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  1. Article ; Online: Preventing dementia through correcting hearing: huge progress but more to do.

    Livingston, Gill / Costafreda, Sergi

    publication RETRACTED

    The Lancet. Public health

    2023  Volume 8, Issue 5, Page(s) e319–e320

    MeSH term(s) Humans ; Dementia/epidemiology ; Dementia/prevention & control ; Hearing
    Language English
    Publishing date 2023-04-14
    Publishing country England
    Document type Journal Article ; Comment ; Retracted Publication
    ISSN 2468-2667
    ISSN (online) 2468-2667
    DOI 10.1016/S2468-2667(23)00058-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Interventions to prevent dementia should target those at high risk.

    Livingston, Gill / Costafreda, Sergi G

    Lancet (London, England)

    2023  Volume 402, Issue 10404, Page(s) 750–751

    MeSH term(s) Humans ; Dementia/prevention & control ; Risk Factors
    Language English
    Publishing date 2023-07-18
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/S0140-6736(23)01472-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Health conditions linked to heightened risk of Alzheimer's disease.

    Kivimäki, Mika / Livingston, Gill

    The Lancet. Digital health

    2022  Volume 4, Issue 3, Page(s) e150–e151

    MeSH term(s) Alzheimer Disease/etiology ; Humans ; Risk Factors
    Language English
    Publishing date 2022-02-24
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ISSN 2589-7500
    ISSN (online) 2589-7500
    DOI 10.1016/S2589-7500(21)00293-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Implementation should now be considered in parallel with designing clinical research.

    Livingston, Gill / Rapaport, Penny

    International psychogeriatrics

    2020  Volume 32, Issue 12, Page(s) 1393–1395

    MeSH term(s) Dementia ; Humans ; Research Design ; United Kingdom
    Language English
    Publishing date 2020-12-30
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 1038825-4
    ISSN 1741-203X ; 1041-6102
    ISSN (online) 1741-203X
    ISSN 1041-6102
    DOI 10.1017/S1041610220001064
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: The Association Between Impaired Awareness and Depression, Anxiety, and Apathy in Mild to Moderate Alzheimer's Disease: A Systematic Review.

    Azocar, Ignacia / Livingston, Gill / Huntley, Jonathan

    Frontiers in psychiatry

    2021  Volume 12, Page(s) 633081

    Abstract: Objectives: ...

    Abstract Objectives:
    Language English
    Publishing date 2021-02-04
    Publishing country Switzerland
    Document type Systematic Review
    ZDB-ID 2564218-2
    ISSN 1664-0640
    ISSN 1664-0640
    DOI 10.3389/fpsyt.2021.633081
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Experience of UK Latin Americans caring for a relative living with dementia: A qualitative study of family carers.

    Guerra, Stefanny / James, Tiffeny / Rapaport, Penny / Livingston, Gill

    Dementia (London, England)

    2022  Volume 21, Issue 5, Page(s) 1574–1595

    Abstract: Introduction: Most studies of the Latin American immigrant experience and care for relatives living with dementia have been in the United States (US). In the United Kingdom (UK), unlike the US, most Latin Americans are first generation immigrants and ... ...

    Abstract Introduction: Most studies of the Latin American immigrant experience and care for relatives living with dementia have been in the United States (US). In the United Kingdom (UK), unlike the US, most Latin Americans are first generation immigrants and are a rapidly increasing population. Therefore, we aimed to explore the UK experiences of Latin Americans caring for a relative with dementia.
    Methods: We purposively recruited UK-based Latin American family carers of people with dementia ensuring maximum diversity. We conducted semi-structured qualitative interviews (in English or Spanish) with 11 family carers, stopping recruiting when we reached thematic saturation. We took an inductive thematic analytic approach.
    Findings: Four main themes were identified: (1) Family comes first, particularly older people, leading to an obligation to care; (2) dementia as an illness that is accepted and talked about, which is regarded as positive with close networks but not wider society; (3) difficult behaviours are not the responsibility of the person with dementia, who is often conceptualised as a child; and (4) caring expectations lead to incompatibility with formal services, and a reluctance to leave people with dementia alone.
    Conclusions: Familial obligation is the driver for family carers and acceptance of the illness helped despite adversities. Openness to talk about dementia with close networks was distinctive and helpful, contrasting with wider society, where greater awareness of dementia is needed. Considering the person with dementia as a child did not seem to undermine personhood and enabled maintenance of compassion. The relative with dementia was a priority. There was a lack of culturally and linguistically appropriate services, thus restricting family carers' ability to fulfil other roles, such as parental.
    MeSH term(s) Aged ; Caregivers ; Dementia ; Humans ; Qualitative Research ; United Kingdom
    Language English
    Publishing date 2022-04-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 2084045-7
    ISSN 1741-2684 ; 1471-3012
    ISSN (online) 1741-2684
    ISSN 1471-3012
    DOI 10.1177/14713012221076954
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Mild Traumatic Brain Injuries and Future Risk of Developing Alzheimer's Disease: Systematic Review and Meta-Analysis.

