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Article: New Chitosan Polymer Scaffold Schiff Bases as Potential Cytotoxic Activity: Synthesis, Molecular Docking, and Physiochemical Characterization.

Packialakshmi, Ponnusamy / Gobinath, Perumal / Ali, Daoud / Alarifi, Saud / Gurusamy, Raman / Idhayadhulla, Akbar / Surendrakumar, Radhakrishnan

Frontiers in chemistry

2022 Volume 9, Page(s) 796599

Abstract: In this work, we synthesize the sulfonated Schiff bases of the chitosan derivatives 2a-2j without the use of a catalyst in two moderately straightforward steps with good yield within a short reaction time. The morphology and chemical structure of ... ...

Abstract	In this work, we synthesize the sulfonated Schiff bases of the chitosan derivatives 2a-2j without the use of a catalyst in two moderately straightforward steps with good yield within a short reaction time. The morphology and chemical structure of chitosan derivatives were investigated using FT-IR, NMR (
Language	English
Publishing date	2022-01-17
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2711776-5
ISSN	2296-2646
ISSN	2296-2646
DOI	10.3389/fchem.2021.796599
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Correction: Gobinath, P., et al. Grindstone Chemistry: Design, One-Pot Synthesis, and Promising Anticancer Activity of Spiro[acridine-9,2'-indoline]-1,3,8-trione Derivatives against the MCF-7 Cancer Cell Line.

Gobinath, Perumal / Packialakshmi, Ponnusamy / Daoud, Ali / Alarifi, Saud / Idhayadhulla, Akbar / Surendrakumar, Radhakrishnan

Molecules (Basel, Switzerland)

2021 Volume 26, Issue 4

Abstract: In the original article [ ... ]. ...

Abstract	In the original article [...].
Language	English
Publishing date	2021-02-20
Publishing country	Switzerland
Document type	Published Erratum
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules26041131
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Article ; Online: New Chitosan Polymer Scaffold Schiff Bases as Potential Cytotoxic Activity

Ponnusamy Packialakshmi / Perumal Gobinath / Daoud Ali / Saud Alarifi / Raman Gurusamy / Akbar Idhayadhulla / Radhakrishnan Surendrakumar

Frontiers in Chemistry, Vol

Synthesis, Molecular Docking, and Physiochemical Characterization

2022 Volume 9

Abstract	In this work, we synthesize the sulfonated Schiff bases of the chitosan derivatives 2a-2j without the use of a catalyst in two moderately straightforward steps with good yield within a short reaction time. The morphology and chemical structure of chitosan derivatives were investigated using FT-IR, NMR (1H—13C), XRD, and SEM. Furthermore, our chitosan derivatives were tested for their anticancer activity against the MCF-7 cancer cell line, and doxorubicin was used as a standard. In addition, the normal cell lines of the breast cancer cell MCF-10A, and of the lung cell MRC-5 were tested. Compound 2 h, with a GI50 value of 0.02 µM for MCF-7, is highly active compared with the standard doxorubicin and other compounds. The synthesized compounds 2a-2j exhibit low cytotoxicity, with IC50 > 100 μg/ml, against normal cell lines MCF-10A, MRC-5. We also provide the results of an in-silico study involving the Methoxsalen protein (1Z11). Compound 2h exhibits a higher binding affinity for 1Z11 protein (−5.9 kcal/mol) and a lower binding affinity for Doxorubicin (−5.3 kcal/mol) than certain other compounds. As a result of the aforementioned findings, the use of compound 2h has an anticancer drug will be researched in the future.
Keywords	schiff base ; SEM ; anticancer activity ; MCF-7 ; in-silico molecular docking ; structure activity relationship ; Chemistry ; QD1-999
Subject code	540
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Correction

Perumal Gobinath / Ponnusamy Packialakshmi / Ali Daoud / Saud Alarifi / Akbar Idhayadhulla / Radhakrishnan Surendrakumar

Molecules, Vol 26, Iss 4, p

Gobinath, P., et al. Grindstone Chemistry: Design, One-Pot Synthesis, and Promising Anticancer Activity of Spiro[acridine-9,2′-indoline]-1,3,8-trione Derivatives against the MCF-7 Cancer Cell Line. Molecules 2020, 25 , 5862

2021 Volume 1131

Abstract: In the original article [.] ...

