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Article ; Conference proceedings: Generierung eines humanen 3D-Knochenmodells zur Simulation von Glukokortikoid-induzierter Osteoporose in vitro

Pfeiffenberger, Moritz / Plank, Johannes / Damerau, Alexandra / Gaber, Timo / Buttgereit, Frank

2024

Event/congress	OSTEOLOGIE 2024, Wiesbaden, 2024-03-14
Language	German
Publishing date	2024-03-13
Publisher	Georg Thieme Verlag
Publishing place	Stuttgart ; New York
Document type	Article ; Conference proceedings
ZDB-ID	2113634-8
ISSN	2567-5818 ; 1019-1291
ISSN (online)	2567-5818
ISSN	1019-1291
DOI	10.1055/s-0044-1782051
Database	Thieme publisher's database

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Article ; Online: Adsorbed layer thickness of polycarboxylate and polyphosphate superplasticizers on polystyrene nanoparticles measured via dynamic light scattering.

Stecher, Johannes / Plank, Johann

Journal of colloid and interface science

2019 Volume 562, Page(s) 204–212

Abstract: Hypothesis: Common superplasticizers (dispersants) for cementitious materials such as concrete include carboxylated comb polymers which strongly chelate Ca: Experiments: Using octadecyl phosphate as emulsifier, phosphate modified polystyrene ... ...

Abstract	Hypothesis: Common superplasticizers (dispersants) for cementitious materials such as concrete include carboxylated comb polymers which strongly chelate Ca Experiments: Using octadecyl phosphate as emulsifier, phosphate modified polystyrene nanoparticles (d Findings: The phosphate-modified polystyrene nanoparticles were found to present a suitable substrate for ALT measurements of adsorbed polycarboxylate comb polymers. DLS measurements revealed that with progressing adsorption, these polymers develop a concentration-dependent isothermal ALT. At saturation point, layer thicknesses of 3 to 8 nm were observed. The values correlate well with molecular properties of the polymers whereby increasing side-chain length, side-chain density and molecular weight provoke higher ALTs.
Language	English
Publishing date	2019-12-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	241597-5
ISSN	1095-7103 ; 0021-9797
ISSN (online)	1095-7103
ISSN	0021-9797
DOI	10.1016/j.jcis.2019.11.108
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: A case report on the successful interventional treatment of a rare cause of left heart failure in a 69-year-old woman.

Podnar, Tomaz / Plank, Fabian / Müller, Silvana / Mair, Johannes

European heart journal. Case reports

2020 Volume 4, Issue 6, Page(s) 1–5

Abstract: Background: Dyspnoea is very common in elderly patients and can be caused by a variety of different diseases. However, the initial diagnosis of patent ductus arteriosus (PDA) as a cause of left heart failure is very rare in this patient population.: ... ...

Abstract	Background: Dyspnoea is very common in elderly patients and can be caused by a variety of different diseases. However, the initial diagnosis of patent ductus arteriosus (PDA) as a cause of left heart failure is very rare in this patient population. Case summary: A 69-year-old physically active woman with known hypertension presented with worsening exertional dyspnoea. Echocardiography showed a dilated left ventricle with moderately reduced left ventricular ejection fraction, and evidence for PDA. The PDA was confirmed by computed tomography angiography and successfully closed by implantation of an Amplatzer PDA occluder II 06-06 mm. As a result, the heart failure symptoms receded completely. Discussion: Congenital heart diseases should be considered as heart failure causes even in older adults. In addition to the standard medical therapy, there may be effective interventional treatment options to reverse the symptoms of heart failure in such patients.
Language	English
Publishing date	2020-11-30
Publishing country	England
Document type	Journal Article
ISSN	2514-2119
ISSN (online)	2514-2119
DOI	10.1093/ehjcr/ytaa440
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Adsorbed layer thickness of polycarboxylate and polyphosphate superplasticizers on polystyrene nanoparticles measured via dynamic light scattering

Stecher, Johannes / Plank, Johann

Journal of colloid and interface science. 2020 Mar. 07, v. 562

2020

Abstract: Common superplasticizers (dispersants) for cementitious materials such as concrete include carboxylated comb polymers which strongly chelate Ca2+ ions. Thus, a substrate holding Ca2+ as docking site on its surface and of a narrow particle size ... ...