    Graham, Alicia / Livingston, Gill / Purnell, Lucy / Huntley, Jonathan

    Journal of Alzheimer's disease : JAD

    2022  Volume 87, Issue 3, Page(s) 969–979

    Abstract: Background: Traumatic brain injury (TBI) increases the risk of future dementia and Alzheimer's disease (AD). However, it is unclear whether this is true for mild TBI (mTBI).: Objective: To explore the association between mTBI and subsequent risk of ... ...

    Abstract Background: Traumatic brain injury (TBI) increases the risk of future dementia and Alzheimer's disease (AD). However, it is unclear whether this is true for mild TBI (mTBI).
    Objective: To explore the association between mTBI and subsequent risk of developing AD.
    Method: We systematically searched four electronic databases from January 1954 to April 2020. We included studies reporting primary data and where mTBI preceded AD by≥5 years. We meta-analyzed included studies for both high quality studies and studies with a follow up of > 10 years.
    Result: We included 5 of the 10,435 results found. Meta-analysis found a history of mTBI increased risk of AD (pooled relative risk = 1.18, 95% CI 1.11-1.25, N = 3,149,740). The sensitivity analysis including only studies in which mTBI preceded AD by > 10 years, excluded two very large studies and resulted in wider confidence intervals (RR = 2.02, 95% CI 0.66-6.21, N = 2307).
    Conclusion: There is an increased risk of AD following mTBI. Our findings of increased risk even with mTBI means it cannot be assumed that mild head injuries from sports are harmless. The sensitivity analysis suggests that we cannot exclude reverse causation, and longer follow up times are needed. Implementation of policy to reduce mTBIs, including in children and sportsmen, are urgently needed. Further research is needed on the effect of frequency and age at injury of mTBIs.
    MeSH term(s) Alzheimer Disease/epidemiology ; Alzheimer Disease/etiology ; Brain Concussion/complications ; Brain Concussion/epidemiology ; Brain Injuries, Traumatic/complications ; Brain Injuries, Traumatic/epidemiology ; Humans ; Risk
    Language English
    Publishing date 2022-05-02
    Publishing country Netherlands
    Document type Meta-Analysis ; Systematic Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 1440127-7
    ISSN 1875-8908 ; 1387-2877
    ISSN (online) 1875-8908
    ISSN 1387-2877
    DOI 10.3233/JAD-220069
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Minimum clinically important difference of the Social Functioning in Dementia Scale (SF-DEM): cross-sectional study and Delphi survey.

    Levene, Tamara / Livingston, Gill / Banerjee, Sube / Sommerlad, Andrew

    BMJ open

    2022  Volume 12, Issue 3, Page(s) e058252

    Abstract: Objectives: Good social functioning is important for people living with dementia and their families. The Social Functioning in Dementia Scale (SF-DEM) is a valid and reliable instrument measuring social functioning in dementia. However the minimum ... ...

