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  1. Article ; Online: T

    Khant, Zaw Aung / Hirai, Toshinori / Kadota, Yoshihito / Masuda, Rie / Yano, Takanori / Azuma, Minako / Suzuki, Yukiko / Tashiro, Kuniyuki

    Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine

    2017  Volume 16, Issue 1, Page(s) 84–86

    Abstract: We report a 34-year-old male who manifested T ...

    Abstract We report a 34-year-old male who manifested T
    MeSH term(s) Adult ; Cerebral Cortex/drug effects ; Cerebral Cortex/pathology ; Contrast Media/adverse effects ; Gadolinium ; Gadolinium DTPA/adverse effects ; Humans ; Image Enhancement/methods ; Magnetic Resonance Imaging/methods ; Male ; Retrospective Studies
    Chemical Substances Contrast Media ; Gadolinium (AU0V1LM3JT) ; Gadolinium DTPA (K2I13DR72L)
    Language English
    Publishing date 2017-01-10
    Publishing country Japan
    Document type Case Reports ; Journal Article
    ZDB-ID 2217833-8
    ISSN 1880-2206 ; 1347-3182
    ISSN (online) 1880-2206
    ISSN 1347-3182
    DOI 10.2463/mrms.mp.2016-0054
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Stem-like progenitor and terminally differentiated T

    Zhou, Wenhao / Kawashima, Shusuke / Ishino, Takamasa / Kawase, Katsushige / Ueda, Youki / Yamashita, Kazuo / Watanabe, Tomofumi / Kawazu, Masahito / Dansako, Hiromichi / Suzuki, Yutaka / Nishikawa, Hiroyoshi / Inozume, Takashi / Nagasaki, Joji / Togashi, Yosuke

    Cell reports

    2024  Volume 43, Issue 2, Page(s) 113797

    Abstract: Immune checkpoint inhibitors exert clinical efficacy against various types of cancer through reinvigoration of exhausted ... ...

    Abstract Immune checkpoint inhibitors exert clinical efficacy against various types of cancer through reinvigoration of exhausted CD8
    MeSH term(s) Animals ; Mice ; T-Cell Exhaustion ; Tumor Microenvironment ; CD8-Positive T-Lymphocytes ; Cell Differentiation ; CD4-Positive T-Lymphocytes
    Language English
    Publishing date 2024-02-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2649101-1
    ISSN 2211-1247 ; 2211-1247
    ISSN (online) 2211-1247
    ISSN 2211-1247
    DOI 10.1016/j.celrep.2024.113797
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The two sides of the γδ T cell coin.

    Coffelt, Seth B / Suzuki, Toshiyasu

    Nature cancer

    2023  Volume 4, Issue 8, Page(s) 1056–1057

    MeSH term(s) Receptors, Antigen, T-Cell, gamma-delta ; Intraepithelial Lymphocytes
    Chemical Substances Receptors, Antigen, T-Cell, gamma-delta
    Language English
    Publishing date 2023-07-21
    Publishing country England
    Document type Journal Article
    ISSN 2662-1347
    ISSN (online) 2662-1347
    DOI 10.1038/s43018-023-00587-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Resident memory T cell contributes to the phenotype of inflammatory vitiligo.

    Okamura, Ken / Kabasawa, Takanobu / Saito, Toru / Arai, Yosuke / Futakuchi, Mitsuru / Suzuki, Tamio

    Journal of dermatological science

    2024  Volume 113, Issue 2, Page(s) 74–76

    MeSH term(s) Humans ; Vitiligo ; Memory T Cells ; Hypopigmentation ; Skin ; Phenotype ; CD8-Positive T-Lymphocytes ; Immunologic Memory
    Language English
    Publishing date 2024-01-20
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 1024446-3
    ISSN 1873-569X ; 0923-1811
    ISSN (online) 1873-569X
    ISSN 0923-1811
    DOI 10.1016/j.jdermsci.2024.01.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2870: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article: Structural features of T-DNA that induce transcriptional gene silencing during agroinfiltration.

