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Article ; Online: Characteristics of Patients with Crohn's Disease With or Without Perianal Fistulae in the CorEvitas Inflammatory Bowel Disease Registry.

Fan, Yanni / Delgado-Aros, Sílvia / Valdecantos, Wendell C / Janak, Jud C / Moore, Page C / Crabtree, Margaux M / Stidham, Ryan W

Digestive diseases and sciences

2022 Volume 68, Issue 1, Page(s) 214–222

Abstract: Background: There are limited real-world data characterizing perianal fistulae in patients with Crohn's disease (CD).: Aim: To describe characteristics of patients with CD with and without perianal fistulae.: Methods: In this cross-sectional study, ...

Abstract	Background: There are limited real-world data characterizing perianal fistulae in patients with Crohn's disease (CD). Aim: To describe characteristics of patients with CD with and without perianal fistulae. Methods: In this cross-sectional study, characteristics, treatment history, and health outcomes of patients with CD enrolled in the CorEvitas IBD Registry were described according to perianal fistula status (current/previous or none). Results: Eight hundred and seventy-eight patients were included. Compared with patients with no perianal fistulae (n = 723), patients with current/previous perianal fistulae (n = 155) had longer disease duration since CD diagnosis (mean 16.5 vs 12.3 years; difference 4.3 years; 95% CI, 2.0, 6.6) and fewer had Harvey-Bradshaw Index scores indicative of remission (0-4, 56.8% vs 69.6%; difference - 12.9%; 95% CI, - 21.6, - 4.2). More patients with current/previous fistulae reported a history of IBD-related emergency room visits (67.7% vs 56.1%; difference 11.6%; 95% CI, 3.4, 19.8), hospitalizations (76.1% vs 58.4%; difference 17.7%; 95% CI, 10.1, 25.4), and surgeries (59.4% vs 27.7%; difference 31.7%; 95% CI, 23.3, 40.1), and a history of treatment with tumor necrosis factor inhibitors (81.3% vs 60.7%; difference 20.6%; 95% CI, 13.5, 27.7), immunosuppressants (51.6% vs 31.2%; difference 20.4%; 95% CI, 11.9, 29.0), and antibiotics (50.3% vs 23.7%; difference 26.6%; 95% CI, 18.2, 35.1) than patients without perianal fistulae. Conclusions: Patients with CD with current/previous perianal fistulae have more symptomatic experiences of disease, higher medication use, hospitalization rates, and emergency room visits than patients without perianal fistulae. Interventions to prevent/reduce risk of developing fistulae may help improve outcomes in CD.
MeSH term(s)	Humans ; Crohn Disease/complications ; Crohn Disease/diagnosis ; Crohn Disease/drug therapy ; Cross-Sectional Studies ; Rectal Fistula/epidemiology ; Rectal Fistula/etiology ; Rectal Fistula/drug therapy ; Registries ; Treatment Outcome
Language	English
Publishing date	2022-04-25
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	304250-9
ISSN	1573-2568 ; 0163-2116
ISSN (online)	1573-2568
ISSN	0163-2116
DOI	10.1007/s10620-022-07491-y
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Impact of bread diet on intestinal dysbiosis and irritable bowel syndrome symptoms in quiescent ulcerative colitis: A pilot study.

Lluansí, Aleix / Llirós, Marc / Carreras-Torres, Robert / Bahí, Anna / Capdevila, Montserrat / Feliu, Anna / Vilà-Quintana, Laura / Elias-Masiques, Núria / Cueva, Emilio / Peries, Laia / Torrealba, Leyanira / Miquel-Cusachs, Josep Oriol / Sàbat, Míriam / Busquets, David / López, Carmen / Delgado-Aros, Sílvia / Garcia-Gil, Librado Jesús / Elias, Isidre / Aldeguer, Xavier

PloS one

2024 Volume 19, Issue 2, Page(s) e0297836

Abstract: Gut microbiota may be involved in the presence of irritable bowel syndrome (IBS)-like symptomatology in ulcerative colitis (UC) patients in remission. Bread is an important source of dietary fiber, and a potential prebiotic. To assess the effect of a ... ...

