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Article ; Online: Differential mitochondrial and cellular responses between H vs. J mtDNA haplogroup-containing human RPE transmitochondrial cybrid cells.

Panvini, Ana Rubin / Gvritishvili, Anzor / Galvan, Hannah / Nashine, Sonali / Atilano, Shari R / Kenney, M Cristina / Tombran-Tink, Joyce

Experimental eye research

2022 Volume 219, Page(s) 109013

Abstract: ... compare the effects of mtDNA haplogroups H and J on transcriptome regulation and cellular resilience ... mtDNA haplogroups H and J were created by fusing platelets obtained from normal individuals containing H ... to oxidative stress using 300 μM hydrogen peroxide (H ...

Abstract	Mitochondrial dysfunction is associated with several retinal degenerative diseases including Age-related Macular Degeneration (AMD). Human mitochondrial DNA (mtDNA) haplogroups are inherited from a common ancestral clan and are defined by specific sets of genetic differences. The purpose of this study was to determine and compare the effects of mtDNA haplogroups H and J on transcriptome regulation and cellular resilience to oxidative stress in human RPE cytoplasmic hybrid (cybrid) cell lines in vitro. ARPE-19 cybrid cell lines containing mtDNA haplogroups H and J were created by fusing platelets obtained from normal individuals containing H and J haplogroups with mitochondria-deficient (Rho0) ARPE-19 cell lines. These cybrids were exposed to oxidative stress using 300 μM hydrogen peroxide (H
MeSH term(s)	Calcium/metabolism ; DNA, Mitochondrial/genetics ; Humans ; Hydrogen Peroxide/metabolism ; Hydrogen Peroxide/pharmacology ; Macular Degeneration/genetics ; Macular Degeneration/metabolism ; Mitochondria/metabolism
Chemical Substances	DNA, Mitochondrial ; Hydrogen Peroxide (BBX060AN9V) ; Calcium (SY7Q814VUP)
Language	English
Publishing date	2022-03-10
Publishing country	England
Document type	Journal Article
ZDB-ID	80122-7
ISSN	1096-0007 ; 0014-4835
ISSN (online)	1096-0007
ISSN	0014-4835
DOI	10.1016/j.exer.2022.109013
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Article ; Online: A 24-h activity profile and adiposity among children and adolescents

David Janda / Aleš Gába / Ondřej Vencálek / Stuart J Fairclough / Jan Dygrýn / Lukáš Jakubec / Lukáš Rubín

PLoS ONE, Vol 18, Iss 5, p e

Does the difference between school and weekend days matter?

2023 Volume 0285952

Abstract: ... However, no study has addressed how 24-h activity profiles vary between structured and less structured days ... differences between school day and weekend day 24-h activity profiles and their associations with adiposity ... who wore wrist accelerometers for 24 hours a day for seven consecutive days. The 24-h activity profile ...

Abstract	Background Twenty-four-hour movement behaviours are gaining attention in the research community. However, no study has addressed how 24-h activity profiles vary between structured and less structured days and whether an unfavourable activity profile is associated with childhood obesity. We aimed to analyse differences between school day and weekend day 24-h activity profiles and their associations with adiposity indicators among children and adolescents. Methods Participants were 382 children and 338 adolescents who wore wrist accelerometers for 24 hours a day for seven consecutive days. The 24-h activity profile expressed by the average acceleration (AvAcc) and intensity gradient (IG) were estimated from multi-day raw accelerometer data. Adiposity indicators included body mass index (BMI) z-score, fat mass percentage (FM%), fat mass index (FMI), and visceral adipose tissue (VAT). Multiple linear regression of activity profile metrics and adiposity indicators was performed separately for school and weekend days. Results Weekend days AvAcc and IG were lower compared to school days in both age groups (p <0.001 for all). Specifically, AvAcc was lower by 9.4% and 11.3% in children and adolescents, respectively. IG on weekend days was lower (more negative) by 3.4% in children and 3.1% in adolescents. Among children, on school days AvAcc and IG were negatively associated with FM%, FMI, and VAT, whilst on weekend days AvAcc was positively associated with BMI z-score, FMI, and VAT (p < 0.05 for all). Among adolescents, negative associations were found between weekend day AvAcc and IG and FM% and FMI (p < 0.05 for all), respectively. Conclusions This study confirms the importance of 24-h activity profile as a potentially protective factor against excess adiposity. The variability of movement behaviours during structured and less structured days should be considered when optimizing the 24-h movement behaviours to prevent childhood obesity.
Keywords	Medicine ; R ; Science ; Q
Subject code	796
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
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Article ; Online: A 24-h activity profile and adiposity among children and adolescents: Does the difference between school and weekend days matter?