    Abstract Objectives: Good social functioning is important for people living with dementia and their families. The Social Functioning in Dementia Scale (SF-DEM) is a valid and reliable instrument measuring social functioning in dementia. However the minimum clinically important difference (MCID) has not yet been derived for SF-DEM. This study aims to define the MCID for the SF-DEM.
    Design: We used triangulation, incorporating data from a cross-sectional study to calculate the MCID using distribution-based and anchor-based methods, and a Delphi survey.
    Setting and participants: The cross-sectional survey comprised 299 family carers of people with dementia. Twenty dementia experts (researchers, clinicians, family carers) rated whether changes on clinical vignettes represented a meaningful change in the Delphi survey.
    Primary outcome measures: We calculated the distribution-based MCID as 0.5 of an SD for each of the three SF-DEM domains (1-spending time with others, 2-communicating with others, 3-sensitivity to others). We used the carers' rating of social functioning to calculate the anchor-based MCID. For the Delphi survey, we defined consensus as ≥75% agreement. Where there was lack of consensus, experts were asked to complete a further survey round.
    Results: We found that 0.5 SD of SF-DEM was 1.9 points, 2.2 and 1.4 points in domains 1, 2 and 3, respectively. Using the anchoring analysis, the MCIDs were 1.7 points, 1.7 points, and 0.9 points in domains 1, 2 and 3, respectively. The Delphi method required two rounds. In the second round, a consensus was reached that a 2-point change was considered significant in all three domains, but no consensus was reached on a 1-point change.
    Conclusions: By triangulating all three methods, the SF-DEM's MCIDs were 1.9, 2.0 and 1.4 points for domains 1, 2 and 3, respectively. For individuals, these values should be rounded to a 2-point change for each domain.
    MeSH term(s) Cross-Sectional Studies ; Dementia/diagnosis ; Humans ; Minimal Clinically Important Difference ; Social Interaction ; Surveys and Questionnaires
    Language English
    Publishing date 2022-03-29
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2599832-8
    ISSN 2044-6055 ; 2044-6055
    ISSN (online) 2044-6055
    ISSN 2044-6055
    DOI 10.1136/bmjopen-2021-058252
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  9. Article ; Online: Risk factors, ethnicity and dementia: A UK Biobank prospective cohort study of White, South Asian and Black participants.

    Mukadam, Naaheed / Marston, Louise / Lewis, Gemma / Livingston, Gill

    PloS one

    2022  Volume 17, Issue 10, Page(s) e0275309

    Abstract: Background: Our knowledge of the effect of potentially modifiable risks factors on people developing dementia is mostly from European origin populations. We aimed to explore if these risk factors had similar effects in United Kingdom (UK) White, South ... ...

    Abstract Background: Our knowledge of the effect of potentially modifiable risks factors on people developing dementia is mostly from European origin populations. We aimed to explore if these risk factors had similar effects in United Kingdom (UK) White, South Asian and Black UK Biobank participants recruited from 2006-2010 and followed up until 2020.
    Methods: We reviewed the literature to 25.09.2020 for meta-analyses identifying potentially modifiable risk factors preceding dementia diagnosis by ≥10 years. We calculated prevalence of each identified risk factor and association with dementia for participants aged ≥55 at registration in UK Biobank. We calculated hazard ratios using Cox regression for each risk factor, stratified by ethnic group, and tested for differences using interaction effects between each risk factor and ethnicity.
    Findings: We included education, hearing loss, hypertension, obesity, excess alcohol consumption, physical inactivity, smoking, high total cholesterol, depression, diabetes, social isolation, and air pollution as risks. Out of 294,162 participants, there were 287,806 White, 3590 South Asian and 2766 Black people, followed up for up to 14.8 years, with a total follow-up time of 3,392,095 years. During follow-up, 5,972 people (2.03%) developed dementia. Risk of dementia was higher in Black participants than White participants (HR for dementia compared to White participants as reference 1.43, 95% CI 1.16-1.77, p = 0.001) but South Asians had a similar risk. Association between each risk factor and dementia was similar in each ethnic group with no evidence to support any differences.
    Interpretation: We find that Black participants were more likely to develop dementia than White participants, but South Asians were not. Identified risk factors in White European origin participants had a similar effect in Black and South Asian origin participants. Volunteers in UK Biobank are not representative of the population and interaction effects were underpowered so further work is needed.
    MeSH term(s) Biological Specimen Banks ; Cholesterol ; Dementia/epidemiology ; Dementia/etiology ; Ethnicity ; Humans ; Prospective Studies ; Risk Factors ; United Kingdom/epidemiology ; White People
    Chemical Substances Cholesterol (97C5T2UQ7J)
    Language English
    Publishing date 2022-10-12
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0275309
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  10. Article ; Online: Socially assistive robots for people with dementia: Systematic review and meta-analysis of feasibility, acceptability and the effect on cognition, neuropsychiatric symptoms and quality of life.