    Iida, Emi / Kuriyama, Kazunori / Tabara, Midori / Takeda, Atsushi / Suzuki, Nobuhiro / Moriyama, Hiromitsu / Fukuhara, Toshiyuki

    Plant biotechnology (Tokyo, Japan)

    2024  Volume 40, Issue 4, Page(s) 289–299

    Abstract: Agrobacterium ... ...

    Abstract Agrobacterium tumefaciens
    Language English
    Publishing date 2024-02-23
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 2210142-1
    ISSN 1347-6114 ; 1342-4580
    ISSN (online) 1347-6114
    ISSN 1342-4580
    DOI 10.5511/plantbiotechnology.23.0719a
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Nivolumab receptor occupancy on effector regulatory T cells predicts clinical benefit.

    Hosonuma, Masahiro / Hirasawa, Yuya / Kuramasu, Atsuo / Murayama, Masakazu / Narikawa, Yoichiro / Toyoda, Hitoshi / Baba, Yuta / Isobe, Junya / Funayama, Eiji / Tajima, Kohei / Shida, Midori / Hamada, Kazuyuki / Tsurui, Toshiaki / Ariizumi, Hirotsugu / Ishiguro, Tomoyuki / Suzuki, Risako / Ohkuma, Ryotaro / Kubota, Yutaro / Horiike, Atsushi /
    Sambe, Takehiko / Tsuji, Mayumi / Wada, Satoshi / Kiuchi, Yuji / Kobayashi, Shinichi / Tsunoda, Takuya / Yoshimura, Kiyoshi

    Cancer science

    2024  Volume 115, Issue 3, Page(s) 752–762

    Abstract: ... each T-cell subset differently, the RO of each cell population must be characterized. However, relevant ... we aimed to clarify the association between the nivolumab RO in each T-cell population and patient ... T cells (eTregs) was significantly lower in the group that presented clinical benefits, and a significant ...

    Abstract Immune checkpoint inhibitor discovery represents a turning point in cancer treatment. However, the response rates of solid tumors remain ~10%-30%; consequently, prognostic and immune-related adverse event (irAE) predictors are being explored. The programmed cell death protein 1 (PD-1) receptor occupancy (RO) of PD-1 inhibitors depends on the number of peripheral blood lymphocytes and their PD-1 expression levels, suggesting that the RO may be related to efficacy and adverse events. As PD-1 inhibition affects each T-cell subset differently, the RO of each cell population must be characterized. However, relevant data have not been reported, and the prognostic relevance of this parameter is not known. In this study, we aimed to clarify the association between the nivolumab RO in each T-cell population and patient prognosis and reveal the development of irAEs in nivolumab-treated patients. Thirty-two patients were included in the study, and the mean follow-up period was 364 days. The nivolumab RO on effector regulatory T cells (eTregs) was significantly lower in the group that presented clinical benefits, and a significant negative association was observed between PD-1 occupancy on eTregs and all-cause mortality. The results suggest that the nivolumab RO on eTregs may be a prognostic factor in PD-1 inhibitor therapy, implying that the inhibition of PD-1/PD-ligand 1 (PD-L1) signaling on eTregs may attenuate antitumor effects.
    MeSH term(s) Humans ; Nivolumab/adverse effects ; Programmed Cell Death 1 Receptor ; T-Lymphocytes, Regulatory/metabolism ; Neoplasms/drug therapy ; Neoplasms/chemically induced ; Immune Checkpoint Inhibitors
    Chemical Substances Nivolumab (31YO63LBSN) ; Programmed Cell Death 1 Receptor ; Immune Checkpoint Inhibitors
    Language English
    Publishing date 2024-01-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 2115647-5
    ISSN 1349-7006 ; 1349-7006
    ISSN (online) 1349-7006
    ISSN 1349-7006
    DOI 10.1111/cas.16061
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: γδ T cells turn the tables on immune-evasive colon cancer.

