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  1. Article: The role of early cardiac resynchronization therapy implantation in dilated cardiomyopathy patients with narrow QRS carrying lamin A/C mutation.

    Blich, Miry / Darawsha, Wisam / Eyal, Allon / Shehadeh, Faheem / Boulous, Monther / Gepstein, Lior / Suleiman, Mahmoud

    American journal of cardiovascular disease

    2024  Volume 14, Issue 1, Page(s) 47–53

    Abstract: Background: Dilated cardiomyopathy (DCM) caused by Lamin A/C gene (LMNA) mutation is complicated with atrioventricular conduction disturbances, malignant ventricular arrhythmias and progressive severe heart failure.: Objective: We hypothesized that ... ...

    Abstract Background: Dilated cardiomyopathy (DCM) caused by Lamin A/C gene (LMNA) mutation is complicated with atrioventricular conduction disturbances, malignant ventricular arrhythmias and progressive severe heart failure.
    Objective: We hypothesized that early cardiac resynchronization therapy (CRT) implantation in LMNA mutation carriers with an established indication for pacemaker or implantable cardioverter defibrillator (ICD), may preserve ejection fraction, and delay disease progression to end stage heart failure.
    Methods: We compared the primary outcomes: time to heart transplantation, death due to end stage heart failure or ventricular tachycardia (VT) ablation and secondary outcomes: change in left ventricular ejection fraction (EF) and ventricular arrhythmia burden between LMNA DCM patients in the early CRT and non-CRT groups.
    Results: Of ten LMNA DCM patients (age 51±10 years, QRS 96±14 msec, EF 55±7%) with indication for pacemaker or ICD implantation, five underwent early CRT-D implantation. After 7.2±4 years, three patients (60%) in the non-CRT group reached the primary outcome, compared to no patients in the CRT group (P=0.046). Four patients in non-CRT group (80%) experienced sustained ventricular tachycardia or received appropriate ICD shock compared to 1 patient (20%) in the CRT group (P=0.058). LMNA patients without early CRT had a higher burden of VPC/24 h in 12-lead holter (median 2352 vs 185, P=0.09). Echocardiography showed statistically lower LVEF in the non-CRT group compared to CRT group [(32±15)% vs (61±4)%, 95% CI: 32.97-61.03, P=0.016].
    Conclusion: Early CRT implantation in LMNA cardiomyopathy patients, with an indication for pacemaker or ICD, may reduce heart failure deterioration and life-threatening heart failure complications.
    Language English
    Publishing date 2024-02-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2616844-3
    ISSN 2160-200X
    ISSN 2160-200X
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Erratum to "Empiric antibiotic protocols for cancer patients with neutropenia: a single-center study of treatment efficacy and mortality in patients with bacteremia" [International Journal of Antimicrobial Agents Volume 51/1 (2018) 71-76].

    Kleinhendler, Eyal / Cohen, Matan J / Moses, Allon E / Paltiel, Ora / Strahilevitz, Jacob / Cahan, Amos

    International journal of antimicrobial agents

    2023  Volume 62, Issue 3, Page(s) 106928

    Language English
    Publishing date 2023-08-01
    Publishing country Netherlands
    Document type Published Erratum
    ZDB-ID 1093977-5
    ISSN 1872-7913 ; 0924-8579
    ISSN (online) 1872-7913
    ISSN 0924-8579
    DOI 10.1016/j.ijantimicag.2023.106928
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Loss-of-function variants in UBAP1L cause autosomal recessive retinal degeneration.

    Han, Ji Hoon / Rodenburg, Kim / Hayman, Tamar / Calzetti, Giacomo / Kaminska, Karolina / Quinodoz, Mathieu / Marra, Molly / Wallerich, Sandrine / Allon, Gilad / Nagy, Zoltán Z / Knézy, Krisztina / Li, Yumei / Chen, Rui / Barboni, Mirella Telles Salgueiro / Yang, Paul / Pennesi, Mark E / van den Born, L Ingeborgh / Varsányi, Balázs / Szabó, Viktória /
    Sharon, Dror / Banin, Eyal / Ben-Yosef, Tamar / Roosing, Susanne / Koenekoop, Robert K / Rivolta, Carlo

    Genetics in medicine : official journal of the American College of Medical Genetics

    2024  , Page(s) 101106

    Abstract: Purpose: Inherited retinal diseases (IRDs) are a group of monogenic conditions that can lead to progressive blindness. Their missing heritability is still considerable, due in part to the presence of disease genes that await molecular identification. ... ...

