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  1. AU=Roy Pierre-Marie
  2. AU="Kroeger, Caitlin E"
  3. AU="Hsiao, Susan J"
  4. AU="Ajani, G D"
  5. AU="Abrantes, F. Goncalves"
  6. AU="Ghagane, Shridhar C"
  7. AU="Villesuzanne, Camille"
  8. AU="Daoudi, A"
  9. AU=Trombini Amanda B
  10. AU="Ravender, Raja"
  11. AU="Sheng, Honghao"
  12. AU="Bezler, Valerie"
  13. AU="Kevin Rostásy"
  14. AU=van Helden Mary J.
  15. AU="Grzegorz Adamczyk"
  16. AU="Longo, M"
  17. AU="Debarnot, Cecilé"
  18. AU="Thomas, Sophie"
  19. AU=Steyer Terence E AU=Steyer Terence E
  20. AU="Retrouvey, Jean-Marc"
  21. AU="Crecchio, Carmine"
  22. AU=Moll Philip J. W.
  23. AU="Coombs, Catherine C"
  24. AU="Safaei, Naser"
  25. AU="Bachouche, Imene"
  26. AU="Roignant, Jean-Yves"
  27. AU="Thabet, Nagwa"
  28. AU="Asor, Eyal"
  29. AU="Rahaman, Md Hasibur"
  30. AU="Angela Di Capua"
  31. AU=De Vitis R
  32. AU="Young, Kaelin C"

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  1. Artikel ; Online: Pulmonary Embolism and Respiratory Deterioration in Chronic Cardiopulmonary Disease

    Delphine Douillet / Tahar Chouihed / Laurent Bertoletti / Pierre-Marie Roy

    Diagnostics, Vol 13, Iss 1, p

    A Narrative Review

    2023  Band 141

    Abstract: Patients with chronic cardiopulmonary pathologies have an increased risk of developing venous thromboembolic events. The worsening of dyspnoea is a frequent occurrence and often leads patients to consult the emergency department. Pulmonary embolism can ... ...

    Abstract Patients with chronic cardiopulmonary pathologies have an increased risk of developing venous thromboembolic events. The worsening of dyspnoea is a frequent occurrence and often leads patients to consult the emergency department. Pulmonary embolism can then be an exacerbation factor, a differential diagnosis or even a secondary diagnosis. The prevalence of pulmonary embolism in these patients is unknown, especially in cases of chronic heart failure. The challenge lies in needing to carry out a systematic or targeted diagnostic strategy for pulmonary embolism. The occurrence of a pulmonary embolism in patients with chronic cardiopulmonary disease clearly worsens their prognosis. In this narrative review, we study pulmonary embolism and chronic obstructive pulmonary disease, after which we turn to pulmonary embolism and chronic heart failure.
    Schlagwörter pulmonary embolism ; acute heart failure ; trigger ; chronic obstructive pulmonary disease ; diagnostic strategy ; Medicine (General) ; R5-920
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2023-01-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  2. Artikel ; Online: Prolonged anticoagulation in VTE with direct oral anticoagulants: towards an individual analysis of net clinical benefit?

    Roy, Pierre-Marie

    The European respiratory journal

    2016  Band 48, Heft 5, Seite(n) 1268–1270

    Sprache Englisch
    Erscheinungsdatum 2016-11
    Erscheinungsland England
    Dokumenttyp Editorial
    ZDB-ID 639359-7
    ISSN 1399-3003 ; 0903-1936
    ISSN (online) 1399-3003
    ISSN 0903-1936
    DOI 10.1183/13993003.01646-2016
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: How to Combat Over-Testing for Patients Suspected of Pulmonary Embolism

    Pierre-Marie Roy / Thomas Moumneh / Thomas Bizouard / Damien Duval / Delphine Douillet

    Diagnostics, Vol 13, Iss 1326, p

    A Narrative Review

    2023  Band 1326

    Abstract: The diagnosis of PE remains difficult in 2023 because the signs and symptoms are not sensible nor specific. The consequences of potential diagnostic errors can be dramatic, whether by default or by excess. Furthermore, the achievement of a simple ... ...