    Coffelt, Seth B / Suzuki, Toshiyasu

    Med (New York, N.Y.)

    2023  Volume 4, Issue 3, Page(s) 141–142

    Abstract: Why is checkpoint blockade immunotherapy still effective in tumors that are unrecognizable to ... ...

    Abstract Why is checkpoint blockade immunotherapy still effective in tumors that are unrecognizable to CD8
    MeSH term(s) Humans ; CD8-Positive T-Lymphocytes/metabolism ; Colonic Neoplasms/metabolism
    Language English
    Publishing date 2023-03-10
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ISSN 2666-6340
    ISSN (online) 2666-6340
    DOI 10.1016/j.medj.2023.02.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: An anticodon-sensing T-boxzyme generates the elongator nonproteinogenic aminoacyl-tRNA in situ of a custom-made translation system for incorporation.

    Lu, Wei / Terasaka, Naohiro / Sakaguchi, Yuriko / Suzuki, Takeo / Suzuki, Tsutomu / Suga, Hiroaki

    Nucleic acids research

    2024  Volume 52, Issue 7, Page(s) 3938–3949

    Abstract: ... of a primitive translation apparatus. We previously reported a T-boxzyme, Tx2.1, which selectively charges ... T-boxzymes (elT-boxzymes), using para-azido-l-phenylalanine (PheAZ) as an acyl-donor. We implemented ...

    Abstract In the hypothetical RNA world, ribozymes could have acted as modern aminoacyl-tRNA synthetases (ARSs) to charge tRNAs, thus giving rise to the peptide synthesis along with the evolution of a primitive translation apparatus. We previously reported a T-boxzyme, Tx2.1, which selectively charges initiator tRNA with N-biotinyl-phenylalanine (BioPhe) in situ in a Flexible In-vitro Translation (FIT) system to produce BioPhe-initiating peptides. Here, we performed in vitro selection of elongation-capable T-boxzymes (elT-boxzymes), using para-azido-l-phenylalanine (PheAZ) as an acyl-donor. We implemented a new strategy to enrich elT-boxzyme-tRNA conjugates that self-aminoacylated on the 3'-terminus selectively. One of them, elT32, can charge PheAZ onto tRNA in trans in response to its cognate anticodon. Further evolution of elT32 resulted in elT49, with enhanced aminoacylation activity. We have demonstrated the translation of a PheAZ-containing peptide in an elT-boxzyme-integrated FIT system, revealing that elT-boxzymes are able to generate the PheAZ-tRNA in response to the cognate anticodon in situ of a custom-made translation system. This study, together with Tx2.1, illustrates a scenario where a series of ribozymes could have overseen aminoacylation and co-evolved with a primitive RNA-based translation system.
    MeSH term(s) RNA, Catalytic/metabolism ; RNA, Catalytic/genetics ; Anticodon/genetics ; RNA, Transfer, Amino Acyl/metabolism ; RNA, Transfer, Amino Acyl/genetics ; Protein Biosynthesis ; Phenylalanine/metabolism ; Phenylalanine/analogs & derivatives ; Amino Acyl-tRNA Synthetases/metabolism ; Amino Acyl-tRNA Synthetases/genetics ; Transfer RNA Aminoacylation ; Aminoacylation ; Peptide Chain Elongation, Translational
    Chemical Substances RNA, Catalytic ; Anticodon ; RNA, Transfer, Amino Acyl ; Phenylalanine (47E5O17Y3R) ; Amino Acyl-tRNA Synthetases (EC 6.1.1.-)
    Language English
    Publishing date 2024-03-13
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 186809-3
    ISSN 1362-4962 ; 1362-4954 ; 0301-5610 ; 0305-1048
    ISSN (online) 1362-4962 ; 1362-4954
    ISSN 0301-5610 ; 0305-1048
    DOI 10.1093/nar/gkae151
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1067: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Idiotope-Driven T-Cell/B-Cell Collaboration-Based T-Cell Epitope Prediction Using B-Cell Receptor Repertoire Sequences in Infectious Diseases.