    Abstract Purpose: Inherited retinal diseases (IRDs) are a group of monogenic conditions that can lead to progressive blindness. Their missing heritability is still considerable, due in part to the presence of disease genes that await molecular identification. The purpose of this work was to identify novel genetic associations with IRDs.
    Methods: Patients underwent a comprehensive ophthalmological evaluation using standard-of-care tests, such as detailed retinal imaging (macular optical coherence tomography and short-wavelength fundus autofluorescence) and electrophysiological testing. Exome and genome sequencing, as well as computer-assisted data analysis were used for genotyping and detection of DNA variants. A minigene-driven splicing assay was performed to validate the deleterious effects of 1 of such variants.
    Results: We identified 8 unrelated families from Hungary, the United States, Israel, and The Netherlands with members presenting with a form of autosomal recessive and nonsyndromic retinal degeneration, predominantly described as rod-cone dystrophy but also including cases of cone/cone-rod dystrophy. Age of disease onset was very variable, with some patients experiencing first symptoms during their fourth decade of life or later. Myopia greater than 5 diopters was present in 5 of 7 cases with available refractive data, and retinal detachment was reported in 2 cases. All ascertained patients carried biallelic loss-of-function variants in UBAP1L (HGNC: 40028), a gene with unknown function and with homologies to UBAP1, encoding a protein involved in ubiquitin metabolism. One of these pathogenic variants, the intronic NM_001163692.2:c.910-7G>A substitution, was identified in 5 unrelated families. Minigene-driven splicing assays in HEK293T cells confirmed that this DNA change is responsible for the creation of a new acceptor splice site, resulting in aberrant splicing.
    Conclusion: We identified UBAP1L as a novel IRD gene. Although its function is currently unknown, UBAP1L is almost exclusively expressed in photoreceptors and the retinal pigment epithelium, hence possibly explaining the link between pathogenic variants in this gene and an ocular phenotype.
    Language English
    Publishing date 2024-02-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1455352-1
    ISSN 1530-0366 ; 1098-3600
    ISSN (online) 1530-0366
    ISSN 1098-3600
    DOI 10.1016/j.gim.2024.101106
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Retinal Vascular Signs as Screening and Prognostic Factors for Chronic Kidney Disease: A Systematic Review and Meta-Analysis of Current Evidence.

    Aronov, Michael / Allon, Raviv / Stave, Danielle / Belkin, Michael / Margalit, Eyal / Fabian, Ido Didi / Rosenzweig, Barak

    Journal of personalized medicine

    2021  Volume 11, Issue 7

    Abstract: Background: The substantial burden of kidney disease fosters interest in new ways of screening for early disease diagnosis, especially by non-invasive imaging. Increasing evidence for an association between retinal microvascular signs and kidney disease ...

    Abstract Background: The substantial burden of kidney disease fosters interest in new ways of screening for early disease diagnosis, especially by non-invasive imaging. Increasing evidence for an association between retinal microvascular signs and kidney disease prompted us to investigate the relevant current literature on such an association systematically by performing a meta-analysis of our findings.
    Methods: We scrutinized the current literature by searching PubMed and Embase databases from for clinical studies of the association between retinal microvascular signs and prevalent or incident kidney disease. After excluding cases that did not meet our criteria, we extracted relevant data from 42 published studies (9 prospective, 32 cross-sectional, and 1 retrospective).
    Results: Our investigation yielded significant associations between retinal vascular changes (including retinopathy and retinal vascular diameter) and kidney dysfunction (including chronic kidney disease (CKD), end-stage renal disease (ESRD), albuminuria, and estimated glomerular filtration rate (eGFR) decline). According to our meta-analysis, retinopathy was associated with ESRD (hazard ratio (HR) 2.12 (95% confidence interval CI; 1.39-3.22)) and with CKD prevalence in the general population (odds ratio (OR) 1.31 (95% CI; 1.14-1.50)), and specifically in type 2 diabetic patients (OR 1.68 (95% CI; 1.68-2.16)). CRAE was associated with prevalent CKD (OR 1.41 (95% CI; 1.09-1.82)).
    Conclusions: Our findings suggest that the retinal microvasculature can provide essential data about concurrent kidney disease status and predict future risk for kidney disease development and progression.
    Language English
    Publishing date 2021-07-15
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662248-8
    ISSN 2075-4426
    ISSN 2075-4426
    DOI 10.3390/jpm11070665
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Clinical management of conduction abnormalities following transcatheter aortic valve replacement: prospective evaluation of a standardized management pathway.

