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  1. Article ; Online: Zinc acquisition and its contribution to

    Maunders, Eve A / Giles, Matthew W / Ganio, Katherine / Cunningham, Bliss A / Bennett-Wood, Vicki / Cole, Gregory B / Ng, Dixon / Lai, Christine C / Neville, Stephanie L / Moraes, Trevor F / McDevitt, Christopher A / Tan, Aimee

    Frontiers in cellular and infection microbiology

    2024  Volume 13, Page(s) 1322973

    Abstract: Klebsiella ... ...

    Abstract Klebsiella pneumoniae
    MeSH term(s) Klebsiella pneumoniae/genetics ; Zinc ; Virulence ; Klebsiella ; Membrane Transport Proteins
    Chemical Substances Zinc (J41CSQ7QDS) ; Membrane Transport Proteins
    Language English
    Publishing date 2024-01-05
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2619676-1
    ISSN 2235-2988 ; 2235-2988
    ISSN (online) 2235-2988
    ISSN 2235-2988
    DOI 10.3389/fcimb.2023.1322973
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Book: Transient ischemic attack and stroke

    Pendlebury, Sarah T. / Giles, Matthew F. / Rothwell, Peter M.

    diagnosis, investigation and management

    2009  

    Author's details Sarah T. Pendlebury ; Matthew F. Giles ; Peter M. Rothwell
    Keywords Ischemic Attack, Transient / diagnosis ; Stroke / diagnosis ; Ischemic Attack, Transient / therapy ; Stroke / therapy
    Language English
    Size VII, 395 S. : Ill., graph. Darst., 24cm
    Publisher Cambridge Univ. Press
    Publishing place Cambridge
    Publishing country Great Britain
    Document type Book
    Note Includes bibliographical references and index. - Formerly CIP
    HBZ-ID HT016178868
    ISBN 0-521-73512-2 ; 978-0-521-73512-4
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2009 A 6849 order for loan Magazin

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  3. Article: Management of transient ischaemic attack.

    Giles, Matthew F

    British journal of hospital medicine (London, England : 2005)

    2011  Volume 72, Issue 7, Page(s) 372–378

    MeSH term(s) Clinical Trials as Topic ; Diagnosis, Differential ; Diagnostic Imaging ; Humans ; Ischemic Attack, Transient/diagnosis ; Ischemic Attack, Transient/therapy ; Risk Assessment
    Language English
    Publishing date 2011-08-12
    Publishing country England
    Document type Journal Article ; Review
    ISSN 1750-8460
    ISSN 1750-8460
    DOI 10.12968/hmed.2011.72.7.372
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  4. Article ; Online: Risk of stroke and lifestyle.

    Giles, Matthew F

    BMJ (Clinical research ed.)

    2009  Volume 338, Page(s) b14

    MeSH term(s) Humans ; Life Style ; Risk Factors ; Stroke/etiology
    Language English
    Publishing date 2009-02-19
    Publishing country England
    Document type Comment ; Editorial
    ZDB-ID 1362901-3
    ISSN 1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    ISSN (online) 1756-1833
    ISSN 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    DOI 10.1136/bmj.b14
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  5. Article ; Online: Local Wind Regime Induced by Giant Linear Dunes: Comparison of ERA5-Land Reanalysis with Surface Measurements

    Gadal, Cyril / Delorme, Pauline / Narteau, Clément / Wiggs, Giles F. S. / Baddock, Matthew / Nield, Joanna M. / Claudin, Philippe

    Boundary-Layer Meteorol. 2022 Dec., v. 185, no. 3 p.309-332

    2022  

    Abstract: Emergence and growth of sand dunes results from the dynamic interaction between topography, wind flow and sediment transport. While feedbacks between these variables are well studied at the scale of a single and relatively small dune, the average effect ... ...

