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Article ; Online: Editorial: The tsunami of steatotic liver disease in India, the Asia-Pacific region and the world.

Shaheen, Abdel-Aziz / Brahmania, Mayur

2024 Volume 59, Issue 7, Page(s) 900–901

MeSH term(s)	Humans ; Asia/epidemiology ; India/epidemiology ; Fatty Liver
Language	English
Publishing date	2024-03-10
Publishing country	England
Document type	Editorial
ZDB-ID	639012-2
ISSN	1365-2036 ; 0269-2813 ; 0953-0673
ISSN (online)	1365-2036
ISSN	0269-2813 ; 0953-0673
DOI	10.1111/apt.17903
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Article ; Online: Mapping the impacts of the anthropogenic activities and seawater intrusion on the shallow coastal aquifer of Port Said, Egypt

Mohamed Abdelfattah / Heba Abdel-Aziz Abu-Bakr / Zakari Aretouyap / Mariam Hassan Sheta / Taher Mohammed Hassan / Mohamed H. Geriesh / Shams El-Din Shaheen / Haya M. Alogayell / Eman Mohamed M. EL-Bana / Ahmed Gaber

Frontiers in Earth Science, Vol

2023 Volume 11

Abstract: The quality and quantity of groundwater resources have been continuously deteriorating as a result of anthropogenic activities and their excessive usage. This has intensified seawater intrusion, particularly in the coastal area of Egypt. The management ... ...

Abstract	The quality and quantity of groundwater resources have been continuously deteriorating as a result of anthropogenic activities and their excessive usage. This has intensified seawater intrusion, particularly in the coastal area of Egypt. The management of this issue and preventing ongoing groundwater contamination are crucial responsibilities. Thus, an integrated strategy using remote sensing, geophysical technique, and hydrogeochemical analysis is used in this work to identify the causes of degradation and evaluate their impacts on the groundwater quality in East Port Said, Egypt. The following points were identified: 1) Remote sensing analysis between 1984 and 2015 showed an increase in anthropogenic activities, such as the construction of fish farms and vegetation, which became their areas of 12.5 and 37.8 km2 respectively. 2) Field observations demonstrated that the groundwater resources are being overexploited and it is expected that these human activities could have an impact on the groundwater quality. 3) The results of the resistivity approach indicated that sand and clay constitute the underlying layers and the shallow subsurface strata contain a high concentration of saline water. As a result, the aquifer is vulnerable to seawater intrusion due to its homogeneity. 4) Nineteen samples of groundwater were collected from the shallow Quaternary aquifer and the hydrochemical characteristic of the samples was identified. The hydrochemical analysis showed that the groundwater across the research area is of the Na-Cl water type and is highly saline (from 7,558 to 23,218 mg/L). By integrating the aforementioned techniques, it is evident that the research region is affected by anthropogenic activities as well as seawater intrusion on groundwater quality. These results serve as a solid base for further research on groundwater-surface water interactions and the evaluation of possible sources of contamination in the shallow aquifers under stress from anthropogenic activity in such environments.
Keywords	coastal aquifer ; Port Said ; Egypt ; groundwater quality ; over-pumping ; seawater intrusion ; Science ; Q
Subject code	550
Language	English
Publishing date	2023-06-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
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Article ; Online: Real-world tertiary referral centre experience stopping nucleos(t)ide analogue therapy in patients with chronic hepatitis B.

Azhari, Hassan / Frolkis, Alexandra D / Shaheen, Abdel Aziz / Israelson, Heidi / Pinto, Jacqueline / Congly, Stephen E / Borman, Meredith A / Aspinall, Alexander A / Stinton, Laura M / Nguyen, Henry H / Swain, Mark G / Burak, Kelly W / Lee, Sam S / Sadler, Matthew D / Coffin, Carla S

Canadian liver journal

2022 Volume 5, Issue 4, Page(s) 453–465

Abstract: BACKGROUND: ...

Abstract	BACKGROUND:
Language	English
Publishing date	2022-11-07
Publishing country	Canada
Document type	Journal Article
ISSN	2561-4444
ISSN (online)	2561-4444
DOI	10.3138/canlivj-2022-0002
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Article ; Online: Yoga in Patients With Inflammatory Bowel Disease: A Narrative Review.