    Haouzi, Alice / Tuttle, Mark / Eyal, Allon / Tandon, Kunal / Tung, Patricia / Zimetbaum, Peter J / Kramer, Daniel B

    Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing

    2022  Volume 64, Issue 1, Page(s) 195–202

    Abstract: Purpose: Limited evidence guides management of conduction abnormalities following TAVR. Standardized clinical pathways may reduce variability in care while minimizing bradyarrhythmic morbidity, length of stay (LOS), and pacemaker (PPM) implantation ... ...

    Abstract Purpose: Limited evidence guides management of conduction abnormalities following TAVR. Standardized clinical pathways may reduce variability in care while minimizing bradyarrhythmic morbidity, length of stay (LOS), and pacemaker (PPM) implantation rates.
    Methods: A multidisciplinary consensus pathway to standardize post-TAVR management was developed. We evaluated (1) pathway adherence; (2) LOS; (3) PPM implantation rates; (4) 1-month survival, and (5) late heart block. Exploratory analyses evaluated factors associated with PPM implantation.
    Results: A total of 181 consecutive patients without prior PPM who underwent TAVR between February 2020 and February 2021 (mean age 77.9 ± 9.1, 38% women) were included. Average LOS was 3.0 days (± 2.7), and no deaths related to syncope/bradyarrhythmia were reported by 1 month. Overall, 93% of the 181 patients were managed by pathway; deviations were due to failure of discharge with a heart monitor when it was clinically indicated for either pre-existing RBBB or new PR prolongation/new LBBB. PPM implantation occurred in 19 patients by discharge, and 21 by 1-month (13%). In our exploratory analysis, pre-existing RBBB, transient peri-procedural heart block, and LOTUS valves were associated with pacemaker implantation: OR (CI) of 8.16 (3.06-21.78), 6.83 (1.94-24.03), and 8.32 (1.11-62.49), respectively.
    Conclusions: This report illustrates that a standardized protocol for the management of conduction abnormalities after TAVR can be implemented with high compliance, safe management of conduction disturbance, and relatively short LOS with discharge supported by ambulatory monitoring.
    MeSH term(s) Aged ; Aged, 80 and over ; Aortic Valve/surgery ; Aortic Valve Stenosis/surgery ; Atrioventricular Block/therapy ; Cardiac Pacing, Artificial/methods ; Female ; Humans ; Male ; Pacemaker, Artificial/adverse effects ; Risk Factors ; Transcatheter Aortic Valve Replacement/methods ; Treatment Outcome
    Language English
    Publishing date 2022-02-25
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1329179-8
    ISSN 1572-8595 ; 1383-875X
    ISSN (online) 1572-8595
    ISSN 1383-875X
    DOI 10.1007/s10840-022-01156-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Cardiology Patient Page. Magnetic Resonance Imaging in Patients With Cardiac Implantable Electronic Devices.

    Eyal, Allon / Roguin, Ariel

    Circulation

    2015  Volume 132, Issue 14, Page(s) e176–8

    MeSH term(s) Artifacts ; Burns, Electric/etiology ; Burns, Electric/prevention & control ; Cardiac Resynchronization Therapy Devices/adverse effects ; Contraindications ; Defibrillators, Implantable/adverse effects ; Electrodes, Implanted/adverse effects ; Equipment Failure ; Equipment Safety ; Foreign-Body Migration/etiology ; Foreign-Body Migration/prevention & control ; Humans ; Magnetic Resonance Imaging/adverse effects ; Magnetic Resonance Imaging/methods ; Pacemaker, Artificial/adverse effects
    Language English
    Publishing date 2015-10-06
    Publishing country United States
    Document type Journal Article ; Patient Education Handout
    ZDB-ID 80099-5
    ISSN 1524-4539 ; 0009-7322 ; 0069-4193 ; 0065-8499
    ISSN (online) 1524-4539
    ISSN 0009-7322 ; 0069-4193 ; 0065-8499
    DOI 10.1161/CIRCULATIONAHA.114.014640
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Jerusalem's CoVID-19 Experience-The Effect of Ethnicity on Disease Prevalence and Adherence to Testing.