    Abstract Emergence and growth of sand dunes results from the dynamic interaction between topography, wind flow and sediment transport. While feedbacks between these variables are well studied at the scale of a single and relatively small dune, the average effect of a periodic large-scale dune pattern on atmospheric flows remains poorly constrained, due to a pressing lack of data in major sand seas. Here, we compare local measurements of surface winds to the predictions of the ERA5-Land climate reanalysis at four locations in Namibia, both within and outside the giant linear dune field of the Namib Sand Sea. In the desert plains to the north of the sand sea, observations and predictions agree well. This is also the case in the interdune areas of the sand sea during the day. During the night, however, an additional wind component aligned with the giant dune orientation is measured, in contrast to the easterly wind predicted by the ERA5-Land reanalysis. For the given dune orientation and measured wind regime, we link the observed wind deviation (over [Formula: see text]) to the daily cycle of the turbulent atmospheric boundary layer. During the night, a shallow boundary layer induces a flow confinement above the giant dunes, resulting in large flow deviations, especially for the slower easterly winds. During the day, the feedback of the giant dunes on the atmospheric flow is much weaker due to the thicker boundary layer and higher wind speeds. Finally, we propose that the confinement mechanism and the associated wind deflections induced by giant dunes could explain the development of smaller-scale secondary dunes, which elongate obliquely in the interdune areas of the primary dune pattern.
    Keywords climate ; sand ; sediment transport ; topography ; troposphere ; wind direction ; Namibia
    Language English
    Dates of publication 2022-12
    Size p. 309-332.
    Publishing place Springer Netherlands
    Document type Article ; Online
    ZDB-ID 1477639-X
    ISSN 1573-1472 ; 0006-8314
    ISSN (online) 1573-1472
    ISSN 0006-8314
    DOI 10.1007/s10546-022-00733-6
    Database NAL-Catalogue (AGRICOLA)

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  6. Article ; Online: Bridging of childhood obsessive-compulsive personality disorder traits and adult eating disorder symptoms: A network analysis approach.

    Giles, Sarah / Hughes, Elizabeth K / Fuller-Tyszkiewicz, Matthew / Treasure, Janet / Fernandez-Aranda, Fernando / Karwautz, Andreas F K / Wagner, Gudrun / Anderluh, Marija / Collier, David A / Krug, Isabel

    European eating disorders review : the journal of the Eating Disorders Association

    2022  Volume 30, Issue 2, Page(s) 110–123

    Abstract: Objectives: Obsessive-compulsive personality disorder (OCDP) traits are commonly associated with eating disorders (EDs), with evidence demonstrating that these traits predispose and exacerbate the ED illness course. However, limited research has ... ...

    Abstract Objectives: Obsessive-compulsive personality disorder (OCDP) traits are commonly associated with eating disorders (EDs), with evidence demonstrating that these traits predispose and exacerbate the ED illness course. However, limited research has examined the symptomatic interplay between ED and OCDP traits. We used network analysis to (1) identify the most central symptoms in a network comprised of OCPD traits retrospectively assessed in childhood and ED symptoms and (2) to identify symptoms which bridged OCPD traits and ED symptoms.
    Methods: Participants were 320 females with an ED (anorexia nervosa n = 227, bulimia nervosa n = 93), who completed the semi-structured EATATE interview and the Eating Disorder Inventory-2. Expected influence (EI) was computed to determine each symptom's influence in the network. Bridge symptoms were identified by computing bridge EI.
    Results: A regularised partial correlation network showed that ascetism, social insecurity, ineffectiveness, and impulsivity had the highest EI in the OCPD and ED network. With respect to bridging symptoms, interpersonal distrust emerged as a possible bridging node between the OCPD and ED trait/symptom clusters.
    Discussion: These findings highlight the centrality of non-specific ED symptoms in the ED symptom network and suggest that interpersonal distrust may play a functional role through which childhood OCPD traits and ED symptoms are connected.
    MeSH term(s) Adult ; Bulimia Nervosa ; Compulsive Personality Disorder/diagnosis ; Feeding and Eating Disorders ; Female ; Humans ; Obsessive-Compulsive Disorder ; Retrospective Studies
    Language English
    Publishing date 2022-01-21
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1159507-3
    ISSN 1099-0968 ; 1067-1633 ; 1072-4133
    ISSN (online) 1099-0968
    ISSN 1067-1633 ; 1072-4133
    DOI 10.1002/erv.2885
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3760: Show issues Location:
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  7. Article ; Online: Prone position during venovenous extracorporeal membrane oxygenation: survival analysis needed for a time-dependent intervention.

