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  1. Article ; Online: mRNA expression levels of cytochrome P450

    Makihara, Hiroko / Maezawa, Mika / Kaiga, Kazusa / Satake, Toshihiko / Muto, Mayu / Tsunoda, Yui / Shimada, Tsutomu / Akase, Tomoko

    Xenobiotica; the fate of foreign compounds in biological systems

    2024  , Page(s) 1–7

    Abstract: Various cytochrome P450 enzymes (CYPs) that contribute to drug metabolism are expressed in the skin. However, variation among individuals in CYP expression profiles is not well-understood.To investigate CYPs related to the metabolism of transdermal ... ...

    Abstract Various cytochrome P450 enzymes (CYPs) that contribute to drug metabolism are expressed in the skin. However, variation among individuals in CYP expression profiles is not well-understood.To investigate CYPs related to the metabolism of transdermal preparations in Japan, multiple skin tissue specimens of individuals of Japanese descent were prepared, and the mRNA expression levels of
    Language English
    Publishing date 2024-04-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 120287-x
    ISSN 1366-5928 ; 0049-8254
    ISSN (online) 1366-5928
    ISSN 0049-8254
    DOI 10.1080/00498254.2024.2344664
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 782: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Changes in Collective Efficacy's Preventive Effect on Intimate Partner Violence during the COVID-19 Pandemic.

    Souma, Toshihiko / Komura, Kentaro / Arai, Takashi / Shimada, Takahito / Kanemasa, Yuji

    International journal of environmental research and public health

    2022  Volume 19, Issue 19

    Abstract: Following the logic of studies showing that collective efficacy within neighborhoods deters intimate partner violence (IPV), the promotion of social distancing during the COVID-19 pandemic may have weakened that effect. To examine that possibility, we ... ...

    Abstract Following the logic of studies showing that collective efficacy within neighborhoods deters intimate partner violence (IPV), the promotion of social distancing during the COVID-19 pandemic may have weakened that effect. To examine that possibility, we analyzed panel data from 318 adults in Japan regarding IPV victimization and perceived collective efficacy at four time points. A latent growth model (LGM) analysis for each measure revealed that informal social control, a subscale of collective efficacy, has declined since the pandemic began, whereas no significant changes have occurred in social cohesion and trust, another subscale of collective efficacy, and IPV victimization. Furthermore, two parallel LGM analyses revealed that although collective efficacy before the pandemic suppressed subsequent IPV victimization, changes in collective efficacy during the pandemic have been positively associated with changes in IPV. Those results suggest that collective efficacy's protective effect on IPV is moderated by whether interactions between intimate partners and their neighbors are socially normative.
    MeSH term(s) Adult ; Bullying ; COVID-19/epidemiology ; COVID-19/prevention & control ; Crime Victims ; Humans ; Intimate Partner Violence/prevention & control ; Pandemics/prevention & control
    Language English
    Publishing date 2022-10-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2175195-X
    ISSN 1660-4601 ; 1661-7827
    ISSN (online) 1660-4601
    ISSN 1661-7827
    DOI 10.3390/ijerph191912849
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Hyperprogressive disease under anti-PD-1 rechallenge after initial response to anti-PD-1 treatment for non-small cell lung cancer: a case report.

    Xu, Shiting / Shukuya, Takehito / Shimamura, Shoko / Hayashi, Takuo / Sato, Yoshihiko / Shiozaki, Hitomi / Nishioki, Toshihiko / Nishino, Koichi / Kato, Motoyasu / Hattori, Aritoshi / Shimada, Naoko / Suzuki, Kenji / Kitano, Shigehisa / Takahashi, Kazuhisa

    Translational lung cancer research

    2024  Volume 13, Issue 3, Page(s) 666–672

    Abstract: Background: Hyperprogressive disease is an unexpected response pattern observed in immune checkpoint therapy and associated with poor prognosis. The rechallenge of programmed cell death 1/programmed cell death ligand 1 (PD-1/PD-L1) inhibitors can be a ... ...

    Abstract Background: Hyperprogressive disease is an unexpected response pattern observed in immune checkpoint therapy and associated with poor prognosis. The rechallenge of programmed cell death 1/programmed cell death ligand 1 (PD-1/PD-L1) inhibitors can be a treatment option in non-small cell lung cancer (NSCLC) patients who once responded to them. Here, we reported the hyperprogressive phenomenon after PD-1/PD-L1 rechallenge in a patient with NSCLC.
    Case description: This case report described a patient with recurrent large cell lung cancer undergoing hyperprogressive disease with pleural and pericardial dissemination shortly after the pembrolizumab rechallenge, although he had a favorable response to the initial pembrolizumab treatment. A lower ratio of CD8
    Conclusions: For the first time, we reported that a patient who showed a favorable response to initial anti-PD-1 treatment underwent hyperprogressive disease when rechallenging the same immunotherapy. The increased Foxp3
    Language English
    Publishing date 2024-03-27
    Publishing country China
    Document type Case Reports
    ZDB-ID 2754335-3
    ISSN 2226-4477 ; 2218-6751
    ISSN (online) 2226-4477
    ISSN 2218-6751
    DOI 10.21037/tlcr-23-765
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Quantitative analysis of selective glycosylation of saccharides with aromatic amines.