Abstract	Gut microbiota may be involved in the presence of irritable bowel syndrome (IBS)-like symptomatology in ulcerative colitis (UC) patients in remission. Bread is an important source of dietary fiber, and a potential prebiotic. To assess the effect of a bread baked using traditional elaboration, in comparison with using modern elaboration procedures, in changing the gut microbiota and relieving IBS-like symptoms in patients with quiescent ulcerative colitis. Thirty-one UC patients in remission with IBS-like symptoms were randomly assigned to a dietary intervention with 200 g/d of either treatment or control bread for 8 weeks. Clinical symptomatology was tested using questionnaires and inflammatory parameters. Changes in fecal microbiota composition were assessed by high-throughput sequencing of the 16S rRNA gene. A decrease in IBS-like symptomatology was observed after both the treatment and control bread interventions as reductions in IBS-Symptom Severity Score values (p-value < 0.001) and presence of abdominal pain (p-value < 0.001). The treatment bread suggestively reduced the Firmicutes/Bacteroidetes ratio (p-value = 0.058). In addition, the Firmicutes/Bacteroidetes ratio seemed to be associated with improving IBS-like symptoms as suggested by a slight decrease in patient without abdominal pain (p-value = 0.059). No statistically significant differential abundances were found at any taxonomic level. The intake of a bread baked using traditional elaboration decreased the Firmicutes/Bacteroidetes ratio, which seemed to be associated with improving IBS-like symptoms in quiescent ulcerative colitis patients. These findings suggest that the traditional bread elaboration has a potential prebiotic effect improving gut health (ClinicalTrials.gov ID number of study: NCT05656391).
MeSH term(s)	Humans ; Irritable Bowel Syndrome/diagnosis ; Colitis, Ulcerative/complications ; Pilot Projects ; Dysbiosis/complications ; RNA, Ribosomal, 16S ; Bread ; Diet ; Abdominal Pain
Chemical Substances	RNA, Ribosomal, 16S
Language	English
Publishing date	2024-02-16
Publishing country	United States
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0297836
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Article: Vaciado gástrico y dispepsia funcional.

Delgado-Aros, S

Gastroenterologia y hepatologia

2005 Volume 29, Issue 1, Page(s) 34–39

Abstract: Dyspeptic syndrome includes symptoms such as upper abdominal pain, nausea and/or vomiting. These symptoms are common to highly diverse processes such as duodenal ulcer, pancreatitis and even intestinal ischemia, among many others. However, most patients ... ...

Title translation	Gastric emptying and functional dyspepsia.
Abstract	Dyspeptic syndrome includes symptoms such as upper abdominal pain, nausea and/or vomiting. These symptoms are common to highly diverse processes such as duodenal ulcer, pancreatitis and even intestinal ischemia, among many others. However, most patients who consult for this syndrome do not have any of these well known processes. New mechanisms have been proposed that could explain the symptoms presented by these patients. Among these mechanisms are those relating to an alteration of normal gastroduodenal motor function, such as alterations of gastric compliance, antral distension, gastric accommodation to anomalous ingestion, and alterations of gastric emptying. The present review evaluates the role of gastric emptying in producing dyspeptic symptoms according to the evidence available to date. We discuss gastric emptying in patients with functional or idiopathic dyspepsia compared with that in the healthy population, the correlation between gastric emptying and dyspeptic symptoms, and the response of dyspeptic symptoms to the prokinetic therapies carried out to date.
MeSH term(s)	Dyspepsia/physiopathology ; Gastric Emptying/physiology ; Humans
Language	Spanish
Publishing date	2005-12-12
Publishing country	Spain
Document type	English Abstract ; Journal Article ; Review
ZDB-ID	632502-6
ISSN	0210-5705
ISSN	0210-5705
DOI	10.1157/13083250
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Article: Visceral hypersensitivity.

Delgado-Aros, Silvia / Camilleri, Michael

Journal of clinical gastroenterology

2005 Volume 39, Issue 5 Suppl 3, Page(s) S194–203; discussion S210

Abstract: Visceral hypersensitivity is considered one of the causes of functional gastrointestinal disorders. The objectives of this review are to provide a practical description of neuroanatomy and physiology of gut sensation, to describe the diverse tests of ... ...

Abstract	Visceral hypersensitivity is considered one of the causes of functional gastrointestinal disorders. The objectives of this review are to provide a practical description of neuroanatomy and physiology of gut sensation, to describe the diverse tests of visceral sensation and the potential role of brain imaging to further our understanding of visceral sensitivity in health and disease. Changes in motor function in the gut may influence sensory levels, eg, during contractions or as a result of changes in viscus compliance. New insights on sensory end organs, such as intraganglionic laminar endings, and basic neurophysiologic studies showing afferent firing during changes in stretch rather than tension illustrate the importance of different types of stimuli, not just tension, to stimulate afferent sensation. These insights provide the basis for understanding visceral sensation in health and disease, which will be extensively discussed in subsequent articles.
MeSH term(s)	Animals ; Colonic Diseases, Functional/physiopathology ; Humans ; Hyperalgesia/physiopathology ; Neurotransmitter Agents/physiology ; Nociceptors/physiopathology ; Sensation/physiology ; Sensory Thresholds/physiology ; Visceral Afferents/physiopathology
Chemical Substances	Neurotransmitter Agents
Language	English
Publishing date	2005-03-23
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, P.H.S. ; Review
ZDB-ID	448460-5
ISSN	1539-2031 ; 0192-0790
ISSN (online)	1539-2031
ISSN	0192-0790
DOI	10.1097/01.mcg.0000156114.22598.1b
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Article: Manejo clínico de la seudoobstrucción aguda de colon en el enfermo hospitalizado: revisión sistemática de la bibliografía.