Abstract	Common superplasticizers (dispersants) for cementitious materials such as concrete include carboxylated comb polymers which strongly chelate Ca2+ ions. Thus, a substrate holding Ca2+ as docking site on its surface and of a narrow particle size distribution was expected to produce reliable values for the adsorbed layer thickness (ALT) of polycarboxylate comb polymers, as measured via dynamic light scattering. ALT presents a key parameter which controls the dispersion power of these polymers and provides the steric hindrance effect between cement particles.Using octadecyl phosphate as emulsifier, phosphate modified polystyrene nanoparticles (dH(z)~86 nm) of narrow size distribution were successfully synthesized and characterized via scanning electron microscopy, dynamic light scattering (DLS) and zeta potential measurements. The particles allowed to measure concentration dependent adsorbed layer thicknesses of a series of structurally different, self-synthesized polycarboxylate superplasticizers.The phosphate-modified polystyrene nanoparticles were found to present a suitable substrate for ALT measurements of adsorbed polycarboxylate comb polymers. DLS measurements revealed that with progressing adsorption, these polymers develop a concentration-dependent isothermal ALT. At saturation point, layer thicknesses of 3 to 8 nm were observed. The values correlate well with molecular properties of the polymers whereby increasing side-chain length, side-chain density and molecular weight provoke higher ALTs.
Keywords	adsorption ; calcium ; carboxylation ; cement ; concrete ; dispersants ; emulsifiers ; ions ; light scattering ; molecular weight ; nanoparticles ; particle size distribution ; phosphates ; polystyrenes ; scanning electron microscopy ; zeta potential
Language	English
Dates of publication	2020-0307
Size	p. 204-212.
Publishing place	Elsevier Inc.
Document type	Article
ZDB-ID	241597-5
ISSN	1095-7103 ; 0021-9797
ISSN (online)	1095-7103
ISSN	0021-9797
DOI	10.1016/j.jcis.2019.11.108
Database	NAL-Catalogue (AGRICOLA)

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Book ; Online ; Thesis: Addressing Workability Challenges in Clay-bearing OPC and Low Carbon Alkali-activated Slag Systems through Innovative PCE Structural Design

Zhang, Yue Verfasser] / [Plank, Johann [Akademischer Betreuer] / Plank, Johann [Gutachter] / Eisenreich, Wolfgang [Gutachter]

2023

Author's details	Yue Zhang ; Gutachter: Johann Peter Plank, Wolfgang Eisenreich ; Betreuer: Johann Peter Plank
Keywords	Technische Chemie ; Technical Chemistry
Subject code	sg660
Language	English
Publisher	Universitätsbibliothek der TU München
Publishing place	München
Document type	Book ; Online ; Thesis
Database	Digital theses on the web

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Article ; Online: Comparison of C-Reactive Protein in Dried Blood Spots and Saliva of Healthy Adolescents.

Plank, Anne-Christine / Maschke, Janina / Rohleder, Nicolas / Fasching, Peter A / Beckmann, Matthias W / Kornhuber, Johannes / Eichler, Anna / Moll, Gunther H / Kratz, Oliver

Frontiers in immunology

2021 Volume 12, Page(s) 795580

Abstract: Background/aim: Determining C-reactive protein (CRP) by non-invasive methods is of great interest for research addressing inflammation in young people. However, direct comparisons of such methods applied in children and adolescents are lacking so far. ... ...

