple links between autophagy and the primary cilium. The primary cilium is an organelle present on the cell surface and is important for keeping cellular integrity by transducing extracellular stimuli inside the cell. Recent studies have revealed that autophagy selectively degrades the ciliogenesis inhibitory proteins OFD1 and MYH9, promoting ciliogenesis. Conversely, autophagy also inhibits ciliogenesis under growth conditions. The primary cilium can also regulate autophagic activity. These findings suggest that the relationship between autophagy and the primary cilia is bidirectional, and that both are important for maintaining the normal function of various organs.
    Language English
    Publishing date 2021-07-06
    Publishing country Japan
    Document type Journal Article ; Review
    ZDB-ID 3053329-6
    ISSN 2433-3298 ; 2433-328X
    ISSN (online) 2433-3298
    ISSN 2433-328X
    DOI 10.31662/jmaj.2021-0090
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  10. Article ; Online: Mutual Effects of Orexin and Bone Morphogenetic Proteins on Catecholamine Regulation Using Adrenomedullary Cells.

    Soejima, Yoshiaki / Iwata, Nahoko / Yamamoto, Koichiro / Suyama, Atsuhito / Nakano, Yasuhiro / Otsuka, Fumio

    International journal of molecular sciences

    2024  Volume 25, Issue 3

    Abstract: Orexins are neuronal peptides that play a prominent role in sleep behavior and feeding behavior in the central nervous system, though their receptors also exist in peripheral organs, including the adrenal gland. In this study, the effects of orexins on ... ...

    Abstract Orexins are neuronal peptides that play a prominent role in sleep behavior and feeding behavior in the central nervous system, though their receptors also exist in peripheral organs, including the adrenal gland. In this study, the effects of orexins on catecholamine synthesis in the rat adrenomedullary cell line PC12 were investigated by focusing on their interaction with the adrenomedullary bone morphogenetic protein (BMP)-4. Orexin A treatment reduced the mRNA levels of key enzymes for catecholamine synthesis, including tyrosine hydroxylase (Th), 3,4-dihydroxyphenylalanie decarboxylase (Ddc) and dopamine β-hydroxylase (Dbh), in a concentration-dependent manner. On the other hand, treatment with BMP-4 suppressed the expression of Th and Ddc but enhanced that of Dbh with or without co-treatment with orexin A. Of note, orexin A augmented BMP-receptor signaling detected by the phosphorylation of Smad1/5/9 through the suppression of inhibitory Smad6/7 and the upregulation of BMP type-II receptor (BMPRII). Furthermore, treatment with BMP-4 upregulated the mRNA levels of OX1R in PC12 cells. Collectively, the results indicate that orexin and BMP-4 suppress adrenomedullary catecholamine synthesis by mutually upregulating the pathway of each other in adrenomedullary cells.
    MeSH term(s) Animals ; Rats ; Bone Morphogenetic Proteins/metabolism ; Catecholamines/metabolism ; Orexins/pharmacology ; Orexins/metabolism ; RNA, Messenger ; Signal Transduction ; Tyrosine 3-Monooxygenase/genetics ; Tyrosine 3-Monooxygenase/metabolism ; PC12 Cells/metabolism
    Chemical Substances Bone Morphogenetic Proteins ; Catecholamines ; Orexins ; RNA, Messenger ; Tyrosine 3-Monooxygenase (EC 1.14.16.2)
    Language English
    Publishing date 2024-01-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25031585
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