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  1. Article: Infection of Norway lobster (

    Molto-Martin, Irene / Neil, Douglas M / Coates, Christopher J / MacKenzie, Simon A / Bass, David / Stentiford, Grant D / Albalat, Amaya

    Royal Society open science

    2024  Volume 11, Issue 1, Page(s) 231147

    Abstract: The Norway lobster, ...

    Abstract The Norway lobster,
    Language English
    Publishing date 2024-01-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 2787755-3
    ISSN 2054-5703
    ISSN 2054-5703
    DOI 10.1098/rsos.231147
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Effect of statin treatment on the risk of cancer in patients with heart failure: A target trial emulation study.

    Ju, Chengsheng / Lau, Wallis C Y / Chambers, Pinkie / Man, Kenneth K C / Forster, Martin D / Mackenzie, Isla S / Manisty, Charlotte / Wei, Li

    Pharmacoepidemiology and drug safety

    2024  Volume 33, Issue 3, Page(s) e5775

    Abstract: Purpose: A recent observational study suggested statins could reduce cancer diagnosis in patients with heart failure (HF). The findings need to be validated using robust epidemiological methods. This study aimed to evaluate the effect of statin ... ...

    Abstract Purpose: A recent observational study suggested statins could reduce cancer diagnosis in patients with heart failure (HF). The findings need to be validated using robust epidemiological methods. This study aimed to evaluate the effect of statin treatment on the risk of cancer in patients with HF.
    Methods: We conducted two target trial emulations using primary care data from IQVIA Medical Research Database-UK (2000 to 2019) with a clone-censor-weight design. The first emulated trial addressed the treatment initiation effect: initiating within 1 year versus not initiating a statin after the HF diagnosis. The second emulated trial addressed the cumulative exposure effect: continuing a statin for ≤3 years, 3-6 years, and >6 years after initiation. The study outcomes were any incident cancer and site-specific cancer diagnoses. Weighted pooled logistic regression models were used to estimate 10-year risk ratios (RR). 95% confidence intervals (CIs) were estimated using non-parametric bootstrapping.
    Results: The first emulated trial showed that, compared to no statin, statins did not reduce the cancer risk in patients with HF (RR, 1.05; 95% CI, 0.94-1.15). The second emulated trial showed that, compared to treatment ≤3 years, statins with longer durations did not reduce the cancer risk (3-6 years: RR, 0.94; 95% CI, 0.70-1.33. >6 years: RR, 0.97; 95% CI, 0.79-1.26). No significant risk difference was observed on any site-specific cancer diagnoses.
    Conclusions: The results from the target trial emulations suggest that statin treatment is not associated with cancer risk in patients with HF.
    MeSH term(s) Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/adverse effects ; Neoplasms/epidemiology ; Research Design ; Heart Failure/epidemiology ; Cognition
    Chemical Substances Hydroxymethylglutaryl-CoA Reductase Inhibitors
    Language English
    Publishing date 2024-03-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 1099748-9
    ISSN 1099-1557 ; 1053-8569
    ISSN (online) 1099-1557
    ISSN 1053-8569
    DOI 10.1002/pds.5775
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  3. Article ; Online: Infection of Norway lobster (Nephrops norvegicus) by the parasite Hematodinium sp.

    Irene Molto-Martin / Douglas M. Neil / Christopher J. Coates / Simon A. MacKenzie / David Bass / Grant D. Stentiford / Amaya Albalat

    Royal Society Open Science, Vol 11, Iss

    insights from 30 years of field observations

    2024  Volume 1

    Abstract: The Norway lobster, Nephrops norvegicus, is an important representative of the benthos and also supports valuable fisheries across Europe. Nephrops are susceptible to infection by Hematodinium sp., an endoparasitic dinoflagellate that causes morbidity ... ...

