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  1. Article ; Online: Concluding Remarks for the Special Issue on RNA Viruses and Antibody Response.

    Kam, Yiu-Wing

    Viruses

    2023  Volume 15, Issue 5

    Abstract: Infectious diseases represent one of the major public health concerns on the global level [ ... ]. ...

    Abstract Infectious diseases represent one of the major public health concerns on the global level [...].
    MeSH term(s) Antibody Formation ; RNA Viruses ; Public Health
    Language English
    Publishing date 2023-05-22
    Publishing country Switzerland
    Document type Editorial ; Research Support, Non-U.S. Gov't
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v15051214
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  2. Article ; Online: Insights from Avian Influenza: A Review of Its Multifaceted Nature and Future Pandemic Preparedness.

    He, Jianning / Kam, Yiu-Wing

    Viruses

    2024  Volume 16, Issue 3

    Abstract: Avian influenza viruses (AIVs) have posed a significant pandemic threat since their discovery. This review mainly focuses on the epidemiology, virology, pathogenesis, and treatments of avian influenza viruses. We delve into the global spread, past ... ...

    Abstract Avian influenza viruses (AIVs) have posed a significant pandemic threat since their discovery. This review mainly focuses on the epidemiology, virology, pathogenesis, and treatments of avian influenza viruses. We delve into the global spread, past pandemics, clinical symptoms, severity, and immune response related to AIVs. The review also discusses various control measures, including antiviral drugs, vaccines, and potential future directions in influenza treatment and prevention. Lastly, by summarizing the insights from previous pandemic control, this review aims to direct effective strategies for managing future influenza pandemics.
    MeSH term(s) Animals ; Humans ; Influenza in Birds/epidemiology ; Influenza in Birds/prevention & control ; Influenza, Human/epidemiology ; Influenza, Human/prevention & control ; Pandemic Preparedness ; Influenza Vaccines ; Influenza A virus/genetics ; Pandemics/prevention & control
    Chemical Substances Influenza Vaccines
    Language English
    Publishing date 2024-03-17
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v16030458
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  3. Article: The clinical utility of Nanopore 16S rRNA gene sequencing for direct bacterial identification in normally sterile body fluids.

    Lao, Hiu-Yin / Wong, Lily Lok-Yee / Hui, Yan / Ng, Timothy Ting-Leung / Chan, Chloe Toi-Mei / Lo, Hazel Wing-Hei / Yau, Miranda Chong-Yee / Leung, Eddie Chi-Man / Wong, River Chun-Wai / Ho, Alex Yat-Man / Yip, Kam-Tong / Lam, Jimmy Yiu-Wing / Chow, Viola Chi-Ying / Luk, Kristine Shik / Que, Tak-Lun / Chow, Franklin Wang Ngai / Siu, Gilman Kit-Hang

    Frontiers in microbiology

    2024  Volume 14, Page(s) 1324494

    Abstract: The prolonged incubation period of traditional culture methods leads to a delay in diagnosing invasive infections. Nanopore 16S rRNA gene sequencing (Nanopore 16S) offers a potential rapid diagnostic approach for directly identifying bacteria in infected ...