    Sorotzky, Michael / Raphael, Allon / Breuer, Adin / Odeh, Ma'aran / Gillis, Roni / Gillis, Michal / Shibli, Roaia / Fiszlinski, Judith / Algur, Nurit / Magen, Sophie / Megged, Orli / Schlesinger, Yechiel / Mendelovich, Joseph / Weiser, Giora / Berliner, Elihay / Barak-Corren, Yuval / Heiman, Eyal

    Journal of racial and ethnic health disparities

    2024  

    Abstract: Background: The management of the SARS-CoV-2 pandemic depends amongst other factors on disease prevalence in the general population. The gap between the true rate of infection and the detected rate of infection may vary, especially between sub-groups of ...

    Abstract Background: The management of the SARS-CoV-2 pandemic depends amongst other factors on disease prevalence in the general population. The gap between the true rate of infection and the detected rate of infection may vary, especially between sub-groups of the population. Identifying subpopulations with high rates of undetected infection can guide authorities to direct resource distribution in order to improve health equity.
    Methods: A cross-sectional epidemiological survey was conducted between April and July 2021 in the Pediatric Emergency Department of the Shaare Zedek Medical Center, Jerusalem, Israel. We compared three categories: unconfirmed disease (UD), positive serology test result with no history of positive PCR; confirmed disease (CD), history of a positive PCR test result, regardless of serology test result; and no disease (ND), negative serology and no history of PCR. These categories were applied to local prevailing subpopulations: ultra-orthodox Jews (UO), National Religious Jews (NRJ), secular Jews (SJ), and Muslim Arabs (MA).
    Results: Comparing the different subpopulations groups, MAs and UOs had the greatest rate of confirmed or unconfirmed disease. MA had the highest rate of UD and UO had the highest rate of CD. UD significantly correlated with ethnicity, with a low prevalence in NRJ and SJ. UD was also associated with larger family size and housing density defined as family size per number of rooms.
    Conclusion: This study highlights the effect of ethnicity on disease burden. These findings should serve to heighten awareness to disease burden in weaker populations and direct a suitable prevention program to each subpopulation's needs. Early awareness and possible intervention may lower morbidity and mortality.
    Language English
    Publishing date 2024-03-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2760524-3
    ISSN 2196-8837 ; 2197-3792
    ISSN (online) 2196-8837
    ISSN 2197-3792
    DOI 10.1007/s40615-024-01965-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: CPAP (Continuous Positive Airway Pressure) is an effective and stable solution for heart sparing radiotherapy of left sided breast cancer.

    Allen, Aaron M / Ceder, Yasmin Korzets / Shochat, Tzippy / Fenig, Eyal / Popovtzer, Aron / Bragilofsky, Dimitry / Alfassy, Adi / Allon, Helena

    Radiation oncology (London, England)

    2020  Volume 15, Issue 1, Page(s) 59

    Abstract: Purpose: Limiting the heart dose in left sided breast cancer radiotherapy is critical. We sought to study the effect of using CPAP (continuous positive airway pressure) as an aid in reducing heart dose in breast cancer radiotherapy.: Methods: ... ...

    Abstract Purpose: Limiting the heart dose in left sided breast cancer radiotherapy is critical. We sought to study the effect of using CPAP (continuous positive airway pressure) as an aid in reducing heart dose in breast cancer radiotherapy.
    Methods: Patients with left sided breast cancer receiving adjuvant radiotherapy were enrolled on a prospective IRB (institutional review board) approved clinical trial utilizing CPAP during radiotherapy. Each patient was simulated and planned with and without CPAP and the best dosimetric results determined the patient's treatment. Data on the differences in lung and heart volume and position as well as boost cavity position with and without CPAP were analyzed.
    Results: Twenty-four women from 10/16 to 10/18 were enrolled. Seven patients were not treated on study; only two of these were due to treatment issues. Median age was 54 years. 70% had breast only radiation and 30% were treated to breast\CW (chest wall) and regional nodes. The median lung volume with CPAP was 60% larger than without CPAP. (1637 vs. 996 cc) p < 0.001. The median heart volume decreased 12% with CPAP. (338 vs. 382 cc) In regards to the DVH, CPAP decreased mean heart dose from 3.02 to 1.6Gy (p = .0075) and V20 of the lungs from 17.1 to 13.8 with CPAP but this was not significant.
    Conclusion: CPAP assisted radiotherapy was tolerable and produced superior treatment plans in left sided breast cancer. This method is worthy of further investigation as a method to normal tissue sparing treatment of left sided breast cancer patients.
    MeSH term(s) Breath Holding ; Continuous Positive Airway Pressure ; Female ; Four-Dimensional Computed Tomography ; Heart/drug effects ; Humans ; Middle Aged ; Organs at Risk ; Prospective Studies ; Radiotherapy Dosage ; Unilateral Breast Neoplasms/radiotherapy
    Language English
    Publishing date 2020-03-06
    Publishing country England
    Document type Clinical Trial, Phase II ; Journal Article
    ISSN 1748-717X
    ISSN (online) 1748-717X
    DOI 10.1186/s13014-020-01505-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Book ; Online: Privacy-preserving record linkage using local sensitive hash and private set intersection