    Hanai, Toshihiko / Shimada, Keiko / Koyama, Nobuhiro / Nohara, Yukio

    Carbohydrate research

    2020  Volume 498, Page(s) 108171

    Abstract: Glycosylation, a part of the Maillard reaction, occurs non-enzymatically in food and biological processes. The selectivity of N-glycosylation was analyzed based on the reactivity of monosaccharides with aromatic amines, including aromatic amino acids, ... ...

    Abstract Glycosylation, a part of the Maillard reaction, occurs non-enzymatically in food and biological processes. The selectivity of N-glycosylation was analyzed based on the reactivity of monosaccharides with aromatic amines, including aromatic amino acids, and the degree of molecular interaction (MI) measured using liquid chromatography. Furthermore, the chemical structures of reaction products were determined using X-ray crystallography and/or NMR. The possible reaction products were estimated in silico using the optimized energy values of different conformations. The MI energy values of amino groups and saccharides were calculated using in silico analysis using a model phase. Saccharides having larger MI values easily produced stable crystals of N-glycosides. The reaction rate of glucose (an energy saccharide) was slow, and it easily produced the Amadori compounds. The study of the reactivity of aromatic amines with saccharides, the measurement of the retention of monosaccharides on amino phase in chromatography, and the synthesis of N-glycosides for the determination of their structures will provide useful information about selective glycosylation for the modification of drug candidates to improve their water solubility.
    MeSH term(s) Amines/chemistry ; Carbohydrate Conformation ; Glycosylation ; Models, Molecular ; Monosaccharides/chemistry
    Chemical Substances Amines ; Monosaccharides
    Language English
    Publishing date 2020-10-07
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1435-7
    ISSN 1873-426X ; 0008-6215
    ISSN (online) 1873-426X
    ISSN 0008-6215
    DOI 10.1016/j.carres.2020.108171
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: How Much Experience is Required to Acquire the Skills to Independently Perform Spine Surgery? What Milestones are Needed for Successful Surgery?

    Fukushi, Ryunosuke / Teramoto, Atsushi / Yoshimoto, Mitsunori / Miyakoshi, Naohisa / Kudo, Daisuke / Emori, Makoto / Shimada, Yoichi / Yamashita, Toshihiko

    Advances in medical education and practice

    2023  Volume 14, Page(s) 657–667

    Abstract: Purpose: To assess the number of surgeries needed to acquire the necessary skills to perform spine surgery independently.: Patients and methods: A questionnaire on 12 different spinal procedures was sent to orthopedic surgeons affiliated with the ... ...

    Abstract Purpose: To assess the number of surgeries needed to acquire the necessary skills to perform spine surgery independently.
    Patients and methods: A questionnaire on 12 different spinal procedures was sent to orthopedic surgeons affiliated with the spine teams of orthopedic departments at either the Akita University or Sapporo Medical University. Participants were asked to identify whether they (A) could independently perform each procedure, (B) could perform each procedure with the assistance of a senior doctor, or (C) were unable to perform each procedure. Those whose response was (A) were asked how many surgeries were required to acquire the necessary skills. Those who responded to (B) or (C) were asked how many surgeries they believed were required to acquire the skills necessary to operate independently. Participants also responded to 10 questions on surgical training techniques and rated the usefulness of each method.
    Results: A total of 55 spine surgeons responded to the questionnaire. Group A required significantly fewer surgeries in the following categories to become independent than required Group C: upper cervical spine surgery (7.3/19.3), anterior cervical decompression/fusion (6.7/28.8), posterior cervical decompression/fusion (9.5/27.3), lumbar discectomy (12.6/26.7), endoscopic lumbar discectomy (10.2/24.2), spinal tumor resection (6.5/37.2), and spinal kyphosis surgery (10.3/32.3). Over 80% of participants responded that the following were effective methods: "surgeries where a senior doctor is the main surgeon, and the respondent is the assistant and observer"; "surgeries where the respondent is the main surgeon, and a senior doctor is an assistant"; "self-study using surgery manuals, articles, and textbooks"; and "training through video surgery sessions".
    Conclusion: Surgeons who do not perform specific procedures independently require more surgical experience than those who operate independently. Our results may help develop more efficient training methods for spine surgeons.
    Language English
    Publishing date 2023-06-28
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 2578539-4
    ISSN 1179-7258
    ISSN 1179-7258
    DOI 10.2147/AMEP.S411047
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Gastrointestinal bleeding among 151 patients undergoing maintenance hemodialysis for end-stage renal failure: A 5-year follow-up study.