Janda, David / Gába, Aleš / Vencálek, Ondřej / Fairclough, Stuart J / Dygrýn, Jan / Jakubec, Lukáš / Rubín, Lukáš

PloS one

2023 Volume 18, Issue 5, Page(s) e0285952

Abstract	Background: Twenty-four-hour movement behaviours are gaining attention in the research community. However, no study has addressed how 24-h activity profiles vary between structured and less structured days and whether an unfavourable activity profile is associated with childhood obesity. We aimed to analyse differences between school day and weekend day 24-h activity profiles and their associations with adiposity indicators among children and adolescents. Methods: Participants were 382 children and 338 adolescents who wore wrist accelerometers for 24 hours a day for seven consecutive days. The 24-h activity profile expressed by the average acceleration (AvAcc) and intensity gradient (IG) were estimated from multi-day raw accelerometer data. Adiposity indicators included body mass index (BMI) z-score, fat mass percentage (FM%), fat mass index (FMI), and visceral adipose tissue (VAT). Multiple linear regression of activity profile metrics and adiposity indicators was performed separately for school and weekend days. Results: Weekend days AvAcc and IG were lower compared to school days in both age groups (p <0.001 for all). Specifically, AvAcc was lower by 9.4% and 11.3% in children and adolescents, respectively. IG on weekend days was lower (more negative) by 3.4% in children and 3.1% in adolescents. Among children, on school days AvAcc and IG were negatively associated with FM%, FMI, and VAT, whilst on weekend days AvAcc was positively associated with BMI z-score, FMI, and VAT (p < 0.05 for all). Among adolescents, negative associations were found between weekend day AvAcc and IG and FM% and FMI (p < 0.05 for all), respectively. Conclusions: This study confirms the importance of 24-h activity profile as a potentially protective factor against excess adiposity. The variability of movement behaviours during structured and less structured days should be considered when optimizing the 24-h movement behaviours to prevent childhood obesity.
MeSH term(s)	Humans ; Child ; Adolescent ; Pediatric Obesity ; Adiposity ; Body Mass Index ; Sedentary Behavior ; Exercise
Language	English
Publishing date	2023-05-18
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0285952
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Article: The Surface Distributions of the Production of the Major Volatile Species, H

Combi, Michael / Shou, Yinsi / Fougere, Nicolas / Tenishev, Valeriy / Altwegg, Kathrin / Rubin, Martin / Bockelée-Morvan, Dominique / Capaccioni, Fabrizio / Cheng, Yu-Chi / Fink, Uwe / Gombosi, Tamas / Hansen, Kenneth C / Huang, Zhenguang / Marshall, David / Toth, Gabor

Icarus

2019 Volume 335

Abstract: ... species in the coma of the comet, H ...

Abstract	The Rosetta Orbiter Spectrometer for Ion and Neutral Analysis (ROSINA) suite of instruments operated throughout the over two years of the Rosetta mission operations in the vicinity of comet 67P/Churyumov-Gerasimenko. It measured gas densities and composition throughout the comet's atmosphere, or coma. Here we present two-years' worth of measurements of the relative densities of the four major volatile species in the coma of the comet, H
Language	English
Publishing date	2019-10-20
Publishing country	United States
Document type	Journal Article
ISSN	0019-1035
ISSN	0019-1035
DOI	10.1016/j.icarus.2019.113421
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Article ; Online: Associations of novel 24-h accelerometer-derived metrics with adiposity in children and adolescents.

Dygrýn, Jan / Medrano, María / Molina-Garcia, Pablo / Rubín, Lukáš / Jakubec, Lukáš / Janda, David / Gába, Aleš

Environmental health and preventive medicine

2021 Volume 26, Issue 1, Page(s) 66

Abstract: Background: Further research is required to explore the associations between 24-h movement ... the associations between novel data-driven 24-h activity metrics and adiposity among children and adolescents ... for the most active time periods of the 24-h cycle were calculated from raw acceleration data. Adiposity ...