Abstract	Background/aim: Determining C-reactive protein (CRP) by non-invasive methods is of great interest for research addressing inflammation in young people. However, direct comparisons of such methods applied in children and adolescents are lacking so far. This study aimed to evaluate the association between CRP measured in dried blood spots (DBS CRP) and in saliva (sCRP), two less invasive alternatives to venipuncture, in 12- to 14-year-old adolescents. To evaluate the validity of both measurements in the context of biobehavioral studies, the potential of DBS CRP and sCRP to discriminate between defined BMI subgroups was assessed. Materials and methods: CRP levels in DBS and saliva collected from 87 healthy adolescents ( Results: In the total sample, DBS CRP and sCRP were significantly associated ( Conclusions: The significant correlation of DBS CRP with sCRP was independent of the investigated BMI range groups, yet BMI-dependent distinction was only provided by DBS CRP mean values. Overall, our results suggest that DBS CRP is likely to reflect systemic inflammation more precisely. Salivary CRP can be alternatively determined in studies with adolescents when conditions require it, given the oral health status is assessed. Considering that DBS CRP and sCRP share only 35% of common variance, further studies should examine their specific validity.
MeSH term(s)	Adolescent ; Age Factors ; Biomarkers/analysis ; Body Mass Index ; C-Reactive Protein/analysis ; Dried Blood Spot Testing ; Enzyme-Linked Immunosorbent Assay ; Female ; Healthy Volunteers ; Humans ; Inflammation Mediators/analysis ; Inflammation Mediators/blood ; Male ; Predictive Value of Tests ; Reproducibility of Results ; Saliva/chemistry
Chemical Substances	Biomarkers ; Inflammation Mediators ; C-Reactive Protein (9007-41-4)
Language	English
Publishing date	2021-12-16
Publishing country	Switzerland
Document type	Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't ; Validation Study
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2021.795580
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Evaluation of an implemented new insulin chart to improve quality and safety of diabetes care in a large university hospital: a follow-up study.

Kopanz, Julia / Sendlhofer, Gerald / Lichtenegger, Katharina / Semlitsch, Barbara / Riedl, Regina / Pieber, Thomas R / Tax, Christa / Brunner, Gernot / Plank, Johannes

BMJ open

2021 Volume 11, Issue 1, Page(s) e041298

Abstract: Objectives: To evaluate structure, documentation, treatment quality of a new implemented standardised insulin chart in adult medical inpatient wards at a university hospital.: Design: A before-after study (3 to 5 months after implementation) was used ...

Abstract	Objectives: To evaluate structure, documentation, treatment quality of a new implemented standardised insulin chart in adult medical inpatient wards at a university hospital. Design: A before-after study (3 to 5 months after implementation) was used to compare the quality of old versus new insulin charts. Setting: University Hospital Graz, Austria. Participants: Healthcare professionals (n=237) were questioned regarding structure quality of blank insulin charts. Interventions: A new standardised insulin chart was implemented and healthcare professionals were trained regarding features of this chart. Data from insulinised inpatients were evaluated regarding documentation and treatment quality of filled-in insulin charts (n=108 old insulin charts vs n=100 new insulin charts). Main outcomes and measures: The primary endpoint was documentation error for insulin administration. Results: Healthcare professionals reported an improved structure quality of the new insulin chart with a Likert type response scale increase in all nine items. Documentation errors for insulin administration (primary endpoint) occurred more often on old than new insulin charts (77% vs 5%, p<0.001). Documentation errors for insulin prescription were more frequent on old insulin charts (100% vs 42%) whereas documentation errors for insulin management rarely occurred in any group (10% vs 8%). Patients of both chart evaluation groups (age: 71±11 vs 71±12 years, 47% vs 42% women, 75% vs 87% type 2 diabetes for old vs new charts, respectively) had a mean of 4±2 good diabetes days. Overall, 26 vs 18 hypoglycaemic episodes (blood glucose (BG) <4.0 mmol/L (72 mg/dL), p=0.28), including 7 vs 2 severe hypoglycaemic episodes (BG <3.0 mmol/L (54 mg/dL), p=0.17) were documented on old versus new insulin charts. Conclusions: The implementation of a structured documentation form together with training measures for healthcare professionals led to less documentation errors and safe management of glycaemic control in hospitalised patients in a short time follow-up. A rollout at further medical wards is recommended, and sustainability in the long-term has to be demonstrated.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Austria ; Blood Glucose ; Diabetes Mellitus, Type 2/drug therapy ; Female ; Follow-Up Studies ; Humans ; Insulin ; Male ; Middle Aged
Chemical Substances	Blood Glucose ; Insulin
Language	English
Publishing date	2021-01-26
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2599832-8
ISSN	2044-6055 ; 2044-6055
ISSN (online)	2044-6055
ISSN	2044-6055
DOI	10.1136/bmjopen-2020-041298
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Manifestation of Zollinger-Ellison Syndrome With Hypovolemic Shock.