    Nakayama, Shiki / Yamanouchi, Kohei / Takamori, Ayako / Goto, Taku / Shimada, Furitsu / Imamura, Tomohiro / Hirooka, Yoshitaka / Kitajima, Akira / Onozawa, Koji / Kakiuchi, Toshihiko / Takagi, Kuniyasu / Kishi, Takuya / Fujimoto, Kazuma / Sakamoto, Yuichiro

    Medicine

    2024  Volume 103, Issue 7, Page(s) e37274

    Abstract: Gastrointestinal bleeding is one serious complication of patients undergoing hemodialysis with end-stage renal failure. The present study aimed to evaluate risks and clinical features of real-world clinical data on upper and lower gastrointestinal ... ...

    Abstract Gastrointestinal bleeding is one serious complication of patients undergoing hemodialysis with end-stage renal failure. The present study aimed to evaluate risks and clinical features of real-world clinical data on upper and lower gastrointestinal bleeding in patients undergoing hemodialysis during a 5-year longitudinal observation period. This study included 151 patients undergoing maintenance hemodialysis at Takagi Hospital between December 2017 and December 2022. Clinical data from December 2017 were recorded, and upper and lower gastrointestinal bleeding, mortality, prescribed medications, and bone fractures were examined during the five-year observation period. Of 151 patients, 32 (21.2%:4.2% per year) experienced bleeding, 24 had upper gastrointestinal bleeding, 7 had lower gastrointestinal bleeding, and one had an unknown origin of bleeding. Ulcers or erosions primarily cause upper gastrointestinal bleeding without Helicobacter pylori infection, whereas patients with H pylori eradication are more likely to experience bleeding caused by vascular lesions, often accompanied by underlying comorbidities. The prophylactic effects of proton pump inhibitors and histamine-2 receptor blockers were limited in hemodialysis patients, as 15 out of 24 patients with upper gastrointestinal bleeding (62.5%) were prescribed these medications. The mortality rate in patients with lower gastrointestinal bleeding (71.4%) was higher than that in those without bleeding (33.6%) (P < .05). All patients with lower gastrointestinal bleeding were prescribed nonsteroidal anti-inflammatory drugs and/or aspirin. In this study, endoscopic hemostasis was successfully achieved. The present study indicated that the incidence of gastrointestinal bleeding during hemodialysis was relatively high. Upper gastrointestinal bleeding may develop even with the prescription of proton pump inhibitors. Lower gastrointestinal bleeding was a complication in hemodialysis patients under serious pathological condition with nonsteroidal anti-inflammatory drugs and or aspirin.
    MeSH term(s) Humans ; Proton Pump Inhibitors/therapeutic use ; Follow-Up Studies ; Helicobacter Infections/drug therapy ; Helicobacter pylori ; Gastrointestinal Hemorrhage/etiology ; Gastrointestinal Hemorrhage/chemically induced ; Anti-Inflammatory Agents, Non-Steroidal/therapeutic use ; Aspirin/therapeutic use ; Kidney Failure, Chronic/complications ; Kidney Failure, Chronic/therapy ; Kidney Failure, Chronic/chemically induced ; Renal Dialysis/adverse effects
    Chemical Substances Proton Pump Inhibitors ; Anti-Inflammatory Agents, Non-Steroidal ; Aspirin (R16CO5Y76E)
    Language English
    Publishing date 2024-02-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80184-7
    ISSN 1536-5964 ; 0025-7974
    ISSN (online) 1536-5964
    ISSN 0025-7974
    DOI 10.1097/MD.0000000000037274
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ua VI Zs.171: Show issues Location:
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  7. Article ; Online: Novel Filler-Filled-Type Polymer Electrolyte Membrane for PEFC Employing Poly(vinylphosphonic acid)-

    Nohara, Tomohiro / Arita, Toshihiko / Tabata, Keisuke / Saito, Takaaki / Shimada, Ryuichiro / Nakazaki, Haruki / Suzuki, Yukina / Sato, Ryota / Masuhara, Akito

    ACS applied materials & interfaces

    2022  Volume 14, Issue 6, Page(s) 8353–8360

    Abstract: Low-acidity polymer electrolyte membranes are essential to polymer electrolyte fuel cells (PEFCs) and water electrolysis systems, both of which are expected to be next-generation energy and hydrogen sources. We developed a new type of high-performance ... ...