Abstract	Background: Further research is required to explore the associations between 24-h movement behaviours and health outcomes in the paediatric population. Therefore, this study aimed to examine the associations between novel data-driven 24-h activity metrics and adiposity among children and adolescents. Methods: The sample included 382 children (8-13 years) and 338 adolescents (14-18 years). The average acceleration (AvAcc) of activity, intensity gradient (IG), and metrics representing the initial acceleration for the most active time periods of the 24-h cycle were calculated from raw acceleration data. Adiposity measures included body mass index z-score, fat mass percentage (FM%), and visceral adipose tissue (VAT). Data analysis was performed using multiple linear regression adjusted for wear time, sex, maternal education level, and maternal overweight and obesity. Results: Children demonstrated higher values in all 24-h activity metrics than did adolescents (p < 0.001 for all). For children, the initial acceleration for the most active 2, 5, 15, and 30 min of the 24-h cycle were negatively associated with FM% (p ≤ 0.043 for all) and VAT (p <0.001 for all), respectively. For adolescents, the IG was negatively associated with FM% (p = 0.002) and VAT (p = 0.007). Moreover, initial acceleration for the most active 2, 5, 15, 30, 60, and 120 min were associated with FM% (p ≤ 0.007 for all) and with VAT (p ≤ 0.023 for all). Conclusions: The intensity distribution of activity and initial acceleration for the most active 2, 5, 15, 30, 60, and 120 min within the 24-h cycle are beneficial for the prevention of excess adiposity in the paediatric population.
MeSH term(s)	Accelerometry ; Adiposity/physiology ; Adolescent ; Child ; Cross-Sectional Studies ; Czech Republic ; Exercise/physiology ; Female ; Humans ; Male
Language	English
Publishing date	2021-06-12
Publishing country	England
Document type	Journal Article
ZDB-ID	2018758-0
ISSN	1347-4715 ; 1342-078X
ISSN (online)	1347-4715
ISSN	1342-078X
DOI	10.1186/s12199-021-00987-5
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Zs.A 5232: Show issues

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Book ; Online: Volatiles in the H$_2$O and CO$_2$ ices of comet 67P/Churyumov-Gerasimenko

Rubin, Martin / Altwegg, Kathrin / Berthelier, Jean-Jacques / Combi, Michael R. / De Keyser, Johan / Fuselier, Stephen A. / Gombosi, Tamas I. / Gudipati, Murthy S. / Hänni, Nora / Kipfer, Kristina A. / Ligterink, Niels F. W. / Müller, Daniel R. / Shou, Yinsi / Wampfler, Susanne F.

2023

Abstract: ... at 67P, namely H$_2$O and CO$_2$, together with a suite of minor species for almost the entire mission ... reproduced by a linear combination of both H$_2$O and CO$_2$ densities. These findings bear similarities ... volatile species are trapped in H$_2$O and CO$_2$ ices. Our results do not show the presence of ices ...

Abstract	ESA's Rosetta spacecraft at comet 67P/Churyumov-Gerasimenko (67P) was the first mission that accompanied a comet over a substantial fraction of its orbit. On board was the ROSINA mass spectrometer suite to measure the local densities of the volatile species sublimating from the ices inside the comet's nucleus. Understanding the nature of these ices was a key goal of Rosetta. We analyzed the primary cometary molecules at 67P, namely H$_2$O and CO$_2$, together with a suite of minor species for almost the entire mission. Our investigation reveals that the local abundances of highly volatile species, such as CH$_4$ and CO, are reproduced by a linear combination of both H$_2$O and CO$_2$ densities. These findings bear similarities to laboratory-based temperature programmed desorption experiments of amorphous ices and imply that highly volatile species are trapped in H$_2$O and CO$_2$ ices. Our results do not show the presence of ices dominated by these highly volatile molecules. Most likely, they were lost due to thermal processing of 67P's interior prior to its deflection to the inner solar system. Deviations in the proportions co-released with H$_2$O and CO$_2$ can only be observed before the inbound equinox, when the comet was still far from the sun and the abundance of highly volatile molecules associated with CO$_2$ outgassing were lower. The corresponding CO$_2$ is likely seasonal frost, which sublimated and lost its trapped highly volatile species before re-freezing during the previous apparition. CO, on the other hand, was elevated during the same time and requires further investigation. Comment: This is a pre-copyedited, author-produced PDF of an article accepted for publication in Monthly Notices of the Royal Astronomical Society following peer review. The version of record is available online at: https://doi.org/10.1093/mnras/stad3005
Keywords	Astrophysics - Earth and Planetary Astrophysics
Subject code	590
Publishing date	2023-10-06
Publishing country	us
Document type	Book ; Online
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Article ; Online: Real-world prevalence across 159 872 patients with cancer supports the clinical utility of TMB-H to define metastatic solid tumors for treatment with pembrolizumab.

