Article ; Online: Investigating the causal relationship between human blood/urine metabolites and periodontal disease using two-sample Mendelian randomization.
Health science reports
2024 Volume 7, Issue 3, Page(s) e1895
Abstract: Background and aims: The aim is to investigate the cause-and-effect connection between metabolites found in blood/urine and the likelihood of developing periodontal disease (PD) through the utilization of a two-sample Mendelian randomization (MR) method. ...
Abstract | Background and aims: The aim is to investigate the cause-and-effect connection between metabolites found in blood/urine and the likelihood of developing periodontal disease (PD) through the utilization of a two-sample Mendelian randomization (MR) method. Methods: Using an inverse variance weighted (IVW) method and two additional two-sample MR models, we examined the relationship between blood/urine metabolites and PD by analyzing data from a comprehensive metabolome-based genome-wide association study and the Genome-Wide Association Studies (GWAS) of PD. To assess the consistency and dependability of the findings, diversity, cross-effects, and sensitivity analyses were conducted. Results: Out of the 35 metabolites found in blood and urine, a total of eight metabolites (C-reactive protein, Potassium in urine, Urea, Cystatin C, Non-albumin protein, Creatinine, estimated Glomerular Filtration Rate, and Phosphate) displayed a possible causal connection with the risk of dental caries/PD using the inverse variance weighted (IVW) method ( Conclusion: Based on the available evidence, it is not possible to establish a significant causal link between the 35 blood metabolites and the likelihood of developing dental caries and PD. |
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Language | English |
Publishing date | 2024-03-10 |
Publishing country | United States |
Document type | Journal Article |
ISSN | 2398-8835 |
ISSN (online) | 2398-8835 |
DOI | 10.1002/hsr2.1895 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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