Delgado-Aros, S / Camilleri, M

Gastroenterologia y hepatologia

2004 Volume 26, Issue 10, Page(s) 646–655

Abstract: Intestinal pseudoobstruction is a clinical syndrome characterized by impairment of intestinal propulsion, which may resemble intestinal obstruction, in the absence of a mechanical cause. It usually affects the colon but the small intestine may also be ... ...

Title translation	Clinical management of acute colonic pseudo-obstruction in patients: a systematic review of the literature.
Abstract	Intestinal pseudoobstruction is a clinical syndrome characterized by impairment of intestinal propulsion, which may resemble intestinal obstruction, in the absence of a mechanical cause. It usually affects the colon but the small intestine may also be involved, and may present in acute, subacute or chronic forms. We have performed a systematic review of the acute form of pseudoobstruction, also referred to as Ogilvie's syndrome. We discuss proposed pathophysiological mechanisms, manifestations and management of this clinical condition in post-surgery and critically ill patients. The hallmark of the syndrome is massive intestinal distension, which is detected on clinical inspection and plain abdominal radiography. The underlying pathophysiological mechanisms are not fully understood. Therefore, treatment has focussed on preventing intestinal perforation, which is associated with a 21% mortality rate.
MeSH term(s)	Acute Disease ; Colonoscopy ; Critical Illness ; Decompression/methods ; Humans ; Intestinal Pseudo-Obstruction/diagnosis ; Intestinal Pseudo-Obstruction/physiopathology ; Intestinal Pseudo-Obstruction/therapy
Language	Spanish
Publishing date	2004-03-01
Publishing country	Spain
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S. ; Review ; Systematic Review
ZDB-ID	632502-6
ISSN	0210-5705
ISSN	0210-5705
DOI	10.1016/s0210-5705(03)70426-9
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Article: Clinical response to linaclotide at week 4 predicts sustained response in irritable bowel syndrome with constipation and improvements in digestive and extra-digestive symptoms.

Serrano-Falcón, Blanca / Delgado-Aros, Sílvia / Mearin, Fermín / Ciriza de Los Ríos, Constanza / Serra, Jordi / Mínguez, Miguel / Montoro Huguet, Miguel / Perelló, Antonia / Santander, Cecilio / Pérez Aisa, Ángeles / Bañón-Rodríguez, Inmaculada / Rey, Enrique

Therapeutic advances in gastroenterology

2019 Volume 12, Page(s) 1756284819857358

Abstract: Background: Linaclotide is approved for the treatment of moderate-to-severe irritable bowel syndrome (IBS) with constipation (IBS-C) in adults. This study aimed to assess factors predictive of a clinical response and improvements in non-IBS symptoms ... ...

Abstract	Background: Linaclotide is approved for the treatment of moderate-to-severe irritable bowel syndrome (IBS) with constipation (IBS-C) in adults. This study aimed to assess factors predictive of a clinical response and improvements in non-IBS symptoms with linaclotide treatment in a Spanish patient population. Methods: In this open-label phase IIIb study, patients with moderate-to-severe IBS-C received linaclotide 290 μg once daily for 12 weeks. The primary endpoint was clinical response at week 12, defined as >30% reduction in IBS symptom severity score (IBS-SSS) or IBS-SSS <75 plus self-reported response of feeling 'better' or 'much better' Results: A total of 96 patients were eligible; 91 were female and the mean age was 47.4 years. Mean (SD) baseline IBS-SSS was 371 (72.5). In the intention-to-treat and per-protocol populations, 22.9% and 31.7% were clinical responders at week 4, respectively, and 25.0% and 36.7% were clinical responders at week 12. Digestive nonintestinal and extra-digestive symptom scores were significantly improved at weeks 4 and 12. Baseline characteristic was not associated with week 12 clinical response; however, clinical response at week 4 was predictive of response at week 12 (OR: 6.5; 95%IC: 2.1-19.8). The most common adverse event was diarrhea inclusive of loose or watery stools (35.4%). Conclusions: Linaclotide improves IBS-C symptoms, including digestive nonintestinal and extra-digestive symptoms. A clinical response at week 4 may predict response at week 12.
Language	English
Publishing date	2019-08-05
Publishing country	England
Document type	Journal Article
ZDB-ID	2440710-0
ISSN	1756-2848 ; 1756-283X
ISSN (online)	1756-2848
ISSN	1756-283X
DOI	10.1177/1756284819857358
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Article: Role of fecal calprotectin test in the work-up of IBS patients.