Fabrizio, D / Cristescu, R / Albacker, L / Snyder, A / Ward, A / Lunceford, J / Aurora-Garg, D / Jin, F / Hopkins, J / Rubin, E / Hegde, P

Annals of oncology : official journal of the European Society for Medical Oncology

2021 Volume 32, Issue 9, Page(s) 1193–1194

MeSH term(s)	Antibodies, Monoclonal, Humanized ; Humans ; Neoplasms/drug therapy ; Neoplasms/epidemiology ; Prevalence
Chemical Substances	Antibodies, Monoclonal, Humanized ; pembrolizumab (DPT0O3T46P)
Language	English
Publishing date	2021-05-31
Publishing country	England
Document type	Letter ; Comment
ZDB-ID	1025984-3
ISSN	1569-8041 ; 0923-7534
ISSN (online)	1569-8041
ISSN	0923-7534
DOI	10.1016/j.annonc.2021.05.805
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Article ; Online: How do short sleepers use extra waking hours? A compositional analysis of 24-h time-use patterns among children and adolescents.

Gába, Aleš / Dygrýn, Jan / Štefelová, Nikola / Rubín, Lukáš / Hron, Karel / Jakubec, Lukáš / Pedišić, Željko

The international journal of behavioral nutrition and physical activity

2020 Volume 17, Issue 1, Page(s) 104

Abstract: ... among children and adolescents.: Methods: Multi-day 24-h data on sleep, SB, LPA and MVPA were collected using ... adolescents with sleep duration of < 9 and < 8 h, respectively, were classified as short sleepers. Robust ...

Abstract	Background: To examine compositional associations between short sleep duration and sedentary behavior (SB), light physical activity (LPA) and moderate-to-vigorous physical activity (MVPA) among children and adolescents. Methods: Multi-day 24-h data on sleep, SB, LPA and MVPA were collected using accelerometers among 343 children (8-13 years old) and 316 adolescents (14-18 years old). Children and adolescents with sleep duration of < 9 and < 8 h, respectively, were classified as short sleepers. Robust compositional regression analysis was used to examine the associations between short sleep duration and the waking-time composition. Results: Seventy-one percent of children and 75.3% of adolescents were classified as short sleepers. In children, being a short sleeper was associated with higher SB by 95 min/day (p < 0.001) and lower MVPA by 16 min/day (p = 0.002). Specifically, it was associated with a higher amount of time spent in long sedentary bouts (β Conclusions: Among children and adolescents, short sleep duration seems to be highly prevalent and associated with less healthy waking time. Public health interventions and strategies to tackle the high prevalence of short sleep duration among children and adolescents are warranted.
MeSH term(s)	Accelerometry ; Adolescent ; Child ; Czech Republic/epidemiology ; Data Analysis ; Exercise ; Female ; Humans ; Male ; Sedentary Behavior ; Sleep
Language	English
Publishing date	2020-08-14
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1479-5868
ISSN (online)	1479-5868
DOI	10.1186/s12966-020-01004-8
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Article ; Online: Associations of novel 24-h accelerometer-derived metrics with adiposity in children and adolescents

Jan Dygrýn / María Medrano / Pablo Molina-Garcia / Lukáš Rubín / Lukáš Jakubec / David Janda / Aleš Gába

Environmental Health and Preventive Medicine, Vol 26, Iss 1, Pp 1-

2021 Volume 8

Abstract: Abstract Background Further research is required to explore the associations between 24-h movement ... the associations between novel data-driven 24-h activity metrics and adiposity among children and adolescents ... for the most active time periods of the 24-h cycle were calculated from raw acceleration data. Adiposity ...