    Abstract The diagnosis of PE remains difficult in 2023 because the signs and symptoms are not sensible nor specific. The consequences of potential diagnostic errors can be dramatic, whether by default or by excess. Furthermore, the achievement of a simple diagnostic strategy, based on clinical probability assessment, D-dimer measurement and computed tomography pulmonary angiography (CTPA) leads to a new challenge for PE diagnosis: over-testing. Indeed, since the 2000s, the wide availability of CTPA resulted in a major increase in investigations with a mod I confirm erate increase in PE diagnosis, without any notable improvement in patient outcomes. Quite the contrary, the complications of anticoagulation for PE increased significantly, and the long-term consequences of imaging diagnostic radiation is an important concern, especially the risk of breast cancer for young women. As a result, several strategies have been proposed to fight over-testing. They are mostly based on defining a subgroup of patients for whom no specific exam should be required to rule-out PE and adjusting the D-dimer cutoff to allow the exclusion of PE without performing CTPA. This narrative review presents the advantages and limitations of these different strategies as well as the perspective in PE diagnosis.
    Schlagwörter over-testing ; pulmonary embolism ; diagnostic ; Medicine (General) ; R5-920
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2023-04-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  4. Artikel ; Online: Safety of the 4PEPS in Patients With a Very Low Prevalence of Pulmonary Embolism-Need for More Than a Point Estimate-Reply.

    Roy, Pierre-Marie / Moumneh, Thomas / Penaloza, Andrea

    JAMA cardiology

    2021  Band 6, Heft 12, Seite(n) 1468–1469

    Mesh-Begriff(e) Humans ; Prevalence ; Pulmonary Embolism/epidemiology
    Sprache Englisch
    Erscheinungsdatum 2021-10-13
    Erscheinungsland United States
    Dokumenttyp Letter ; Comment
    ISSN 2380-6591
    ISSN (online) 2380-6591
    DOI 10.1001/jamacardio.2021.4011
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  5. Artikel: Unexpected carboxyhemoglobin half-life during cardiopulmonary resuscitation: a case report.

    Delvau, Nicolas / Penaloza, Andrea / Franssen, Véronique / Thys, Frédéric / Roy, Pierre-Marie / Hantson, Philippe

    International journal of emergency medicine

    2023  Band 16, Heft 1, Seite(n) 22

    Abstract: Background: Cardiac arrest (CA) following CO poisoning (CO-induced CA) exposes patients to an extremely high risk of mortality and remains challenging to treat effectively. Terminal carboxyhemoglobin elimination half-life (COHbt: Case presentation: ... ...

    Abstract Background: Cardiac arrest (CA) following CO poisoning (CO-induced CA) exposes patients to an extremely high risk of mortality and remains challenging to treat effectively. Terminal carboxyhemoglobin elimination half-life (COHbt
    Case presentation: Asystole occurred in an 18-year-old woman after unintentional exposure to CO in her bathroom. Cardiopulmonary resuscitation (CPR) was started immediately, including mechanical ventilation with a fraction of inspired oxygen (FiO
    Conclusions: This result suggests that prolongation of CPR time needed to back COHb at 10%, a level more compatible with successful return of spontaneous circulation (ROSC), could be compatible with a realistic CPR time. Calculating COHbt
    Sprache Englisch
    Erscheinungsdatum 2023-03-21
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2411462-5
    ISSN 1865-1380 ; 1865-1372
    ISSN (online) 1865-1380
    ISSN 1865-1372
    DOI 10.1186/s12245-023-00492-2
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  6. Artikel: How to Combat Over-Testing for Patients Suspected of Pulmonary Embolism: A Narrative Review.

    Roy, Pierre-Marie / Moumneh, Thomas / Bizouard, Thomas / Duval, Damien / Douillet, Delphine

    Diagnostics (Basel, Switzerland)

    2023  Band 13, Heft 7

    Abstract: The diagnosis of PE remains difficult in 2023 because the signs and symptoms are not sensible nor specific. The consequences of potential diagnostic errors can be dramatic, whether by default or by excess. Furthermore, the achievement of a simple ... ...