    Nakamura, Yukio / Moi, Meng Ling / Shiina, Takashi / Shin-I, Tadasu / Suzuki, Ryuji

    Viruses

    2023  Volume 15, Issue 5

    Abstract: T-cell recognition of antigen epitopes is a crucial step for the induction ... of adaptive immune responses, and the identification of such T-cell epitopes is, therefore, important for understanding diverse ... immune responses and controlling T-cell immunity. A number of bioinformatic tools exist that predict T-cell ...

    Abstract T-cell recognition of antigen epitopes is a crucial step for the induction of adaptive immune responses, and the identification of such T-cell epitopes is, therefore, important for understanding diverse immune responses and controlling T-cell immunity. A number of bioinformatic tools exist that predict T-cell epitopes; however, many of these methods highly rely on evaluating conventional peptide presentation by major histocompatibility complex (MHC) molecules, but they ignore epitope sequences recognized by T-cell receptor (TCR). Immunogenic determinant idiotopes are present on the variable regions of immunoglobulin molecules expressed on and secreted by B-cells. In idiotope-driven T-cell/B-cell collaboration, B-cells present the idiotopes on MHC molecules for recognition by idiotope-specific T-cells. According to the idiotype network theory formulated by Niels Jerne, such idiotopes found on anti-idiotypic antibodies exhibit molecular mimicry of antigens. Here, by combining these concepts and defining the patterns of TCR-recognized epitope motifs (TREMs), we developed a T-cell epitope prediction method that identifies T-cell epitopes derived from antigen proteins by analyzing B-cell receptor (BCR) sequences. This method allowed us to identify T-cell epitopes that contain the same TREM patterns between BCR and viral antigen sequences in two different infectious diseases caused by dengue virus and SARS-CoV-2 infection. The identified epitopes were among the T-cell epitopes detected in previous studies, and T-cell stimulatory immunogenicity was confirmed. Thus, our data support this method as a powerful tool for the discovery of T-cell epitopes from BCR sequences.
    MeSH term(s) Humans ; T-Lymphocytes ; Epitopes, T-Lymphocyte ; Epitopes, B-Lymphocyte ; COVID-19 ; SARS-CoV-2 ; Receptors, Antigen, T-Cell ; Receptors, Antigen, B-Cell
    Chemical Substances Epitopes, T-Lymphocyte ; Epitopes, B-Lymphocyte ; Receptors, Antigen, T-Cell ; Receptors, Antigen, B-Cell
    Language English
    Publishing date 2023-05-17
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v15051186
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: CD83 expression characterizes precursor exhausted T cell population.

    Wu, Zhiwen / Yoshikawa, Toshiaki / Inoue, Satoshi / Ito, Yusuke / Kasuya, Hitomi / Nakashima, Takahiro / Zhang, Haosong / Kotaka, Saki / Hosoda, Waki / Suzuki, Shiro / Kagoya, Yuki

    Communications biology

    2023  Volume 6, Issue 1, Page(s) 258

    Abstract: T cell exhaustion is a main obstacle against effective cancer immunotherapy. Exhausted T ... cells include a subpopulation that maintains proliferative capacity, referred to as precursor exhausted T ... cells (T ...

    Abstract T cell exhaustion is a main obstacle against effective cancer immunotherapy. Exhausted T cells include a subpopulation that maintains proliferative capacity, referred to as precursor exhausted T cells (T
    MeSH term(s) Humans ; Receptors, CCR7/metabolism ; T-Lymphocyte Subsets/metabolism ; Immunotherapy ; Lymphocytes, Tumor-Infiltrating ; Neoplasms
    Chemical Substances Receptors, CCR7
    Language English
    Publishing date 2023-03-11
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2399-3642
    ISSN (online) 2399-3642
    DOI 10.1038/s42003-023-04631-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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