Abstract	Abstract Background Further research is required to explore the associations between 24-h movement behaviours and health outcomes in the paediatric population. Therefore, this study aimed to examine the associations between novel data-driven 24-h activity metrics and adiposity among children and adolescents. Methods The sample included 382 children (8–13 years) and 338 adolescents (14–18 years). The average acceleration (AvAcc) of activity, intensity gradient (IG), and metrics representing the initial acceleration for the most active time periods of the 24-h cycle were calculated from raw acceleration data. Adiposity measures included body mass index z-score, fat mass percentage (FM%), and visceral adipose tissue (VAT). Data analysis was performed using multiple linear regression adjusted for wear time, sex, maternal education level, and maternal overweight and obesity. Results Children demonstrated higher values in all 24-h activity metrics than did adolescents (p < 0.001 for all). For children, the initial acceleration for the most active 2, 5, 15, and 30 min of the 24-h cycle were negatively associated with FM% (p ≤ 0.043 for all) and VAT (p <0.001 for all), respectively. For adolescents, the IG was negatively associated with FM% (p = 0.002) and VAT (p = 0.007). Moreover, initial acceleration for the most active 2, 5, 15, 30, 60, and 120 min were associated with FM% (p ≤ 0.007 for all) and with VAT (p ≤ 0.023 for all). Conclusions The intensity distribution of activity and initial acceleration for the most active 2, 5, 15, 30, 60, and 120 min within the 24-h cycle are beneficial for the prevention of excess adiposity in the paediatric population.
Keywords	Measurement ; Accelerometer ; Health ; Body composition ; Youth ; Public aspects of medicine ; RA1-1270
Subject code	796
Language	English
Publishing date	2021-06-01T00:00:00Z
Publisher	Komiyama Printing Co. Ltd
Document type	Article ; Online
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Article ; Online: A role for H/ACA and C/D small nucleolar RNAs in viral replication.

Murray, James L / Sheng, Jinsong / Rubin, Donald H

Molecular biotechnology

2014 Volume 56, Issue 5, Page(s) 429–437

Abstract: ... encoding H/ACA-class and C/D-class small nucleolar RNAs (SNORAs and SNORDs, respectively). Of these, 79 ...

Abstract	We have employed gene-trap insertional mutagenesis to identify candidate genes whose disruption confer phenotypic resistance to lytic infection, in independent studies using 12 distinct viruses and several different cell lines. Analysis of >2,000 virus-resistant clones revealed >1,000 candidate host genes, approximately 20 % of which were disrupted in clones surviving separate infections with 2-6 viruses. Interestingly, there were 83 instances in which the insertional mutagenesis vector disrupted transcripts encoding H/ACA-class and C/D-class small nucleolar RNAs (SNORAs and SNORDs, respectively). Of these, 79 SNORAs and SNORDs reside within introns of 29 genes (predominantly protein-coding), while 4 appear to be independent transcription units. siRNA studies targeting candidate SNORA/Ds provided independent confirmation of their roles in infection when tested against cowpox virus, Dengue Fever virus, influenza A virus, human rhinovirus 16, herpes simplex virus 2, or respiratory syncytial virus. Significantly, eight of the nine SNORA/Ds targeted with siRNAs enhanced cellular resistance to multiple viruses suggesting widespread involvement of SNORA/Ds in virus-host interactions and/or virus-induced cell death.
MeSH term(s)	Cell Line ; Humans ; Mutagenesis, Insertional ; RNA, Small Interfering/genetics ; RNA, Small Nucleolar/genetics ; RNA, Small Nucleolar/physiology ; Virus Replication/genetics ; Virus Replication/physiology
Chemical Substances	RNA, Small Interfering ; RNA, Small Nucleolar
Keywords	covid19
Language	English
Publishing date	2014-01-30
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	1193057-3
ISSN	1559-0305 ; 1073-6085
ISSN (online)	1559-0305
ISSN	1073-6085
DOI	10.1007/s12033-013-9730-0
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