    Adir, Allon / Aharoni, Ehud / Drucker, Nir / Kushnir, Eyal / Masalha, Ramy / Mirkin, Michael / Soceanu, Omri

    2022  

    Abstract: The amount of data stored in data repositories increases every year. This makes it challenging to link records between different datasets across companies and even internally, while adhering to privacy regulations. Address or name changes, and even ... ...

    Abstract The amount of data stored in data repositories increases every year. This makes it challenging to link records between different datasets across companies and even internally, while adhering to privacy regulations. Address or name changes, and even different spelling used for entity data, can prevent companies from using private deduplication or record-linking solutions such as private set intersection (PSI). To this end, we propose a new and efficient privacy-preserving record linkage (PPRL) protocol that combines PSI and local sensitive hash (LSH) functions, and runs in linear time. We explain the privacy guarantees that our protocol provides and demonstrate its practicality by executing the protocol over two datasets with $2^{20}$ records each, in $11-45$ minutes, depending on network settings.
    Keywords Computer Science - Cryptography and Security
    Publishing date 2022-03-27
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Retinal Vascular Signs as Screening and Prognostic Factors for Chronic Kidney Disease

    Michael Aronov / Raviv Allon / Danielle Stave / Michael Belkin / Eyal Margalit / Ido Didi Fabian / Barak Rosenzweig

    Journal of Personalized Medicine, Vol 11, Iss 665, p

    A Systematic Review and Meta-Analysis of Current Evidence

    2021  Volume 665

    Abstract: Background: The substantial burden of kidney disease fosters interest in new ways of screening for early disease diagnosis, especially by non-invasive imaging. Increasing evidence for an association between retinal microvascular signs and kidney disease ... ...

    Abstract Background: The substantial burden of kidney disease fosters interest in new ways of screening for early disease diagnosis, especially by non-invasive imaging. Increasing evidence for an association between retinal microvascular signs and kidney disease prompted us to investigate the relevant current literature on such an association systematically by performing a meta-analysis of our findings. Methods: We scrutinized the current literature by searching PubMed and Embase databases from for clinical studies of the association between retinal microvascular signs and prevalent or incident kidney disease. After excluding cases that did not meet our criteria, we extracted relevant data from 42 published studies (9 prospective, 32 cross-sectional, and 1 retrospective). Results: Our investigation yielded significant associations between retinal vascular changes (including retinopathy and retinal vascular diameter) and kidney dysfunction (including chronic kidney disease (CKD), end-stage renal disease (ESRD), albuminuria, and estimated glomerular filtration rate (eGFR) decline). According to our meta-analysis, retinopathy was associated with ESRD (hazard ratio (HR) 2.12 (95% confidence interval CI; 1.39–3.22)) and with CKD prevalence in the general population (odds ratio (OR) 1.31 (95% CI; 1.14–1.50)), and specifically in type 2 diabetic patients (OR 1.68 (95% CI; 1.68–2.16)). CRAE was associated with prevalent CKD (OR 1.41 (95% CI; 1.09–1.82)). Conclusions: Our findings suggest that the retinal microvasculature can provide essential data about concurrent kidney disease status and predict future risk for kidney disease development and progression.
    Keywords chronic kidney disease ; end-stage renal disease ; fundus photography ; glomerular filtration rate ; retinal vascular diameter ; diabetic retinopathy ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2021-07-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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