Kaur, Sandeep / D'Silva, Adrijana / Shaheen, Abdel-Aziz / Raman, Maitreyi

Crohn's & colitis 360

2022 Volume 4, Issue 2, Page(s) otac014

Abstract: Despite advancements in the treatment of inflammatory bowel disease (IBD), the global prevalence of IBD is increasing. Patients with IBD often experience a high psychosocial burden, worsening their IBD symptoms and increasing relapse, hospitalization ... ...

Abstract	Despite advancements in the treatment of inflammatory bowel disease (IBD), the global prevalence of IBD is increasing. Patients with IBD often experience a high psychosocial burden, worsening their IBD symptoms and increasing relapse, hospitalization rates, and healthcare costs, which impairs their quality of life (QoL). Evidence suggests that mind-body intervention in many chronic illnesses is effective in improving symptoms and QoL. Yoga is the most frequently used mind-body practice globally. Meta-analyses of randomized clinical trials and prospective studies have highlighted that yoga improves symptoms and QoL of patients with IBD; however, recommendations about indications for yoga as well as dose and frequency of yoga are lacking. The present narrative review aims to describe the available evidence regarding the effects of yoga on common patient-reported outcome measures in IBD, including depression, anxiety, stress, and QoL. Physicians can hence promote yoga interventions in their discussions with patients to help control these IBD-related outcome measures.
Language	English
Publishing date	2022-04-14
Publishing country	England
Document type	Journal Article
ISSN	2631-827X
ISSN (online)	2631-827X
DOI	10.1093/crocol/otac014
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Article ; Online: Hospitalization Rates for Inflammatory Bowel Disease Are Decreasing Over Time: A Population-based Cohort Study.

Buie, Michael J / Coward, Stephanie / Shaheen, Abdel-Aziz / Holroyd-Leduc, Jayna / Hracs, Lindsay / Ma, Christopher / Panaccione, Remo / Benchimol, Eric I / Bernstein, Charles N / Bitton, Alain / Otley, Anthony R / Jones, Jennifer L / Murthy, Sanjay K / Ellen Kuenzig, M / Peña-Sánchez, Juan-Nicolás / Targownik, Laura E / Singh, Harminder / Avina-Zubieta, Antonio / Kaplan, Gilaad G

Inflammatory bowel diseases

2023 Volume 29, Issue 10, Page(s) 1536–1545

Abstract: Background: Recent advances in the management of inflammatory bowel disease (IBD) striving for new treatment targets may have decreased rates of hospitalization for flares. We compared all-cause, IBD-related, and non-IBD-related hospitalizations while ... ...

Abstract	Background: Recent advances in the management of inflammatory bowel disease (IBD) striving for new treatment targets may have decreased rates of hospitalization for flares. We compared all-cause, IBD-related, and non-IBD-related hospitalizations while accounting for the rising prevalence of IBD. Methods: Population-based, administrative health care databases identified all individuals living with IBD in Alberta between fiscal year 2002 and 2018. Hospitalization rates (all-cause, IBD-related, and non-IBD-related) were calculated using the prevalent Alberta IBD population. Hospitalizations were stratified by disease type, age, sex, and metropolitan status. Data were age and sex standardized to the 2019 Canadian population. Log-linear models calculated Average Annual Percentage Change (AAPC) in hospitalization rates with associated 95% confidence intervals (CIs). Results: From 2002-2003 to 2018-2019, all-cause hospitalization rates decreased from 36.57 to 16.72 per 100 IBD patients (AAPC, -4.18%; 95% CI, -4.69 to -3.66). Inflammatory bowel disease-related hospitalization rate decreased from 26.44 to 9.24 per 100 IBD patients (AAPC, -5.54%; 95% CI, -6.19 to -4.88). Non-IBD-related hospitalization rate decreased from 10.13 to 7.48 per 100 IBD patients (AAPC, -1.82%; 95% CI, -2.14 to -1.49). Those over 80 years old had the greatest all-cause and non-IBD-related hospitalization rates. Temporal trends showing decreasing hospitalization rates were observed across age, sex, IBD type, and metropolitan status. Conclusions: Hospitalization rates are decreasing for all-cause, IBD-related, and non-IBD-related hospitalizations. Over the past 20 years, the care of IBD has transitioned from hospital-based care to ambulatory-centric IBD management.
MeSH term(s)	Humans ; Aged, 80 and over ; Cohort Studies ; Canada ; Inflammatory Bowel Diseases/epidemiology ; Inflammatory Bowel Diseases/therapy ; Hospitalization ; Delivery of Health Care ; Colitis, Ulcerative/epidemiology
Language	English
Publishing date	2023-05-30
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1340971-2
ISSN	1536-4844 ; 1078-0998
ISSN (online)	1536-4844
ISSN	1078-0998
DOI	10.1093/ibd/izad020
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Article ; Online: Clinical Course and Treatment Implications of Combination Immune Checkpoint Inhibitor-Mediated Hepatitis: A Multicentre Cohort.