    Zaaqoq, Akram M / Barnett, Adrian G / Heinsar, Silver / Griffee, Matthew J / MacLaren, Graeme / Jacobs, Jeffrey P / Suen, Jacky Y / Bassi, Gianluigi Li / Fraser, John F / Dalton, Heidi J / Peek, Giles J

    Critical care (London, England)

    2022  Volume 26, Issue 1, Page(s) 39

    MeSH term(s) Extracorporeal Membrane Oxygenation ; Humans ; Prone Position ; Respiratory Distress Syndrome/therapy ; Retrospective Studies ; Survival Analysis
    Language English
    Publishing date 2022-02-08
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 2041406-7
    ISSN 1466-609X ; 1364-8535
    ISSN (online) 1466-609X
    ISSN 1364-8535
    DOI 10.1186/s13054-022-03923-3
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    Zs.A 5517: Show issues Location:
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  8. Article ; Online: A program of successive gene expression in mouse one-cell embryos.

    Asami, Maki / Lam, Brian Y H / Hoffmann, Martin / Suzuki, Toru / Lu, Xin / Yoshida, Naoko / Ma, Marcella K / Rainbow, Kara / Gužvić, Miodrag / VerMilyea, Matthew D / Yeo, Giles S H / Klein, Christoph A / Perry, Anthony C F

    Cell reports

    2023  Volume 42, Issue 2, Page(s) 112023

    Abstract: At the moment of union in fertilization, sperm and oocyte are transcriptionally silent. The ensuing onset of embryonic transcription (embryonic genome activation [EGA]) is critical for development, yet its timing and profile remain elusive in any ... ...

    Abstract At the moment of union in fertilization, sperm and oocyte are transcriptionally silent. The ensuing onset of embryonic transcription (embryonic genome activation [EGA]) is critical for development, yet its timing and profile remain elusive in any vertebrate species. We here dissect transcription during EGA by high-resolution single-cell RNA sequencing of precisely synchronized mouse one-cell embryos. This reveals a program of embryonic gene expression (immediate EGA [iEGA]) initiating within 4 h of fertilization. Expression during iEGA produces canonically spliced transcripts, occurs substantially from the maternal genome, and is mostly downregulated at the two-cell stage. Transcribed genes predict regulation by transcription factors (TFs) associated with cancer, including c-Myc. Blocking c-Myc or other predicted regulatory TF activities disrupts iEGA and induces acute developmental arrest. These findings illuminate intracellular mechanisms that regulate the onset of mammalian development and hold promise for the study of cancer.
    MeSH term(s) Male ; Animals ; Mice ; Embryo, Mammalian/metabolism ; Gene Expression Profiling ; Gene Expression Regulation, Developmental ; Semen ; Gene Expression ; Embryonic Development/genetics ; Mammals/genetics
    Language English
    Publishing date 2023-01-31
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2649101-1
    ISSN 2211-1247 ; 2211-1247
    ISSN (online) 2211-1247
    ISSN 2211-1247
    DOI 10.1016/j.celrep.2023.112023
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  9. Article ; Online: A program of successive gene expression in mouse one-cell embryos

    Maki Asami / Brian Y.H. Lam / Martin Hoffmann / Toru Suzuki / Xin Lu / Naoko Yoshida / Marcella K. Ma / Kara Rainbow / Miodrag Gužvić / Matthew D. VerMilyea / Giles S.H. Yeo / Christoph A. Klein / Anthony C.F. Perry

    Cell Reports, Vol 42, Iss 2, Pp 112023- (2023)

    2023  

    Abstract: Summary: At the moment of union in fertilization, sperm and oocyte are transcriptionally silent. The ensuing onset of embryonic transcription (embryonic genome activation [EGA]) is critical for development, yet its timing and profile remain elusive in ... ...