    Abstract Low-acidity polymer electrolyte membranes are essential to polymer electrolyte fuel cells (PEFCs) and water electrolysis systems, both of which are expected to be next-generation energy and hydrogen sources. We developed a new type of high-performance polymer electrolyte membrane (PEM) in which the core particles are precisely electrolyte polymer coated and filled into binder resin. Cellulose nanocrystals (CNCs), which have attracted attention as light, rigid, and sustainable materials, were selected as the core material for the filler. The CNC surface was coated with a new block copolymer containing a proton conductive polymer of poly(vinylphosphonic acid) (PVPA) and a hydrophobic polymer of polystyrene (PS) using RAFT polymerization with particles (PwP) we developed. The pelletized fillers and the filler-filled polycarbonate membranes achieved proton conductivities of over 10
    Language English
    Publishing date 2022-01-22
    Publishing country United States
    Document type Journal Article
    ISSN 1944-8252
    ISSN (online) 1944-8252
    DOI 10.1021/acsami.1c18695
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Quantitative analysis of selective glycosylation of saccharides with aromatic amines

    Hanai, Toshihiko / Shimada, Keiko / Koyama, Nobuhiro / Nohara, Yukio

    Carbohydrate research. 2020 Dec., v. 498

    2020  

    Abstract: Glycosylation, a part of the Maillard reaction, occurs non-enzymatically in food and biological processes. The selectivity of N-glycosylation was analyzed based on the reactivity of monosaccharides with aromatic amines, including aromatic amino acids, ... ...

    Abstract Glycosylation, a part of the Maillard reaction, occurs non-enzymatically in food and biological processes. The selectivity of N-glycosylation was analyzed based on the reactivity of monosaccharides with aromatic amines, including aromatic amino acids, and the degree of molecular interaction (MI) measured using liquid chromatography. Furthermore, the chemical structures of reaction products were determined using X-ray crystallography and/or NMR. The possible reaction products were estimated in silico using the optimized energy values of different conformations. The MI energy values of amino groups and saccharides were calculated using in silico analysis using a model phase. Saccharides having larger MI values easily produced stable crystals of N-glycosides. The reaction rate of glucose (an energy saccharide) was slow, and it easily produced the Amadori compounds. The study of the reactivity of aromatic amines with saccharides, the measurement of the retention of monosaccharides on amino phase in chromatography, and the synthesis of N-glycosides for the determination of their structures will provide useful information about selective glycosylation for the modification of drug candidates to improve their water solubility.
    Keywords Maillard reaction ; X-ray diffraction ; computer simulation ; drugs ; energy ; glucose ; glycosides ; glycosylation ; liquid chromatography ; quantitative analysis ; research ; water solubility
    Language English
    Dates of publication 2020-12
    Publishing place Elsevier Ltd
    Document type Article
    Note NAL-AP-2-clean
    ZDB-ID 1435-7
    ISSN 1873-426X ; 0008-6215
    ISSN (online) 1873-426X
    ISSN 0008-6215
    DOI 10.1016/j.carres.2020.108171
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

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  9. Article: Kampo Formula-Pattern Models: The Development of 13 New Clinically Useful Standard Abdominal Pattern Models in the Fukushin Simulator.

    Yakubo, Shuji / Baba, Masaki / Odaguchi, Hiroshi / Wakasugi, Akino / Sekine, Mariko / Hanawa, Toshihiko / Mitsuma, Tadamichi / Namiki, Takao / Arai, Makoto / Muramatsu, Shin-Ichi / Shimada, Yutaka / Shibahara, Naotoshi

    Frontiers in pharmacology

    2022  Volume 13, Page(s) 688074

    Abstract: Aim: ...

    Abstract Aim:
    Language English
    Publishing date 2022-04-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2022.688074
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Real-World Data of Trastuzumab Deruxtecan for Advanced Gastric Cancer: A Multi-Institutional Retrospective Study.

    Matsumoto, Toshihiko / Yamamura, Shogo / Ikoma, Tatsuki / Kurioka, Yusuke / Doi, Keitaro / Boku, Shogen / Shibata, Nobuhiro / Nagai, Hiroki / Shimada, Takanobu / Tsuduki, Takao / Tsumura, Takehiko / Takatani, Masahiro / Yasui, Hisateru / Satake, Hironaga

    Journal of clinical medicine

    2022  Volume 11, Issue 8

    Abstract: Trastuzumab deruxtecan (T-DXd) has shown promising efficacy ... ...

    Abstract Trastuzumab deruxtecan (T-DXd) has shown promising efficacy against
    Language English
    Publishing date 2022-04-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm11082247
    Database MEDical Literature Analysis and Retrieval System OnLINE

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