Smith, Matthew K / Chan, Yin / Suo, Aleksi E / Shaheen, Abdel Aziz / Congly, Stephen E / Tandon, Puneeta / Bhanji, Rahima A / Wells, Malcolm M / Cheng, Tina / Ma, Christopher

Journal of the Canadian Association of Gastroenterology

2021 Volume 5, Issue 1, Page(s) 39–47

Abstract: Background: Immune-related adverse events can occur after treatment with immune checkpoint inhibitors (ICI), limiting treatment persistence. We aimed to evaluate the clinical course of ICI-mediated hepatitis (IMH) associated with combination ipilimumab ... ...

Abstract	Background: Immune-related adverse events can occur after treatment with immune checkpoint inhibitors (ICI), limiting treatment persistence. We aimed to evaluate the clinical course of ICI-mediated hepatitis (IMH) associated with combination ipilimumab and nivolumab treatment. Methods: A retrospective cohort study including consecutive patients with metastatic melanoma treated with ipilimumab and nivolumab between 2013 and 2018 was conducted at two tertiary care centres. IMH was defined by the Common Terminology Criteria for Adverse Events (CTCAE). We determined the proportion of patients developing IMH, and compared the duration, treatment patterns and outcomes, stratified by hepatitis severity. Kaplan-Meier survival analysis was used to evaluate time to hepatitis resolution, and a linear mixed-effects model was used to compare longitudinal outcomes by treatment. Results: A total of 63 patients were included. Thirty-two patients (51%) developed IMH (34% Grade 1-2, 66% Grade 3-4), at a median of 34 days (IQR 20 to 43.5 days) after the first dose. Baseline FIB4 index ≥1.45 was associated with IMH (OR 3.71 [95% CI: 1.03 to 13.38], Conclusions: Approximately half of the patients treated with combination ipilimumab and nivolumab developed IMH in this cohort. However, most patients experienced uncomplicated IMH resolution.
Language	English
Publishing date	2021-07-28
Publishing country	England
Document type	Journal Article
ZDB-ID	2940642-0
ISSN	2515-2092 ; 2515-2084
ISSN (online)	2515-2092
ISSN	2515-2084
DOI	10.1093/jcag/gwab019
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Article ; Online: Variation in Testing for and Incidence of Celiac Autoimmunity in Canada: A Population-Based Study.

Gastroenterology

2023 Volume 164, Issue 4, Page(s) 567–578.e7

Abstract: Background & aims: The incidence of biopsy-confirmed celiac disease has increased. However, few studies have explored the incidence of celiac autoimmunity based on positive serology results.: Methods: A population-based cohort study assessed testing ... ...

