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  1. Article ; Online: Image enhanced colonoscopy: updates and prospects-a review.

    Shahsavari, Dariush / Waqar, Muhammad / Thoguluva Chandrasekar, Viveksandeep

    Translational gastroenterology and hepatology

    2023  Volume 8, Page(s) 26

    Abstract: Colonoscopy has been proven to be a successful approach in both identifying and preventing colorectal cancer. The incorporation of advanced imaging technologies, such as image-enhanced endoscopy (IEE), plays a vital role in real-time diagnosis. The ... ...

    Abstract Colonoscopy has been proven to be a successful approach in both identifying and preventing colorectal cancer. The incorporation of advanced imaging technologies, such as image-enhanced endoscopy (IEE), plays a vital role in real-time diagnosis. The advancements in endoscopic imaging technology have been continuous, from replacing fiber optics with charge-coupled devices to the introduction of chromoendoscopy in the 1970s. Recent technological advancements include "push-button" technologies like autofluorescence imaging (AFI), narrowed-spectrum endoscopy, and confocal laser endomicroscopy (CLE). Dye-based chromoendoscopy (DCE) is falling out of favor due to the longer time required for application and removal of the dye and the difficulty of identifying lesions in certain situations. Narrow band imaging (NBI) is a technology that filters the light used for illumination leading to improved contrast and better visibility of structures on the mucosal surface and has shown a consistently higher adenoma detection rate (ADR) compared to white light endoscopy. CLE has high sensitivity and specificity for polyp detection and characterization, and several classifications have been developed for accurate identification of normal, regenerative, and dysplastic epithelium. Other IEE technologies, such as blue laser imaging (BLI), linked-color imaging (LCI), i-SCAN, and AFI, have also shown promise in improving ADR and characterizing polyps. New technologies, such as Optivista, red dichromatic imaging (RDI), texture and color enhancement imaging (TXI), and computer-aided detection (CAD) using artificial intelligence (AI), are being developed to improve polyp detection and pathology prediction prior to widespread use in clinical practice.
    Language English
    Publishing date 2023-07-25
    Publishing country China
    Document type Journal Article ; Review
    ISSN 2415-1289
    ISSN (online) 2415-1289
    DOI 10.21037/tgh-23-17
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Endoscopic visualization of lymphangitic spread of metastatic cholangiocarcinoma to the duodenum.

    Cai, Jacqueline / Thoguluva Chandrasekar, Viveksandeep / Pannala, Rahul

    Gastrointestinal endoscopy

    2021  Volume 93, Issue 5, Page(s) 1185–1186

    Language English
    Publishing date 2021-01-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 391583-9
    ISSN 1097-6779 ; 0016-5107
    ISSN (online) 1097-6779
    ISSN 0016-5107
    DOI 10.1016/j.gie.2021.01.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Improving the ADR: Narrow Band, Broad Benefits.

    Aziz, Muhammad / Thoguluva Chandrasekar, Viveksandeep

    Digestive diseases and sciences

    2019  Volume 65, Issue 6, Page(s) 1586–1587

    MeSH term(s) Adenoma/diagnosis ; Colonoscopy/standards ; Colorectal Neoplasms/diagnosis ; Humans ; Quality Control
    Language English
    Publishing date 2019-12-13
    Publishing country United States
    Document type Editorial
    ZDB-ID 304250-9
    ISSN 1573-2568 ; 0163-2116
    ISSN (online) 1573-2568
    ISSN 0163-2116
    DOI 10.1007/s10620-019-05997-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Eosinophilic enteritis in a case of cystic fibrosis: an elusive diagnosis with an elementary cure.

    Nageswaran, Gomathy Aarthy / Chandrasekar, Viveksandeep Thoguluva / Ghleilib, Intisar / Yap, John Erikson

    BMJ case reports

    2023  Volume 16, Issue 12

    Abstract: A late adolescent man diagnosed with cystic fibrosis and presenting with predominantly gastrointestinal symptoms, including chronic constipation, exocrine pancreatic insufficiency and gastro-oesophageal reflux disease, experienced recurrent episodes of ... ...

