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  1. Article ; Online: Assessing remission in major depressive disorder using a functional-structural data fusion pipeline: A CAN-BIND-1 study.

    Ayyash, Sondos / Davis, Andrew D / Alders, Gésine L / MacQueen, Glenda / Strother, Stephen C / Hassel, Stefanie / Zamyadi, Mojdeh / Arnott, Stephen R / Harris, Jacqueline K / Lam, Raymond W / Milev, Roumen / Müller, Daniel J / Kennedy, Sidney H / Rotzinger, Susan / Frey, Benicio N / Minuzzi, Luciano / Hall, Geoffrey B

    IBRO neuroscience reports

    2024  Volume 16, Page(s) 135–146

    Abstract: Neural network-level changes underlying symptom remission in major depressive disorder (MDD) are often studied from a single perspective. Multimodal approaches to assess neuropsychiatric disorders are evolving, as they offer richer information about ... ...

    Abstract Neural network-level changes underlying symptom remission in major depressive disorder (MDD) are often studied from a single perspective. Multimodal approaches to assess neuropsychiatric disorders are evolving, as they offer richer information about brain networks. A
    Language English
    Publishing date 2024-01-04
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2667-2421
    ISSN (online) 2667-2421
    DOI 10.1016/j.ibneur.2023.12.011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Aerobic exercise and hippocampal change in youth at risk of serious mental illness.

    Corbett, Syl / Metzak, Paul / MacQueen, Glenda / Farris, Megan / Addington, Jean

    Psychiatry research. Neuroimaging

    2020  Volume 305, Page(s) 111199

    MeSH term(s) Adolescent ; Exercise ; Hippocampus ; Humans ; Mental Disorders/epidemiology
    Language English
    Publishing date 2020-10-03
    Publishing country Netherlands
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 445361-x
    ISSN 1872-7506 ; 1872-7123 ; 0925-4927 ; 0165-1781
    ISSN (online) 1872-7506 ; 1872-7123
    ISSN 0925-4927 ; 0165-1781
    DOI 10.1016/j.pscychresns.2020.111199
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1541: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  3. Article ; Online: Childhood trauma, depression, resilience and suicide risk in individuals with inflammatory bowel disease.

    Tripp, Dean A / Jones, Krista / Mihajlovic, Valentina / Westcott, Sandra / MacQueen, Glenda

    Journal of health psychology

    2021  Volume 27, Issue 7, Page(s) 1626–1634

    Abstract: Despite the prevalence of suicide risk in inflammatory bowel disease populations, research has yet to examine associations between childhood trauma, resilience, depression and suicide risk. In the present online study, 172 participants responded to ... ...

    Abstract Despite the prevalence of suicide risk in inflammatory bowel disease populations, research has yet to examine associations between childhood trauma, resilience, depression and suicide risk. In the present online study, 172 participants responded to measures of childhood trauma, resilience, depression and suicide risk. A moderated mediation revealed that resilience does not moderate the associations between childhood trauma, depressive symptoms and suicide risk. However, a serial mediation revealed that childhood trauma is associated with decreased resilience, which is related to higher depressive symptoms, and ultimately higher suicide risk, thus suggesting resilience and depression as significant intervention targets.
    MeSH term(s) Adverse Childhood Experiences ; Cross-Sectional Studies ; Depression/epidemiology ; Humans ; Inflammatory Bowel Diseases ; Resilience, Psychological ; Suicide
    Language English
    Publishing date 2021-03-15
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2021897-7
    ISSN 1461-7277 ; 1359-1053
    ISSN (online) 1461-7277
    ISSN 1359-1053
    DOI 10.1177/1359105321999085
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  4. Article ; Online: Pilot aerobic exercise intervention for youth at-risk for serious mental illness.

    Corbett, Syl / Farris, Megan S / MacQueen, Glenda / Addington, Jean

    Early intervention in psychiatry

    2020  Volume 15, Issue 3, Page(s) 547–553

    Abstract: Background: This study was conducted as a pilot exercise intervention in youth at-risk for serious mental illness (SMI). The objectives were to examine the feasibility of an exercise intervention and to determine what improvement was observed, following ...