Abstract	In the original article [.]
Keywords	n/a ; Organic chemistry ; QD241-441
Language	English
Publishing date	2021-02-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Nanobased Antibacterial Drug Discovery to Treat Skin Infections o

Gobinath, Perumal / Packialakshmi, Ponnusamy / Ali, Daoud / Alarifi, Saud / Gurusamy, Raman / Idhayadhulla, Akbar / SurendraKumar, Radhakrishnan

publication RETRACTED

BioMed research international

2022 Volume 2022, Page(s) 7228259

Abstract: In addition to the physical barrier, the epidermis acts as a natural barrier against microbial proliferation. It is prone to bacterial infections on the skin and in the nose, such as Staphylococcus aureus, as well as a variety of other skin illnesses. ... ...

Abstract	In addition to the physical barrier, the epidermis acts as a natural barrier against microbial proliferation. It is prone to bacterial infections on the skin and in the nose, such as Staphylococcus aureus, as well as a variety of other skin illnesses. Green nanomaterial production, which eliminates the use of harmful chemicals while simultaneously reducing time, is gaining popularity in the nanotechnology area. Using the leaf extract of the pharmacologically valuable plant Moringa oleifera, we described a green synthesis of ZnO NPs (zinc oxide nanoparticles). ZnO NPs had a particle size of 201.6 nm and a zeta potential of -56.80 mV, respectively. A novel aminoketone antibacterial medication was synthesized and tested for antibacterial activity using ZnO NPs as a phytocatalyst in this work. This method produces high yields while maintaining efficient and gentle reaction conditions. Moringa oleifera extract can reduce ZnO to ZnO NPs in a straightforward manner. FT-IR,
MeSH term(s)	Anti-Bacterial Agents/chemical synthesis ; Green Chemistry Technology ; Molecular Docking Simulation ; Molecular Structure ; Moringa oleifera/chemistry ; Nanoparticles/chemistry ; Plant Extracts/chemistry ; Plant Extracts/pharmacology ; Staphylococcal Skin Infections/drug therapy ; Staphylococcus aureus/drug effects ; Zinc Oxide/chemistry ; Zinc Oxide/pharmacology
Chemical Substances	Anti-Bacterial Agents ; Plant Extracts ; Zinc Oxide (SOI2LOH54Z)
Language	English
Publishing date	2022-02-10
Publishing country	United States
Document type	Journal Article ; Retracted Publication
ZDB-ID	2698540-8
ISSN	2314-6141 ; 2314-6133
ISSN (online)	2314-6141
ISSN	2314-6133
DOI	10.1155/2022/7228259
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Article: Corrigendum: Synthesis and Cytotoxic Activity of Novel Indole Derivatives and Their

Gobinath, Perumal / Packialakshmi, Ponnusamy / Vijayakumar, Kaliappillai / Abdellattif, Magda H / Shahbaaz, Mohd / Idhayadhulla, Akbar / Surendrakumar, Radhakrishnan

Frontiers in molecular biosciences

2021 Volume 8, Page(s) 716238

Abstract: This corrects the article DOI: 10.3389/fmolb.2021.637989.]. ...

Abstract	[This corrects the article DOI: 10.3389/fmolb.2021.637989.].
Language	English
Publishing date	2021-08-05
Publishing country	Switzerland
Document type	Published Erratum
ZDB-ID	2814330-9
ISSN	2296-889X
ISSN	2296-889X
DOI	10.3389/fmolb.2021.716238
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Article ; Online: Grindstone Chemistry: Design, One-Pot Synthesis, and Promising Anticancer Activity of Spiro[acridine-9,2'-indoline]-1,3,8-trione Derivatives against the MCF-7 Cancer Cell Line.

Gobinath, Perumal / Packialakshmi, Ponnusamy / Daoud, Ali / Alarifi, Saud / Idhayadhulla, Akbar / Radhakrishnan, Surendrakumar

Molecules (Basel, Switzerland)

2020 Volume 25, Issue 24

Abstract: In this study, the synthesis of one-pot 10-phenyl-3,4,6,7-tetrahydro- ... ...