    Abstract The prolonged incubation period of traditional culture methods leads to a delay in diagnosing invasive infections. Nanopore 16S rRNA gene sequencing (Nanopore 16S) offers a potential rapid diagnostic approach for directly identifying bacteria in infected body fluids. To evaluate the clinical utility of Nanopore 16S, we conducted a study involving the collection and sequencing of 128 monomicrobial samples, 65 polymicrobial samples, and 20 culture-negative body fluids. To minimize classification bias, taxonomic classification was performed using 3 analysis pipelines: Epi2me, Emu, and NanoCLUST. The result was compared to the culture references. The limit of detection of Nanopore 16S was also determined using simulated bacteremic blood samples. Among the three classifiers, Emu demonstrated the highest concordance with the culture results. It correctly identified the taxon of 125 (97.7%) of the 128 monomicrobial samples, compared to 109 (85.2%) for Epi2me and 102 (79.7%) for NanoCLUST. For the 230 cultured species in the 65 polymicrobial samples, Emu correctly identified 188 (81.7%) cultured species, compared to 174 (75.7%) for Epi2me and 125 (54.3%) for NanoCLUST. Through ROC analysis on the monomicrobial samples, we determined a threshold of relative abundance at 0.058 for distinguishing potential pathogens from background in Nanopore 16S. Applying this threshold resulted in the identification of 107 (83.6%), 117 (91.4%), and 114 (91.2%) correctly detected samples for Epi2me, Emu, and NanoCLUST, respectively, in the monomicrobial samples. Nanopore 16S coupled with Epi2me could provide preliminary results within 6 h. However, the ROC analysis of polymicrobial samples exhibited a random-like performance, making it difficult to establish a threshold. The overall limit of detection for Nanopore 16S was found to be about 90 CFU/ml.
    Language English
    Publishing date 2024-01-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2023.1324494
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  4. Article ; Online: Phosphorogenic Iridium(III) bis-Tetrazine Complexes for Bioorthogonal Peptide Stapling, Bioimaging, Photocytotoxic Applications, and the Construction of Nanosized Hydrogels.

    Yip, Alex Man-Hei / Lai, Calvin Kin-Ho / Yiu, Ken Shek-Man / Lo, Kenneth Kam-Wing

    Angewandte Chemie (International ed. in English)

    2022  Volume 61, Issue 16, Page(s) e202116078

    Abstract: The dual functionality of 1,2,4,5-tetrazine as a bioorthogonal reactive unit and a luminescence quencher has shaped tetrazine-based probes as attractive candidates for luminogenic labeling of biomolecules in living systems. In this work, three ... ...

    Abstract The dual functionality of 1,2,4,5-tetrazine as a bioorthogonal reactive unit and a luminescence quencher has shaped tetrazine-based probes as attractive candidates for luminogenic labeling of biomolecules in living systems. In this work, three cyclometalated iridium(III) complexes featuring two tetrazine units were synthesized and characterized. Upon photoexcitation, the complexes were non-emissive but displayed up to 3900-fold emission enhancement upon the inverse electron-demand Diels-Alder (IEDDA) [4+2] cycloaddition with (1R,8S,9s)-bicyclo[6.1.0]non-4-yne (BCN) substrates. The rapid reaction kinetics (k
    MeSH term(s) Cycloaddition Reaction ; Heterocyclic Compounds ; Hydrogels ; Iridium/chemistry ; Peptides
    Chemical Substances Heterocyclic Compounds ; Hydrogels ; Peptides ; Iridium (44448S9773)
    Language English
    Publishing date 2022-02-22
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2011836-3
    ISSN 1521-3773 ; 1433-7851
    ISSN (online) 1521-3773
    ISSN 1433-7851
    DOI 10.1002/anie.202116078
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  5. Article ; Online: Luminescent Neutral Cyclometalated Iridium(III) Complexes Featuring a Cubic Polyhedral Oligomeric Silsesquioxane for Lipid Droplet Imaging and Photocytotoxic Applications.

    Zhu, Jing-Hui / Yiu, Shek-Man / Tang, Ben Zhong / Lo, Kenneth Kam-Wing

    Inorganic chemistry

    2021  Volume 60, Issue 15, Page(s) 11672–11683

    Abstract: New neutral iridium(III) complexes featuring a cubic polyhedral oligomeric silsesquioxane (POSS) unit, [Ir( ... ...