Reisinger, Alexander C / Eller, Philipp / Schilcher, Gernot / Eisner, Florian / Kreuzer, Philipp / Hackl, Gerald / Spindelböck, Walter / Plank, Johannes / Kump, Patrizia

The American journal of medicine

2020 Volume 133, Issue 9, Page(s) e460–e462

MeSH term(s)	Humans ; Male ; Middle Aged ; Pantoprazole/therapeutic use ; Proton Pump Inhibitors/therapeutic use ; Shock/etiology ; Shock/therapy ; Zollinger-Ellison Syndrome/complications ; Zollinger-Ellison Syndrome/diagnosis ; Zollinger-Ellison Syndrome/therapy
Chemical Substances	Proton Pump Inhibitors ; Pantoprazole (D8TST4O562)
Language	English
Publishing date	2020-02-19
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	80015-6
ISSN	1555-7162 ; 1873-2178 ; 0002-9343 ; 1548-2766
ISSN (online)	1555-7162 ; 1873-2178
ISSN	0002-9343 ; 1548-2766
DOI	10.1016/j.amjmed.2019.12.037
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Three-Dimensional Nanothermistors for Thermal Probing.

Sattelkow, Jürgen / Fröch, Johannes E / Winkler, Robert / Hummel, Stefan / Schwalb, Christian / Plank, Harald

ACS applied materials & interfaces

2019 Volume 11, Issue 25, Page(s) 22655–22667

Abstract: Accessing the thermal properties of materials or even full devices is a highly relevant topic in research and development. Along with the ongoing trend toward smaller feature sizes, the demands on appropriate instrumentation to access surface ... ...

Abstract	Accessing the thermal properties of materials or even full devices is a highly relevant topic in research and development. Along with the ongoing trend toward smaller feature sizes, the demands on appropriate instrumentation to access surface temperatures with high thermal and lateral resolution also increase. Scanning thermal microscopy is one of the most powerful technologies to fulfill this task down to the sub-100 nm regime, which, however, strongly depends on the nanoprobe design. In this study, we introduce a three-dimensional (3D) nanoprobe concept, which acts as a nanothermistor to access surface temperatures. Fabrication of nanobridges is done via 3D nanoprinting using focused electron beams, which allows direct-write fabrication on prestructured, self-sensing cantilever. As individual branch dimensions are in the sub-100 nm regime, mechanical stability is first studied by a combined approach of finite-element simulation and scanning electron microscopy-assisted in situ atomic force microscopy (AFM) measurements. After deriving the design rules for mechanically stable 3D nanobridges with vertical stiffness up to 50 N m
Language	English
Publishing date	2019-06-17
Publishing country	United States
Document type	Journal Article
ISSN	1944-8252
ISSN (online)	1944-8252
DOI	10.1021/acsami.9b04497
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Segmented poly(A) tails significantly reduce recombination of plasmid DNA without affecting mRNA translation efficiency or half-life.

Trepotec, Zeljka / Geiger, Johannes / Plank, Christian / Aneja, Manish K / Rudolph, Carsten

RNA (New York, N.Y.)

2019 Volume 25, Issue 4, Page(s) 507–518

Abstract: Extensive research in the past decade has brought mRNA closer to the clinical realization of its therapeutic potential. One common structural feature for all cellular messenger RNAs is a poly(A) tail, which can either be brought in cotranscriptionally ... ...

Abstract	Extensive research in the past decade has brought mRNA closer to the clinical realization of its therapeutic potential. One common structural feature for all cellular messenger RNAs is a poly(A) tail, which can either be brought in cotranscriptionally via the DNA template (plasmid- or PCR-based) or added to the mRNA in a post-transcriptional enzymatic process. Plasmids containing poly(A) regions recombine in
MeSH term(s)	A549 Cells ; Animals ; Base Sequence ; Escherichia coli/genetics ; Escherichia coli/metabolism ; Genetic Engineering/methods ; HEK293 Cells ; Half-Life ; Humans ; Plasmids/chemistry ; Plasmids/metabolism ; Poly A/genetics ; Poly A/metabolism ; Protein Biosynthesis ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Recombination, Genetic ; Transfection
Chemical Substances	RNA, Messenger ; Poly A (24937-83-5)
Language	English
Publishing date	2019-01-15
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1241540-6
ISSN	1469-9001 ; 1355-8382
ISSN (online)	1469-9001
ISSN	1355-8382
DOI	10.1261/rna.069286.118
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