    Abstract The diagnosis of PE remains difficult in 2023 because the signs and symptoms are not sensible nor specific. The consequences of potential diagnostic errors can be dramatic, whether by default or by excess. Furthermore, the achievement of a simple diagnostic strategy, based on clinical probability assessment, D-dimer measurement and computed tomography pulmonary angiography (CTPA) leads to a new challenge for PE diagnosis: over-testing. Indeed, since the 2000s, the wide availability of CTPA resulted in a major increase in investigations with a mod I confirm erate increase in PE diagnosis, without any notable improvement in patient outcomes. Quite the contrary, the complications of anticoagulation for PE increased significantly, and the long-term consequences of imaging diagnostic radiation is an important concern, especially the risk of breast cancer for young women. As a result, several strategies have been proposed to fight over-testing. They are mostly based on defining a subgroup of patients for whom no specific exam should be required to rule-out PE and adjusting the D-dimer cutoff to allow the exclusion of PE without performing CTPA. This narrative review presents the advantages and limitations of these different strategies as well as the perspective in PE diagnosis.
    Sprache Englisch
    Erscheinungsdatum 2023-04-03
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2662336-5
    ISSN 2075-4418
    ISSN 2075-4418
    DOI 10.3390/diagnostics13071326
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  7. Artikel ; Online: Overcrowding in the Dispatching Centre During the COVID-19 Crisis: Are Medical Students a Resource?

    Douillet, Delphine / Plard, Delphine / Morin, François / Courjault, Yannick / Gaultier, Gwladys / Lerolle, Nicolas / Templier, François / Roy, Pierre-Marie / Savary, Dominique

    Disaster medicine and public health preparedness

    2024  Band 18, Seite(n) e38

    Abstract: Introduction: In February, the emergence of COronaVIrus Disease 2019 (COVID - 19) in France made it necessary to rapidly adapt emergency and SAMU services in order to take care of many infected patients. To respond to the increase in the number of calls ...

    Abstract Introduction: In February, the emergence of COronaVIrus Disease 2019 (COVID - 19) in France made it necessary to rapidly adapt emergency and SAMU services in order to take care of many infected patients. To respond to the increase in the number of calls in the dispatch centers, reinforcements were necessary on the fronts of the Medical Regulation Assistants (ARM). The aim of this study was to assess the relevance of medical students' responses to first calls exclusively concerning COVID-19.
    Methods: This prospective, observational cohort study was carried out at the University Hospital Centre (CHU) in Angers. Twenty medical students mostly in the 5th year were voluntarily enrolled in the first line COVID-19 call taker team. Calls on the 1st, 3
    Results: From March 18 to April 23, 2020, 302 calls from medical students (n = 20 students) and 40 calls from experienced first-line call handlers were analyzed. The average prioritization agreement rate between the expert and students was 76.16% (95% Confidence Interval: 71.04 to 80.62%) (n = 230/302) compared to 87.50% (95% CI: 73.9 to 94.5%) (n = 45/50) for the experienced first-line call handlers
    Conclusion: The lessons to be observed from this COVID-19 crisis are that in the early days of increasing calls heralding a strain on the healthcare system, support by medical students must be considered.
    Mesh-Begriff(e) Humans ; COVID-19/epidemiology ; Emergency Medical Services ; Students, Medical ; Prospective Studies ; France/epidemiology
    Sprache Englisch
    Erscheinungsdatum 2024-02-28
    Erscheinungsland United States
    Dokumenttyp Observational Study ; Journal Article
    ZDB-ID 2375268-3
    ISSN 1938-744X ; 1935-7893
    ISSN (online) 1938-744X
    ISSN 1935-7893
    DOI 10.1017/dmp.2024.15
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  8. Artikel ; Online: Contemporary management of acute pulmonary embolism.

    Roy, Pierre-Marie / Douillet, Delphine / Penaloza, Andrea

    Trends in cardiovascular medicine

    2021  Band 32, Heft 5, Seite(n) 259–268

    Abstract: This review examines the recent progress in the initial management of pulmonary embolism (PE). Diagnostic strategies allowing the safe decrease of imaging testing have been proposed. New modalities of catheter-based interventions have emerged for ... ...