    Abstract New neutral iridium(III) complexes featuring a cubic polyhedral oligomeric silsesquioxane (POSS) unit, [Ir(N
    MeSH term(s) HeLa Cells ; Humans ; Iridium/chemistry ; Lipid Droplets/metabolism ; Luminescent Agents/chemistry ; Molecular Imaging/methods ; Organosilicon Compounds/chemistry ; Photochemical Processes ; Polyethylene Glycols/chemistry ; Quantum Theory
    Chemical Substances Luminescent Agents ; Organosilicon Compounds ; polysilsesquioxane ; Polyethylene Glycols (3WJQ0SDW1A) ; Iridium (44448S9773)
    Language English
    Publishing date 2021-07-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1484438-2
    ISSN 1520-510X ; 0020-1669
    ISSN (online) 1520-510X
    ISSN 0020-1669
    DOI 10.1021/acs.inorgchem.1c01728
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  6. Article ; Online: Correction to: Nicotinamide riboside as a neuroprotective therapy for glaucoma: study protocol for a randomized, double-blind, placebo-control trial.

    Leung, Christopher Kai Shun / Ren, Seraph Tianmin / Chan, Poemen Pui Man / Wan, Kelvin Ho Nam / Kam, Aziz Ka Wai / Lai, Gilda Wing Ki / Chiu, Vivian Sheung Man / Ko, Match Wai Lun / Yiu, Cedric Ka Fai / Yu, Marco Chak Yan

    Trials

    2022  Volume 23, Issue 1, Page(s) 134

    Language English
    Publishing date 2022-02-10
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2040523-6
    ISSN 1745-6215 ; 1468-6694 ; 1745-6215
    ISSN (online) 1745-6215
    ISSN 1468-6694 ; 1745-6215
    DOI 10.1186/s13063-022-06079-1
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  7. Article: Potential Therapeutic Targets of Rehmannia Formulations on Diabetic Nephropathy: A Comparative Network Pharmacology Analysis.

    Chan, Kam Wa / Yu, Kam Yan / Yiu, Wai Han / Xue, Rui / Lok, Sarah Wing-Yan / Li, Hongyu / Zou, Yixin / Ma, Jinyuan / Lai, Kar Neng / Tang, Sydney Chi-Wai

    Frontiers in pharmacology

    2022  Volume 13, Page(s) 794139

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2022-03-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2022.794139
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  8. Article: Erratum: Novel differential linear B-cell epitopes to identify Zika and dengue virus infections in patients.

    Amrun, Siti Naqiah / Yee, Wearn-Xin / Abu Bakar, Farhana / Lee, Bernett / Kam, Yiu-Wing / Lum, Fok-Moon / Tan, Jeslin Jl / Lim, Vanessa Wx / Watthanaworawit, Wanitda / Ling, Clare / Nosten, Francois / Renia, Laurent / Leo, Yee-Sin / Ng, Lisa Fp

    Clinical & translational immunology

    2020  Volume 9, Issue 2, Page(s) e01118

    Abstract: This corrects the article DOI: 10.1002/cti2.1066.]. ...

    Abstract [This corrects the article DOI: 10.1002/cti2.1066.].
    Language English
    Publishing date 2020-02-19
    Publishing country Australia
    Document type Published Erratum
    ZDB-ID 2694482-0
    ISSN 2050-0068
    ISSN 2050-0068
    DOI 10.1002/cti2.1118
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  9. Article: Systematic analysis of disease-specific immunological signatures in patients with febrile illness from Saudi Arabia.

    Kam, Yiu-Wing / Ahmed, Mohamed Yousif / Amrun, Siti Naqiah / Lee, Bernett / Refaie, Tarik / Elgizouli, Kamla / Fong, Siew-Wai / Renia, Laurent / Ng, Lisa Fp

    Clinical & translational immunology

    2020  Volume 9, Issue 8, Page(s) e1163

    Abstract: Objectives: Little is known about the prevalence of febrile illness in the Arabian region as clinical, laboratory and immunological profiling remains largely uncharacterised.: Methods: A total of 2018 febrile patients from Jazan, Saudi Arabia, were ... ...