Abstract	Background & aims: The incidence of biopsy-confirmed celiac disease has increased. However, few studies have explored the incidence of celiac autoimmunity based on positive serology results. Methods: A population-based cohort study assessed testing of tissue transglutaminase antibodies (tTG-IgA) in Alberta from 2012 to 2020. After excluding prevalent cases, incident celiac autoimmunity was defined as the first positive tTG-IgA result between 2015 and 2020. Testing and incidence rates for celiac autoimmunity were calculated per 1000 and 100,000 person-years, respectively. Incidence rate ratios (IRRs) were calculated to identify differences by demographic and regional factors. Average annual percent changes (AAPCs) assessed trends over time. Results: The testing rate of tTG-IgA was 20.2 per 1000 person-years and remained stable from 2012 to 2020 (AAPC, 1.2%; 95% confidence interval [CI], -0.5 to 2.9). Testing was higher in female patients (IRR, 1.66; 95% CI, 1.65-1.66), those living in metropolitan areas (IRR, 1.39; 95% CI, 1.38-1.40), and in areas of lower socioeconomic deprivation (lowest compared to highest IRR, 1.24; 95% CI, 1.23-1.25). Incidence of celiac autoimmunity was 33.8 per 100,000 person-years and increased from 2015 to 2020 (AAPC, 6.2%; 95% CI, 3.1-9.5). Among those with tTG-IgA results ≥10 times the upper limit of normal, the incidence was 12.9 per 100,000 person-years. The incidence of celiac autoimmunity was higher in metropolitan settings (IRR, 1.28; 95% CI, 1.21-1.35) and in the least socioeconomically deprived areas compared to the highest (IRR, 1.22; 95% CI, 1.14-1.32). Conclusions: Incidence of celiac autoimmunity is high and increasing, despite stable testing rates. Variation in testing patterns may lead to underreporting the incidence of celiac autoimmunity in nonmetropolitan areas and more socioeconomically deprived neighborhoods.
MeSH term(s)	Humans ; Female ; Autoimmunity ; Incidence ; Transglutaminases ; Cohort Studies ; Immunoglobulin A ; Autoantibodies ; Canada ; Celiac Disease/diagnosis ; Celiac Disease/epidemiology
Chemical Substances	Transglutaminases (EC 2.3.2.13) ; Immunoglobulin A ; Autoantibodies
Language	English
Publishing date	2023-01-10
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80112-4
ISSN	1528-0012 ; 0016-5085
ISSN (online)	1528-0012
ISSN	0016-5085
DOI	10.1053/j.gastro.2022.12.040
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Article ; Online: Hepatitis C, alcohol abuse, and unintentional overdoses are risk factors for acetaminophen-related hepatotoxicity.

Myers, Robert P / Shaheen, Abdel Aziz M

Hepatology (Baltimore, Md.)

2009 Volume 49, Issue 4, Page(s) 1399–1400

MeSH term(s)	Acetaminophen/poisoning ; Alcoholism/epidemiology ; Analgesics, Non-Narcotic/poisoning ; Canada/epidemiology ; Chemical and Drug Induced Liver Injury/epidemiology ; Chemical and Drug Induced Liver Injury/etiology ; Comorbidity ; Drug Overdose/epidemiology ; Hepatitis C/epidemiology ; Humans ; Risk Factors
Chemical Substances	Analgesics, Non-Narcotic ; Acetaminophen (362O9ITL9D)
Language	English
Publishing date	2009-04
Publishing country	United States
Document type	Letter ; Research Support, Non-U.S. Gov't ; Comment
ZDB-ID	604603-4
ISSN	1527-3350 ; 0270-9139
ISSN (online)	1527-3350
ISSN	0270-9139
DOI	10.1002/hep.22798
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Article ; Online: The outcomes of pregnancy in patients with cirrhosis: a population-based study.

Shaheen, Abdel Aziz M / Myers, Robert P

Liver international : official journal of the International Association for the Study of the Liver

2010 Volume 30, Issue 2, Page(s) 275–283

Abstract: Background: The outcomes of pregnancy in patients with cirrhosis are poorly described. Our objective was to assess obstetric outcomes in cirrhotic women and their infants from a population-based perspective.: Methods: We analysed the 1993-2005 US ... ...