    Abstract This review examines the recent progress in the initial management of pulmonary embolism (PE). Diagnostic strategies allowing the safe decrease of imaging testing have been proposed. New modalities of catheter-based interventions have emerged for hemodynamically unstable PE patients. For normotensive PE patients, direct oral anticoagulant treatment has become the new norm and a large proportion of patients are eligible for home treatment.
    Mesh-Begriff(e) Acute Disease ; Anticoagulants/adverse effects ; Humans ; Pulmonary Embolism/diagnostic imaging ; Pulmonary Embolism/drug therapy ; Thrombolytic Therapy/adverse effects
    Chemische Substanzen Anticoagulants
    Sprache Englisch
    Erscheinungsdatum 2021-06-29
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Review
    ZDB-ID 1097434-9
    ISSN 1873-2615 ; 1050-1738
    ISSN (online) 1873-2615
    ISSN 1050-1738
    DOI 10.1016/j.tcm.2021.06.002
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 3419: Hefte anzeigen Standort:
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  9. Artikel ; Online: Do Not Throw Out the Baby With the Bathwater.

    Moumneh, Thomas / Douillet, Delphine / Savary, Dominique / Roy, Pierre-Marie

    Annals of emergency medicine

    2021  Band 79, Heft 1, Seite(n) 85–86

    Sprache Englisch
    Erscheinungsdatum 2021-12-23
    Erscheinungsland United States
    Dokumenttyp Letter ; Comment
    ZDB-ID 603080-4
    ISSN 1097-6760 ; 0196-0644
    ISSN (online) 1097-6760
    ISSN 0196-0644
    DOI 10.1016/j.annemergmed.2021.09.429
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  10. Artikel ; Online: Pulmonary embolism risk stratification: external validation of the 4-level Clinical Pretest Probability Score (4PEPS).

    Chiang, Philip / Robert-Ebadi, Helia / Perrier, Arnaud / Roy, Pierre-Marie / Sanchez, Olivier / Righini, Marc / Le Gal, Grégoire

    Research and practice in thrombosis and haemostasis

    2024  Band 8, Heft 1, Seite(n) 102348

    Abstract: Background: The 4-level clinical pretest probability score (4PEPS) was recently introduced as a clinical decision rule for the diagnosis of pulmonary embolism (PE). Based on the score, patients are classified into clinical pretest probability categories ...

    Abstract Background: The 4-level clinical pretest probability score (4PEPS) was recently introduced as a clinical decision rule for the diagnosis of pulmonary embolism (PE). Based on the score, patients are classified into clinical pretest probability categories (c-PTP). The "very low" category aims at excluding PE without further testing; "low" and "moderate" categories require D-dimer testing with specific thresholds, while patients with a "high" pretest directly proceed to imaging.
    Objectives: To provide further external validation of the 4PEPS model.
    Methods: The 4PEPS was applied to a previously collected prospective database of 756 patients with clinically suspected PE enrolled from European emergency departments in 2002 to 2003. The safety threshold for the failure rate in our study was calculated at 1.95% based on a 26% prevalence of PE in our study, as per the International Society on Thrombosis and Haemostasis Scientific and Standardization Committee guidance.
    Results: Patients were classified as follows: 90 (12%) in the very low c-PTP group, of whom 5 (5.6%; 95% CI, 2.4%-12.4%) had PE; 363 (49%) in the low c-PTP group, of whom 34 had PE (9.4%); 246 (34%) in the moderate c-PTP group, of whom 124 (50%) had PE; and 35 (5%) in the high c-PTP group of whom 30 (86%) had PE. Overall, the failure rate of the 4PEPS was 9/734 (1.2%; 95% CI, 0.59%-2.23%) Overall, 9 out of 734 patients (1.2%; 95% CI, 0.59%-2.23%) were diagnosed with PE despite a negative 4PEPS rule; 5 (5.6%) from the very low c-PTP group, 3 (1.4%) in the low c-PTP group, and 1 (3.2%) in the moderate c-PTP group.
    Conclusion: We provide external validation data of the 4PEPS. In this high-prevalence cohort (26% prevalence), PE prevalence in the very low-risk group was higher than expected. A prospective validation study is needed before implementing the 4PEPS model in routine clinical practice.
    Sprache Englisch
    Erscheinungsdatum 2024-02-15
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ISSN 2475-0379
    ISSN (online) 2475-0379
    DOI 10.1016/j.rpth.2024.102348
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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