    Abstract Objectives: Little is known about the prevalence of febrile illness in the Arabian region as clinical, laboratory and immunological profiling remains largely uncharacterised.
    Methods: A total of 2018 febrile patients from Jazan, Saudi Arabia, were recruited between 2014 and 2017. Patients were screened for dengue and chikungunya virus,
    Results: Approximately 20% of febrile patients were tested positive for one of the pathogens, and they presented overlapping clinical and laboratory parameters. Nonetheless, eight disease-specific immune mediators were identified as potential biomarkers for dengue (MIP-1α, MCP-1), malaria (TNF-α), streptococcal and meningococcal (eotaxin, GRO-α, RANTES, SDF-1α and PIGF-1) infections, with high specificity and sensitivity profiles. Notably, based on the conditional inference model, six of these mediators (MIP-1α, TNF-α, GRO-α, RANTES, SDF-1α and PIGF-1) were revealed to be 68.4% accurate in diagnosing different febrile infections, including those of unknown diseases.
    Conclusions: This study is the first extensive characterisation of the clinical analysis and immune biomarkers of several clinically important febrile infections in Saudi Arabia. Importantly, an immune signature with robust accuracy, specificity and sensitivity in differentiating several febrile infections was identified, providing useful insights into patient disease management in the Arabian Peninsula.
    Keywords covid19
    Language English
    Publishing date 2020-08-22
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 2694482-0
    ISSN 2050-0068
    ISSN 2050-0068
    DOI 10.1002/cti2.1163
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  10. Article ; Online: The 2016 Singapore Zika virus outbreak did not cause a surge in Guillain-Barré syndrome.

    Umapathi, Thirugnanam / Kam, Yiu-Wing / Ohnmar, O / Ng, Brandon C J / Ng, Yixiang / Premikha, M / Leo, Yee-Sin / Ng, Lisa F P

    Journal of the peripheral nervous system : JPNS

    2018  Volume 23, Issue 3, Page(s) 197–201

    Abstract: Although individuals with Zika virus (ZIKV) antibodies were reported in Malaya in mid-1950s, entomological and human surveillance in Singapore did not identify autochthonous transmission until the outbreak of August-November, 2016. A total of 455 cases ... ...

    Abstract Although individuals with Zika virus (ZIKV) antibodies were reported in Malaya in mid-1950s, entomological and human surveillance in Singapore did not identify autochthonous transmission until the outbreak of August-November, 2016. A total of 455 cases from 15 separate clusters were identified. We asked if this ZIKV outbreak increased the incidence of Guillain-Barré syndrome (GBS) and aimed to characterize these cases. Eleven GBS cases, consecutively enrolled into our prospective GBS database from onset to 4 weeks after outbreak, and six controls, comprising three GBS patients enrolled before outbreak and three non-GBS patients, were examined for evidence of recent ZIKV infection. We performed serum, urine ZIKV RT-PCR, ZIKV serology, and virus neutralization assays, accounting for cross-reaction and co-infection with dengue (DENV). We found five GBS cases with only serological evidence of recent ZIKV infection (including one ZIKV-DENV co-infection). A temporal relationship with ZIKV outbreak was unlikely as two cases were GBS controls enrolled 3 months before outbreak. None reported symptoms of ZIKV infection. In addition, compared to last 10 years the national number of GBS hospitalizations did not increase during and immediately after outbreak. We conclude the 2016 Singapore ZIKV outbreak did not cause a change in GBS epidemiology.
    MeSH term(s) Adult ; Aged, 80 and over ; Disease Outbreaks ; Female ; Guillain-Barre Syndrome/epidemiology ; Humans ; Incidence ; Male ; Middle Aged ; Singapore/epidemiology ; Zika Virus Infection/epidemiology
    Language English
    Publishing date 2018-08-21
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1364009-4
    ISSN 1529-8027 ; 1085-9489
    ISSN (online) 1529-8027
    ISSN 1085-9489
    DOI 10.1111/jns.12284
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