    Abstract The Norway lobster, Nephrops norvegicus, is an important representative of the benthos and also supports valuable fisheries across Europe. Nephrops are susceptible to infection by Hematodinium sp., an endoparasitic dinoflagellate that causes morbidity and mortality. From an epizootiological perspective, the Clyde Sea Area (CSA; west of Scotland) is the best-studied Hematodinium–Nephrops pathosystem, with historical data available between 1988 and 2008. We have revisited this pathosystem by curating and updating prevalence values, differentiating host traits associated with disease exposure and progression, and comparing Hematodinium sp. disease dynamics in the CSA to other locations and to other decapod hosts (Cancer pagurus, Carcinus maenas). Prevalence from a 2018/2019 survey (involving 1739 lobsters) revealed Hematodinium sp. still mounts a synchronized patent infection in the CSA; hence this pathogen can be considered as enzootic in this location. We highlight for the first time that Nephrops size is associated with high severity infection, while females are more exposed to Hematodinium sp. More generally, regardless of the host (Norway lobster, brown and shore crabs) or the geographical area (Ireland, Wales, Scotland), Hematodinium sp. patent infections peak in spring/summer and reach their nadir during autumn. We contend that Hematodinium must be considered one of the most important pathogens of decapod crustaceans in temperate waters.
    Keywords marine parasite ; dinoflagellate ; fisheries ; decapod crustaceans ; disease connectivity ; long-term datasets ; Science ; Q
    Language English
    Publishing date 2024-01-01T00:00:00Z
    Publisher The Royal Society
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: The Case for Assessing and Reporting on Facilitator Fidelity: Introducing the Fidelity of Implementation in Parenting Programs Guideline.

    Martin, Mackenzie / Shenderovich, Yulia / Caron, E B / Smith, Justin D / Siu, Godfrey / Breitenstein, Susan M

    Global implementation research and applications

    2023  Volume 4, Issue 1, Page(s) 1–10

    Abstract: The sizeable body of evidence indicating that parenting programs have a positive impact on children and families highlights the potential public health benefits of their implementation on a large scale. Despite evidence and global attention, beyond the ... ...

    Abstract The sizeable body of evidence indicating that parenting programs have a positive impact on children and families highlights the potential public health benefits of their implementation on a large scale. Despite evidence and global attention, beyond the highly controlled delivery of parenting programs via randomized trials, little is known about program effectiveness or how to explain the poorer results commonly observed when implemented in community settings. Researchers, practitioners, and policymakers must work together to identify what is needed to spur adoption and sustainment of evidence-based parenting programs in real-world service systems and how to enhance program effectiveness when delivered via these systems. Collecting, analyzing, and using facilitator fidelity data is an important frontier through which researchers and practitioners can contribute. In this commentary, we outline the value of assessing facilitator fidelity and utilizing the data generated from these assessments; describe gaps in research, knowledge, and practice; and recommend directions for research and practice. In making recommendations, we describe a collaborative process to develop a preliminary guideline-the Fidelity of Implementation in Parenting Programs Guideline or FIPP-to use when reporting on facilitator fidelity. Readers are invited to complete an online survey to provide comments and feedback on the first draft of the guideline.
    Supplementary information: The online version contains supplementary material available at 10.1007/s43477-023-00092-5.
    Language English
    Publishing date 2023-09-09
    Publishing country Switzerland
    Document type Editorial
    ISSN 2662-9275
    ISSN (online) 2662-9275
    DOI 10.1007/s43477-023-00092-5
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  5. Article ; Online: Quantitative differentiation of benign and misfolded glaucoma-causing myocilin variants on the basis of protein thermal stability.

    Scelsi, Hailee F / Hill, Kamisha R / Barlow, Brett M / Martin, Mackenzie D / Lieberman, Raquel L

    Disease models & mechanisms

    2023  Volume 16, Issue 1

    Abstract: Accurate predictions of the pathogenicity of mutations associated with genetic diseases are key to the success of precision medicine. Inherited missense mutations in the myocilin (MYOC) gene, within its olfactomedin (OLF) domain, constitute the strongest ...