    Abstract Background: This study was conducted as a pilot exercise intervention in youth at-risk for serious mental illness (SMI). The objectives were to examine the feasibility of an exercise intervention and to determine what improvement was observed, following participation in a moderate- to high-intensity aerobic exercise programme.
    Methods: Forty-four male and female youth at-risk for SMI were recruited. Participants completed clinical, lifestyle and fitness assessments prior to and following a 16-week moderate- to high-intensity aerobic exercise intervention. Sixty-minute exercise sessions were held three times per week.
    Results: Forty-one participants completed the entire intervention and assessments; thus, the retention rate was 93.2%. Exercise participants achieved a mean of 98.3 (standard deviation (SD) 26.1) minutes/week of high-intensity and a mean of 32.8 (SD 8.7) minutes/week of moderate-intensity aerobic exercise over the course of 16 weeks. Improvements in aerobic fitness and body composition as well as reductions in anxiety and depression were observed after the exercise intervention.
    Conclusion: Aerobic exercise is a feasible and sound intervention strategy in youth at-risk for SMI. Further research is required to expand upon these initial findings and develop knowledge of the mechanisms, optimum dose and factors that influence the efficacy of exercise.
    MeSH term(s) Adolescent ; Anxiety ; Exercise ; Exercise Therapy ; Female ; Health Services ; Humans ; Male ; Mental Disorders/therapy ; Pilot Projects
    Language English
    Publishing date 2020-05-26
    Publishing country Australia
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2272425-4
    ISSN 1751-7893 ; 1751-7885
    ISSN (online) 1751-7893
    ISSN 1751-7885
    DOI 10.1111/eip.12977
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: The gut microbiota and psychiatric illness.

    MacQueen, Glenda / Surette, Michael / Moayyedi, Paul

    Journal of psychiatry & neuroscience : JPN

    2017  Volume 42, Issue 2, Page(s) 75–77

    MeSH term(s) Animals ; Gastrointestinal Microbiome ; Humans ; Mental Disorders/microbiology ; Mental Disorders/therapy
    Language English
    Publishing date 2017-02-28
    Publishing country Canada
    Document type Editorial ; Research Support, Non-U.S. Gov't
    ZDB-ID 1077443-9
    ISSN 1488-2434 ; 1180-4882
    ISSN (online) 1488-2434
    ISSN 1180-4882
    DOI 10.1503/jpn.170028
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2105: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  6. Article ; Online: Will there be a role for neuroimaging in clinical psychiatry?

    Macqueen, Glenda M

    Journal of psychiatry & neuroscience : JPN

    2010  Volume 35, Issue 5, Page(s) 291–293

    MeSH term(s) Brain/physiopathology ; Diagnostic Imaging/methods ; Humans ; Mental Disorders/diagnosis ; Psychiatry
    Language English
    Publishing date 2010-08-24
    Publishing country Canada
    Document type Editorial
    ZDB-ID 1077443-9
    ISSN 1488-2434 ; 1180-4882
    ISSN (online) 1488-2434
    ISSN 1180-4882
    DOI 10.1503/jpn.100129
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2105: Show issues Location:
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  7. Article ; Online: Adolescence as a unique developmental period.

    Jaworska, Natalia / MacQueen, Glenda

    Journal of psychiatry & neuroscience : JPN

    2015  Volume 40, Issue 5, Page(s) 291–293

    MeSH term(s) Adolescent ; Adolescent Behavior/psychology ; Adolescent Development ; Age Factors ; Brain/growth & development ; Health Policy ; Humans ; Mental Disorders/diagnosis ; Neuroimaging ; Young Adult
    Language English
    Publishing date 2015-08-19
    Publishing country Canada
    Document type Editorial
    ZDB-ID 1077443-9
    ISSN 1488-2434 ; 1180-4882
    ISSN (online) 1488-2434
    ISSN 1180-4882
    DOI 10.1503/jpn.150268
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2105: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  8. Article: Recruitment Challenges for Studies of Deep Brain Stimulation for Treatment-Resistant Depression.

    Ramasubbu, Rajamannar / Golding, Sandra / Williams, Kimberly / Mackie, Aaron / MacQueen, Glenda / Kiss, Zelma H T

    Neuropsychiatric disease and treatment

    2021  Volume 17, Page(s) 765–775

    Abstract: Introduction: Deep brain stimulation (DBS) is currently an investigational treatment for treatment-resistant depression (TRD). There is a need for more DBS trials to strengthen existing evidence of its efficacy for both regulatory and clinical reasons. ... ...