Delgado-Aros, Silvia / Cremonini, Filippo

Gastroenterology

2003 Volume 124, Issue 4, Page(s) 1164–1165

MeSH term(s)	Feces/chemistry ; Humans ; Inflammatory Bowel Diseases/diagnosis ; Leukocyte L1 Antigen Complex/analysis
Chemical Substances	Leukocyte L1 Antigen Complex
Language	English
Publishing date	2003-04
Publishing country	United States
Document type	Comment ; Letter
ZDB-ID	80112-4
ISSN	1528-0012 ; 0016-5085
ISSN (online)	1528-0012
ISSN	0016-5085
DOI	10.1053/gast.2003.50197
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Article: Pseudo-obstruction in the critically ill.

Delgado-Aros, Silvia / Camilleri, Michael

Best practice & research. Clinical gastroenterology

2003 Volume 17, Issue 3, Page(s) 427–444

Abstract: Intestinal pseudo-obstruction is defined as a clinical syndrome characterized by impairment of intestinal propulsion, which may resemble intestinal obstruction, in the absence of a mechanical cause. It may involve the small and/or the large bowel, and ... ...

Abstract	Intestinal pseudo-obstruction is defined as a clinical syndrome characterized by impairment of intestinal propulsion, which may resemble intestinal obstruction, in the absence of a mechanical cause. It may involve the small and/or the large bowel, and may present in acute, subacute or chronic forms. We have performed a systematic review of acute pseudo-obstruction, also referred to as Ogilvie's syndrome in the literature, and focused on proposed mechanisms, manifestations and management of post-surgery and critically ill patients who suffer from one or more underlying clinical conditions. The hallmark of the syndrome is massive intestinal distension, which is detected on clinical inspection and plain abdominal radiography. The underlying pathophysiological mechanisms are not fully understood. Therefore, treatment focuses on preventing intestinal perforation, which is associated with an average 21% mortality rate.
MeSH term(s)	Critical Illness ; Humans ; Intestinal Pseudo-Obstruction/diagnosis ; Intestinal Pseudo-Obstruction/physiopathology ; Intestinal Pseudo-Obstruction/therapy
Language	English
Publishing date	2003-04-24
Publishing country	Netherlands
Document type	Journal Article ; Research Support, U.S. Gov't, P.H.S. ; Review ; Systematic Review
ZDB-ID	2048181-0
ISSN	1521-6918
ISSN	1521-6918
DOI	10.1016/s1521-6918(03)00023-4
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Article: Endoscopia digestiva. Ante un paciente con un cuadro de seudoobstrucción intestinal aguda, también conocido como síndrome de Ogilvie, está indicada la realización de una endoscopia descompresiva como primera medida terapéutica?

Delgado-Aros, Sílvia / Ilzarbe Sánchez, Lucas

Gastroenterologia y hepatologia

2008 Volume 31, Issue 9, Page(s) 620–621

Title translation	Gastrointestinal endoscopy. Is decompressive endoscopy indicated as the first-line measure in patients with acute colonic pseudoobstruction, also known as Ogilvie syndrome?.
MeSH term(s)	Acute Disease ; Cholinesterase Inhibitors/therapeutic use ; Colonic Pseudo-Obstruction/drug therapy ; Colonic Pseudo-Obstruction/surgery ; Decompression, Surgical ; Double-Blind Method ; Humans ; Neostigmine/therapeutic use ; Randomized Controlled Trials as Topic ; Unnecessary Procedures
Chemical Substances	Cholinesterase Inhibitors ; Neostigmine (3982TWQ96G)
Language	Spanish
Publishing date	2008-11-24
Publishing country	Spain
Document type	Journal Article
ZDB-ID	632502-6
ISSN	0210-5705
ISSN	0210-5705
DOI	10.1157/13128306
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Article: In vitro

Frontiers in microbiology

2021 Volume 12, Page(s) 716307

Abstract: Inflammatory bowel disease (IBD), including its two main categories (Crohn's disease and ulcerative colitis), has been linked both to gut microbiota and to diet. Bread is a daily food that has a potential capacity as a prebiotic. Our aim was to evaluate ... ...

Abstract	Inflammatory bowel disease (IBD), including its two main categories (Crohn's disease and ulcerative colitis), has been linked both to gut microbiota and to diet. Bread is a daily food that has a potential capacity as a prebiotic. Our aim was to evaluate different bread-making processes and their effect on fecal colonic microbiota in IBD patients. The microbial composition of several sourdoughs and dough samples was analyzed by high-throughput sequencing of 16S and 18S rRNA genes. Three types of bread, which followed different bread-making processes, were
Language	English
Publishing date	2021-10-11
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587354-4
ISSN	1664-302X
ISSN	1664-302X
DOI	10.3389/fmicb.2021.716307
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