Abstract	Background: The outcomes of pregnancy in patients with cirrhosis are poorly described. Our objective was to assess obstetric outcomes in cirrhotic women and their infants from a population-based perspective. Methods: We analysed the 1993-2005 US Nationwide Inpatient Sample database to identify obstetric hospitalizations among patients with cirrhosis (n=339) and controls matched on age, hospital and year (n=6625). The effect of cirrhosis on maternal and fetal outcomes was evaluated using regression models with adjustment for patient and hospital factors. Results: Between 1993 and 2005, 114 antepartum and 225 delivery admissions in cirrhotic patients were identified. The estimated mean number of deliveries nationwide increased from 68 to 106 annually between 1993 and 1999 and 2000 and 2005 (P=0.0004). Patients with cirrhosis were more likely to deliver by caesarean [42 vs. 28%; adjusted odds ratio (OR) 1.41; 95% confidence interval (CI) 1.06-1.88]. Maternal (1.8 vs. 0%; P<0.0001) and fetal mortality (5.2 vs. 2.1%; P<0.0001), antepartum admission (OR 2.97; 95% CI 2.24-3.96), and maternal (OR 2.03; 95% CI 1.60-2.57) and fetal complications (OR 3.66; 95% CI 2.74-4.88) were greater among cirrhotic patients than controls. Gestational hypertension, placental abruption and uterovaginal haemorrhage were more common in patients with cirrhosis; their infants had higher rates of prematurity and growth restriction. Hepatic decompensation occurred in 15%, including ascites in 11% and variceal haemorrhage in 5%. In women with decompensation, maternal and fetal mortality were 6 and 12% respectively. Conclusions: Although rare, pregnancies among women with cirrhosis are increasing. Cirrhotic patients and their infants have an increased risk of obstetric complications, emphasizing the importance of close maternal-fetal monitoring during pregnancy.
MeSH term(s)	Adult ; Canada/epidemiology ; Cesarean Section/statistics & numerical data ; Comorbidity ; Databases, Factual ; Female ; Fetal Mortality ; Humans ; Liver Cirrhosis/complications ; Liver Cirrhosis/epidemiology ; Liver Cirrhosis/pathology ; Odds Ratio ; Pregnancy ; Pregnancy Complications/epidemiology ; Pregnancy Complications/etiology ; Pregnancy Complications/pathology ; Pregnancy Outcome/epidemiology ; Survival Rate
Language	English
Publishing date	2010-02
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2102783-3
ISSN	1478-3231 ; 1478-3223
ISSN (online)	1478-3231
ISSN	1478-3223
DOI	10.1111/j.1478-3231.2009.02153.x
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Article: Empagliflozin Protects against Haloperidol Experimentally-Induced Ovarian Toxicity.

Abdelzaher, Walaa Yehia / De Waard, Michel / Abdelmonaem, Alyaa Abdelfattah / Ali, Dalia Mohamed / El-Tahawy, Nashwa Fathy Gamal / Rifaai, Rehab Ahmed / Mohamed, Hatem A / Shaheen, Kareem / Zeen El-Din, Mohamed Ahmed / Welson, Nermeen N / Tawfeek, Shereen ELsayed / Batiha, Gaber El-Saber / Abdel-Aziz, Asmaa Mohamed

Pharmaceuticals (Basel, Switzerland)

2023 Volume 16, Issue 2

Abstract: The present experiment aimed to identify the potential protective role of empagliflozin (EMPA) on haloperidol (HAL)-induced ovarian damage in female rats because of its anti-inflammatory, antioxidant, and antiapoptotic effects. EMPA was administered in ... ...

Abstract	The present experiment aimed to identify the potential protective role of empagliflozin (EMPA) on haloperidol (HAL)-induced ovarian damage in female rats because of its anti-inflammatory, antioxidant, and antiapoptotic effects. EMPA was administered in the presence and absence of HAL. Thirty-two adult female albino rats were divided into four groups. Control group, EMPA group: received EMPA (10 mg/kg/day) p.o., HAL group: received HAL (2 mg/kg/day) p.o., HAL + EMPA group: HAL (2 mg/kg/day) combined with EMPA for 28 days. Serum follicle-stimulating hormone (FSH), luteinizing hormone (LH), and anti-mullerian hormone (AMH) levels were measured. Ovarian oxidative stress parameters, besides inflammatory and apoptotic biomarkers, and ovarian Sirtuin-1 (Sirt-1) were evaluated. Ovarian histopathological examination and heat shock protein 70 (Hsp70) immunohistochemical study were performed. HAL significantly increased serum levels of FSH, LH, and ovarian inflammatory, apoptotic, and oxidative stress biomarkers and decreased serum AMH levels and Sirt-1 expression. Histopathological findings of ovarian damage and high Hsp70 immunoexpression were detected. EMPA significantly normalized the distributed hormonal levels, oxidative stress, inflammatory, and apoptotic biomarkers with a prompt improvement in the histopathological picture and a decrease in Hsp70 immunoexpression. Accordingly, EMPA protected against HAL-induced ovarian toxicity by modulating the Sirt-1/Hsp70/TNF-α/caspase-3 signaling pathway.
Language	English
Publishing date	2023-01-23
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2193542-7
ISSN	1424-8247
ISSN	1424-8247
DOI	10.3390/ph16020168
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