    Abstract Introduction: Deep brain stimulation (DBS) is currently an investigational treatment for treatment-resistant depression (TRD). There is a need for more DBS trials to strengthen existing evidence of its efficacy for both regulatory and clinical reasons. Recruitment for DBS trials remains challenging due to unproven efficacy in sham-controlled DBS trials, invasive nature of the intervention and stringent eligibility criteria in patient selection. Here, we examined the referral patterns and reasons for exclusion of subjects in our DBS trial.
    Methods: Data were collected from all patients who expressed interest in participating in a DBS study involving subcallosal cingulate region from 2014 to 2016. Referral sources were categorized as either self-referral or professional referral. Evaluation for eligibility was performed in three stages; initial contact, brief telephone assessment, and in-person psychiatric evaluation. The reasons for exclusion were documented. Descriptive and inferential statistics were used for analysis.
    Results: Of the 225 patients who contacted us initially, 22 (9.2%) underwent DBS surgery. Self-referral was higher than the referral from professionals (72% versus 28%, P<0.0001). However, the acceptance rate for surgery was higher among the professional referrals than from self-referrals (40% versus 15%, P=0.03). The common reasons for exclusion were self-withdrawal (38.4%), residing out of province or country (26.1%) and psychiatric/medical comorbidity (21.7%).
    Conclusion: These findings provide insight into DBS candidacy for future TRD trials. It suggests a need for comprehensive recruitment strategies including active engagement of patients and professionals throughout trials, and effective referral communication with education to optimize recruitment for future DBS trials.
    Language English
    Publishing date 2021-03-10
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 2186503-6
    ISSN 1178-2021 ; 1176-6328
    ISSN (online) 1178-2021
    ISSN 1176-6328
    DOI 10.2147/NDT.S299913
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    Zs.A 6068: Show issues Location:
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  9. Article: Neuroimaging and electrophysiology in predicting treatment responsiveness in depression: bridging the lab-to-clinic divide?

    MacQueen, Glenda

    Canadian journal of psychiatry. Revue canadienne de psychiatrie

    2013  Volume 58, Issue 9, Page(s) 497–498

    MeSH term(s) Depressive Disorder, Treatment-Resistant/diagnosis ; Depressive Disorder, Treatment-Resistant/physiopathology ; Depressive Disorder, Treatment-Resistant/therapy ; Electrophysiological Phenomena ; Humans ; Neuroimaging/methods ; Predictive Value of Tests ; Prognosis
    Language English
    Publishing date 2013-09
    Publishing country United States
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 304227-3
    ISSN 1497-0015 ; 0706-7437 ; 0008-4824
    ISSN (online) 1497-0015
    ISSN 0706-7437 ; 0008-4824
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 110: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  10. Article: Functional neuroimaging biomarkers of anhedonia response to escitalopram plus adjunct aripiprazole treatment for major depressive disorder.

    Vaccarino, Sophie R / Wang, Shijing / Rizvi, Sakina J / Lou, Wendy / Hassel, Stefanie / MacQueen, Glenda M / Ho, Keith / Frey, Benicio N / Lam, Raymond W / Milev, Roumen V / Rotzinger, Susan / Ravindran, Arun V / Strother, Stephen C / Kennedy, Sidney H

    BJPsych open

    2024  Volume 10, Issue 1, Page(s) e18

    Abstract: Background: Identifying neuroimaging biomarkers of antidepressant response may help guide treatment decisions and advance precision medicine.: Aims: To examine the relationship between anhedonia and functional neurocircuitry in key reward processing ... ...

    Abstract Background: Identifying neuroimaging biomarkers of antidepressant response may help guide treatment decisions and advance precision medicine.
    Aims: To examine the relationship between anhedonia and functional neurocircuitry in key reward processing brain regions in people with major depressive disorder receiving aripiprazole adjunct therapy with escitalopram.
    Method: Data were collected as part of the CAN-BIND-1 study. Participants experiencing a current major depressive episode received escitalopram for 8 weeks; escitalopram non-responders received adjunct aripiprazole for an additional 8 weeks. Functional magnetic resonance imaging (on weeks 0 and 8) and clinical assessment of anhedonia (on weeks 0, 8 and 16) were completed. Seed-based correlational analysis was employed to examine the relationship between baseline resting-state functional connectivity (rsFC), using the nucleus accumbens (NAc) and anterior cingulate cortex (ACC) as key regions of interest, and change in anhedonia severity after adjunct aripiprazole.
    Results: Anhedonia severity significantly improved after treatment with adjunct aripiprazole.There was a positive correlation between anhedonia improvement and rsFC between the ACC and posterior cingulate cortex, ACC and posterior praecuneus, and NAc and posterior praecuneus. There was a negative correlation between anhedonia improvement and rsFC between the ACC and anterior praecuneus and NAc and anterior praecuneus.
    Conclusions: Eight weeks of aripiprazole, adjunct to escitalopram, was associated with improved anhedonia symptoms. Changes in functional connectivity between key reward regions were associated with anhedonia improvement, suggesting aripiprazole may be an effective treatment for individuals experiencing reward-related deficits. Future studies are required to replicate our findings and explore their generalisability, using other agents with partial dopamine (D2) agonism and/or serotonin (5-HT2A) antagonism.
    Language English
    Publishing date 2024-01-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 2829557-2
    ISSN 2056-4724
    ISSN 2056-4724
    DOI 10.1192/bjo.2023.588
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