    Abstract Accurate predictions of the pathogenicity of mutations associated with genetic diseases are key to the success of precision medicine. Inherited missense mutations in the myocilin (MYOC) gene, within its olfactomedin (OLF) domain, constitute the strongest genetic link to primary open-angle glaucoma via a toxic gain of function, and thus MYOC is an attractive precision-medicine target. However, not all mutations in MYOC cause glaucoma, and common variants are expected to be neutral polymorphisms. The Genome Aggregation Database (gnomAD) lists ∼100 missense variants documented within OLF, all of which are relatively rare (allele frequency <0.001%) and nearly all are of unknown pathogenicity. To distinguish disease-causing OLF variants from benign OLF variants, we first characterized the most prevalent population-based variants using a suite of cellular and biophysical assays, and identified two variants with features of aggregation-prone familial disease variants. Next, we considered all available biochemical and clinical data to demonstrate that pathogenic and benign variants can be differentiated statistically based on a single metric: the thermal stability of OLF. Our results motivate genotyping MYOC in patients for clinical monitoring of this widespread, painless and irreversible ocular disease.
    MeSH term(s) Humans ; Glaucoma, Open-Angle/genetics ; Glaucoma, Open-Angle/metabolism ; Glaucoma/genetics ; Glaucoma/metabolism ; Cytoskeletal Proteins/genetics ; Cytoskeletal Proteins/metabolism ; Eye Proteins/genetics ; Eye Proteins/metabolism ; Mutation/genetics
    Chemical Substances trabecular meshwork-induced glucocorticoid response protein ; Cytoskeletal Proteins ; Eye Proteins
    Language English
    Publishing date 2023-01-13
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2451104-3
    ISSN 1754-8411 ; 1754-8403
    ISSN (online) 1754-8411
    ISSN 1754-8403
    DOI 10.1242/dmm.049816
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  6. Article ; Online: Quantitative differentiation of benign and misfolded glaucoma-causing myocilin variants on the basis of protein thermal stability

    Hailee F. Scelsi / Kamisha R. Hill / Brett M. Barlow / Mackenzie D. Martin / Raquel L. Lieberman

    Disease Models & Mechanisms, Vol 16, Iss

    2023  Volume 1

    Keywords glaucoma ; misfolding ; genetic mutation ; protein homeostasis ; thermal stability ; Medicine ; R ; Pathology ; RB1-214
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher The Company of Biologists
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article: Cencurut virus: A novel

    Low, Dolyce H W / Ch'ng, Lena / Su, Yvonne C F / Linster, Martin / Zhang, Rong / Zhuang, Yan / Kwak, Mackenzie L / Borthwick, Sophie A / Hitch, Alan T / Smith, Gavin J D / Mendenhall, Ian H

    One health (Amsterdam, Netherlands)

    2023  Volume 16, Page(s) 100529

    Abstract: ... ...

    Abstract Orthonairovirus
    Language English
    Publishing date 2023-03-29
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2834831-X
    ISSN 2352-7714
    ISSN 2352-7714
    DOI 10.1016/j.onehlt.2023.100529
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  8. Article ; Online: Depression, hostility, attributional biases, and paranoia in schizophrenia and healthy controls: intercorrelations and associations with self-assessment of social functioning.

    Strassnig, Martin / Jones, Mackenzie T / Pinkham, Amy / Penn, David / Jarskog, L Frederik / Harvey, Philip D

    Psychiatry research

    2020  Volume 293, Page(s) 113388

    Language English
    Publishing date 2020-08-17
    Publishing country Ireland
    Document type Letter
    ZDB-ID 445361-x
    ISSN 1872-7123 ; 1872-7506 ; 0925-4927 ; 0165-1781
    ISSN (online) 1872-7123 ; 1872-7506
    ISSN 0925-4927 ; 0165-1781
    DOI 10.1016/j.psychres.2020.113388
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    Zs.A 1541: Show issues Location:
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  9. Article ; Online: Layered metals as polarized transparent conductors.