Abstract	In this study, the synthesis of one-pot 10-phenyl-3,4,6,7-tetrahydro-1
Language	English
Publishing date	2020-12-11
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules25245862
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Synthesis and Cytotoxic Activity of Novel Indole Derivatives and Their

Gobinath, Perumal / Packialakshmi, Ponnusamy / Vijayakumar, Kaliappillai / Abdellattif, Magda H. / Shahbaaz, Mohd / Idhayadhulla, Akbar / Surendrakumar, Radhakrishnan

Frontiers in molecular biosciences

2021 Volume 8, Page(s) 637989

Abstract: This work investigated the interaction of indole with SARS-CoV-2. Indole is widely used as a medical material owing to its astounding biological activities. Indole and its derivatives belong to a significant category of heterocyclic compounds that have ... ...

Abstract	This work investigated the interaction of indole with SARS-CoV-2. Indole is widely used as a medical material owing to its astounding biological activities. Indole and its derivatives belong to a significant category of heterocyclic compounds that have been used as a crucial component for several syntheses of medicine. A straightforward one-pot three-component synthesis of indole, coupled with Mannich base derivatives 1a-1j, was synthesized without a catalyst. The products were confirmed by IR,
Language	English
Publishing date	2021-05-11
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2814330-9
ISSN	2296-889X
ISSN	2296-889X
DOI	10.3389/fmolb.2021.637989
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Synthesis and Characterization of a Minophosphonate Containing Chitosan Polymer Derivatives: Investigations of Cytotoxic Activity and in Silico Study of SARS-CoV-19.

Packialakshmi, Ponnusamy / Gobinath, Perumal / Ali, Daoud / Alarifi, Saud / Alsaiari, Norah Salem / Idhayadhulla, Akbar / Surendrakumar, Radhakrishnan

Polymers

2021 Volume 13, Issue 7

Abstract: Chitosan is broadly used as a biological material since of its excellent biological activities. This work describes investigations of chitosan interaction with SARS-CoV-2, which is occupied by human respiratory epithelial cells through communication with ...

Abstract	Chitosan is broadly used as a biological material since of its excellent biological activities. This work describes investigations of chitosan interaction with SARS-CoV-2, which is occupied by human respiratory epithelial cells through communication with the human angiotension-converting enzyme II (ACE2). The β-chitosan derivatives are synthesized and characterized by FT-IR, nuclear magnetic resonance (
Language	English
Publishing date	2021-03-26
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527146-5
ISSN	2073-4360 ; 2073-4360
ISSN (online)	2073-4360
ISSN	2073-4360
DOI	10.3390/polym13071046
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Nanobased Antibacterial Drug Discovery to Treat Skin Infections of Staphylococcus aureus Using Moringa oleifera-Assisted Zinc Oxide Nanoparticle and Molecular Simulation Study

Perumal Gobinath / Ponnusamy Packialakshmi / Daoud Ali / Saud Alarifi / Raman Gurusamy / Akbar Idhayadhulla / Radhakrishnan SurendraKumar

BioMed Research International, Vol

2022 Volume 2022

Abstract	In addition to the physical barrier, the epidermis acts as a natural barrier against microbial proliferation. It is prone to bacterial infections on the skin and in the nose, such as Staphylococcus aureus, as well as a variety of other skin illnesses. Green nanomaterial production, which eliminates the use of harmful chemicals while simultaneously reducing time, is gaining popularity in the nanotechnology area. Using the leaf extract of the pharmacologically valuable plant Moringa oleifera, we described a green synthesis of ZnO NPs (zinc oxide nanoparticles). ZnO NPs had a particle size of 201.6 nm and a zeta potential of -56.80 mV, respectively. A novel aminoketone antibacterial medication was synthesized and tested for antibacterial activity using ZnO NPs as a phytocatalyst in this work. This method produces high yields while maintaining efficient and gentle reaction conditions. Moringa oleifera extract can reduce ZnO to ZnO NPs in a straightforward manner. FT-IR, 1H-NMR, 13C-NMR, mass spectra, elemental analysis, and morphological analysis were used to synthesize and describe the antibacterial medicines (1a-1g) and (2a-2g). In addition, antibacterial activity was evaluated against bacteria such as Enterococcus faecalis and Staphylococcus aureus, and compound 1c (63 μg/mL, E. faecalis) and compound 2e (0.12 μg/mL, S. aureus) were found to be very active when compared to other medications. mupirocin is used as a reference. In addition, studies of in silico molecular docking for the bacterial DsbA protein were conducted. The strong molecules 1c (-4.3 kcal/mol) and 2e (-5.1 kcal/mol) exhibit a high binding affinity through hydrogen bonding, according to docking tests.
Keywords	Medicine ; R
Subject code	540
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	Hindawi Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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