    Abstract A late adolescent man diagnosed with cystic fibrosis and presenting with predominantly gastrointestinal symptoms, including chronic constipation, exocrine pancreatic insufficiency and gastro-oesophageal reflux disease, experienced recurrent episodes of nausea, vomiting and abdominal pain. CT of the abdomen unveiled the presence of chronic appendicitis, alongside constipation without evidence of distal intestinal obstruction syndrome. Endoscopic biopsies revealed small bowel eosinophilic infiltrates. Subsequently, the patient underwent an appendectomy, and a tailored regimen was established to address constipation, resulting in an initial alleviation of his symptoms. Three months later, a resurgence of symptoms occurred, coinciding with persistent intestinal eosinophilic infiltrates. A diagnosis of eosinophilic enteritis was rendered, and treatment commenced with an oral dosage of 40 mg of prednisone. Two weeks later, the patient experienced symptom resolution, corroborated by the findings of an endoscopic biopsy conducted 8 weeks later. During a follow-up examination 6 months later, the patient remained asymptomatic.
    MeSH term(s) Male ; Adolescent ; Humans ; Cystic Fibrosis/complications ; Cystic Fibrosis/diagnosis ; Enteritis/complications ; Enteritis/diagnosis ; Enteritis/drug therapy ; Gastritis/complications ; Gastritis/diagnosis ; Gastritis/drug therapy ; Constipation
    Language English
    Publishing date 2023-12-16
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2023-257553
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: A Case Report of CHEK2 and MUTYH Germline Mutations Associated With Cholangiocarcinoma in a Young Patient.

    Rehman, Obaid / Sackfield, Bradley / Thoguluva Chandrasekar, Viveksandeep / Oliver, Jorge / Aswath, Ganesh

    Cureus

    2022  Volume 14, Issue 2, Page(s) e22631

    Abstract: Cholangiocarcinoma (CCA) is a major cause of primary liver carcinoma and has been associated with the penetrance of several germline mutations. We present a 31-year-old female evaluated for left upper quadrant pain and abnormal liver function tests. ... ...

    Abstract Cholangiocarcinoma (CCA) is a major cause of primary liver carcinoma and has been associated with the penetrance of several germline mutations. We present a 31-year-old female evaluated for left upper quadrant pain and abnormal liver function tests. Ultrasound revealed a nodule in the liver, and biopsy showed intrahepatic adenocarcinoma. Germline testing was positive for two mutations: c.1100delC and c.1227_1228dupGG on the CHEK2 gene and the MUTYH gene, respectively. The patient was started on chemotherapy and tolerated it well. We aimed to demonstrate an association between CHEK2 and MUTYH mutations with CCA and highlight the importance of genetic testing for at-risk patients.
    Language English
    Publishing date 2022-02-26
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.22631
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Emphysematous cholangitis with pneumoperitoneum at ERCP.

    Pisipati, Sailaja / Thoguluva Chandrasekar, Viveksandeep / Faigel, Douglas O / Fukami, Norio / Pannala, Rahul

    Gastrointestinal endoscopy

    2021  Volume 94, Issue 4, Page(s) 860–862

    MeSH term(s) Abdomen ; Cholangiopancreatography, Endoscopic Retrograde ; Cholangitis/etiology ; Humans ; Insufflation ; Pneumoperitoneum/diagnostic imaging ; Pneumoperitoneum/etiology
    Language English
    Publishing date 2021-06-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 391583-9
    ISSN 1097-6779 ; 0016-5107
    ISSN (online) 1097-6779
    ISSN 0016-5107
    DOI 10.1016/j.gie.2021.05.039
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Deroofing and Excision of Duodenal Duplication Cyst.

    Thoguluva Seshadri, Chandrasekar / Bollu Janakan, Gokul / Suriyanarayanan, Sathiamoorthy / Kalamegam, Raja Yogesh / Thoguluva Chandrasekar, Viveksandeep

    ACG case reports journal

    2019  Volume 6, Issue 11, Page(s) e00224

    Language English
    Publishing date 2019-11-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2814825-3
    ISSN 2326-3253
    ISSN 2326-3253
    DOI 10.14309/crj.0000000000000224
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Distressing Trespass.

    Chandrasekar, Thoguluva Seshadri / Sathiamoorthy, Suriyanarayanan / Chandrasekar, Viveksandeep Thoguluva

    Gastroenterology

    2016  Volume 151, Issue 2, Page(s) e15–7

    Language English
    Publishing date 2016-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80112-4
    ISSN 1528-0012 ; 0016-5085
    ISSN (online) 1528-0012
    ISSN 0016-5085
    DOI 10.1053/j.gastro.2016.04.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Jejunal Diverticulitis: A Rare Diverticular Disease of the Bowel.