    Abstract Summary: At the moment of union in fertilization, sperm and oocyte are transcriptionally silent. The ensuing onset of embryonic transcription (embryonic genome activation [EGA]) is critical for development, yet its timing and profile remain elusive in any vertebrate species. We here dissect transcription during EGA by high-resolution single-cell RNA sequencing of precisely synchronized mouse one-cell embryos. This reveals a program of embryonic gene expression (immediate EGA [iEGA]) initiating within 4 h of fertilization. Expression during iEGA produces canonically spliced transcripts, occurs substantially from the maternal genome, and is mostly downregulated at the two-cell stage. Transcribed genes predict regulation by transcription factors (TFs) associated with cancer, including c-Myc. Blocking c-Myc or other predicted regulatory TF activities disrupts iEGA and induces acute developmental arrest. These findings illuminate intracellular mechanisms that regulate the onset of mammalian development and hold promise for the study of cancer.
    Keywords CP: Developmental biology ; Biology (General) ; QH301-705.5
    Subject code 572
    Language English
    Publishing date 2023-02-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: CD151 Maintains Endolysosomal Protein Quality to Inhibit Vascular Inflammation.

    Chen, Junxiong / Ding, Yingjun / Jiang, Chao / Qu, Rongmei / Wren, Jonathan D / Georgescu, Constantin / Wang, Xuejun / Reuter, Darlene N / Liu, Beibei / Giles, Cory B / Mayr, Christoph H / Schiller, Herbert B / Dai, Jingxing / Stipp, Christopher S / Subramaniyan, Bharathiraja / Wang, Jie / Zuo, Houjuan / Huang, Chao / Fung, Kar-Ming /
    Rice, Heather C / Sonnenberg, Arnoud / Wu, David / Walters, Matthew S / Zhao, You-Yang / Kanie, Tomoharu / Hays, Franklin A / Papin, James F / Wang, Dao Wen / Zhang, Xin A

    Circulation research

    2024  

    Abstract: Background: Tetraspanin CD151 is highly expressed in endothelia and reinforces cell adhesion, but its role in vascular inflammation remains largely unknown.: Methods: In vitro molecular and cellular biological analyses on genetically modified ... ...

    Abstract Background: Tetraspanin CD151 is highly expressed in endothelia and reinforces cell adhesion, but its role in vascular inflammation remains largely unknown.
    Methods: In vitro molecular and cellular biological analyses on genetically modified endothelial cells, in vivo vascular biological analyses on genetically engineered mouse models, and in silico systems biology and bioinformatics analyses on CD151-related events.
    Results: Endothelial ablation of
    Conclusions: Distinct from its canonical function in strengthening cell adhesion at cell surface, CD151 maintains endolysosome function by sustaining VCP/p97-mediated protein unfolding and turnover. By supporting protein quality control and protein degradation, CD151 prevents proteins from (1) buildup in endolysosomes and (2) discharge through exosomes, to limit vascular inflammation. Also, our study conceptualizes that balance between degradation and discharge of proteins in endothelial cells determines vascular information. Thus, the IFITM3/V-ATPase-tetraspanin-VCP/p97 complexes on endolysosome, as a protein quality control and inflammation-inhibitory machinery, could be beneficial for therapeutic intervention against vascular inflammation.
    Language English
    Publishing date 2024-04-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80100-8
    ISSN 1524-4571 ; 0009-7330 ; 0931-6876
    ISSN (online) 1524-4571
    ISSN 0009-7330 ; 0931-6876
    DOI 10.1161/CIRCRESAHA.123.323190
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