    Putzke, Carsten / Guo, Chunyu / Plisson, Vincent / Kroner, Martin / Chervy, Thibault / Simoni, Matteo / Wevers, Pim / Bachmann, Maja D / Cooper, John R / Carrington, Antony / Kikugawa, Naoki / Fowlie, Jennifer / Gariglio, Stefano / Mackenzie, Andrew P / Burch, Kenneth S / Îmamoğlu, Ataç / Moll, Philip J W

    Nature communications

    2023  Volume 14, Issue 1, Page(s) 3147

    Abstract: The quest to improve transparent conductors balances two key goals: increasing electrical conductivity and increasing optical transparency. To improve both simultaneously is hindered by the physical limitation that good metals with high electrical ... ...

    Abstract The quest to improve transparent conductors balances two key goals: increasing electrical conductivity and increasing optical transparency. To improve both simultaneously is hindered by the physical limitation that good metals with high electrical conductivity have large carrier densities that push the plasma edge into the ultra-violet range. Technological solutions reflect this trade-off, achieving the desired transparencies only by reducing the conductor thickness or carrier density at the expense of a lower conductance. Here we demonstrate that highly anisotropic crystalline conductors offer an alternative solution, avoiding this compromise by separating the directions of conduction and transmission. We demonstrate that slabs of the layered oxides Sr
    Language English
    Publishing date 2023-05-30
    Publishing country England
    Document type Journal Article
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-023-38848-0
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  10. Article ; Online: Emerging 5-HT receptor antagonists for the treatment of Schizophrenia.

    Jones, Mackenzie T / Strassnig, Martin T / Harvey, Philip D

    Expert opinion on emerging drugs

    2020  Volume 25, Issue 2, Page(s) 189–200

    Abstract: Introduction: While antipsychotics have been generally successful in treating psychosis in schizophrenia, there is a major treatment gap for negative symptoms and cognitive deficits. Given that these aspects of the disease contribute to poor functional ... ...

    Abstract Introduction: While antipsychotics have been generally successful in treating psychosis in schizophrenia, there is a major treatment gap for negative symptoms and cognitive deficits. Given that these aspects of the disease contribute to poor functional outcomes independently of positive symptoms, treatments would have profound implications for quality of life. The 5-HT
    Areas covered: Ritanserin and volinanserin, are historically important compounds in this area, while pimavanserin, roluperidone, and lumateperone are either newly approved, in late stages of development, or currently being tested for efficacy in schizophrenia-related features. The focus will be on their efficacy in the treatment of negative symptoms, with a limited secondary discussion of cognition.
    Expert opinion: In addition to their efficacy in treating negative symptoms and cognition, these compounds may also have a role in modulating antipsychotic-induced dopamine super-sensitivity and preventing relapse. They may also show efficacy in treating patients with milder symptoms such as patients with schizotypal personality disorder and attenuated psychosis syndrome. Their utility may also expand outside the spectrum of schizophrenia to encompass Parkinson's Disease psychosis, major depression, bipolar depression, and dementia-associated apathy.
    MeSH term(s) Animals ; Antipsychotic Agents/pharmacology ; Cognition Disorders/drug therapy ; Cognition Disorders/etiology ; Drug Design ; Drug Development ; Humans ; Quality of Life ; Schizophrenia/drug therapy ; Schizophrenia/physiopathology ; Serotonin Antagonists/pharmacology
    Chemical Substances Antipsychotic Agents ; Serotonin Antagonists
    Language English
    Publishing date 2020-06-08
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2061369-6
    ISSN 1744-7623 ; 1472-8214
    ISSN (online) 1744-7623
    ISSN 1472-8214
    DOI 10.1080/14728214.2020.1773792
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