    Matli, Venkata Vinod Kumar / Thoguluva Chandrasekar, Viveksandeep / Campbell, Jason L / Karanam, Chandana / Jaganmohan, Sathya

    Cureus

    2022  Volume 14, Issue 1, Page(s) e21386

    Abstract: Diverticulosis is an out-pocketing of the bowel wall that can affect the small bowel through the large bowel. Small bowel diverticulosis is rare and not as common as colonic diverticulosis, which is an important diagnosis for hospitalizations. Moreover, ... ...

    Abstract Diverticulosis is an out-pocketing of the bowel wall that can affect the small bowel through the large bowel. Small bowel diverticulosis is rare and not as common as colonic diverticulosis, which is an important diagnosis for hospitalizations. Moreover, jejunal diverticulosis is rare among cases of small bowel diverticulosis. Jejunal diverticulitis is one of the complications of jejunal diverticulosis that can be conservatively managed with antibiotics instead of surgery. We report a case of a 41-year-old African American man who presented with vague epigastric pain and was diagnosed with adhesive jejunal diverticulitis upon contrast-enhanced computed tomography of the abdomen. The patient did not develop any life-threatening complications such as perforation or peritonitis, and recovered after conservative management with antibiotics. Adhesive jejunal diverticulitis with fat stranding was the distinctive finding in our patient, as he might have had multiple asymptomatic episodes. Initial diagnostic modalities include radiography and contrast-enhanced computed tomography. Enteroclysis is the most reliable and accurate diagnostic modality, but is not available in all urgent settings. Recently, endoscopy has replaced radiological studies. Conservative management is adequate for uncomplicated cases of jejunal diverticulitis. However, surgical intervention is required in most cases of complicated jejunal diverticulosis, or mortality rates will be high.
    Language English
    Publishing date 2022-01-18
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.21386
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Analyzing methods for reducing recurrence rates after EMR of large nonpedunculated colorectal polyps: an indirect pairwise comparison.

    Radadiya, Dhruvil / Desai, Madhav / Patel, Harsh / Srinivasan, Sachin / Chandrasekar, Viveksandeep Thoguluva / Hassan, Cesare / Repici, Alessandro / Rex, Douglas / Sharma, Prateek

    Gastrointestinal endoscopy

    2023  Volume 99, Issue 3, Page(s) 326–336.e6

    Abstract: Background and aims: Despite advances in EMR techniques, a high polyp recurrence rate remains a challenge. Due to the scarcity of direct comparisons, we performed an indirect comparison of conventional EMR (EMR alone), underwater EMR (U-EMR), and EMR + ... ...

    Abstract Background and aims: Despite advances in EMR techniques, a high polyp recurrence rate remains a challenge. Due to the scarcity of direct comparisons, we performed an indirect comparison of conventional EMR (EMR alone), underwater EMR (U-EMR), and EMR + adjuvant thermal ablation of polypectomy margins to assess polyp recurrence rates.
    Methods: Electronic databases were searched from inception to January 12, 2023, for studies reporting polyp recurrence rates after EMR for large nonpedunculated polyps (>15 mm) with or without adjuvant techniques (snare tip soft coagulation [STSC]/argon plasma coagulation [APC]). An indirect comparison was performed by using the frequentist method. The p-score was calculated to identify preferred intervention. Publication bias was assessed by using a comparison-adjusted funnel plot.
    Results: A total of 9 full articles were identified. On direct comparisons, EMR + STSC had 82% reduced odds (odds ratio, .18; 95% confidence interval, .13-.26; P < .001), whereas U-EMR alone had 77% reduced odds (odds ratio, .23; 95% confidence interval, .08-.67; P = .007) of polyp recurrence compared with EMR alone. On indirect comparison, all interventions had significantly lower odds of polyp recurrence compared with EMR alone. The p-score ranking showed that EMR + STSC seems a potential first method in reducing the odds of polyp recurrence, followed by U-EMR, EMR + APC, and EMR alone.
    Conclusions: EMR + STSC seems to provide favorable odds for reducing polyp recurrence postresection for large nonpedunculated polyps. Standardization of methods to detect residual polyp and prevent polyp recurrence at the time of EMR are required.
    MeSH term(s) Humans ; Colonic Polyps/surgery ; Colonoscopy/methods ; Endoscopic Mucosal Resection/methods ; Colorectal Neoplasms/surgery
    Language English
    Publishing date 2023-12-06
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 391583-9
    ISSN 1097-6779 ; 0016-5107
    ISSN (online) 1097-6779
    ISSN 0016-5107
    DOI 10.1016/j.gie.2023.11.060
    Database MEDical Literature Analysis and Retrieval System OnLINE

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