    Yu, Clare / Sommerlad, Andrew / Sakure, Lena / Livingston, Gill

    Ageing research reviews

    2022  Volume 78, Page(s) 101633

    Abstract: Background: There is increasing interest in using robots to support dementia care but little consensus on the evidence for their use. The aim of the study is to review evidence about feasibility, acceptability and clinical effectiveness of socially ... ...

    Abstract Background: There is increasing interest in using robots to support dementia care but little consensus on the evidence for their use. The aim of the study is to review evidence about feasibility, acceptability and clinical effectiveness of socially assistive robots used for people with dementia.
    Method: We conducted a systematic review and meta-analysis. We searched MEDLINE, EMBASE, PsychINFO, CINHAL, IEEE Xplore Digital Library, and EI Engineering Village from inception to 04 - 02-2022 - included primary studies assessing feasibility, acceptability, or effectiveness of socially assistive robots for people with dementia. Two independent reviewers screened studies for eligibility, and assessed quality. Narrative synthesis prioritized higher quality studies, and random-effect meta-analyses compared robots with usual care (UC) or active control (AC) immediately after the intervention (short-term; ST) or long-term (LT) on cognition, neuropsychiatric symptoms, and quality of life.
    Findings: 66 studies and four categories of robots were eligible: Companion robots (Pet and humanoid companion robots), telepresence communication robots, homecare assistive robots and multifunctional robots. PARO (companion robot seal) was feasible and acceptable but limited by its weight, cost, and sound. On meta-analysis, PARO had no ST or LT compared to UC or AC over 5-12 weeks on agitation (ST vs UC, 4 trials, 153 participants: pooled standardized mean difference (SMD) 0.25; - 0.57 to 0.06; LT vs UC; 2 trials, 77 participants, SMD = -0.24; - 0.94, 0.46), cognition (ST vs UC, 3 trials, 128 participants: SMD= 0.03; -0.32, 0.38), overall neuropsychiatric symptoms (ST vs UC, 3 trials, 169 participants: SMD= -0.01; -0.32, 0.29; ST vs AC, 2 trials, 145 participants: SMD =0.02, -0.71, 0.85), apathy (ST vs AC, 2 trials, 81 participants: SMD= 0.14; 0.29, 0.58), depression (ST vs UC, 4 trials, 181 participants; SMD= 0.08; -0.52, 0.69; LT vs UC: 2 trials, 77 participants: SMD =0.01; -0.75, 0.77), anxiety (ST vs UC: 2 trials, 104 participants, SMD= 0.24; -0.85, 1.33) and quality of life (ST vs UC, 2 trials, 127 participants: SMD=-0.05; -0.52, 0.42; ST vs AC: 2 trials, 159 participants, SMD =-0.36, -0.76, 0.05). Robotic animals, humanoid companion robots, telepresence robots and multifunctional robots were feasible and acceptable. However, humanoid companion robots have speech recognition problems, and telepresence robots and multifunctional robots were often difficult to use. There was mixed evidence about the feasibility of homecare robots. There was little evidence on any of these robots' effectiveness.
    Conclusion: Although robots were generally feasible and acceptable, there is no clear evidence that people with dementia derive benefit from robots for cognition, neuropsychiatric symptoms, or quality of life. We recommend that future research should use high quality designs to establish evidence of effectiveness.
    MeSH term(s) Animals ; Cognition ; Dementia/psychology ; Dementia/therapy ; Feasibility Studies ; Humans ; Quality of Life ; Robotics
    Language English
    Publishing date 2022-04-21
    Publishing country England
    Document type Journal Article ; Meta-Analysis ; Review ; Systematic Review
    ZDB-ID 2075672-0
    ISSN 1872-9649 ; 1568-1637
    ISSN (online) 1872-9649
    ISSN 1568-1637
    DOI 10.1016/j.arr.2022.101633
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